JP5592891B2 - 抗微生物組成物 - Google Patents
抗微生物組成物 Download PDFInfo
- Publication number
- JP5592891B2 JP5592891B2 JP2011531447A JP2011531447A JP5592891B2 JP 5592891 B2 JP5592891 B2 JP 5592891B2 JP 2011531447 A JP2011531447 A JP 2011531447A JP 2011531447 A JP2011531447 A JP 2011531447A JP 5592891 B2 JP5592891 B2 JP 5592891B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- terpineol
- composition
- thymol
- antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000000203 mixture Substances 0.000 title claims description 137
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- 239000005844 Thymol Substances 0.000 claims description 65
- 229960000790 thymol Drugs 0.000 claims description 65
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- 229940116411 terpineol Drugs 0.000 claims description 64
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- DUKPKQFHJQGTGU-UHFFFAOYSA-N Hexyl salicylic acid Chemical compound CCCCCCOC(=O)C1=CC=CC=C1O DUKPKQFHJQGTGU-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-ONEGZZNKSA-N Isoeugenol Natural products COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 description 1
- ZPUKHRHPJKNORC-UHFFFAOYSA-N Longifolene Natural products CC1(C)CCCC2(C)C3CCC1(C3)C2=C ZPUKHRHPJKNORC-UHFFFAOYSA-N 0.000 description 1
- PDSNLYSELAIEBU-UHFFFAOYSA-N Longifolene Chemical compound C1CCC(C)(C)C2C3CCC2C1(C)C3=C PDSNLYSELAIEBU-UHFFFAOYSA-N 0.000 description 1
- WSTYNZDAOAEEKG-UHFFFAOYSA-N Mayol Natural products CC1=C(O)C(=O)C=C2C(CCC3(C4CC(C(CC4(CCC33C)C)=O)C)C)(C)C3=CC=C21 WSTYNZDAOAEEKG-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical group C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 1
- 244000021150 Orbignya martiana Species 0.000 description 1
- 235000014643 Orbignya martiana Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
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- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 244000157222 Thymus zygis Species 0.000 description 1
- 235000017826 Thymus zygis Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical group 0.000 description 1
- GUUHFMWKWLOQMM-NTCAYCPXSA-N alpha-hexylcinnamaldehyde Chemical compound CCCCCC\C(C=O)=C/C1=CC=CC=C1 GUUHFMWKWLOQMM-NTCAYCPXSA-N 0.000 description 1
- GUUHFMWKWLOQMM-UHFFFAOYSA-N alpha-n-hexylcinnamic aldehyde Natural products CCCCCCC(C=O)=CC1=CC=CC=C1 GUUHFMWKWLOQMM-UHFFFAOYSA-N 0.000 description 1
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
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- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
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- 238000003556 assay Methods 0.000 description 1
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- 239000007621 bhi medium Substances 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- IRAQOCYXUMOFCW-CXTNEJHOSA-N cedrene Chemical compound C1[C@]23[C@H](C)CC[C@H]3C(C)(C)[C@H]1C(C)=CC2 IRAQOCYXUMOFCW-CXTNEJHOSA-N 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- NNWHUJCUHAELCL-UHFFFAOYSA-N cis-Methyl isoeugenol Natural products COC1=CC=C(C=CC)C=C1OC NNWHUJCUHAELCL-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229910052570 clay Inorganic materials 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229930007927 cymene Natural products 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- IRAQOCYXUMOFCW-UHFFFAOYSA-N di-epi-alpha-cedrene Natural products C1C23C(C)CCC3C(C)(C)C1C(C)=CC2 IRAQOCYXUMOFCW-UHFFFAOYSA-N 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- XSNQECSCDATQEL-UHFFFAOYSA-N dihydromyrcenol Chemical compound C=CC(C)CCCC(C)(C)O XSNQECSCDATQEL-UHFFFAOYSA-N 0.000 description 1
- 229930008394 dihydromyrcenol Natural products 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- NYNCZOLNVTXTTP-UHFFFAOYSA-N ethyl 2-(1,3-dioxoisoindol-2-yl)acetate Chemical compound C1=CC=C2C(=O)N(CC(=O)OCC)C(=O)C2=C1 NYNCZOLNVTXTTP-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
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- 230000001815 facial effect Effects 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
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- 235000021323 fish oil Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
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- 239000011521 glass Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000002363 herbicidal effect Effects 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940116837 methyleugenol Drugs 0.000 description 1
- PRHTXAOWJQTLBO-UHFFFAOYSA-N methyleugenol Natural products COC1=CC=C(C(C)=C)C=C1OC PRHTXAOWJQTLBO-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 229960000969 phenyl salicylate Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
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- 229920003023 plastic Polymers 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229940095696 soap product Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 229930006978 terpinene Natural products 0.000 description 1
- 150000003507 terpinene derivatives Chemical class 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- WUCQRXWCJPCWTQ-UHFFFAOYSA-N trans-3-pentenal Natural products CC=CCC=O WUCQRXWCJPCWTQ-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/04—Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/2037—Terpenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/14—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
- C11D1/146—Sulfuric acid esters
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Insects & Arthropods (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
(a)チモール0.01から5重量%、
(b)テルピネオール0.01から5重量%、および
(c)担体を含む、抗微生物組成物が提供される。
(a)本発明の第1の態様の組成物を表面に適用するステップ、および
(b)表面を適切な溶媒で洗い流すステップを含む、表面を消毒する方法が提供される。
a.チモール0.05重量%超および0.3重量%未満、
b.テルピネオール0.05重量%超および1重量%未満、および
c.担体を含む。
a.チモール0.05から5重量%、
b.テルピネオール0.05から5重量%、
c.水10から99.9重量%、および
d.界面活性剤1から30重量%を含む。
a.チモール0.05から5重量%、
b.テルピネオール0.05から5重量%、
c.水5から30重量%、および
d.界面活性剤30から90重量%を含む。
(a)本発明の第1の態様の組成物を表面に適用するステップ、および
(b)表面を適切な溶媒で洗い流すステップを含む、表面を消毒する方法が提供される。
本発明をここで実施例によって実証する。これらの実施例は例示のみを目的とするものであり、いかなる方法によっても請求の範囲を限定しない。
短い時間枠(15秒)での細菌殺生の提供におけるチモールとテルピネオールの相乗的相互作用
それぞれ個々の活性剤および組み合わせを含む組成物を、担体として水を用いて調製した(詳細は下記の表1に示す)。テルピネオールおよびチモールは、Nishant aromas、Indiaから得た。
短い時間枠(15秒)での細菌殺生に対する他の抗菌剤組み合わせの効果
表2に示した他の種々の抗菌剤組み合わせを用いて、実施例1から3と類似の実験を行った。オイカリプトールおよびリナロールは、Flukaから得た。メントール、シトラール、およびゲラニオールは、Som Santi Corporation、Indiaから得た。最初に108個の細菌細胞(E.Coli ATCC10536)を採った。15秒の接触時間後の種々の組み合わせに関するlog(生存E.Coli)のデータを表2に示す。
TCCと比較した、他の種々の細菌の増殖阻害におけるチモールとテルピネオールの組み合わせの効果
チモール(0.2%)およびテルピネオール(0.5%)の組み合わせを、他の種々の細菌をこの組み合わせと約15秒間接触させた後の細菌の増殖阻害における有効性に関して試験した。別の周知の抗菌活性剤TCC(トリクロロカルバニリド)を用いて、同様の実験を行った。これらの実験は、実施例1から3と同様に行い、15秒間活性剤と接触させた後に残存する生存細菌に関するデータを表3に要約する。
種々の抗菌活性剤を含有する石鹸の抗菌有効性
種々の抗菌活性剤を含有する石鹸バー(72TFM石鹸含有)を調製した。これらの石鹸バーを、実施例1から3に用いた手順通り、インビトロアッセイで試験した。これらのアッセイに用いたサンプルは、石鹸バーの8%水溶液であった。最初に添加したE−Coliの量は、約107であった。調製した種々の石鹸バー、および15秒間活性剤と接触させた後に残存する生存細菌に関する抗菌有効性の結果を、表4に要約する。
細菌で人工的に汚染した手の洗浄における石鹸組成物の抗菌活性
以下のプロトコルを用いて、ヒトの手に付加した細菌を除去する能力における種々の組成物の抗菌有効性を試験した。
継続的防御
本発明の組成物で洗浄した手に継続的防御を提供する本発明の組成物の能力を調べた。プロトコルは以下に示したとおりであった。
口腔細菌に対する本発明の組成物の抗菌活性
通常見出されるグラム陽性口腔細菌、即ちストレプトコッカス・ミュータンス(Streptococcus mutans)ATCC25175およびグラム陰性口腔細菌ナイセリア・サブフラバ(Neisseria subflava)ATCC19243に対する本発明の組成物の抗菌活性を判定した。これはOxoplateを用いて調べた。Oxoplateは、反応系内(細菌、培地、および活性剤を含有する。)の酸素欠乏をモニターする。
活性剤溶液を試験するために、グラム陽性(ストレプトコッカス・ミュータンス ATCC25175)およびグラム陰性(ナイセリア・サブフラバ ATCC19243)細菌を選択した。両方の細菌をBHIS寒天プレートで24時間、37℃/15%CO2で培養し、次いでこれをマクファーランド標準2まで(細胞から6×108)PBSに懸濁した。
各活性剤を試験のために50%エタノール溶液に溶解した。すべての溶液は10倍濃度で製造し、プレートでの希釈を可能にした。ナイセリア・サブフラバでは、この生物体の殺生物剤に対する感受性が高いため、低い濃度を用いた。
以下の成分をOxoplateのウェルに入れた。
20□l 試験溶液
10□1 細菌
最初に培地をOxoplateに入れ、その後、試験溶液、次いで細菌を入れた。各プレートにおいて、水または50%エタノールのコントロールを用いた。すべての溶液は4回反復で試験を行った。プレートを蛍光プレートリーダーに入れ、37℃でインキュベートし、18時間15分毎に測定した。ウェル底部のセンサは2つの波長指標(650/540nM)、参照(590/540nm)で測定した。
様々な量のチモールおよびテルピネオールで調製された石鹸組成物
種々の石鹸バー(72TFMのもの)を、表8に示したとおり、抗菌活性剤を用いて調製した。訓練を受けた香料専門家によって、におい強度の受容性に関して、バーを評価した。これらの評価を表8に示す。
Claims (17)
- (i)a.チモール0.01から5重量%、
b.テルピネオール0.01から5重量%、および
c.担体を含む組成物を表面に適用するステップ、ならびに
(ii)表面を適切な溶媒で洗い流すか、または表面を適切なワイプで拭き取るステップを含む、表面を消毒する方法。 - 表面を洗い流すか、または拭き取る前記ステップが、組成物を表面に適用するステップ後、5分未満に行われる、請求項1に記載の方法。
- 前記組成物が、
a.チモール0.05重量%超および0.3重量%未満、
b.テルピネオール0.05重量%超および1重量%未満、および
c.担体を含む、請求項1または2に記載の方法。 - 界面活性剤1から80%を含む、請求項1から3のいずれか一項に記載の方法。
- a.チモール0.01重量%から5重量%、
b.テルピネオール0.01重量%から5重量%、
c.アニオン性界面活性剤1から80重量%、および
d.担体を含む、抗微生物組成物。 - 界面活性剤が、石鹸、アルキルスルファート、または直鎖アルキルベンゼンスルホナートである、請求項5に記載の抗微生物組成物。
- テルピネオールが、α−テルピネオール、β−テルピネオール、γ−テルピネオール、またはこれらの混合物から選択される、請求項5または6に記載の抗微生物組成物。
- 前記テルピネオールが、α−テルピネオールである、請求項7に記載の抗微生物組成物。
- 担体が水である、請求項5から8のいずれか一項に記載の抗微生物組成物。
- a.チモール0.05から5重量%、
b.テルピネオール0.05から5重量%、
c.水10から99.9重量%、および
d.界面活性剤0.5から10重量%を含む、液体抗微生物組成物。 - 界面活性剤1から5重量%を含む、請求項10に記載の組成物。
- a.チモール0.05から5重量%、
b.テルピネオール0.05から5重量%、
c.水5から30重量%、および
d.界面活性剤30から90重量%を含む、固体抗微生物組成物。 - 前記界面活性剤が石鹸である、請求項12に記載の固体抗微生物組成物。
- 手の衛生を改善するための、チモール0.01から5重量%、テルピネオール0.01から5重量%、および担体を含む組成物の使用。
- 口腔の衛生を改善するための、チモール0.01から5重量%、テルピネオール0.01から5重量%、および担体を含む組成物の使用。
- a.チモール0.01から5重量%、
b.テルピネオール0.01から5重量%、および
c.担体を含む、純粋な油/溶媒ベース中の抗微生物無水スティック身体ケア組成物。 - a.チモール0.01から5重量%、
b.テルピネオール0.01から5重量%、
c.担体、および
d.噴射剤を含む、純粋な油/溶媒ベース中の抗微生物噴射剤含有身体ケア組成物。
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CA2739843C (en) | 2008-10-20 | 2018-01-09 | Unilever Plc | Antimicrobial composition comprising thymol and terpineol for disinfecting surfaces |
WO2010077278A1 (en) | 2008-12-09 | 2010-07-08 | Becton, Dickinson And Company | Dual-chambered drug delivery device for high pressure injections |
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EP2470156A2 (de) | 2009-08-26 | 2012-07-04 | Basf Se | Verwendung von 1,3-diolen als biozide |
EA019746B1 (ru) | 2009-09-24 | 2014-05-30 | Юнилевер Нв | Противомикробная композиция, содержащая эвгенол, терпинеол и тимол, и способ дезинфицирования поверхности |
JP2013506650A (ja) | 2009-10-02 | 2013-02-28 | イッスム リサーチ デベロプメント カンパニー オブ ザ ヘブライ ユニバーシティ オブ エルサレム リミテッド | サニタイジング組成物 |
CN101874531A (zh) | 2010-04-10 | 2010-11-03 | 邯郸市天养生物科技有限公司 | 一种添加茶多酚微乳液的葡萄籽油及制备方法 |
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CN102229861A (zh) | 2011-05-16 | 2011-11-02 | 安徽华香香料股份有限公司 | L-香芹酮 |
JP6203469B2 (ja) | 2011-06-03 | 2017-09-27 | 花王株式会社 | 歯磨組成物 |
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AU2009306592B2 (en) | 2013-05-23 |
CA2739843A1 (en) | 2010-04-29 |
WO2010046238A1 (en) | 2010-04-29 |
EA019846B1 (ru) | 2014-06-30 |
BRPI0914031A2 (pt) | 2016-05-17 |
AU2009306592A1 (en) | 2010-04-29 |
EA201100656A1 (ru) | 2011-10-31 |
ES2414158T3 (es) | 2013-07-18 |
CA2739843C (en) | 2018-01-09 |
ZA201102078B (en) | 2012-06-27 |
MY180935A (en) | 2020-12-12 |
BRPI0914031B1 (pt) | 2023-12-12 |
US20110223114A1 (en) | 2011-09-15 |
KR101632091B1 (ko) | 2016-06-20 |
MX2011004155A (es) | 2011-05-23 |
AR073903A1 (es) | 2010-12-09 |
EP2348838A1 (en) | 2011-08-03 |
CN102186341B (zh) | 2013-12-25 |
CN102186341A (zh) | 2011-09-14 |
KR20110081198A (ko) | 2011-07-13 |
PL2348838T3 (pl) | 2013-10-31 |
US8945596B2 (en) | 2015-02-03 |
JP2012505851A (ja) | 2012-03-08 |
EP2348838B1 (en) | 2013-05-08 |
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