JP5753779B2 - 生理学的ｐＨの緩衝液中で向上した溶解性及び安定性を示すグルカゴン類縁体 - Google Patents

生理学的ｐＨの緩衝液中で向上した溶解性及び安定性を示すグルカゴン類縁体 Download PDF

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JP5753779B2
JP5753779B2 JP2011514733A JP2011514733A JP5753779B2 JP 5753779 B2 JP5753779 B2 JP 5753779B2 JP 2011514733 A JP2011514733 A JP 2011514733A JP 2011514733 A JP2011514733 A JP 2011514733A JP 5753779 B2 JP5753779 B2 JP 5753779B2
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glucagon
amino acid
peptide
seq
acid
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JP2011524418A5 (OSRAM
JP2011524418A (ja
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ディマルキ，リチャード，ディー．
スマイリー，デイヴィッド，エル．
ディマルキ，マリア
シャベンヌ，ジョセフ
デイ，ジョナサン
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Indiana University Research and Technology Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011514733A 2008-06-17 2009-06-16 生理学的ｐＨの緩衝液中で向上した溶解性及び安定性を示すグルカゴン類縁体 Expired - Fee Related JP5753779B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US7319308P 2008-06-17 2008-06-17
US61/073,193 2008-06-17
US7816508P 2008-07-03 2008-07-03
US61/078,165 2008-07-03
US9041508P 2008-08-20 2008-08-20
US61/090,415 2008-08-20
PCT/US2009/047437 WO2009155257A1 (en) 2008-06-17 2009-06-16 Glucagon analogs exhibiting enhanced solubility and stability physiological ph buffers

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JP2015076332A Division JP2015147791A (ja) 2008-06-17 2015-04-02 生理学的ｐＨの緩衝液中で向上した溶解性及び安定性を示すグルカゴン類縁体

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JP2011524418A JP2011524418A (ja) 2011-09-01
JP2011524418A5 JP2011524418A5 (OSRAM) 2013-12-19
JP5753779B2 true JP5753779B2 (ja) 2015-07-22

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JP2015076332A Pending JP2015147791A (ja) 2008-06-17 2015-04-02 生理学的ｐＨの緩衝液中で向上した溶解性及び安定性を示すグルカゴン類縁体

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US (1) US8450270B2 (OSRAM)
EP (1) EP2307037A4 (OSRAM)
JP (2) JP5753779B2 (OSRAM)
KR (1) KR20110039230A (OSRAM)
CN (2) CN104447980A (OSRAM)
AU (1) AU2009260301B2 (OSRAM)
CA (1) CA2727161A1 (OSRAM)
IL (1) IL209287A (OSRAM)
MX (1) MX2010012695A (OSRAM)
RU (1) RU2560254C2 (OSRAM)
TW (1) TWI541023B (OSRAM)
WO (1) WO2009155257A1 (OSRAM)

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