SMT201500071B - Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi - Google Patents

Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi

Info

Publication number
SMT201500071B
SMT201500071B SM201500071T SM201500071T SMT201500071B SM T201500071 B SMT201500071 B SM T201500071B SM 201500071 T SM201500071 T SM 201500071T SM 201500071 T SM201500071 T SM 201500071T SM T201500071 B SMT201500071 B SM T201500071B
Authority
SM
San Marino
Prior art keywords
dihydro
inhibitors
antimalarial agents
orotate dehydrogenase
orotate
Prior art date
Application number
SM201500071T
Other languages
English (en)
Italian (it)
Inventor
Pradipsinh K Rathod
David Floyd
Jeremy Burrows
Alka Marwaha
Ramesh Gujjar
Jose Coteron-Lopez
Margaret Phillips
Susan A Charman
David Matthews
Original Assignee
Univ Texas
Univ Monash
Medicines Malaria Venture Mmv
Univ Washington
Glaxosmithkline Investigacion Y Desarrollo S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Univ Monash, Medicines Malaria Venture Mmv, Univ Washington, Glaxosmithkline Investigacion Y Desarrollo S L filed Critical Univ Texas
Publication of SMT201500071B publication Critical patent/SMT201500071B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SM201500071T 2009-09-29 2015-03-18 Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi SMT201500071B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (1)

Publication Number Publication Date
SMT201500071B true SMT201500071B (it) 2015-05-05

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201500071T SMT201500071B (it) 2009-09-29 2015-03-18 Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi

Country Status (16)

Country Link
US (1) US9238653B2 (xx)
EP (1) EP2483274B1 (xx)
JP (1) JP5818266B2 (xx)
CN (1) CN102741255B (xx)
BR (1) BR112012007179B8 (xx)
CA (1) CA2775354C (xx)
DK (1) DK2483274T3 (xx)
ES (1) ES2527835T3 (xx)
HK (1) HK1174639A1 (xx)
HR (1) HRP20150066T1 (xx)
ME (1) ME02020B (xx)
PL (1) PL2483274T3 (xx)
PT (1) PT2483274E (xx)
SI (1) SI2483274T1 (xx)
SM (1) SMT201500071B (xx)
WO (1) WO2011041304A2 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA030823B1 (ru) * 2013-12-19 2018-10-31 Новартис Аг СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТОЗОЙНОЙ ПРОТЕОСОМЫ ДЛЯ ЛЕЧЕНИЯ ПАРАЗИТАРНОГО ЗАБОЛЕВАНИЯ, ТАКОГО КАК ЛЕЙШМАНИОЗ
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
US20200048259A1 (en) * 2016-10-12 2020-02-13 Merck Sharp & Dohme Corp. Kdm5 inhibitors
JP2020502070A (ja) 2016-11-30 2020-01-23 ケース ウエスタン リザーブ ユニバーシティ １５−ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用
EP3576737A4 (en) * 2017-02-06 2021-04-21 Case Western Reserve University COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF SHORT CHAIN DEHYDROGENASE
CN110891568A (zh) 2017-04-07 2020-03-17 凯斯西储大学 用于治疗冠状动脉病症的短链脱氢酶活性的抑制剂
EP3842100A1 (en) 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208693B (en) 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
WO2007149211A1 (en) 2006-06-22 2007-12-27 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
US20100056494A1 (en) * 2007-01-26 2010-03-04 Irm Llc Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
PT2483274E (pt) 2015-02-04
US9238653B2 (en) 2016-01-19
DK2483274T3 (en) 2015-01-19
WO2011041304A2 (en) 2011-04-07
US20120302586A1 (en) 2012-11-29
CN102741255B (zh) 2015-10-07
SI2483274T1 (sl) 2015-02-27
BR112012007179B8 (pt) 2021-05-25
CN102741255A (zh) 2012-10-17
CA2775354A1 (en) 2011-04-07
HRP20150066T1 (hr) 2015-02-27
JP2013506004A (ja) 2013-02-21
BR112012007179A2 (pt) 2017-07-25
CA2775354C (en) 2019-01-15
ES2527835T3 (es) 2015-01-30
PL2483274T3 (pl) 2015-04-30
JP5818266B2 (ja) 2015-11-18
EP2483274A4 (en) 2013-03-06
BR112012007179B1 (pt) 2020-12-01
EP2483274A2 (en) 2012-08-08
EP2483274B1 (en) 2014-10-29
BR112012007179A8 (pt) 2018-01-23
WO2011041304A3 (en) 2011-08-04
HK1174639A1 (en) 2013-06-14
ME02020B (me) 2015-05-20

Similar Documents

Publication Publication Date Title
CY2020024I1 (el) Αναστολεiς βητα-λακταμασων
SMT201600135B (it) Nuovi inibitori della s-nitrosoglutatione riduttasi
SMT201500071B (it) Agenti antimalarici che sono inibitori della diidro-orotato deidrogenasi
SMT201500271B (it) Inibitori di neprilisina
SMT201500043B (it) Indazoli ossazolo-sostituiti come inibitori di pi13-chinasi
SMT201500262B (it) Trattamento della sclerosi multipla con laquinimod
DOP2012000114A (es) Inhibidor bromodominio de benzodiazepina
BR112013012078A2 (pt) inibidores de nampt e rock
DK3590934T3 (da) Pyrazolylquinoxalinkinasehæmmere
DK2470526T3 (da) Forbindelser og sammensætninger som proteinkinase-inhibitorer
DK2421825T3 (da) Azetidinyldiamider som monoacylglycerollipase-inhibitorer
DK2496236T3 (da) Prolylhydroxylasehæmmere
DK2448938T3 (da) Pyrimidinoner som pi3k-inhibitorer
SMT201200009B (it) Terapia con pirfenidone che evita la fluvoxamina
BRPI0918564A2 (pt) inibidores
DK2513105T3 (da) 2-arylimidazolderivater som pde10a-enzyminhibitorer
DK2453858T3 (da) Fremgangsmåde
BRPI0920681A2 (pt) inibidores de decahidro-1h-indenoquinolinona e decahidro-3h-ciclopentafenantridinona de cyp17
ITFI20070288A1 (it) Inibitori delle deacetilasi istoniche
BR112012003059A2 (pt) inibidores de jnk
SMT201500178B (it) Inibitori di nf-kb
SMT201500123B (it) Dosaggio unitario di apadenoson
IT1400448B1 (it) Struttura di dispositivo di protezione
FI20095315A (fi) Iskulaite
IL215486A0 (en) Compositions of cholinesterase inhibitors