PT2483274E - Agentes antimaláricos que são inibidores de di-hidro-orotato desidrogenase - Google Patents
Agentes antimaláricos que são inibidores de di-hidro-orotato desidrogenase Download PDFInfo
- Publication number
- PT2483274E PT2483274E PT108211053T PT10821105T PT2483274E PT 2483274 E PT2483274 E PT 2483274E PT 108211053 T PT108211053 T PT 108211053T PT 10821105 T PT10821105 T PT 10821105T PT 2483274 E PT2483274 E PT 2483274E
- Authority
- PT
- Portugal
- Prior art keywords
- inhibitors
- dihydroorotate dehydrogenase
- antimalarial agents
- antimalarial
- agents
- Prior art date
Links
- 108010052167 Dihydroorotate Dehydrogenase Proteins 0.000 title 1
- 102100032823 Dihydroorotate dehydrogenase (quinone), mitochondrial Human genes 0.000 title 1
- 239000003430 antimalarial agent Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24686309P | 2009-09-29 | 2009-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2483274E true PT2483274E (pt) | 2015-02-04 |
Family
ID=43826848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT108211053T PT2483274E (pt) | 2009-09-29 | 2010-09-28 | Agentes antimaláricos que são inibidores de di-hidro-orotato desidrogenase |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9238653B2 (enExample) |
| EP (1) | EP2483274B1 (enExample) |
| JP (1) | JP5818266B2 (enExample) |
| CN (1) | CN102741255B (enExample) |
| BR (1) | BR112012007179B8 (enExample) |
| CA (1) | CA2775354C (enExample) |
| DK (1) | DK2483274T3 (enExample) |
| ES (1) | ES2527835T3 (enExample) |
| HR (1) | HRP20150066T1 (enExample) |
| ME (1) | ME02020B (enExample) |
| PL (1) | PL2483274T3 (enExample) |
| PT (1) | PT2483274E (enExample) |
| SI (1) | SI2483274T1 (enExample) |
| SM (1) | SMT201500071B (enExample) |
| WO (1) | WO2011041304A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6392352B2 (ja) * | 2013-12-19 | 2018-09-19 | ノバルティス アーゲー | リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体 |
| EP3072894A1 (en) | 2015-03-26 | 2016-09-28 | Board Of Regents Of the University Of Texas System | New substituted triazolopyrimidines as anti-malarial agents |
| EP3254679A1 (de) | 2016-06-09 | 2017-12-13 | Christian-Albrechts-Universität zu Kiel | Wirkstoffe gegen protozoen und bakterien |
| WO2018071282A1 (en) * | 2016-10-12 | 2018-04-19 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
| EP3548035A4 (en) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES |
| CN110573154A (zh) | 2017-02-06 | 2019-12-13 | 卡斯西部储备大学 | 调节短链脱氢酶活性的组合物和方法 |
| JP7178360B2 (ja) | 2017-04-07 | 2022-11-25 | ケース ウエスタン リザーブ ユニバーシティ | 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤 |
| WO2020106998A1 (en) | 2018-11-21 | 2020-05-28 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| EP3842100A1 (en) * | 2019-12-24 | 2021-06-30 | The Board Of Regents Of The University Of Texas System | Anti-malarial agents |
| AU2021224268A1 (en) | 2020-02-21 | 2022-09-15 | Case Western Reserve University | Compositions and methods for treating renal injury |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU208693B (en) * | 1991-02-22 | 1993-12-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them |
| US5478825A (en) | 1991-02-22 | 1995-12-26 | Egis Gyogyszergyar | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives |
| US8490825B2 (en) | 1999-12-08 | 2013-07-23 | Metal Container Corporation | Can lid closure and method of joining a can lid closure to a can body |
| CZ294535B6 (cs) * | 2001-08-02 | 2005-01-12 | Ústav Experimentální Botaniky Avčr | Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující |
| WO2007149211A1 (en) * | 2006-06-22 | 2007-12-27 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| CA2676138A1 (en) * | 2007-01-26 | 2008-08-07 | Irm Llc | Compounds and compositions as kinase inhibitors |
| WO2009082691A1 (en) | 2007-12-21 | 2009-07-02 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
-
2010
- 2010-09-28 CA CA2775354A patent/CA2775354C/en not_active Expired - Fee Related
- 2010-09-28 EP EP10821105.3A patent/EP2483274B1/en active Active
- 2010-09-28 US US13/499,031 patent/US9238653B2/en not_active Expired - Fee Related
- 2010-09-28 WO PCT/US2010/050532 patent/WO2011041304A2/en not_active Ceased
- 2010-09-28 PT PT108211053T patent/PT2483274E/pt unknown
- 2010-09-28 BR BR112012007179A patent/BR112012007179B8/pt not_active IP Right Cessation
- 2010-09-28 SI SI201030853T patent/SI2483274T1/sl unknown
- 2010-09-28 JP JP2012532236A patent/JP5818266B2/ja not_active Expired - Fee Related
- 2010-09-28 CN CN201080043385.XA patent/CN102741255B/zh not_active Expired - Fee Related
- 2010-09-28 ES ES10821105.3T patent/ES2527835T3/es active Active
- 2010-09-28 DK DK10821105.3T patent/DK2483274T3/en active
- 2010-09-28 PL PL10821105T patent/PL2483274T3/pl unknown
- 2010-09-28 ME MEP-2015-8A patent/ME02020B/me unknown
- 2010-09-28 HR HRP20150066AT patent/HRP20150066T1/hr unknown
-
2015
- 2015-03-18 SM SM201500071T patent/SMT201500071B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1174639A1 (en) | 2013-06-14 |
| PL2483274T3 (pl) | 2015-04-30 |
| CN102741255A (zh) | 2012-10-17 |
| CA2775354A1 (en) | 2011-04-07 |
| BR112012007179A8 (pt) | 2018-01-23 |
| WO2011041304A3 (en) | 2011-08-04 |
| US20120302586A1 (en) | 2012-11-29 |
| CA2775354C (en) | 2019-01-15 |
| EP2483274A4 (en) | 2013-03-06 |
| WO2011041304A2 (en) | 2011-04-07 |
| SMT201500071B (it) | 2015-05-05 |
| BR112012007179B1 (pt) | 2020-12-01 |
| SI2483274T1 (sl) | 2015-02-27 |
| BR112012007179B8 (pt) | 2021-05-25 |
| BR112012007179A2 (pt) | 2017-07-25 |
| ME02020B (me) | 2015-05-20 |
| DK2483274T3 (en) | 2015-01-19 |
| EP2483274A2 (en) | 2012-08-08 |
| JP2013506004A (ja) | 2013-02-21 |
| US9238653B2 (en) | 2016-01-19 |
| ES2527835T3 (es) | 2015-01-30 |
| JP5818266B2 (ja) | 2015-11-18 |
| HRP20150066T1 (hr) | 2015-02-27 |
| CN102741255B (zh) | 2015-10-07 |
| EP2483274B1 (en) | 2014-10-29 |
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