ME02020B - Anti-malarijski agensi kao inhibitori dihidroorotat dehidrogenaze - Google Patents
Anti-malarijski agensi kao inhibitori dihidroorotat dehidrogenazeInfo
- Publication number
- ME02020B ME02020B MEP-2015-8A MEP815A ME02020B ME 02020 B ME02020 B ME 02020B ME P815 A MEP815 A ME P815A ME 02020 B ME02020 B ME 02020B
- Authority
- ME
- Montenegro
- Prior art keywords
- compound
- compound according
- pharmaceutically acceptable
- tautomers
- stereoisomers
- Prior art date
Links
- 108010052167 Dihydroorotate Dehydrogenase Proteins 0.000 title claims 2
- 102100032823 Dihydroorotate dehydrogenase (quinone), mitochondrial Human genes 0.000 title claims 2
- 239000003430 antimalarial agent Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 15
- 208000030852 Parasitic disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 230000037396 body weight Effects 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 claims 1
- VERUFXOALATMPS-UHFFFAOYSA-N 5,5-diamino-2-(2-phenylethenyl)cyclohex-3-ene-1,1-disulfonic acid Chemical compound C1=CC(N)(N)CC(S(O)(=O)=O)(S(O)(=O)=O)C1C=CC1=CC=CC=C1 VERUFXOALATMPS-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 241000224016 Plasmodium Species 0.000 claims 1
- 229950003153 amsonate Drugs 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 1
- -1 benzonate Chemical compound 0.000 claims 1
- 239000000292 calcium oxide Substances 0.000 claims 1
- 235000012255 calcium oxide Nutrition 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 230000036281 parasite infection Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229940075930 picrate Drugs 0.000 claims 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24686309P | 2009-09-29 | 2009-09-29 | |
| EP10821105.3A EP2483274B1 (en) | 2009-09-29 | 2010-09-28 | Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase |
| PCT/US2010/050532 WO2011041304A2 (en) | 2009-09-29 | 2010-09-28 | Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02020B true ME02020B (me) | 2015-05-20 |
Family
ID=43826848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-8A ME02020B (me) | 2009-09-29 | 2010-09-28 | Anti-malarijski agensi kao inhibitori dihidroorotat dehidrogenaze |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9238653B2 (enExample) |
| EP (1) | EP2483274B1 (enExample) |
| JP (1) | JP5818266B2 (enExample) |
| CN (1) | CN102741255B (enExample) |
| BR (1) | BR112012007179B8 (enExample) |
| CA (1) | CA2775354C (enExample) |
| DK (1) | DK2483274T3 (enExample) |
| ES (1) | ES2527835T3 (enExample) |
| HR (1) | HRP20150066T1 (enExample) |
| ME (1) | ME02020B (enExample) |
| PL (1) | PL2483274T3 (enExample) |
| PT (1) | PT2483274E (enExample) |
| SI (1) | SI2483274T1 (enExample) |
| SM (1) | SMT201500071B (enExample) |
| WO (1) | WO2011041304A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY175865A (en) * | 2013-12-19 | 2020-07-14 | Novartis Ag | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis |
| EP3072894A1 (en) | 2015-03-26 | 2016-09-28 | Board Of Regents Of the University Of Texas System | New substituted triazolopyrimidines as anti-malarial agents |
| EP3254679A1 (de) | 2016-06-09 | 2017-12-13 | Christian-Albrechts-Universität zu Kiel | Wirkstoffe gegen protozoen und bakterien |
| US20200048259A1 (en) * | 2016-10-12 | 2020-02-13 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
| WO2018102552A1 (en) | 2016-11-30 | 2018-06-07 | Case Western Reserve University | Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof |
| JP2020514323A (ja) * | 2017-02-06 | 2020-05-21 | ケース ウエスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物と方法 |
| JP7178360B2 (ja) | 2017-04-07 | 2022-11-25 | ケース ウエスタン リザーブ ユニバーシティ | 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤 |
| SG11202105345TA (en) | 2018-11-21 | 2021-06-29 | Univ Case Western Reserve | Compositions and methods of modulating short-chain dehydrogenase activity |
| EP3842100A1 (en) * | 2019-12-24 | 2021-06-30 | The Board Of Regents Of The University Of Texas System | Anti-malarial agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU208693B (en) * | 1991-02-22 | 1993-12-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them |
| US5478825A (en) | 1991-02-22 | 1995-12-26 | Egis Gyogyszergyar | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives |
| US8490825B2 (en) | 1999-12-08 | 2013-07-23 | Metal Container Corporation | Can lid closure and method of joining a can lid closure to a can body |
| CZ294535B6 (cs) * | 2001-08-02 | 2005-01-12 | Ústav Experimentální Botaniky Avčr | Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující |
| WO2007149211A1 (en) * | 2006-06-22 | 2007-12-27 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| WO2008094737A2 (en) * | 2007-01-26 | 2008-08-07 | Irm Llc | Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases |
| US9216983B2 (en) | 2007-12-21 | 2015-12-22 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
-
2010
- 2010-09-28 CA CA2775354A patent/CA2775354C/en not_active Expired - Fee Related
- 2010-09-28 HR HRP20150066AT patent/HRP20150066T1/hr unknown
- 2010-09-28 US US13/499,031 patent/US9238653B2/en not_active Expired - Fee Related
- 2010-09-28 SI SI201030853T patent/SI2483274T1/sl unknown
- 2010-09-28 PT PT108211053T patent/PT2483274E/pt unknown
- 2010-09-28 ES ES10821105.3T patent/ES2527835T3/es active Active
- 2010-09-28 DK DK10821105.3T patent/DK2483274T3/en active
- 2010-09-28 EP EP10821105.3A patent/EP2483274B1/en active Active
- 2010-09-28 CN CN201080043385.XA patent/CN102741255B/zh not_active Expired - Fee Related
- 2010-09-28 ME MEP-2015-8A patent/ME02020B/me unknown
- 2010-09-28 JP JP2012532236A patent/JP5818266B2/ja not_active Expired - Fee Related
- 2010-09-28 PL PL10821105T patent/PL2483274T3/pl unknown
- 2010-09-28 WO PCT/US2010/050532 patent/WO2011041304A2/en not_active Ceased
- 2010-09-28 BR BR112012007179A patent/BR112012007179B8/pt not_active IP Right Cessation
-
2015
- 2015-03-18 SM SM201500071T patent/SMT201500071B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2483274E (pt) | 2015-02-04 |
| CA2775354C (en) | 2019-01-15 |
| BR112012007179B8 (pt) | 2021-05-25 |
| BR112012007179A2 (pt) | 2017-07-25 |
| WO2011041304A3 (en) | 2011-08-04 |
| CN102741255A (zh) | 2012-10-17 |
| CN102741255B (zh) | 2015-10-07 |
| SI2483274T1 (sl) | 2015-02-27 |
| DK2483274T3 (en) | 2015-01-19 |
| JP5818266B2 (ja) | 2015-11-18 |
| US9238653B2 (en) | 2016-01-19 |
| PL2483274T3 (pl) | 2015-04-30 |
| ES2527835T3 (es) | 2015-01-30 |
| EP2483274B1 (en) | 2014-10-29 |
| EP2483274A4 (en) | 2013-03-06 |
| HK1174639A1 (en) | 2013-06-14 |
| CA2775354A1 (en) | 2011-04-07 |
| SMT201500071B (it) | 2015-05-05 |
| JP2013506004A (ja) | 2013-02-21 |
| WO2011041304A2 (en) | 2011-04-07 |
| BR112012007179A8 (pt) | 2018-01-23 |
| HRP20150066T1 (hr) | 2015-02-27 |
| BR112012007179B1 (pt) | 2020-12-01 |
| US20120302586A1 (en) | 2012-11-29 |
| EP2483274A2 (en) | 2012-08-08 |
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