JP5731066B2 - 核酸のための周期変動性増幅反応 - Google Patents
核酸のための周期変動性増幅反応 Download PDFInfo
- Publication number
- JP5731066B2 JP5731066B2 JP2014506607A JP2014506607A JP5731066B2 JP 5731066 B2 JP5731066 B2 JP 5731066B2 JP 2014506607 A JP2014506607 A JP 2014506607A JP 2014506607 A JP2014506607 A JP 2014506607A JP 5731066 B2 JP5731066 B2 JP 5731066B2
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- temperature
- nucleic acid
- primer
- dna polymerase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
- C12Q2522/10—Nucleic acid binding proteins
- C12Q2522/101—Single or double stranded nucleic acid binding proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/101—Temperature
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477437P | 2011-04-20 | 2011-04-20 | |
| US201161477357P | 2011-04-20 | 2011-04-20 | |
| US61/477,357 | 2011-04-20 | ||
| US61/477,437 | 2011-04-20 | ||
| PCT/US2012/034589 WO2012145725A2 (en) | 2011-04-20 | 2012-04-20 | Oscillating amplification reaction for nucleic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513534A JP2014513534A (ja) | 2014-06-05 |
| JP2014513534A5 JP2014513534A5 (https=) | 2014-12-04 |
| JP5731066B2 true JP5731066B2 (ja) | 2015-06-10 |
Family
ID=47042196
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506607A Active JP5731066B2 (ja) | 2011-04-20 | 2012-04-20 | 核酸のための周期変動性増幅反応 |
| JP2014506611A Active JP5879667B2 (ja) | 2011-04-20 | 2012-04-20 | 核酸の検出および同定のための一体型デバイス |
| JP2015185214A Active JP6014227B2 (ja) | 2011-04-20 | 2015-09-18 | 核酸の検出および同定のための一体型デバイス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506611A Active JP5879667B2 (ja) | 2011-04-20 | 2012-04-20 | 核酸の検出および同定のための一体型デバイス |
| JP2015185214A Active JP6014227B2 (ja) | 2011-04-20 | 2015-09-18 | 核酸の検出および同定のための一体型デバイス |
Country Status (10)
| Country | Link |
|---|---|
| US (9) | US10519492B2 (https=) |
| EP (2) | EP2699698B9 (https=) |
| JP (3) | JP5731066B2 (https=) |
| KR (3) | KR101508670B1 (https=) |
| CN (2) | CN103649333B (https=) |
| CA (2) | CA2856304C (https=) |
| DK (2) | DK2699698T4 (https=) |
| ES (2) | ES2583135T3 (https=) |
| PT (1) | PT2699698T (https=) |
| WO (2) | WO2012145725A2 (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008105814A2 (en) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| EP2140033B1 (en) | 2007-03-28 | 2012-10-10 | Signal Diagnostics | System and method for high resolution analysis of nucleic acids to detect sequence variations |
| US10669574B2 (en) | 2008-11-18 | 2020-06-02 | XCR Diagnostics, Inc. | DNA amplification technology |
| US8837159B1 (en) * | 2009-10-28 | 2014-09-16 | Amazon Technologies, Inc. | Low-profile circuit board assembly |
| US10519492B2 (en) | 2011-04-20 | 2019-12-31 | Mesa Biotech, Inc. | Integrated device for nucleic acid detection and identification |
| US9758837B2 (en) * | 2011-08-02 | 2017-09-12 | The United States Of America, As Represented By The Secretary Of Agriculture | Sensitive and rapid method for Candidatus Liberibacter species detection |
| US9121046B2 (en) * | 2011-11-16 | 2015-09-01 | New England Biolabs, Inc. | Reducing template independent primer extension and threshold time for loop mediated isothermal amplification |
| WO2015017413A1 (en) * | 2013-07-29 | 2015-02-05 | Mbio Diagnostics, Inc. | Assay cartridge processing systems and methods and associated assay cartridges |
| RU2016117929A (ru) | 2013-10-09 | 2017-11-15 | Флюоресентрик, Инк. | Мультиплексные зонды |
| US10195610B2 (en) | 2014-03-10 | 2019-02-05 | Click Diagnostics, Inc. | Cartridge-based thermocycler |
| KR101809645B1 (ko) | 2014-05-30 | 2017-12-15 | 주식회사 이지다이아텍 | 자동 면역분석 수행장치 |
| MX372869B (es) | 2014-06-18 | 2020-07-07 | Zoetis Denmark Aps | Un sistema de detección microfluídico y un cartucho microfluídico. |
| EP3168287A4 (en) | 2014-07-08 | 2018-01-24 | National Institute of Advanced Industrial Science and Technology | Nucleic acid amplification device, nucleic acid amplification method, and chip for nucleic acid amplification |
| DE102014015586B3 (de) * | 2014-10-21 | 2016-03-31 | Webasto SE | Heizgerät |
| EP4029606A1 (en) | 2014-12-31 | 2022-07-20 | Visby Medical, Inc. | Molecular diagnostic testing |
| US9671303B2 (en) * | 2015-03-10 | 2017-06-06 | Ford Global Technologies, Llc | Method and system for laser pressure transducer |
| US20160310948A1 (en) * | 2015-04-24 | 2016-10-27 | Mesa Biotech, Inc. | Fluidic Test Cassette |
| DE102015110092B4 (de) * | 2015-06-23 | 2017-08-10 | Endress + Hauser Gmbh + Co. Kg | Feldgerät zum Einsatz in hygienischen Anwendungen in der Prozess- und Automatisierungstechnik und Verfahren zu dessen Herstellung |
| US10775370B2 (en) | 2015-07-17 | 2020-09-15 | Stat-Diagnostica & Innovation, S.L. | Fluidic system for performing assays |
| US10040069B2 (en) | 2015-07-23 | 2018-08-07 | General Electric Company | Amplification and detection of nucleic acids |
| ES2927062T3 (es) * | 2016-03-14 | 2022-11-02 | Lucira Health Inc | Dispositivos y procedimientos para modificar propiedades ópticas |
| US10987674B2 (en) | 2016-04-22 | 2021-04-27 | Visby Medical, Inc. | Printed circuit board heater for an amplification module |
| WO2017197040A1 (en) | 2016-05-11 | 2017-11-16 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
| USD800331S1 (en) | 2016-06-29 | 2017-10-17 | Click Diagnostics, Inc. | Molecular diagnostic device |
| MX2018015889A (es) | 2016-06-29 | 2019-05-27 | Click Diagnostics Inc | Dispositivos y metodos para la deteccion de moleculas usando una celda de flujo. |
| AU2017290753B2 (en) * | 2016-06-30 | 2021-12-09 | Visby Medical, Inc. | Devices and methods for nucleic acid extraction |
| USD800913S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Detection window for molecular diagnostic device |
| USD800914S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Status indicator for molecular diagnostic device |
| GB201611469D0 (en) | 2016-06-30 | 2016-08-17 | Lumiradx Tech Ltd | Improvements in or relating to nucleic acid amplification processes |
| JP2018023360A (ja) * | 2016-07-29 | 2018-02-15 | セイコーエプソン株式会社 | 核酸増幅反応方法、試薬、および試薬の使用方法 |
| CN108431603B (zh) | 2016-12-28 | 2020-04-21 | 纽勤有限公司 | 流体限位器筒式组件及其使用方法 |
| KR101997097B1 (ko) | 2016-12-30 | 2019-07-05 | 주식회사 이지다이아텍 | 거대 자성입자 복합체를 이용한 자동 면역분석장치 및 방법 |
| USD834721S1 (en) | 2017-03-03 | 2018-11-27 | Neogen Corporation | Assay cartridge |
| JP7111706B2 (ja) | 2017-06-07 | 2022-08-02 | タカラバイオ株式会社 | オリゴヌクレオチドの保存方法 |
| KR20190032810A (ko) | 2017-09-20 | 2019-03-28 | 주식회사 이지다이아텍 | 자성 면역분석장치 및 방법 |
| EP3459632A1 (en) * | 2017-09-26 | 2019-03-27 | Lunaphore Technologies SA | Microfluidic cartrige with built-in sampling device |
| SG11202002931VA (en) | 2017-11-09 | 2020-04-29 | Visby Medical Inc | Portable molecular diagnostic device and methods for the detection of target viruses |
| GB2569965A (en) * | 2018-01-04 | 2019-07-10 | Lumiradx Uk Ltd | Improvements in or relating to amplification of nucleic acids |
| CN110240999B (zh) * | 2018-03-09 | 2022-09-06 | 浙江品级基因科技有限公司 | 一种提高循环肿瘤dna检出率的检测装置及方法 |
| GB201812192D0 (en) | 2018-07-26 | 2018-09-12 | Ttp Plc | Variable temperature reactor, heater and control circuit for the same |
| GB201813429D0 (en) * | 2018-08-17 | 2018-10-03 | Touchlight Ip Ltd | Synthesis of DNA with improved yield |
| KR20210081335A (ko) | 2018-09-03 | 2021-07-01 | 비스비 메디컬, 인코포레이티드 | 항생제 감수성 시험을 위한 장치 및 방법 |
| WO2020079274A1 (en) * | 2018-10-19 | 2020-04-23 | Univercells S.A. | Method for decontaminating a biomolecule production system and a system suitable for decontamination |
| US12390812B2 (en) | 2018-12-19 | 2025-08-19 | Nuclein, Llc | Apparatus and methods for molecular diagnostics |
| JP2022530323A (ja) | 2019-04-28 | 2022-06-29 | ビスビュー メディカル，インコーポレイテッド | デジタル検出能力および無線接続性を有する分子診断デバイス |
| US11352675B2 (en) | 2020-01-03 | 2022-06-07 | Visby Medical, Inc. | Devices and methods for antibiotic susceptability testing |
| CN113528624B (zh) * | 2020-04-17 | 2025-12-02 | 青岛简码基因科技有限公司 | 扩增和检测核酸的方法及试剂盒 |
| WO2021147910A1 (en) * | 2020-01-21 | 2021-07-29 | Qingdao Navid Biotechnology Co., Ltd. | Methods and kits for amplification and detection of nucleic acids |
| CN113215224A (zh) * | 2020-01-21 | 2021-08-06 | 青岛大学 | 扩增和检测核酸的方法及试剂盒 |
| US20230143118A1 (en) * | 2020-06-15 | 2023-05-11 | Arizona Board Of Regents On Behalf Of Arizona State University | Point of need diagnostic with thermal control |
| JP2023539299A (ja) * | 2020-08-26 | 2023-09-13 | センス バイオディテクション リミテッド | デバイス |
| WO2022043697A1 (en) * | 2020-08-26 | 2022-03-03 | Sense Biodetection Limited | Devices |
| USD1064314S1 (en) | 2021-08-13 | 2025-02-25 | Visby Medical, Inc. | Molecular diagnostic device |
| WO2023023638A1 (en) | 2021-08-20 | 2023-02-23 | Singular Genomics Systems, Inc. | Chemical and thermal assisted nucleic acid amplification methods |
| WO2023095018A1 (en) * | 2021-11-24 | 2023-06-01 | D-Nome Private Limited | Rapid method for room temperature reverse transcription loop-mediated isothermal amplification (rt-lamp) and reagent kit |
| US20240102085A1 (en) * | 2022-02-15 | 2024-03-28 | Cepheid | EXPONENTIAL BASE-GREATER-THAN-BASE 2 NUCLEIC ACID AMPLIFICATION USING HIGH- AND LOW-Tm PRIMERS |
| WO2023159127A1 (en) * | 2022-02-17 | 2023-08-24 | One Lambda, Inc. | Systems and methods for protein detection |
| WO2023196973A1 (en) * | 2022-04-08 | 2023-10-12 | The Broad Institute, Inc. | Amplification assays using crispr-cas based detection |
| AU2023263416A1 (en) | 2022-04-29 | 2024-11-07 | Cepheid | Nucleic acid extraction and isolation with heat labile silanes and chemically modified solid supports |
| EP4526479A1 (en) | 2022-05-19 | 2025-03-26 | Cepheid | Mvp cartridge and methods of use and manufacture |
| CN114934044B (zh) * | 2022-05-27 | 2023-11-10 | 国网电力科学研究院武汉南瑞有限责任公司 | 一种重组大肠杆菌在养护铅酸蓄电池中的应用 |
| US12582985B2 (en) | 2022-08-02 | 2026-03-24 | City University Of Hong Kong | Sample-in-result-out closed microfluidic device for nucleic acid molecular point-of-care testing detection |
| CN115290606A (zh) * | 2022-08-22 | 2022-11-04 | 凤凰医学诊断科技有限公司 | 一种检测装置 |
| DE102022211087A1 (de) * | 2022-10-19 | 2024-04-25 | Robert Bosch Gesellschaft mit beschränkter Haftung | Verfahren und Vorrichtung zur Voramplifikation eines Nukleinsäuregemisches |
| CN115678764B (zh) * | 2022-11-07 | 2023-09-08 | 苏州思迈德生物科技有限公司 | 一种快速分子诊断的微流控芯片 |
| CN120641576A (zh) | 2022-12-16 | 2025-09-12 | 塞弗德公司 | Mpox演化支ii生物标志物组 |
| CN116121349B (zh) * | 2022-12-20 | 2024-04-09 | 南京诺唯赞生物科技股份有限公司 | 一种扩增含乙醇的核酸样本的方法 |
| KR20250138809A (ko) | 2023-01-30 | 2025-09-22 | 세페이드 | 호흡기 바이오마커 패널 |
| CN121693563A (zh) * | 2023-04-13 | 2026-03-17 | 5端生物科技股份有限公司 | 上调逆转录和降低rna测序中序列偏好性的组合物和方法 |
| WO2025006633A1 (en) | 2023-06-27 | 2025-01-02 | Cepheid | Pancoronavirus biomarker panel |
| US20250073701A1 (en) | 2023-08-29 | 2025-03-06 | Cepheid | Integrated valve body and syringe tube component for assay cartridges |
| WO2025064410A1 (en) | 2023-09-18 | 2025-03-27 | Cepheid | Three-phase nested amplification and multi-phasic detection |
| WO2025165828A1 (en) | 2024-01-29 | 2025-08-07 | Cepheid | Universal assay cartridge with integrated valve body and syringe tube use |
| WO2025175133A1 (en) | 2024-02-14 | 2025-08-21 | Cepheid | Melt shape genotyping |
| WO2025179142A1 (en) | 2024-02-22 | 2025-08-28 | Cepheid | Maximizing optical channel capabilities for target detection |
| WO2025199454A1 (en) | 2024-03-21 | 2025-09-25 | Cepheid | Compositions and methods for selective extraction of oligonucleotides from complex matrices |
| WO2025207561A1 (en) | 2024-03-27 | 2025-10-02 | Cepheid | Isothermal amplification using novel synthetic oligonucleotides |
| WO2026055639A1 (en) | 2024-09-06 | 2026-03-12 | Cepheid | Sample in sequencing-ready library out automated library preparation solution |
Family Cites Families (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3667607A (en) | 1970-11-27 | 1972-06-06 | Baker Chem Co J T | Chromatographic material |
| US4235601A (en) | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4663277A (en) | 1983-05-20 | 1987-05-05 | Profile Diagnostic Sciences Inc. | Virus detection method and materials |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683105A (en) | 1985-10-31 | 1987-07-28 | Westinghouse Electric Corp. | Testable, fault-tolerant power interface circuit for normally de-energized loads |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4960691A (en) | 1986-09-29 | 1990-10-02 | Abbott Laboratories | Chromatographic test strip for determining ligands or receptors |
| IE940110L (en) | 1989-03-23 | 1990-09-23 | Bunce Roger A | Liquid transfer devices |
| US5541099A (en) | 1989-08-10 | 1996-07-30 | Life Technologies, Inc. | Cloning and expression of T5 DNA polymerase reduced in 3'-to-5' exonuclease activity |
| US5225163A (en) | 1989-08-18 | 1993-07-06 | Angenics, Inc. | Reaction apparatus employing gravitational flow |
| ES2116977T3 (es) | 1990-05-11 | 1998-08-01 | Microprobe Corp | Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente. |
| US6007999A (en) | 1991-07-31 | 1999-12-28 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
| GB9123922D0 (en) | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer devices |
| JP2832117B2 (ja) | 1991-11-29 | 1998-12-02 | キヤノン株式会社 | サンプル測定デバイス及びサンプル測定システム |
| WO1993014217A1 (en) | 1992-01-10 | 1993-07-22 | Life Technologies, Inc. | Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules |
| US6555349B1 (en) | 1993-01-22 | 2003-04-29 | Cornell Research Foundation, Inc. | Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase |
| US5516664A (en) | 1992-12-23 | 1996-05-14 | Hyman; Edward D. | Enzymatic synthesis of repeat regions of oligonucleotides |
| US5432065A (en) | 1993-03-30 | 1995-07-11 | United States Biochemical Corporation | Cycle sequencing with non-thermostable DNA polymerases |
| GB9307319D0 (en) | 1993-04-07 | 1993-06-02 | British Tech Group | Liquid transfer devices |
| WO1995025180A1 (en) | 1994-03-16 | 1995-09-21 | Gen-Probe Incorporated | Isothermal strand displacement nucleic acid amplification |
| US6037127A (en) | 1994-03-31 | 2000-03-14 | E. I. Du Pont De Nemours And Company | Method for detection of non-denatured nucleic acid fragments |
| GB9416002D0 (en) | 1994-08-08 | 1994-09-28 | Univ Cranfield | Fluid transport device |
| GB9502112D0 (en) | 1995-02-03 | 1995-03-22 | British Biocell Int | Assay device and method |
| US20040110167A1 (en) | 1995-07-13 | 2004-06-10 | Gerdes John C. | Lateral flow system for nucleic acid detection |
| US5989813A (en) | 1995-07-13 | 1999-11-23 | Molecular Innovations, Inc. | Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| DE69726404T2 (de) | 1996-01-05 | 2004-09-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mesothelinantigen, verfahren und testsatz zur targetierung |
| US6750031B1 (en) | 1996-01-11 | 2004-06-15 | The United States Of America As Represented By The Secretary Of The Navy | Displacement assay on a porous membrane |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US5741647A (en) | 1996-02-16 | 1998-04-21 | Tam; Joseph Wing On | Flow through nucleic acid hybridisation uses thereof and a device thereof |
| DE19609838A1 (de) | 1996-03-13 | 1997-09-18 | Boehringer Mannheim Gmbh | Verfahren und Teststreifen zur Bestimmung eines Analyten |
| US5824478A (en) | 1996-04-30 | 1998-10-20 | Vysis, Inc. | Diagnostic methods and probes |
| US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| EP0946749A1 (en) | 1996-11-20 | 1999-10-06 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods |
| US5922617A (en) | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
| US6190612B1 (en) | 1998-01-21 | 2001-02-20 | Bayer Corporation | Oxygen sensing membranes and methods of making same |
| ATE328278T1 (de) | 1998-03-30 | 2006-06-15 | Orasure Technologies Inc | Sammelapparat für einschrittigen test von mundflüssigkeiten |
| US7640083B2 (en) | 2002-11-22 | 2009-12-29 | Monroe David A | Record and playback system for aircraft |
| US6207379B1 (en) | 1998-09-11 | 2001-03-27 | One Lambda | Method for amplification of DNA |
| US6261779B1 (en) | 1998-11-10 | 2001-07-17 | Bio-Pixels Ltd. | Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system |
| AU1821700A (en) | 1998-11-18 | 2000-06-05 | Orchid Biosciences, Inc. | One-step nucleic acid dipstick device with movable membrane |
| WO2000031538A1 (en) | 1998-11-23 | 2000-06-02 | Praxsys Biosystems, Inc. | Improved lateral flow assays |
| US6416642B1 (en) | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
| US20020177135A1 (en) | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| US6300069B1 (en) | 1999-05-03 | 2001-10-09 | Qiagen Gmbh | Generation and amplification of nucleic acids from ribonucleic acids |
| US6743399B1 (en) | 1999-10-08 | 2004-06-01 | Micronics, Inc. | Pumpless microfluidics |
| US6471916B1 (en) | 1999-11-09 | 2002-10-29 | Packard Instrument Company | Apparatus and method for calibration of a microarray scanning system |
| US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| US20020058252A1 (en) | 1999-12-06 | 2002-05-16 | Ananiev Evgueni V. | Short shared nucleotide sequences |
| US6468749B1 (en) | 2000-03-30 | 2002-10-22 | Quark Biotech, Inc. | Sequence-dependent gene sorting techniques |
| GB0016813D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (4) |
| GB0016814D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (3) |
| WO2002022884A2 (en) | 2000-09-12 | 2002-03-21 | Transgenetics Incorporated | Microarrayed organization of transcription factor target genes |
| EP1328342A4 (en) | 2000-10-10 | 2006-03-15 | Aviva Biosciences Corp | INTEGRATED BIOCHIP SYSTEM FOR SAMPLE PREPARATION AND ANALYSIS |
| EP1347299B1 (en) | 2000-12-26 | 2006-03-08 | Matsushita Electric Industrial Co., Ltd. | Specific bonding analysis method and specific bonding analysis device using it |
| WO2002072773A2 (en) | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| JP4542312B2 (ja) | 2001-03-09 | 2010-09-15 | ニューゲン テクノロジーズ， インコーポレイテッド | Ｒｎａ配列の増幅のための方法および組成物 |
| AU2002307152A1 (en) | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| US7105311B2 (en) | 2001-05-03 | 2006-09-12 | Immunetics, Inc. | Systems and methods for detection of analytes in biological fluids |
| ATE490267T1 (de) | 2001-06-05 | 2010-12-15 | Curevac Gmbh | Stabilisierte mrna mit erhöhtem g/c-gehalt, kodierend für ein virales antigen |
| US20030044862A1 (en) | 2001-06-22 | 2003-03-06 | The Board Of Trustees Of The Leland Stanford Jr. University | Diagnostic marker for tumor hypoxia and prognosis |
| WO2003014740A1 (en) | 2001-08-09 | 2003-02-20 | Matsushita Electric Industrial Co., Ltd. | Biosensors and measurement method |
| US6916541B2 (en) | 2001-09-07 | 2005-07-12 | Penn State Research Foundation | Modified substrates for the attachment of biomolecules |
| KR100488281B1 (ko) | 2001-09-15 | 2005-05-10 | 아람 바이오시스템 주식회사 | 열 대류를 이용한 염기서열 증폭 방법 및 장치 |
| EP1451584B1 (en) | 2001-11-09 | 2011-05-11 | 3dbiosurfaces Technologies, LLC | High surface area substrates for microarrays and methods to make same |
| US20030170686A1 (en) | 2001-12-07 | 2003-09-11 | Rene Hoet | Method and apparatus for washing magnetically responsive particles |
| US7772383B2 (en) | 2002-01-25 | 2010-08-10 | The Trustees Of Princeton University | Chemical PCR: Compositions for enhancing polynucleotide amplification reactions |
| US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| US20060160078A1 (en) | 2002-07-12 | 2006-07-20 | Cardy Donald L N | Lateral flow assay device and method |
| DE03707568T1 (de) | 2002-07-23 | 2005-11-10 | Microban Products Co. | Antimikrobielles melaminharz und daraus hergestellte produkte |
| US20040064435A1 (en) | 2002-07-26 | 2004-04-01 | Ahmad-Maher Moubayed | Clinical assessment and diagnostic tool for use with peristaltic pump |
| US20040018577A1 (en) | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| JP4632788B2 (ja) | 2002-09-20 | 2011-02-16 | ニュー・イングランド・バイオラブズ・インコーポレイティッド | 核酸のヘリカーゼ依存性増幅 |
| KR100463203B1 (ko) | 2002-12-10 | 2004-12-23 | 삼성전자주식회사 | 활성 영역을 구비하는 반도체 소자 |
| WO2004055159A2 (en) | 2002-12-12 | 2004-07-01 | Chiron Corporation | Identification of oligonucleotides for the capture, detection and quantitation of west nile virus |
| US20050221281A1 (en) | 2003-01-08 | 2005-10-06 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| JP2004263708A (ja) | 2003-01-14 | 2004-09-24 | Kyowa Metal Work Co Ltd | ツインクラッチ式変速機 |
| CA2513880A1 (en) | 2003-01-21 | 2004-08-05 | Micronics Inc. | Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing |
| US20040209309A1 (en) | 2003-02-27 | 2004-10-21 | Muldoon Mark Thomas | Compositions and methods for the specific detection of mammalian muscle proteins |
| TWI333545B (en) | 2003-04-02 | 2010-11-21 | Cholestech Corp | Adhered membranes retaining porosity and biological activity |
| FR2856046B1 (fr) | 2003-06-16 | 2005-07-29 | Biomerieux Sa | Microvanne fluidique a ouverture par commande electrique |
| US7722817B2 (en) | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
| EP1670356A1 (en) | 2003-09-03 | 2006-06-21 | Life Patch International, Inc. | Personal diagnostic devices and related methods |
| US7354706B2 (en) | 2003-09-09 | 2008-04-08 | The Regents Of The University Of Colorado, A Body Corporate | Use of photopolymerization for amplification and detection of a molecular recognition event |
| WO2005026665A2 (en) | 2003-09-15 | 2005-03-24 | Diagnoswiss S.A. | Microfluidic flow monitoring device |
| JP2005110621A (ja) | 2003-10-10 | 2005-04-28 | Aisin Seiki Co Ltd | 核酸増幅方法及び核酸増幅用試薬キット |
| CN100540313C (zh) | 2003-10-24 | 2009-09-16 | 索尼株式会社 | 头模块和液体喷射装置以及它们的制造方法 |
| CN1930304B (zh) | 2003-11-21 | 2016-01-06 | Anp技术公司 | 不对称支化的聚合物缀合物和微阵列检测 |
| JP4250523B2 (ja) | 2003-12-25 | 2009-04-08 | 株式会社東芝 | マイクロリアクタ、分析システム、分析方法、反応システム、反応方法、分離システム、分離方法 |
| AU2005231107B8 (en) | 2004-03-30 | 2011-04-14 | Global Life Sciences Solutions Usa Llc | Lateral flow format, materials and methods |
| US20050250141A1 (en) | 2004-03-30 | 2005-11-10 | Lambert James L | Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots |
| CA2562775C (en) | 2004-04-07 | 2015-08-04 | Access Bio, Inc. | Nucleic acid detection system |
| US8173078B2 (en) | 2004-04-28 | 2012-05-08 | Industrial Technology Research Institute | Gravity-driven micropump |
| US7273590B2 (en) | 2004-04-29 | 2007-09-25 | Industrial Technology Research Institute | gravity-driven apparatus and method for control of microfluidic devices |
| US7796266B2 (en) | 2004-04-30 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Optical detection system using electromagnetic radiation to detect presence or quantity of analyte |
| CA2566962A1 (en) | 2004-05-21 | 2005-12-01 | Atonomics A/S | Surface acoustic wave sensor comprising a hydrogel |
| SE527036C2 (sv) | 2004-06-02 | 2005-12-13 | Aamic Ab | Analysanordning med reglerat flöde och motsvarande förfarande |
| CA2588820A1 (en) | 2004-11-30 | 2006-06-08 | Global Technologies (Nz) Ltd | Method of sample analysis and apparatus therefor |
| US20060127886A1 (en) | 2004-12-15 | 2006-06-15 | Kaylor Rosann M | Sample-efficient lateral flow immunoassay |
| JP2006185972A (ja) | 2004-12-27 | 2006-07-13 | Nikon Corp | マスク及び露光方法 |
| DK1843850T3 (en) | 2005-01-31 | 2015-12-07 | Realbio Technologies Ltd | LATERAL FLOW STEERING CAPILLAR DEVICE |
| US7396689B2 (en) | 2005-02-04 | 2008-07-08 | Decision Biomarkers Incorporated | Method of adjusting the working range of a multi-analyte assay |
| WO2006098804A2 (en) | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| EP1871826A4 (en) | 2005-03-31 | 2011-08-17 | Fujifilm Corp | SURFACE GRAFT MATERIAL AND MANUFACTURING METHOD THEREOF, ELECTRICALLY CONDUCTIVE MATERIAL, METHOD FOR MANUFACTURING THE SAME, AND MATERIAL WITH ELECTRICALLY CONDUCTIVE PATTERN |
| US7439079B2 (en) | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
| WO2006122312A2 (en) | 2005-05-11 | 2006-11-16 | The Trustees Of The University Of Pennsylvania | Methods of testing using a microfluidic cassette |
| JP5033791B2 (ja) | 2005-05-23 | 2012-09-26 | ファディア・アクチボラグ | 二段階側流分析法および装置 |
| US20070015166A1 (en) | 2005-07-14 | 2007-01-18 | Nilsen Thor W | Lateral flow methods and devices for detection of nucleic acid binding proteins |
| AU2006287548A1 (en) | 2005-09-06 | 2007-03-15 | Gen-Probe Incorporated | Methods, compositions and kits for isothermal amplification of nucleic acids |
| CN101400993A (zh) * | 2005-11-10 | 2009-04-01 | 阿普尔拉股份有限公司 | 包括多孔聚合物电极的微流体系统 |
| US20090053773A1 (en) | 2006-01-20 | 2009-02-26 | Toppan Printing Co., Ltd. | Reaction Container and Dna Amplification Reaction Method |
| US7537917B2 (en) | 2006-03-31 | 2009-05-26 | Collins Michael J | Microwave assisted PCR amplification of DNA |
| AU2007265628B2 (en) | 2006-06-23 | 2012-12-06 | Revvity Health Sciences, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
| WO2008105814A2 (en) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| JP2008148690A (ja) | 2006-11-22 | 2008-07-03 | Fujifilm Corp | マイクロチップを用いた核酸増幅方法およびマイクロチップ、それを用いた核酸増幅システム |
| EP1972938B1 (de) | 2007-03-19 | 2014-05-14 | Ivoclar Vivadent | Teststreifen für die Bestimmung des Kariesrisikos |
| US8105783B2 (en) * | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| EP2183379B1 (en) | 2007-08-01 | 2015-04-15 | Dana Farber Cancer Institute | Enrichment of a target sequence |
| TW200909338A (en) | 2007-08-23 | 2009-03-01 | Ind Tech Res Inst | Autonomous microfluidic apparatus |
| US20090086357A1 (en) | 2007-09-28 | 2009-04-02 | Toshiba America Information Systems, Inc. | In drive written spirals for self servo writing |
| CN101409933B (zh) | 2007-10-11 | 2010-08-04 | 华为技术有限公司 | 一种释放资源的方法和设备 |
| US9409166B2 (en) | 2007-12-10 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications |
| DE102007062441A1 (de) | 2007-12-20 | 2009-06-25 | Aj Innuscreen Gmbh | Mobiles Schnelltestsystem für die Nukleinsäureanalytik |
| RU2533234C2 (ru) | 2008-02-22 | 2014-11-20 | Орион Диагностика Ой | Способ и устройство для определения анализируемого вещества |
| US8187808B2 (en) * | 2008-02-29 | 2012-05-29 | Northwestern University | Barriers for facilitating biological reactions |
| EP3067694A1 (en) | 2008-05-05 | 2016-09-14 | Los Alamos National Security, LLC | Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control |
| US20110160090A1 (en) | 2008-05-05 | 2011-06-30 | Los Alamos National Laboratory | Nanocrystal-Based Lateral Flow Microarrays and Low-Voltage Signal Detection Systems |
| US7910309B2 (en) * | 2008-07-31 | 2011-03-22 | Los Alamos National Security, Llc | Multiplexed lateral flow microarray assay for detection of citrus pathogens Xylella fastidiosa and Xanthomonas axonopodis pv citri |
| EP2172260A1 (en) | 2008-09-29 | 2010-04-07 | Corning Incorporated | Multiple flow path microfluidic devices |
| US9034605B2 (en) * | 2009-03-12 | 2015-05-19 | Brandeis University | Reagents and methods for PCR |
| US8084272B2 (en) | 2009-03-25 | 2011-12-27 | Abbott Point Of Care Inc. | Amelioration of heterophile antibody immunosensor interference |
| FR2945097B1 (fr) | 2009-04-30 | 2011-06-03 | Commissariat Energie Atomique | Vanne microfluidique a usage unique. |
| JP5577681B2 (ja) | 2009-11-30 | 2014-08-27 | 住友電気工業株式会社 | 半導体装置 |
| WO2011087813A2 (en) | 2009-12-22 | 2011-07-21 | University Of Washington | Capillarity-based devices for performing chemical processes and associated systems and methods |
| ES2930133T3 (es) * | 2010-03-09 | 2022-12-07 | Ande Corp | Biochip con almacenamiento de reactivo |
| EP2553473A4 (en) * | 2010-03-30 | 2016-08-10 | Advanced Liquid Logic Inc | DROPLET OPERATION PLATFORM |
| US9731297B2 (en) | 2011-01-06 | 2017-08-15 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same |
| EP3564392B1 (en) * | 2010-12-17 | 2021-11-24 | Life Technologies Corporation | Methods for nucleic acid amplification |
| US10519492B2 (en) | 2011-04-20 | 2019-12-31 | Mesa Biotech, Inc. | Integrated device for nucleic acid detection and identification |
| BR112015010695B1 (pt) * | 2013-01-11 | 2023-03-07 | Becton, Dickinson And Company | Dispositivo microfluídico e método para realizar um ensaio de uma amostra líquida, método para formar um dispositivo microfluídico, sistema e kit |
| US20160310948A1 (en) | 2015-04-24 | 2016-10-27 | Mesa Biotech, Inc. | Fluidic Test Cassette |
| WO2018195493A1 (en) | 2017-04-21 | 2018-10-25 | Mesa Biotech, Inc. | Fluidic test cassette |
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