JP5833804B2 - Ｎｏｓ阻害活性を有する置換インドール化合物 - Google Patents

Ｎｏｓ阻害活性を有する置換インドール化合物 Download PDF

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JP5833804B2
JP5833804B2 JP2008505999A JP2008505999A JP5833804B2 JP 5833804 B2 JP5833804 B2 JP 5833804B2 JP 2008505999 A JP2008505999 A JP 2008505999A JP 2008505999 A JP2008505999 A JP 2008505999A JP 5833804 B2 JP5833804 B2 JP 5833804B2
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JP2008535908A (ja
JP2008535908A5 (enExample
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マッダフォード，ショーン
ラムナス，ジェイロール
ラクヒット，スーマン
パットマン，ジョアンヌ
レントン，ポール
アネディ，サブハッシュ，シー．
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ニューラクソン，インコーポレーテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • A—HUMAN NECESSITIES
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
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  • Addiction (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2008505999A 2005-04-13 2006-04-13 Ｎｏｓ阻害活性を有する置換インドール化合物 Expired - Fee Related JP5833804B2 (ja)

Applications Claiming Priority (3)

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US67085605P 2005-04-13 2005-04-13
US60/670,856 2005-04-13
PCT/IB2006/003873 WO2007063418A2 (en) 2005-04-13 2006-04-13 Substituted indole compounds having nos inhibitory activity

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JP2008535908A JP2008535908A (ja) 2008-09-04
JP2008535908A5 JP2008535908A5 (enExample) 2009-05-21
JP5833804B2 true JP5833804B2 (ja) 2015-12-16

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US (4) US7375219B2 (enExample)
EP (1) EP1883451B9 (enExample)
JP (2) JP5833804B2 (enExample)
KR (2) KR101463572B1 (enExample)
CN (1) CN101247853B (enExample)
AR (1) AR055053A1 (enExample)
AT (1) ATE489138T1 (enExample)
AU (1) AU2006321284B2 (enExample)
BR (1) BRPI0607517A2 (enExample)
CA (1) CA2605073C (enExample)
CY (1) CY1111296T1 (enExample)
DE (1) DE602006018447D1 (enExample)
DK (1) DK1883451T3 (enExample)
EA (1) EA013123B1 (enExample)
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IL (1) IL186644A (enExample)
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NO (1) NO20075632L (enExample)
NZ (1) NZ563191A (enExample)
PL (1) PL1883451T3 (enExample)
PT (1) PT1883451E (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015199745A (ja) * 2005-04-13 2015-11-12 ニューラクソン，インコーポレーテッド Ｎｏｓ阻害活性を有する置換インドール化合物

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US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
US7605122B2 (en) * 2005-07-29 2009-10-20 Millennium Medical Spa Human chorionic gonadotropin (hCG) formulations for facilitating weight loss and body contouring
BRPI0615307A2 (pt) * 2005-08-25 2009-08-04 Schering Corp agonistas de adrenorreceptor alfa2c
EP2554162A1 (en) * 2006-02-07 2013-02-06 H. Lundbeck A/S Use of KCNQ-Openers for Treating or Reducing the Symptoms of Schizophrenia
CA2649454A1 (en) * 2006-04-13 2007-10-25 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods of modeling migraine pain and identifying candidate compounds for the treatment of migraine
EP2010527B1 (en) * 2006-04-13 2013-08-14 Neuraxon Inc. 1,5 and 3,6- substituted indole compounds having nos inhibitory activity
US8173813B2 (en) 2007-03-23 2012-05-08 Neuraxon, Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
CA2681764A1 (en) * 2007-03-23 2008-10-02 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods of modeling migraine pain and identifying candidate compounds for the treatment of migraine
EP2018854A1 (en) * 2007-07-27 2009-01-28 Merz Pharma GmbH & Co. KGaA Novel combinations of neramexane for the treatment of neurodegenerative disorders
EP2219449A4 (en) * 2007-11-16 2010-10-27 Univ Arizona State METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING
MX2010005343A (es) * 2007-11-16 2010-08-09 Neuraxon Inc Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina.
KR20100103799A (ko) * 2007-11-16 2010-09-28 네우렉슨 인코포레이티드 내장통을 치료하기 위한 인돌 화합물 및 방법
UA105182C2 (ru) * 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
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US9891219B2 (en) * 2008-10-10 2018-02-13 Mayo Foundation For Medical Education And Research Methods for treating neuromyelitis optica (NMO) by administration of eculizumab to an individual that is aquaporin-4 (AQP4)-IgG autoantibody positive
US8198268B2 (en) * 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
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