HK1174639A1 - Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase - Google Patents

Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Info

Publication number
HK1174639A1
HK1174639A1 HK13101950.1A HK13101950A HK1174639A1 HK 1174639 A1 HK1174639 A1 HK 1174639A1 HK 13101950 A HK13101950 A HK 13101950A HK 1174639 A1 HK1174639 A1 HK 1174639A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
dihydroorotate dehydrogenase
antimalarial agents
antimalarial
agents
Prior art date
Application number
HK13101950.1A
Other languages
English (en)
Chinese (zh)
Inventor
．拉索德
．弗洛伊德
．布羅斯
．馬瓦哈
．古加
．科特隆-洛佩茲
．菲利普斯
．查曼
．馬修斯
Original Assignee
得克薩斯大學體系董事會
莫納什大學
瘧疾藥物投資公司
華盛頓大學
葛蘭素史克研究與發展有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 得克薩斯大學體系董事會, 莫納什大學, 瘧疾藥物投資公司, 華盛頓大學, 葛蘭素史克研究與發展有限公司 filed Critical 得克薩斯大學體系董事會
Publication of HK1174639A1 publication Critical patent/HK1174639A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK13101950.1A 2009-09-29 2013-02-15 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase HK1174639A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (1)

Publication Number Publication Date
HK1174639A1 true HK1174639A1 (en) 2013-06-14

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13101950.1A HK1174639A1 (en) 2009-09-29 2013-02-15 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Country Status (16)

Country Link
US (1) US9238653B2 (xx)
EP (1) EP2483274B1 (xx)
JP (1) JP5818266B2 (xx)
CN (1) CN102741255B (xx)
BR (1) BR112012007179B8 (xx)
CA (1) CA2775354C (xx)
DK (1) DK2483274T3 (xx)
ES (1) ES2527835T3 (xx)
HK (1) HK1174639A1 (xx)
HR (1) HRP20150066T1 (xx)
ME (1) ME02020B (xx)
PL (1) PL2483274T3 (xx)
PT (1) PT2483274E (xx)
SI (1) SI2483274T1 (xx)
SM (1) SMT201500071B (xx)
WO (1) WO2011041304A2 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA030823B1 (ru) * 2013-12-19 2018-10-31 Новартис Аг СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТОЗОЙНОЙ ПРОТЕОСОМЫ ДЛЯ ЛЕЧЕНИЯ ПАРАЗИТАРНОГО ЗАБОЛЕВАНИЯ, ТАКОГО КАК ЛЕЙШМАНИОЗ
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
US20200048259A1 (en) * 2016-10-12 2020-02-13 Merck Sharp & Dohme Corp. Kdm5 inhibitors
JP2020502070A (ja) 2016-11-30 2020-01-23 ケース ウエスタン リザーブ ユニバーシティ １５−ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用
EP3576737A4 (en) * 2017-02-06 2021-04-21 Case Western Reserve University COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF SHORT CHAIN DEHYDROGENASE
CN110891568A (zh) 2017-04-07 2020-03-17 凯斯西储大学 用于治疗冠状动脉病症的短链脱氢酶活性的抑制剂
EP3842100A1 (en) 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208693B (en) 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
WO2007149211A1 (en) 2006-06-22 2007-12-27 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
US20100056494A1 (en) * 2007-01-26 2010-03-04 Irm Llc Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
PT2483274E (pt) 2015-02-04
US9238653B2 (en) 2016-01-19
DK2483274T3 (en) 2015-01-19
WO2011041304A2 (en) 2011-04-07
US20120302586A1 (en) 2012-11-29
CN102741255B (zh) 2015-10-07
SI2483274T1 (sl) 2015-02-27
BR112012007179B8 (pt) 2021-05-25
CN102741255A (zh) 2012-10-17
CA2775354A1 (en) 2011-04-07
HRP20150066T1 (hr) 2015-02-27
JP2013506004A (ja) 2013-02-21
BR112012007179A2 (pt) 2017-07-25
CA2775354C (en) 2019-01-15
ES2527835T3 (es) 2015-01-30
PL2483274T3 (pl) 2015-04-30
JP5818266B2 (ja) 2015-11-18
EP2483274A4 (en) 2013-03-06
SMT201500071B (it) 2015-05-05
BR112012007179B1 (pt) 2020-12-01
EP2483274A2 (en) 2012-08-08
EP2483274B1 (en) 2014-10-29
BR112012007179A8 (pt) 2018-01-23
WO2011041304A3 (en) 2011-08-04
ME02020B (me) 2015-05-20

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200927