JP5658565B2 - ホスホイノシチド３−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法 - Google Patents

ホスホイノシチド３−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法 Download PDF

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JP5658565B2
JP5658565B2 JP2010524965A JP2010524965A JP5658565B2 JP 5658565 B2 JP5658565 B2 JP 5658565B2 JP 2010524965 A JP2010524965 A JP 2010524965A JP 2010524965 A JP2010524965 A JP 2010524965A JP 5658565 B2 JP5658565 B2 JP 5658565B2
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formula
compound
methyl
combination
cancer
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JP2010539177A5 (en:Method
JP2010539177A (ja
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ベルヴィン，マルシア
フリエドマン，ロリ
ホエフリッチ，クラウス
サンパス，ディーパック
ビジャプルカ，ウルカ
ワリン，ジェフリー
ジョンソン，レイサ
シング，マリカ
パテル，ソナル
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F Hoffmann La Roche AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010524965A 2007-09-12 2008-09-10 ホスホイノシチド３−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法 Expired - Fee Related JP5658565B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97177307P 2007-09-12 2007-09-12
US60/971,773 2007-09-12
PCT/US2008/075883 WO2009036082A2 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use

Publications (3)

Publication Number Publication Date
JP2010539177A JP2010539177A (ja) 2010-12-16
JP2010539177A5 JP2010539177A5 (en:Method) 2011-11-04
JP5658565B2 true JP5658565B2 (ja) 2015-01-28

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JP2010524965A Expired - Fee Related JP5658565B2 (ja) 2007-09-12 2008-09-10 ホスホイノシチド３−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法

Country Status (18)

Country Link
US (3) US8247397B2 (en:Method)
EP (1) EP2205242B1 (en:Method)
JP (1) JP5658565B2 (en:Method)
KR (1) KR101584823B1 (en:Method)
CN (1) CN101939006B (en:Method)
AR (1) AR068402A1 (en:Method)
AU (1) AU2008298948B2 (en:Method)
BR (1) BRPI0816769A2 (en:Method)
CA (1) CA2699202C (en:Method)
CL (1) CL2008002687A1 (en:Method)
ES (1) ES2537352T3 (en:Method)
IL (1) IL204333A (en:Method)
MX (1) MX338504B (en:Method)
PE (2) PE20090678A1 (en:Method)
RU (1) RU2523890C2 (en:Method)
TW (1) TWI471134B (en:Method)
WO (1) WO2009036082A2 (en:Method)
ZA (1) ZA201002475B (en:Method)

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MX2010002543A (es) 2010-03-29
KR20100085912A (ko) 2010-07-29
IL204333A (en) 2016-08-31
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WO2009036082A2 (en) 2009-03-19
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BRPI0816769A2 (pt) 2016-11-29
AU2008298948A1 (en) 2009-03-19
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