ES2527835T3 - Agentes anti malaria que son inhibidores de dihidroorotato deshidrogenasa - Google Patents

Agentes anti malaria que son inhibidores de dihidroorotato deshidrogenasa Download PDF

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Publication number
ES2527835T3
ES2527835T3 ES10821105.3T ES10821105T ES2527835T3 ES 2527835 T3 ES2527835 T3 ES 2527835T3 ES 10821105 T ES10821105 T ES 10821105T ES 2527835 T3 ES2527835 T3 ES 2527835T3
Authority
ES
Spain
Prior art keywords
compound
mmol
methyl
synthesis
triazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10821105.3T
Other languages
English (en)
Spanish (es)
Inventor
Pradipsinh K. Rathod
David Floyd
Jeremy Burrows
Alka Marwaha
Ramesh Gujjar
Jose Coteron-Lopez
Margaret Phillips
Susan A. Charman
David Matthews
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WASHINGTON, University of
Monash University
Medicines for Malaria Venture
GlaxoSmithKline Investigacion y Desarrollo SL
University of Washington
The University of Texas System
The University of Texas at Austin
Original Assignee
WASHINGTON, University of
Monash University
Medicines for Malaria Venture
GlaxoSmithKline Investigacion y Desarrollo SL
University of Washington
The University of Texas System
The University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WASHINGTON, University of, Monash University, Medicines for Malaria Venture, GlaxoSmithKline Investigacion y Desarrollo SL, University of Washington, The University of Texas System, The University of Texas at Austin filed Critical WASHINGTON, University of
Application granted granted Critical
Publication of ES2527835T3 publication Critical patent/ES2527835T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES10821105.3T 2009-09-29 2010-09-28 Agentes anti malaria que son inhibidores de dihidroorotato deshidrogenasa Active ES2527835T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
US246863P 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (1)

Publication Number Publication Date
ES2527835T3 true ES2527835T3 (es) 2015-01-30

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10821105.3T Active ES2527835T3 (es) 2009-09-29 2010-09-28 Agentes anti malaria que son inhibidores de dihidroorotato deshidrogenasa

Country Status (15)

Country Link
US (1) US9238653B2 (enExample)
EP (1) EP2483274B1 (enExample)
JP (1) JP5818266B2 (enExample)
CN (1) CN102741255B (enExample)
BR (1) BR112012007179B8 (enExample)
CA (1) CA2775354C (enExample)
DK (1) DK2483274T3 (enExample)
ES (1) ES2527835T3 (enExample)
HR (1) HRP20150066T1 (enExample)
ME (1) ME02020B (enExample)
PL (1) PL2483274T3 (enExample)
PT (1) PT2483274E (enExample)
SI (1) SI2483274T1 (enExample)
SM (1) SMT201500071B (enExample)
WO (1) WO2011041304A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6392352B2 (ja) * 2013-12-19 2018-09-19 ノバルティス アーゲー リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
WO2018071282A1 (en) * 2016-10-12 2018-04-19 Merck Sharp & Dohme Corp. Kdm5 inhibitors
EP3548035A4 (en) 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
JP7178360B2 (ja) 2017-04-07 2022-11-25 ケース ウエスタン リザーブ ユニバーシティ 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤
WO2020106998A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
EP3842100A1 (en) * 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents
AU2021224268A1 (en) 2020-02-21 2022-09-15 Case Western Reserve University Compositions and methods for treating renal injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208693B (en) * 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
WO2007149211A1 (en) * 2006-06-22 2007-12-27 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
CA2676138A1 (en) * 2007-01-26 2008-08-07 Irm Llc Compounds and compositions as kinase inhibitors
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
HK1174639A1 (en) 2013-06-14
PL2483274T3 (pl) 2015-04-30
CN102741255A (zh) 2012-10-17
CA2775354A1 (en) 2011-04-07
BR112012007179A8 (pt) 2018-01-23
WO2011041304A3 (en) 2011-08-04
US20120302586A1 (en) 2012-11-29
CA2775354C (en) 2019-01-15
EP2483274A4 (en) 2013-03-06
PT2483274E (pt) 2015-02-04
WO2011041304A2 (en) 2011-04-07
SMT201500071B (it) 2015-05-05
BR112012007179B1 (pt) 2020-12-01
SI2483274T1 (sl) 2015-02-27
BR112012007179B8 (pt) 2021-05-25
BR112012007179A2 (pt) 2017-07-25
ME02020B (me) 2015-05-20
DK2483274T3 (en) 2015-01-19
EP2483274A2 (en) 2012-08-08
JP2013506004A (ja) 2013-02-21
US9238653B2 (en) 2016-01-19
JP5818266B2 (ja) 2015-11-18
HRP20150066T1 (hr) 2015-02-27
CN102741255B (zh) 2015-10-07
EP2483274B1 (en) 2014-10-29

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