HRP20150066T1 - Anti-malarijski agensi koji su inhibitori dihidroorotat dehidrogenaze - Google Patents

Anti-malarijski agensi koji su inhibitori dihidroorotat dehidrogenaze Download PDF

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Publication number
HRP20150066T1
HRP20150066T1 HRP20150066AT HRP20150066T HRP20150066T1 HR P20150066 T1 HRP20150066 T1 HR P20150066T1 HR P20150066A T HRP20150066A T HR P20150066AT HR P20150066 T HRP20150066 T HR P20150066T HR P20150066 T1 HRP20150066 T1 HR P20150066T1
Authority
HR
Croatia
Prior art keywords
compound
image
pharmaceutically acceptable
compound according
tautomers
Prior art date
Application number
HRP20150066AT
Other languages
English (en)
Croatian (hr)
Inventor
Pradipsinh K. Rathod
David Floyd
Jeremy Burrows
Alka Marwaha
Ramesh Gujjar
Jose Coteron-Lopez
Margaret Phillips
Susan A. Charman
David Matthews
Original Assignee
Board Of Regents Of The University Of Texas System
Monash University
Mmv Medicines For Malaria Venture
University Of Washington
Glaxosmithkline Investigacion Y Desarrollo, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Regents Of The University Of Texas System, Monash University, Mmv Medicines For Malaria Venture, University Of Washington, Glaxosmithkline Investigacion Y Desarrollo, S.L. filed Critical Board Of Regents Of The University Of Texas System
Publication of HRP20150066T1 publication Critical patent/HRP20150066T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HRP20150066AT 2009-09-29 2010-09-28 Anti-malarijski agensi koji su inhibitori dihidroorotat dehidrogenaze HRP20150066T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
EP10821105.3A EP2483274B1 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (1)

Publication Number Publication Date
HRP20150066T1 true HRP20150066T1 (hr) 2015-02-27

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20150066AT HRP20150066T1 (hr) 2009-09-29 2010-09-28 Anti-malarijski agensi koji su inhibitori dihidroorotat dehidrogenaze

Country Status (15)

Country Link
US (1) US9238653B2 (enExample)
EP (1) EP2483274B1 (enExample)
JP (1) JP5818266B2 (enExample)
CN (1) CN102741255B (enExample)
BR (1) BR112012007179B8 (enExample)
CA (1) CA2775354C (enExample)
DK (1) DK2483274T3 (enExample)
ES (1) ES2527835T3 (enExample)
HR (1) HRP20150066T1 (enExample)
ME (1) ME02020B (enExample)
PL (1) PL2483274T3 (enExample)
PT (1) PT2483274E (enExample)
SI (1) SI2483274T1 (enExample)
SM (1) SMT201500071B (enExample)
WO (1) WO2011041304A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6392352B2 (ja) * 2013-12-19 2018-09-19 ノバルティス アーゲー リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
WO2018071282A1 (en) * 2016-10-12 2018-04-19 Merck Sharp & Dohme Corp. Kdm5 inhibitors
EP3548035A4 (en) 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
JP7178360B2 (ja) 2017-04-07 2022-11-25 ケース ウエスタン リザーブ ユニバーシティ 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤
WO2020106998A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
EP3842100A1 (en) * 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents
AU2021224268A1 (en) 2020-02-21 2022-09-15 Case Western Reserve University Compositions and methods for treating renal injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208693B (en) * 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
WO2007149211A1 (en) * 2006-06-22 2007-12-27 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
CA2676138A1 (en) * 2007-01-26 2008-08-07 Irm Llc Compounds and compositions as kinase inhibitors
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
HK1174639A1 (en) 2013-06-14
PL2483274T3 (pl) 2015-04-30
CN102741255A (zh) 2012-10-17
CA2775354A1 (en) 2011-04-07
BR112012007179A8 (pt) 2018-01-23
WO2011041304A3 (en) 2011-08-04
US20120302586A1 (en) 2012-11-29
CA2775354C (en) 2019-01-15
EP2483274A4 (en) 2013-03-06
PT2483274E (pt) 2015-02-04
WO2011041304A2 (en) 2011-04-07
SMT201500071B (it) 2015-05-05
BR112012007179B1 (pt) 2020-12-01
SI2483274T1 (sl) 2015-02-27
BR112012007179B8 (pt) 2021-05-25
BR112012007179A2 (pt) 2017-07-25
ME02020B (me) 2015-05-20
DK2483274T3 (en) 2015-01-19
EP2483274A2 (en) 2012-08-08
JP2013506004A (ja) 2013-02-21
US9238653B2 (en) 2016-01-19
ES2527835T3 (es) 2015-01-30
JP5818266B2 (ja) 2015-11-18
CN102741255B (zh) 2015-10-07
EP2483274B1 (en) 2014-10-29

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