BR112012007179B8 - composto inibidor da di-hidro-orotato desidrogenase, e, formulação farmacêutica - Google Patents
composto inibidor da di-hidro-orotato desidrogenase, e, formulação farmacêuticaInfo
- Publication number
- BR112012007179B8 BR112012007179B8 BR112012007179A BR112012007179A BR112012007179B8 BR 112012007179 B8 BR112012007179 B8 BR 112012007179B8 BR 112012007179 A BR112012007179 A BR 112012007179A BR 112012007179 A BR112012007179 A BR 112012007179A BR 112012007179 B8 BR112012007179 B8 BR 112012007179B8
- Authority
- BR
- Brazil
- Prior art keywords
- dihydro
- pharmaceutical formulation
- compound
- inhibitor compound
- dehydrogenase inhibitor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229940083266 Dihydroorotate dehydrogenase inhibitor Drugs 0.000 title abstract 2
- 239000003363 dihydroorotate dehydrogenase inhibitor Substances 0.000 title abstract 2
- 108010052167 Dihydroorotate Dehydrogenase Proteins 0.000 abstract 1
- 102100032823 Dihydroorotate dehydrogenase (quinone), mitochondrial Human genes 0.000 abstract 1
- 101100085783 Drosophila melanogaster Dhod gene Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229940124598 therapeutic candidate Drugs 0.000 abstract 1
- 150000008523 triazolopyridines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24686309P | 2009-09-29 | 2009-09-29 | |
| US61/246863 | 2009-09-29 | ||
| PCT/US2010/050532 WO2011041304A2 (en) | 2009-09-29 | 2010-09-28 | Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BR112012007179A2 BR112012007179A2 (pt) | 2017-07-25 |
| BR112012007179A8 BR112012007179A8 (pt) | 2018-01-23 |
| BR112012007179B1 BR112012007179B1 (pt) | 2020-12-01 |
| BR112012007179B8 true BR112012007179B8 (pt) | 2021-05-25 |
Family
ID=43826848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012007179A BR112012007179B8 (pt) | 2009-09-29 | 2010-09-28 | composto inibidor da di-hidro-orotato desidrogenase, e, formulação farmacêutica |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9238653B2 (enExample) |
| EP (1) | EP2483274B1 (enExample) |
| JP (1) | JP5818266B2 (enExample) |
| CN (1) | CN102741255B (enExample) |
| BR (1) | BR112012007179B8 (enExample) |
| CA (1) | CA2775354C (enExample) |
| DK (1) | DK2483274T3 (enExample) |
| ES (1) | ES2527835T3 (enExample) |
| HR (1) | HRP20150066T1 (enExample) |
| ME (1) | ME02020B (enExample) |
| PL (1) | PL2483274T3 (enExample) |
| PT (1) | PT2483274E (enExample) |
| SI (1) | SI2483274T1 (enExample) |
| SM (1) | SMT201500071B (enExample) |
| WO (1) | WO2011041304A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6392352B2 (ja) * | 2013-12-19 | 2018-09-19 | ノバルティス アーゲー | リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体 |
| EP3072894A1 (en) | 2015-03-26 | 2016-09-28 | Board Of Regents Of the University Of Texas System | New substituted triazolopyrimidines as anti-malarial agents |
| EP3254679A1 (de) | 2016-06-09 | 2017-12-13 | Christian-Albrechts-Universität zu Kiel | Wirkstoffe gegen protozoen und bakterien |
| WO2018071282A1 (en) * | 2016-10-12 | 2018-04-19 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
| EP3548035A4 (en) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES |
| CN110573154A (zh) | 2017-02-06 | 2019-12-13 | 卡斯西部储备大学 | 调节短链脱氢酶活性的组合物和方法 |
| JP7178360B2 (ja) | 2017-04-07 | 2022-11-25 | ケース ウエスタン リザーブ ユニバーシティ | 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤 |
| WO2020106998A1 (en) | 2018-11-21 | 2020-05-28 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| EP3842100A1 (en) * | 2019-12-24 | 2021-06-30 | The Board Of Regents Of The University Of Texas System | Anti-malarial agents |
| AU2021224268A1 (en) | 2020-02-21 | 2022-09-15 | Case Western Reserve University | Compositions and methods for treating renal injury |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU208693B (en) * | 1991-02-22 | 1993-12-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them |
| US5478825A (en) | 1991-02-22 | 1995-12-26 | Egis Gyogyszergyar | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives |
| US8490825B2 (en) | 1999-12-08 | 2013-07-23 | Metal Container Corporation | Can lid closure and method of joining a can lid closure to a can body |
| CZ294535B6 (cs) * | 2001-08-02 | 2005-01-12 | Ústav Experimentální Botaniky Avčr | Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující |
| WO2007149211A1 (en) * | 2006-06-22 | 2007-12-27 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| CA2676138A1 (en) * | 2007-01-26 | 2008-08-07 | Irm Llc | Compounds and compositions as kinase inhibitors |
| WO2009082691A1 (en) | 2007-12-21 | 2009-07-02 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
-
2010
- 2010-09-28 CA CA2775354A patent/CA2775354C/en not_active Expired - Fee Related
- 2010-09-28 EP EP10821105.3A patent/EP2483274B1/en active Active
- 2010-09-28 US US13/499,031 patent/US9238653B2/en not_active Expired - Fee Related
- 2010-09-28 WO PCT/US2010/050532 patent/WO2011041304A2/en not_active Ceased
- 2010-09-28 PT PT108211053T patent/PT2483274E/pt unknown
- 2010-09-28 BR BR112012007179A patent/BR112012007179B8/pt not_active IP Right Cessation
- 2010-09-28 SI SI201030853T patent/SI2483274T1/sl unknown
- 2010-09-28 JP JP2012532236A patent/JP5818266B2/ja not_active Expired - Fee Related
- 2010-09-28 CN CN201080043385.XA patent/CN102741255B/zh not_active Expired - Fee Related
- 2010-09-28 ES ES10821105.3T patent/ES2527835T3/es active Active
- 2010-09-28 DK DK10821105.3T patent/DK2483274T3/en active
- 2010-09-28 PL PL10821105T patent/PL2483274T3/pl unknown
- 2010-09-28 ME MEP-2015-8A patent/ME02020B/me unknown
- 2010-09-28 HR HRP20150066AT patent/HRP20150066T1/hr unknown
-
2015
- 2015-03-18 SM SM201500071T patent/SMT201500071B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1174639A1 (en) | 2013-06-14 |
| PL2483274T3 (pl) | 2015-04-30 |
| CN102741255A (zh) | 2012-10-17 |
| CA2775354A1 (en) | 2011-04-07 |
| BR112012007179A8 (pt) | 2018-01-23 |
| WO2011041304A3 (en) | 2011-08-04 |
| US20120302586A1 (en) | 2012-11-29 |
| CA2775354C (en) | 2019-01-15 |
| EP2483274A4 (en) | 2013-03-06 |
| PT2483274E (pt) | 2015-02-04 |
| WO2011041304A2 (en) | 2011-04-07 |
| SMT201500071B (it) | 2015-05-05 |
| BR112012007179B1 (pt) | 2020-12-01 |
| SI2483274T1 (sl) | 2015-02-27 |
| BR112012007179A2 (pt) | 2017-07-25 |
| ME02020B (me) | 2015-05-20 |
| DK2483274T3 (en) | 2015-01-19 |
| EP2483274A2 (en) | 2012-08-08 |
| JP2013506004A (ja) | 2013-02-21 |
| US9238653B2 (en) | 2016-01-19 |
| ES2527835T3 (es) | 2015-01-30 |
| JP5818266B2 (ja) | 2015-11-18 |
| HRP20150066T1 (hr) | 2015-02-27 |
| CN102741255B (zh) | 2015-10-07 |
| EP2483274B1 (en) | 2014-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/12/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/09/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2640 DE 10-08-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |