DK2483274T3 - Antimalarials, which are inhibitors of dihydroorotate - Google Patents
Antimalarials, which are inhibitors of dihydroorotate Download PDFInfo
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- DK2483274T3 DK2483274T3 DK10821105.3T DK10821105T DK2483274T3 DK 2483274 T3 DK2483274 T3 DK 2483274T3 DK 10821105 T DK10821105 T DK 10821105T DK 2483274 T3 DK2483274 T3 DK 2483274T3
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- methyl
- synthesis
- triazolo
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- 239000003112 inhibitor Substances 0.000 title description 12
- 239000003430 antimalarial agent Substances 0.000 title description 8
- 229940033495 antimalarials Drugs 0.000 title description 2
- UFIVEPVSAGBUSI-UHFFFAOYSA-N dihydroorotic acid Chemical compound OC(=O)C1CC(=O)NC(=O)N1 UFIVEPVSAGBUSI-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 110
- 239000000203 mixture Substances 0.000 claims description 87
- 150000003839 salts Chemical class 0.000 claims description 19
- 108010052167 Dihydroorotate Dehydrogenase Proteins 0.000 claims description 18
- 102100032823 Dihydroorotate dehydrogenase (quinone), mitochondrial Human genes 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 18
- 201000004792 malaria Diseases 0.000 claims description 17
- -1 benzonate Chemical compound 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 241000223960 Plasmodium falciparum Species 0.000 claims description 10
- 239000012453 solvate Substances 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 208000030852 Parasitic disease Diseases 0.000 claims description 4
- 241000224016 Plasmodium Species 0.000 claims description 4
- 230000037396 body weight Effects 0.000 claims description 4
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 230000036281 parasite infection Effects 0.000 claims description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 2
- ALKYHXVLJMQRLQ-UHFFFAOYSA-N 3-Hydroxy-2-naphthoate Chemical compound C1=CC=C2C=C(O)C(C(=O)O)=CC2=C1 ALKYHXVLJMQRLQ-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 claims description 2
- VERUFXOALATMPS-UHFFFAOYSA-N 5,5-diamino-2-(2-phenylethenyl)cyclohex-3-ene-1,1-disulfonic acid Chemical compound C1=CC(N)(N)CC(S(O)(=O)=O)(S(O)(=O)=O)C1C=CC1=CC=CC=C1 VERUFXOALATMPS-UHFFFAOYSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
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- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 2
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- 229910002651 NO3 Inorganic materials 0.000 claims description 2
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- 229910019142 PO4 Inorganic materials 0.000 claims description 2
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- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 claims description 2
- ACYGYJFTZSAZKR-UHFFFAOYSA-J dicalcium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Ca+2].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O ACYGYJFTZSAZKR-UHFFFAOYSA-J 0.000 claims description 2
- 239000001177 diphosphate Substances 0.000 claims description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 2
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- KWMLJOLKUYYJFJ-VFUOTHLCSA-N glucoheptonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O KWMLJOLKUYYJFJ-VFUOTHLCSA-N 0.000 claims description 2
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- 229940049906 glutamate Drugs 0.000 claims description 2
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- 229940102396 methyl bromide Drugs 0.000 claims description 2
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- ISVLDAIKRGXNCZ-UHFFFAOYSA-N ethyl 2,2-difluoropropanoate Chemical compound CCOC(=O)C(C)(F)F ISVLDAIKRGXNCZ-UHFFFAOYSA-N 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
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- JYTUSYBCFIZPBE-AMTLMPIISA-M lactobionate Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-M 0.000 description 1
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- 206010025482 malaise Diseases 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-L malate(2-) Chemical compound [O-]C(=O)C(O)CC([O-])=O BJEPYKJPYRNKOW-UHFFFAOYSA-L 0.000 description 1
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- YWAWOVTYQZQDFV-UHFFFAOYSA-N n-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-methylsulfanyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Chemical compound N12N=C(SC)N=C2N=C(C)C=C1NC1=CC(F)=C(C(F)(F)F)C(F)=C1 YWAWOVTYQZQDFV-UHFFFAOYSA-N 0.000 description 1
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-M oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC([O-])=O ZQPPMHVWECSIRJ-KTKRTIGZSA-M 0.000 description 1
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- INDBQLZJXZLFIT-UHFFFAOYSA-N primaquine Chemical compound N1=CC=CC2=CC(OC)=CC(NC(C)CCCN)=C21 INDBQLZJXZLFIT-UHFFFAOYSA-N 0.000 description 1
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- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24686309P | 2009-09-29 | 2009-09-29 | |
| PCT/US2010/050532 WO2011041304A2 (en) | 2009-09-29 | 2010-09-28 | Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2483274T3 true DK2483274T3 (en) | 2015-01-19 |
Family
ID=43826848
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10821105.3T DK2483274T3 (en) | 2009-09-29 | 2010-09-28 | Antimalarials, which are inhibitors of dihydroorotate |
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|---|---|
| US (1) | US9238653B2 (enExample) |
| EP (1) | EP2483274B1 (enExample) |
| JP (1) | JP5818266B2 (enExample) |
| CN (1) | CN102741255B (enExample) |
| BR (1) | BR112012007179B8 (enExample) |
| CA (1) | CA2775354C (enExample) |
| DK (1) | DK2483274T3 (enExample) |
| ES (1) | ES2527835T3 (enExample) |
| HR (1) | HRP20150066T1 (enExample) |
| ME (1) | ME02020B (enExample) |
| PL (1) | PL2483274T3 (enExample) |
| PT (1) | PT2483274E (enExample) |
| SI (1) | SI2483274T1 (enExample) |
| SM (1) | SMT201500071B (enExample) |
| WO (1) | WO2011041304A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY175865A (en) * | 2013-12-19 | 2020-07-14 | Novartis Ag | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis |
| EP3072894A1 (en) | 2015-03-26 | 2016-09-28 | Board Of Regents Of the University Of Texas System | New substituted triazolopyrimidines as anti-malarial agents |
| EP3254679A1 (de) | 2016-06-09 | 2017-12-13 | Christian-Albrechts-Universität zu Kiel | Wirkstoffe gegen protozoen und bakterien |
| EP3525786A4 (en) * | 2016-10-12 | 2020-03-18 | Merck Sharp & Dohme Corp. | KDM5 INHIBITORS |
| EP3548035A4 (en) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES |
| AU2018215678A1 (en) * | 2017-02-06 | 2019-08-22 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
| JP7178360B2 (ja) | 2017-04-07 | 2022-11-25 | ケース ウエスタン リザーブ ユニバーシティ | 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤 |
| IL321451A (en) | 2018-11-21 | 2025-08-01 | Univ Case Western Reserve | Compositions and methods of modulating short-chain dehydrogenase activity |
| EP3842100A1 (en) * | 2019-12-24 | 2021-06-30 | The Board Of Regents Of The University Of Texas System | Anti-malarial agents |
| MX2022010258A (es) | 2020-02-21 | 2023-01-24 | Univ Case Western Reserve | Composiciones y métodos para tratar la lesión renal. |
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| HU208693B (en) | 1991-02-22 | 1993-12-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them |
| US5478825A (en) | 1991-02-22 | 1995-12-26 | Egis Gyogyszergyar | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives |
| US8490825B2 (en) | 1999-12-08 | 2013-07-23 | Metal Container Corporation | Can lid closure and method of joining a can lid closure to a can body |
| CZ294535B6 (cs) * | 2001-08-02 | 2005-01-12 | Ústav Experimentální Botaniky Avčr | Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující |
| US20080027079A1 (en) * | 2006-06-22 | 2008-01-31 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| MX2009007944A (es) * | 2007-01-26 | 2009-08-07 | Irm Llc | Compuestos y composiciones de purina como inhibidores de quinasa para el tratamiento de enfermedades relacionadas con plasmodium. |
| WO2009082691A1 (en) * | 2007-12-21 | 2009-07-02 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
-
2010
- 2010-09-28 ME MEP-2015-8A patent/ME02020B/me unknown
- 2010-09-28 EP EP10821105.3A patent/EP2483274B1/en active Active
- 2010-09-28 WO PCT/US2010/050532 patent/WO2011041304A2/en not_active Ceased
- 2010-09-28 JP JP2012532236A patent/JP5818266B2/ja not_active Expired - Fee Related
- 2010-09-28 PT PT108211053T patent/PT2483274E/pt unknown
- 2010-09-28 CN CN201080043385.XA patent/CN102741255B/zh not_active Expired - Fee Related
- 2010-09-28 ES ES10821105.3T patent/ES2527835T3/es active Active
- 2010-09-28 PL PL10821105T patent/PL2483274T3/pl unknown
- 2010-09-28 BR BR112012007179A patent/BR112012007179B8/pt not_active IP Right Cessation
- 2010-09-28 DK DK10821105.3T patent/DK2483274T3/en active
- 2010-09-28 HR HRP20150066AT patent/HRP20150066T1/hr unknown
- 2010-09-28 SI SI201030853T patent/SI2483274T1/sl unknown
- 2010-09-28 US US13/499,031 patent/US9238653B2/en not_active Expired - Fee Related
- 2010-09-28 CA CA2775354A patent/CA2775354C/en not_active Expired - Fee Related
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2015
- 2015-03-18 SM SM201500071T patent/SMT201500071B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2483274T3 (pl) | 2015-04-30 |
| BR112012007179B1 (pt) | 2020-12-01 |
| CA2775354A1 (en) | 2011-04-07 |
| HRP20150066T1 (hr) | 2015-02-27 |
| BR112012007179B8 (pt) | 2021-05-25 |
| US20120302586A1 (en) | 2012-11-29 |
| HK1174639A1 (en) | 2013-06-14 |
| SMT201500071B (it) | 2015-05-05 |
| EP2483274A4 (en) | 2013-03-06 |
| CN102741255A (zh) | 2012-10-17 |
| JP5818266B2 (ja) | 2015-11-18 |
| BR112012007179A2 (pt) | 2017-07-25 |
| SI2483274T1 (sl) | 2015-02-27 |
| PT2483274E (pt) | 2015-02-04 |
| EP2483274B1 (en) | 2014-10-29 |
| WO2011041304A3 (en) | 2011-08-04 |
| ME02020B (me) | 2015-05-20 |
| JP2013506004A (ja) | 2013-02-21 |
| BR112012007179A8 (pt) | 2018-01-23 |
| US9238653B2 (en) | 2016-01-19 |
| ES2527835T3 (es) | 2015-01-30 |
| CA2775354C (en) | 2019-01-15 |
| CN102741255B (zh) | 2015-10-07 |
| WO2011041304A2 (en) | 2011-04-07 |
| EP2483274A2 (en) | 2012-08-08 |
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