JP5818266B2 - ジヒドロオロット酸デヒドロゲナーゼの阻害剤である抗マラリア剤 - Google Patents

ジヒドロオロット酸デヒドロゲナーゼの阻害剤である抗マラリア剤 Download PDF

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Publication number
JP5818266B2
JP5818266B2 JP2012532236A JP2012532236A JP5818266B2 JP 5818266 B2 JP5818266 B2 JP 5818266B2 JP 2012532236 A JP2012532236 A JP 2012532236A JP 2012532236 A JP2012532236 A JP 2012532236A JP 5818266 B2 JP5818266 B2 JP 5818266B2
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Prior art keywords
compound
methyl
mmol
pharmaceutical composition
compounds
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JP2012532236A
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English (en)
Japanese (ja)
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JP2013506004A (ja
JP2013506004A5 (enExample
Inventor
ケイ ラソド、プラディプシン
ケイ ラソド、プラディプシン
フロイド、デイビッド
バロウズ、ジェレミー
マルワハ、アルカ
グジャール、ラメシュ
コテロン−ロペス、ホセ
フィリップス、マーガレット
エイ チャーマン、スーザン
エイ チャーマン、スーザン
マシューズ、デイビッド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monash University
MMV Medicines for Malaria Venture
GlaxoSmithKline Investigacion y Desarrollo SL
Original Assignee
Monash University
MMV Medicines for Malaria Venture
GlaxoSmithKline Investigacion y Desarrollo SL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012532236A 2009-09-29 2010-09-28 ジヒドロオロット酸デヒドロゲナーゼの阻害剤である抗マラリア剤 Expired - Fee Related JP5818266B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
US61/246,863 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (3)

Publication Number Publication Date
JP2013506004A JP2013506004A (ja) 2013-02-21
JP2013506004A5 JP2013506004A5 (enExample) 2013-10-17
JP5818266B2 true JP5818266B2 (ja) 2015-11-18

Family

ID=43826848

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JP2012532236A Expired - Fee Related JP5818266B2 (ja) 2009-09-29 2010-09-28 ジヒドロオロット酸デヒドロゲナーゼの阻害剤である抗マラリア剤

Country Status (15)

Country Link
US (1) US9238653B2 (enExample)
EP (1) EP2483274B1 (enExample)
JP (1) JP5818266B2 (enExample)
CN (1) CN102741255B (enExample)
BR (1) BR112012007179B8 (enExample)
CA (1) CA2775354C (enExample)
DK (1) DK2483274T3 (enExample)
ES (1) ES2527835T3 (enExample)
HR (1) HRP20150066T1 (enExample)
ME (1) ME02020B (enExample)
PL (1) PL2483274T3 (enExample)
PT (1) PT2483274E (enExample)
SI (1) SI2483274T1 (enExample)
SM (1) SMT201500071B (enExample)
WO (1) WO2011041304A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY175865A (en) * 2013-12-19 2020-07-14 Novartis Ag [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
US20200048259A1 (en) * 2016-10-12 2020-02-13 Merck Sharp & Dohme Corp. Kdm5 inhibitors
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
JP2020514323A (ja) * 2017-02-06 2020-05-21 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物と方法
JP7178360B2 (ja) 2017-04-07 2022-11-25 ケース ウエスタン リザーブ ユニバーシティ 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤
SG11202105345TA (en) 2018-11-21 2021-06-29 Univ Case Western Reserve Compositions and methods of modulating short-chain dehydrogenase activity
EP3842100A1 (en) * 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208693B (en) * 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
WO2007149211A1 (en) * 2006-06-22 2007-12-27 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
WO2008094737A2 (en) * 2007-01-26 2008-08-07 Irm Llc Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases
US9216983B2 (en) 2007-12-21 2015-12-22 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
PT2483274E (pt) 2015-02-04
CA2775354C (en) 2019-01-15
BR112012007179B8 (pt) 2021-05-25
BR112012007179A2 (pt) 2017-07-25
WO2011041304A3 (en) 2011-08-04
CN102741255A (zh) 2012-10-17
CN102741255B (zh) 2015-10-07
SI2483274T1 (sl) 2015-02-27
DK2483274T3 (en) 2015-01-19
US9238653B2 (en) 2016-01-19
PL2483274T3 (pl) 2015-04-30
ES2527835T3 (es) 2015-01-30
EP2483274B1 (en) 2014-10-29
EP2483274A4 (en) 2013-03-06
HK1174639A1 (en) 2013-06-14
CA2775354A1 (en) 2011-04-07
SMT201500071B (it) 2015-05-05
JP2013506004A (ja) 2013-02-21
WO2011041304A2 (en) 2011-04-07
BR112012007179A8 (pt) 2018-01-23
HRP20150066T1 (hr) 2015-02-27
BR112012007179B1 (pt) 2020-12-01
ME02020B (me) 2015-05-20
US20120302586A1 (en) 2012-11-29
EP2483274A2 (en) 2012-08-08

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