HK1174639A1 - Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase - Google Patents

Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Info

Publication number
HK1174639A1
HK1174639A1 HK13101950.1A HK13101950A HK1174639A1 HK 1174639 A1 HK1174639 A1 HK 1174639A1 HK 13101950 A HK13101950 A HK 13101950A HK 1174639 A1 HK1174639 A1 HK 1174639A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
dihydroorotate dehydrogenase
antimalarial agents
antimalarial
agents
Prior art date
Application number
HK13101950.1A
Other languages
English (en)
Chinese (zh)
Inventor
．拉索德
．弗洛伊德
．布羅斯
．馬瓦哈
．古加
．科特隆-洛佩茲
．菲利普斯
．查曼
．馬修斯
Original Assignee
得克薩斯大學體系董事會
莫納什大學
瘧疾藥物投資公司
華盛頓大學
葛蘭素史克研究與發展有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 得克薩斯大學體系董事會, 莫納什大學, 瘧疾藥物投資公司, 華盛頓大學, 葛蘭素史克研究與發展有限公司 filed Critical 得克薩斯大學體系董事會
Publication of HK1174639A1 publication Critical patent/HK1174639A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK13101950.1A 2009-09-29 2013-02-15 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase HK1174639A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (1)

Publication Number Publication Date
HK1174639A1 true HK1174639A1 (en) 2013-06-14

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13101950.1A HK1174639A1 (en) 2009-09-29 2013-02-15 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Country Status (16)

Country Link
US (1) US9238653B2 (xx)
EP (1) EP2483274B1 (xx)
JP (1) JP5818266B2 (xx)
CN (1) CN102741255B (xx)
BR (1) BR112012007179B8 (xx)
CA (1) CA2775354C (xx)
DK (1) DK2483274T3 (xx)
ES (1) ES2527835T3 (xx)
HK (1) HK1174639A1 (xx)
HR (1) HRP20150066T1 (xx)
ME (1) ME02020B (xx)
PL (1) PL2483274T3 (xx)
PT (1) PT2483274E (xx)
SI (1) SI2483274T1 (xx)
SM (1) SMT201500071B (xx)
WO (1) WO2011041304A2 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3083627T (lt) * 2013-12-19 2018-12-27 Novartis Ag [1,2,4]triazolo[1,5-a]pirimidino dariniai kaip protozoano proteasomos inhibitoriai, skirti parazitinių ligų tokių kaip leišmaniozė, gydymui
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
EP3525786A4 (en) * 2016-10-12 2020-03-18 Merck Sharp & Dohme Corp. KDM5 INHIBITORS
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
CA3052466A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
WO2018187810A1 (en) 2017-04-07 2018-10-11 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
EP3842100A1 (en) 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
HU208693B (en) 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US20080027079A1 (en) 2006-06-22 2008-01-31 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
EP2124954A2 (en) * 2007-01-26 2009-12-02 Irm Llc Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
US20120302586A1 (en) 2012-11-29
SI2483274T1 (sl) 2015-02-27
WO2011041304A3 (en) 2011-08-04
BR112012007179A2 (pt) 2017-07-25
EP2483274A2 (en) 2012-08-08
JP5818266B2 (ja) 2015-11-18
HRP20150066T1 (hr) 2015-02-27
US9238653B2 (en) 2016-01-19
BR112012007179A8 (pt) 2018-01-23
WO2011041304A2 (en) 2011-04-07
ES2527835T3 (es) 2015-01-30
CA2775354C (en) 2019-01-15
SMT201500071B (it) 2015-05-05
CN102741255B (zh) 2015-10-07
EP2483274A4 (en) 2013-03-06
CN102741255A (zh) 2012-10-17
EP2483274B1 (en) 2014-10-29
BR112012007179B1 (pt) 2020-12-01
ME02020B (me) 2015-05-20
CA2775354A1 (en) 2011-04-07
DK2483274T3 (en) 2015-01-19
PL2483274T3 (pl) 2015-04-30
PT2483274E (pt) 2015-02-04
BR112012007179B8 (pt) 2021-05-25
JP2013506004A (ja) 2013-02-21

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200927