JP5847193B2 - フラビウイルス科ウイルスの大環状インヒビター - Google Patents
フラビウイルス科ウイルスの大環状インヒビター Download PDFInfo
- Publication number
- JP5847193B2 JP5847193B2 JP2013543356A JP2013543356A JP5847193B2 JP 5847193 B2 JP5847193 B2 JP 5847193B2 JP 2013543356 A JP2013543356 A JP 2013543356A JP 2013543356 A JP2013543356 A JP 2013543356A JP 5847193 B2 JP5847193 B2 JP 5847193B2
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- aryl
- mmol
- another aspect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*Cc1cccc(*)c1 Chemical compound C*Cc1cccc(*)c1 0.000 description 2
- XYOCSQHMQWOROK-MPIIZNPZSA-N CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(O[C@H](C)C/C=C/C=C/[C@@H]([C@H](C)[C@H]([C@H]1C)OC)OC)=O)=O)=O)NC1=O Chemical compound CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(O[C@H](C)C/C=C/C=C/[C@@H]([C@H](C)[C@H]([C@H]1C)OC)OC)=O)=O)=O)NC1=O XYOCSQHMQWOROK-MPIIZNPZSA-N 0.000 description 2
- IHKOXYNAMXNNDK-OLQVQODUSA-N C(CO1)[C@H]2[C@@H]1OCC2 Chemical compound C(CO1)[C@H]2[C@@H]1OCC2 IHKOXYNAMXNNDK-OLQVQODUSA-N 0.000 description 1
- IJHLLIALDYFXDW-LBPRGKRZSA-N C=Cc1cc(COC([C@H]2NNCCC2)=O)ncc1 Chemical compound C=Cc1cc(COC([C@H]2NNCCC2)=O)ncc1 IJHLLIALDYFXDW-LBPRGKRZSA-N 0.000 description 1
- DPYKQSSFSGGSNT-LSDHHAIUSA-N C=Cc1cc([C@@H](CC2)OC([C@H]3NNCCC3)=O)c2cc1 Chemical compound C=Cc1cc([C@@H](CC2)OC([C@H]3NNCCC3)=O)c2cc1 DPYKQSSFSGGSNT-LSDHHAIUSA-N 0.000 description 1
- GZCKKRLSAWJOEU-DQEYMECFSA-N CC(C)(C)[Si+](C)(C)Oc1cc(C[C@@H](C(N(CCC2)N[C@@H]2C(OCC(Cl)(Cl)Cl)=O)=O)NC(C(NC(CCC=C)=O)=C(C)C)=O)ccc1 Chemical compound CC(C)(C)[Si+](C)(C)Oc1cc(C[C@@H](C(N(CCC2)N[C@@H]2C(OCC(Cl)(Cl)Cl)=O)=O)NC(C(NC(CCC=C)=O)=C(C)C)=O)ccc1 GZCKKRLSAWJOEU-DQEYMECFSA-N 0.000 description 1
- LHNBIZZXPFDYNG-AZUAFQIBSA-N CC(C)C(C(NC(Cc1cc(O)ccc1)C(N(CCC1)N[C@@H]1C(N[C@H](C)c1cc(/C=C/CC[C@H]([C@H]2C)OC)ccc1)=O)=O)=O)NC2=O Chemical compound CC(C)C(C(NC(Cc1cc(O)ccc1)C(N(CCC1)N[C@@H]1C(N[C@H](C)c1cc(/C=C/CC[C@H]([C@H]2C)OC)ccc1)=O)=O)=O)NC2=O LHNBIZZXPFDYNG-AZUAFQIBSA-N 0.000 description 1
- MNIHBMWGOKKPBZ-JWDFLIAJSA-N CC(C)C(C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(OCCCCC=C)=O)=O)=O)NC(OC(C)(C)C)=O Chemical compound CC(C)C(C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(OCCCCC=C)=O)=O)=O)NC(OC(C)(C)C)=O MNIHBMWGOKKPBZ-JWDFLIAJSA-N 0.000 description 1
- LRSOWJILQYJFLB-VYRBHSGPSA-N CC(C)C(C(N[C@@H](Cc1cccc(O)c1)C(NNC)=O)=O)NC(OC(C)(C)C)=O Chemical compound CC(C)C(C(N[C@@H](Cc1cccc(O)c1)C(NNC)=O)=O)NC(OC(C)(C)C)=O LRSOWJILQYJFLB-VYRBHSGPSA-N 0.000 description 1
- GHRFKOYJXBWCID-PFIFLBKHSA-N CC(C)[C@@H](C(NC(Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(OCc1cc(C=C)ccc1)=O)=O)=O)N Chemical compound CC(C)[C@@H](C(NC(Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(OCc1cc(C=C)ccc1)=O)=O)=O)N GHRFKOYJXBWCID-PFIFLBKHSA-N 0.000 description 1
- YTSTXQUADYXTMD-DUOPKSOCSA-N CC(C)[C@@H](C(NC(Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(O[C@H](C)c1cc(/C=C/CC[C@H](C2)OC)ccc1)=O)=O)=O)NC2=O Chemical compound CC(C)[C@@H](C(NC(Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(O[C@H](C)c1cc(/C=C/CC[C@H](C2)OC)ccc1)=O)=O)=O)NC2=O YTSTXQUADYXTMD-DUOPKSOCSA-N 0.000 description 1
- ZITOUAAPSZMHQW-QMMMGPOBSA-N CC(C)[C@@H](C(NC)=O)NC(OC(C)(C)C)=O Chemical compound CC(C)[C@@H](C(NC)=O)NC(OC(C)(C)C)=O ZITOUAAPSZMHQW-QMMMGPOBSA-N 0.000 description 1
- FNALJKSNELYISB-UPJWGTAASA-N CC(C)[C@@H](C(NC)=O)NC([C@H](C)[C@@H](CCC=C)OC)=O Chemical compound CC(C)[C@@H](C(NC)=O)NC([C@H](C)[C@@H](CCC=C)OC)=O FNALJKSNELYISB-UPJWGTAASA-N 0.000 description 1
- TUUMLKLSQPDNQA-GAILPJNOSA-N CC(C)[C@@H](C(N[C@@H](CC(C=CC1)=CC1O)C(N(CCC1)N[C@@H]1C(OCC/C=C/CCCC[C@H]([C@H]1C)OC)=O)=O)=O)NC1=O Chemical compound CC(C)[C@@H](C(N[C@@H](CC(C=CC1)=CC1O)C(N(CCC1)N[C@@H]1C(OCC/C=C/CCCC[C@H]([C@H]1C)OC)=O)=O)=O)NC1=O TUUMLKLSQPDNQA-GAILPJNOSA-N 0.000 description 1
- KQFGNTNWKMSXJC-BSBJMCSASA-N CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)NC1C(OCCCCC=C)=O)=O)=O)NC([C@H](C)[C@@H](CCC=C)OC)=O Chemical compound CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)NC1C(OCCCCC=C)=O)=O)=O)NC([C@H](C)[C@@H](CCC=C)OC)=O KQFGNTNWKMSXJC-BSBJMCSASA-N 0.000 description 1
- AUWZUEKUKUVCMS-NUWYFAHDSA-N CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(OCCCC/C=C/CCC([C@H]1C)OC)=O)=O)=O)NC1=O Chemical compound CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(OCCCC/C=C/CCC([C@H]1C)OC)=O)=O)=O)NC1=O AUWZUEKUKUVCMS-NUWYFAHDSA-N 0.000 description 1
- SDVRVWXKFPHKSR-IBVKFTFISA-N CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(O[C@H](C)c1cc(/C=C/CC[C@H]([C@H]2C)OC)ccc1)=O)=O)=O)NC2=O Chemical compound CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(O[C@H](C)c1cc(/C=C/CC[C@H]([C@H]2C)OC)ccc1)=O)=O)=O)NC2=O SDVRVWXKFPHKSR-IBVKFTFISA-N 0.000 description 1
- GOAUAWKTCBFLPO-PCZSZCCUSA-N CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(O[C@H]1c2cc(/C=C/CC[C@H]([C@H]3C)OC)ccc2CC1)=O)=O)=O)NC3=O Chemical compound CC(C)[C@@H](C(N[C@@H](Cc1cccc(O)c1)C(N(CCC1)N[C@@H]1C(O[C@H]1c2cc(/C=C/CC[C@H]([C@H]3C)OC)ccc2CC1)=O)=O)=O)NC3=O GOAUAWKTCBFLPO-PCZSZCCUSA-N 0.000 description 1
- MXCXJUNCZQIVDC-SDHOMARFSA-N CC(C)[C@@H](C(N[C@@H](Cc1cccc(O[Si+](C)(C)C(C)(C)C)c1)C(N(CCC1)N[C@@H]1C(OCC(Cl)(Cl)Cl)=O)=O)=O)NC(OC(C)(C)C)=O Chemical compound CC(C)[C@@H](C(N[C@@H](Cc1cccc(O[Si+](C)(C)C(C)(C)C)c1)C(N(CCC1)N[C@@H]1C(OCC(Cl)(Cl)Cl)=O)=O)=O)NC(OC(C)(C)C)=O MXCXJUNCZQIVDC-SDHOMARFSA-N 0.000 description 1
- VVSFHHBZPDOSFQ-ARVWSKGKSA-N CC(C)[C@@H](C(N[C@@H](Cc1cccc(O[Si+](C)(C)C(C)(C)C)c1)C(N(CCC1)N[C@@H]1C(OCc1nccc(C=C)c1)=O)=O)=O)NC([C@H](C)[C@@H](CCC=C)OC)=O Chemical compound CC(C)[C@@H](C(N[C@@H](Cc1cccc(O[Si+](C)(C)C(C)(C)C)c1)C(N(CCC1)N[C@@H]1C(OCc1nccc(C=C)c1)=O)=O)=O)NC([C@H](C)[C@@H](CCC=C)OC)=O VVSFHHBZPDOSFQ-ARVWSKGKSA-N 0.000 description 1
- WPBKXFHONNKPJX-PRGBWPFRSA-N CCO[C@H](CC/C=C/c1cccc(COC([C@H](CCC2)NN2C(C(Cc2cccc(O)c2)NC([C@H](C(C)C)N2)=O)=O)=O)c1)[C@@H](C)C2=O Chemical compound CCO[C@H](CC/C=C/c1cccc(COC([C@H](CCC2)NN2C(C(Cc2cccc(O)c2)NC([C@H](C(C)C)N2)=O)=O)=O)c1)[C@@H](C)C2=O WPBKXFHONNKPJX-PRGBWPFRSA-N 0.000 description 1
- NZVAKURDAGNLAC-RBLIBLIBSA-N CCO[C@H](CCC=C)[C@@H](C)C(N([C@@H](CC1CC2)[C@@]3(C4)C12C3(C)C)S4(=O)=O)=O Chemical compound CCO[C@H](CCC=C)[C@@H](C)C(N([C@@H](CC1CC2)[C@@]3(C4)C12C3(C)C)S4(=O)=O)=O NZVAKURDAGNLAC-RBLIBLIBSA-N 0.000 description 1
- NYOHQGZFGKNHCG-QMUBTCOLSA-N C[C@H]([C@@H](CCC=C)O)C(N([C@@H](CC1CC2)[C@@]3(C4)C12C3(C)C)S4(=O)=O)=O Chemical compound C[C@H]([C@@H](CCC=C)O)C(N([C@@H](CC1CC2)[C@@]3(C4)C12C3(C)C)S4(=O)=O)=O NYOHQGZFGKNHCG-QMUBTCOLSA-N 0.000 description 1
- SEQHEDQNODAFIU-UHFFFAOYSA-N O=C1c2cc(Br)ccc2CC1 Chemical compound O=C1c2cc(Br)ccc2CC1 SEQHEDQNODAFIU-UHFFFAOYSA-N 0.000 description 1
- DXVPKKRFBPLRRN-SECBINFHSA-N O[C@H]1c2cc(Br)ccc2CC1 Chemical compound O[C@H]1c2cc(Br)ccc2CC1 DXVPKKRFBPLRRN-SECBINFHSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42207110P | 2010-12-10 | 2010-12-10 | |
| US61/422,071 | 2010-12-10 | ||
| PCT/US2011/064009 WO2012078915A1 (en) | 2010-12-10 | 2011-12-08 | Macrocyclic inhibitors of flaviviridae viruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503516A JP2014503516A (ja) | 2014-02-13 |
| JP2014503516A5 JP2014503516A5 (enExample) | 2015-01-29 |
| JP5847193B2 true JP5847193B2 (ja) | 2016-01-20 |
Family
ID=45464097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543356A Expired - Fee Related JP5847193B2 (ja) | 2010-12-10 | 2011-12-08 | フラビウイルス科ウイルスの大環状インヒビター |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8513184B2 (enExample) |
| EP (1) | EP2649076B1 (enExample) |
| JP (1) | JP5847193B2 (enExample) |
| KR (1) | KR20140031841A (enExample) |
| CN (1) | CN103403009B (enExample) |
| AR (1) | AR084217A1 (enExample) |
| AU (1) | AU2011338262B2 (enExample) |
| BR (1) | BR112013014063A2 (enExample) |
| CA (1) | CA2819824A1 (enExample) |
| EA (1) | EA026114B1 (enExample) |
| ES (1) | ES2536321T3 (enExample) |
| IL (1) | IL226739A (enExample) |
| MX (1) | MX2013006475A (enExample) |
| NZ (1) | NZ612159A (enExample) |
| PL (1) | PL2649076T3 (enExample) |
| PT (1) | PT2649076E (enExample) |
| PY (1) | PY1153144A (enExample) |
| SI (1) | SI2649076T1 (enExample) |
| TW (1) | TWI520966B (enExample) |
| UY (1) | UY33775A (enExample) |
| WO (1) | WO2012078915A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015518904A (ja) * | 2012-06-08 | 2015-07-06 | ギリアード サイエンシーズ， インコーポレイテッド | フラビウイルス科ウイルスの大環状阻害剤 |
| JP2015525221A (ja) * | 2012-06-08 | 2015-09-03 | ギリアード サイエンシーズ， インコーポレイテッド | フラビウイルス科ウイルスの大環状阻害剤 |
| JP2015525220A (ja) * | 2012-06-08 | 2015-09-03 | ギリアード サイエンシーズ， インコーポレイテッド | フラビウイルス科ウイルスの大環状阻害剤 |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014370125B2 (en) * | 2013-12-23 | 2017-11-16 | Gilead Sciences, Inc. | Synthesis of a macrocyclic HCV NS3 inhibiting tripeptide |
| SG11201701520TA (en) | 2014-09-16 | 2017-04-27 | Gilead Sciences Inc | Solid forms of a toll-like receptor modulator |
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| US9670205B2 (en) | 2015-03-04 | 2017-06-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US20210292327A1 (en) | 2015-08-26 | 2021-09-23 | Gilead Sciences, Inc. | Deuterated toll-like receptor modulators |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| EA201892375A1 (ru) | 2016-05-27 | 2019-08-30 | Джилид Сайэнс, Инк. | Способы лечения инфекций, вызываемых вирусом гепатита b |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| AU2017318601B2 (en) | 2016-09-02 | 2020-09-03 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| KR20230010826A (ko) | 2016-10-14 | 2023-01-19 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| TW202510891A (zh) | 2017-01-31 | 2025-03-16 | 美商基利科學股份有限公司 | 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型 |
| UY37581A (es) | 2017-02-02 | 2018-08-31 | Gilead Sciences Inc | Compuestos para el tratamiento de la infección por virus de la hepatitis b |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| CN111051305A (zh) | 2017-08-22 | 2020-04-21 | 吉利德科学公司 | 治疗性杂环化合物 |
| PT3706762T (pt) | 2017-12-07 | 2024-12-05 | Univ Emory | N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| US10870691B2 (en) | 2018-04-05 | 2020-12-22 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis B virus protein X |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| AU2019297362B2 (en) | 2018-07-06 | 2022-05-26 | Gilead Sciences, Inc. | Therapeutic heterocyclic compounds |
| US11186579B2 (en) | 2018-07-06 | 2021-11-30 | Gilead Sciences, Inc. | Therapeutic heterocyclic compounds |
| SG11202012425QA (en) | 2018-07-13 | 2021-01-28 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| WO2020178770A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI810456B (zh) | 2019-05-22 | 2023-08-01 | 美商基利科學股份有限公司 | Tlr7調節化合物及hiv疫苗之組合 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| CA3140708A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| WO2020263830A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
| US20220257619A1 (en) | 2019-07-18 | 2022-08-18 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| DK4037708T3 (da) | 2019-09-30 | 2024-09-30 | Gilead Sciences Inc | HBV-vacciner og fremgangsmåder til at behandle HBV |
| TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| IL322454A (en) | 2019-11-04 | 2025-09-01 | Revolution Medicines Inc | ras inhibitors |
| AU2020377925A1 (en) | 2019-11-04 | 2022-05-05 | Revolution Medicines, Inc. | Ras inhibitors |
| DK4069729T3 (da) | 2019-12-06 | 2025-04-07 | Prec Biosciences Inc | Optimerede, modificerede meganukleaser med specificitet for en genkendelsessekvens i hepatitis b-virusgenomet |
| WO2021188959A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| EP4192474B1 (en) | 2020-08-07 | 2025-09-10 | Gilead Sciences, Inc. | Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use |
| CA3194067A1 (en) | 2020-09-15 | 2022-03-24 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| KR20240017811A (ko) | 2021-05-05 | 2024-02-08 | 레볼루션 메디슨즈, 인크. | 암의 치료를 위한 ras 억제제 |
| WO2022241134A1 (en) | 2021-05-13 | 2022-11-17 | Gilead Sciences, Inc. | COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| MX2023014762A (es) | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN114796193B (zh) * | 2022-05-13 | 2023-07-18 | 黑龙江八一农垦大学 | 抗牛病毒性腹泻病毒的中药单体 |
| WO2025240243A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with bulevirtide and an inhibitory nucleic acid targeting hepatitis b virus |
| WO2025240244A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR006514A1 (es) | 1995-07-04 | 1999-09-08 | Sandoz Ag | Un macrolido, sus usos, un proceso para producirlo, un aislado biologicamente puro capaz de producirlo, y una composicion farmaceutica quelo comprende |
| US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| AU2006259348B2 (en) * | 2005-06-17 | 2010-07-22 | Novartis Ag | Use of sanglifehrin in HCV |
-
2011
- 2011-12-07 PY PY201101153144A patent/PY1153144A/es unknown
- 2011-12-07 UY UY0001033775A patent/UY33775A/es not_active Application Discontinuation
- 2011-12-07 AR ARP110104596A patent/AR084217A1/es unknown
- 2011-12-08 AU AU2011338262A patent/AU2011338262B2/en not_active Ceased
- 2011-12-08 SI SI201130434T patent/SI2649076T1/sl unknown
- 2011-12-08 EA EA201390822A patent/EA026114B1/ru not_active IP Right Cessation
- 2011-12-08 EP EP11805697.7A patent/EP2649076B1/en active Active
- 2011-12-08 KR KR1020137017607A patent/KR20140031841A/ko not_active Abandoned
- 2011-12-08 PT PT118056977T patent/PT2649076E/pt unknown
- 2011-12-08 JP JP2013543356A patent/JP5847193B2/ja not_active Expired - Fee Related
- 2011-12-08 WO PCT/US2011/064009 patent/WO2012078915A1/en not_active Ceased
- 2011-12-08 PL PL11805697T patent/PL2649076T3/pl unknown
- 2011-12-08 US US13/315,069 patent/US8513184B2/en not_active Expired - Fee Related
- 2011-12-08 MX MX2013006475A patent/MX2013006475A/es active IP Right Grant
- 2011-12-08 CA CA2819824A patent/CA2819824A1/en not_active Abandoned
- 2011-12-08 BR BR112013014063A patent/BR112013014063A2/pt not_active IP Right Cessation
- 2011-12-08 ES ES11805697.7T patent/ES2536321T3/es active Active
- 2011-12-08 NZ NZ612159A patent/NZ612159A/en not_active IP Right Cessation
- 2011-12-08 CN CN201180066396.4A patent/CN103403009B/zh not_active Expired - Fee Related
- 2011-12-09 TW TW100145540A patent/TWI520966B/zh not_active IP Right Cessation
-
2013
- 2013-06-04 IL IL226739A patent/IL226739A/en active IP Right Grant
- 2013-07-15 US US13/942,501 patent/US8933015B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015518904A (ja) * | 2012-06-08 | 2015-07-06 | ギリアード サイエンシーズ， インコーポレイテッド | フラビウイルス科ウイルスの大環状阻害剤 |
| JP2015525221A (ja) * | 2012-06-08 | 2015-09-03 | ギリアード サイエンシーズ， インコーポレイテッド | フラビウイルス科ウイルスの大環状阻害剤 |
| JP2015525220A (ja) * | 2012-06-08 | 2015-09-03 | ギリアード サイエンシーズ， インコーポレイテッド | フラビウイルス科ウイルスの大環状阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2536321T3 (es) | 2015-05-22 |
| EA026114B1 (ru) | 2017-03-31 |
| JP2014503516A (ja) | 2014-02-13 |
| EA201390822A1 (ru) | 2013-12-30 |
| PY1153144A (es) | 2015-01-01 |
| US8933015B2 (en) | 2015-01-13 |
| SI2649076T1 (sl) | 2015-07-31 |
| TWI520966B (zh) | 2016-02-11 |
| EP2649076B1 (en) | 2015-03-04 |
| IL226739A (en) | 2017-05-29 |
| AU2011338262B2 (en) | 2016-12-15 |
| TW201307355A (zh) | 2013-02-16 |
| CN103403009A (zh) | 2013-11-20 |
| US20130022573A1 (en) | 2013-01-24 |
| PL2649076T3 (pl) | 2015-08-31 |
| AU2011338262A1 (en) | 2013-07-11 |
| CN103403009B (zh) | 2016-01-13 |
| US8513184B2 (en) | 2013-08-20 |
| PT2649076E (pt) | 2015-06-02 |
| NZ612159A (en) | 2015-07-31 |
| HK1191000A1 (en) | 2014-07-18 |
| UY33775A (es) | 2012-07-31 |
| WO2012078915A1 (en) | 2012-06-14 |
| US20140023616A1 (en) | 2014-01-23 |
| MX2013006475A (es) | 2013-11-01 |
| AR084217A1 (es) | 2013-05-02 |
| BR112013014063A2 (pt) | 2016-09-13 |
| CA2819824A1 (en) | 2012-06-14 |
| EP2649076A1 (en) | 2013-10-16 |
| KR20140031841A (ko) | 2014-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5847193B2 (ja) | フラビウイルス科ウイルスの大環状インヒビター | |
| US10472392B2 (en) | Macrocyclic inhibitors of flaviviridae viruses | |
| JP5795766B2 (ja) | 抗ウイルス治療のための２′−フルオロ置換カルバ−ヌクレオシド類似体 | |
| JP6209600B2 (ja) | フラビウイルス科ウイルスの大環状阻害剤 | |
| KR20150040265A (ko) | 플라비비리대 바이러스의 마크로시클릭 저해제 | |
| HK1191000B (en) | Macrocyclic inhibitors of flaviviridae viruses | |
| HK1262165A1 (en) | Macrocyclic inhibitors of flaviviridae viruses | |
| HK1262165B (en) | Macrocyclic inhibitors of flaviviridae viruses | |
| HK1209731B (en) | Macrocyclic inhibitors of flaviviridae viruses |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141208 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141208 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20151029 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20151124 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5847193 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |