CY1111296T1 - Ενωσεις υποκατεστημενου ινδολιου που εχουν ανασταλτικη δραστικοτητα nos - Google Patents

Ενωσεις υποκατεστημενου ινδολιου που εχουν ανασταλτικη δραστικοτητα nos

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Publication number
CY1111296T1
CY1111296T1 CY20111100228T CY111100228T CY1111296T1 CY 1111296 T1 CY1111296 T1 CY 1111296T1 CY 20111100228 T CY20111100228 T CY 20111100228T CY 111100228 T CY111100228 T CY 111100228T CY 1111296 T1 CY1111296 T1 CY 1111296T1
Authority
CY
Cyprus
Prior art keywords
nos
migraine headache
inhibitory activity
substituted indole
indole compounds
Prior art date
Application number
CY20111100228T
Other languages
English (en)
Inventor
Shawn Maddaford
Jailall Ramnauth
Suman Rakhit
Joanne Patman
Paul Renton
Subhash C Annedi
Original Assignee
Neuraxon Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuraxon Inc. filed Critical Neuraxon Inc.
Publication of CY1111296T1 publication Critical patent/CY1111296T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/36—Opioid-abuse
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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  • Organic Chemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

Η παρούσα εφεύρεση χαρακτηρίζει αναστολείς συνθάσης νιτρικού οξειδίου (NOS) ιδιαιτέρως αυτές που εκλεκτικώς αναστέλλουν νευρωνική συνθάση νιτρικού οξειδίου (nNOS) κατά προτίμηση προς άλλες NOS ισoμορφές. Οι αναστολείς NOS της εφεύρεσης μόνοι ή σε συνδυασμό με άλλους φαρμακευτικώς δραστικούς παράγοντες μπορεί να χρησιμοποιηθούν για θεραπεία ή αποτροπή καταστάσεων όπως για παράδειγμα, συμφόρησης, βλάβης επαναδιάχυσης, νευροεκφυλισμού, τραύματος κεφαλής, CABG, κεφαλαλγίας ημικρανίας με αύρα και χωρίς αύρα, ημικρανίας με αλλοδυνία, κεντρικού μετά την εμβολή πόνου (CPSP), νευροπαθικού πόνου, προκαλούμενη από μορφίνη/οπιοειδές ανοχή και υπεραναλγησία.
CY20111100228T 2005-04-13 2011-02-24 Ενωσεις υποκατεστημενου ινδολιου που εχουν ανασταλτικη δραστικοτητα nos CY1111296T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67085605P 2005-04-13 2005-04-13
EP06831851A EP1883451B9 (en) 2005-04-13 2006-04-13 Substituted indole compounds having nos inhibitory activity

Publications (1)

Publication Number Publication Date
CY1111296T1 true CY1111296T1 (el) 2015-10-07

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CY20111100228T CY1111296T1 (el) 2005-04-13 2011-02-24 Ενωσεις υποκατεστημενου ινδολιου που εχουν ανασταλτικη δραστικοτητα nos

Country Status (27)

Country Link
US (4) US7375219B2 (el)
EP (1) EP1883451B9 (el)
JP (2) JP5833804B2 (el)
KR (2) KR101463572B1 (el)
CN (1) CN101247853B (el)
AR (1) AR055053A1 (el)
AT (1) ATE489138T1 (el)
AU (1) AU2006321284B2 (el)
BR (1) BRPI0607517A2 (el)
CA (1) CA2605073C (el)
CY (1) CY1111296T1 (el)
DE (1) DE602006018447D1 (el)
DK (1) DK1883451T3 (el)
EA (1) EA013123B1 (el)
ES (1) ES2357129T3 (el)
HK (1) HK1117778A1 (el)
IL (1) IL186644A (el)
MX (1) MX2007012818A (el)
NO (1) NO20075632L (el)
NZ (1) NZ563191A (el)
PL (1) PL1883451T3 (el)
PT (1) PT1883451E (el)
SI (1) SI1883451T1 (el)
TW (1) TWI466879B (el)
UA (1) UA92488C2 (el)
WO (1) WO2007063418A2 (el)
ZA (1) ZA200709038B (el)

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AU2006321284A1 (en) 2007-06-07
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