JP5543966B2 - Ｃａｖ２．２カルシウムチャネルモジュレーターとして使用されるピペラジン誘導体 - Google Patents
Ｃａｖ２．２カルシウムチャネルモジュレーターとして使用されるピペラジン誘導体 Download PDFInfo
- Publication number
- JP5543966B2 JP5543966B2 JP2011517911A JP2011517911A JP5543966B2 JP 5543966 B2 JP5543966 B2 JP 5543966B2 JP 2011517911 A JP2011517911 A JP 2011517911A JP 2011517911 A JP2011517911 A JP 2011517911A JP 5543966 B2 JP5543966 B2 JP 5543966B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- mmol
- pain
- sulfonyl
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc(c(*)c1)c(*)c(*)c1S(N(CC1)C*(*)CN1C(C1=C*(*)C=CN=C1)=O)(=O)=O Chemical compound Cc(c(*)c1)c(*)c(*)c1S(N(CC1)C*(*)CN1C(C1=C*(*)C=CN=C1)=O)(=O)=O 0.000 description 4
- QPGKYGFVCKMTBB-UHFFFAOYSA-N CC(c(cc1)ccc1S(C)(=O)=O)(F)F Chemical compound CC(c(cc1)ccc1S(C)(=O)=O)(F)F QPGKYGFVCKMTBB-UHFFFAOYSA-N 0.000 description 1
- FNVUZZFFWUAAKG-INIZCTEOSA-N C[C@@H](CN(CC1)C(c2ccc(C)nc2)=O)N1S(c(cc1)c(C)cc1C#N)(=O)=O Chemical compound C[C@@H](CN(CC1)C(c2ccc(C)nc2)=O)N1S(c(cc1)c(C)cc1C#N)(=O)=O FNVUZZFFWUAAKG-INIZCTEOSA-N 0.000 description 1
- POOCAFBNTJCFRR-ZDUSSCGKSA-N C[C@@H](CN(CC1)C(c2cccnc2C)=O)N1S(c1ccc(C(F)(F)F)cc1/[O]=C\O)(=O)=O Chemical compound C[C@@H](CN(CC1)C(c2cccnc2C)=O)N1S(c1ccc(C(F)(F)F)cc1/[O]=C\O)(=O)=O POOCAFBNTJCFRR-ZDUSSCGKSA-N 0.000 description 1
- OPUCQHFGYBLCQC-AWEZNQCLSA-N C[C@@H](CN(CC1)S(c2c(C)cc(C(F)(F)F)cc2)(=O)=O)N1C(c1c(C)nccc1)=O Chemical compound C[C@@H](CN(CC1)S(c2c(C)cc(C(F)(F)F)cc2)(=O)=O)N1C(c1c(C)nccc1)=O OPUCQHFGYBLCQC-AWEZNQCLSA-N 0.000 description 1
- DJSNOPRLJXMRGP-ZDUSSCGKSA-N C[C@@H](CN(CC1)S(c2ccc(C(F)(F)F)cc2)(=O)=O)N1C(c(c(C)c1)cnc1F)=O Chemical compound C[C@@H](CN(CC1)S(c2ccc(C(F)(F)F)cc2)(=O)=O)N1C(c(c(C)c1)cnc1F)=O DJSNOPRLJXMRGP-ZDUSSCGKSA-N 0.000 description 1
- GDRUGSHHHSFQCA-UHFFFAOYSA-N O=C(c(cn1)ccc1Cl)N(CC1)CCN1S(c1ccc(C(F)(F)F)cc1)(=O)=O Chemical compound O=C(c(cn1)ccc1Cl)N(CC1)CCN1S(c1ccc(C(F)(F)F)cc1)(=O)=O GDRUGSHHHSFQCA-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0813142.7 | 2008-07-17 | ||
| GBGB0813142.7A GB0813142D0 (en) | 2008-07-17 | 2008-07-17 | Novel compounds |
| PCT/EP2009/059012 WO2010007073A1 (en) | 2008-07-17 | 2009-07-15 | Piperazine derivatives used as cav2.2 calcium channel modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528020A JP2011528020A (ja) | 2011-11-10 |
| JP2011528020A5 JP2011528020A5 (enExample) | 2012-08-30 |
| JP5543966B2 true JP5543966B2 (ja) | 2014-07-09 |
Family
ID=39737239
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517911A Expired - Fee Related JP5543966B2 (ja) | 2008-07-17 | 2009-07-15 | Ｃａｖ２．２カルシウムチャネルモジュレーターとして使用されるピペラジン誘導体 |
| JP2011517910A Expired - Fee Related JP5688850B2 (ja) | 2008-07-17 | 2009-07-15 | Ｃａｖ２．２カルシウムチャネルモジュレーターとして使用されるピペラジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517910A Expired - Fee Related JP5688850B2 (ja) | 2008-07-17 | 2009-07-15 | Ｃａｖ２．２カルシウムチャネルモジュレーターとして使用されるピペラジン誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8530478B2 (enExample) |
| EP (2) | EP2300432B1 (enExample) |
| JP (2) | JP5543966B2 (enExample) |
| KR (1) | KR101599087B1 (enExample) |
| CN (1) | CN102099337B (enExample) |
| AR (1) | AR072809A1 (enExample) |
| AU (1) | AU2009272762B2 (enExample) |
| BR (1) | BRPI0916622A2 (enExample) |
| CA (1) | CA2730471C (enExample) |
| EA (1) | EA018621B1 (enExample) |
| ES (2) | ES2396960T3 (enExample) |
| GB (1) | GB0813142D0 (enExample) |
| IL (1) | IL210446A (enExample) |
| MX (1) | MX2011000600A (enExample) |
| PL (1) | PL2300432T3 (enExample) |
| TW (1) | TW201016677A (enExample) |
| UY (1) | UY31990A (enExample) |
| WO (2) | WO2010007073A1 (enExample) |
| ZA (1) | ZA201100014B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0813142D0 (en) * | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| GB201000685D0 (en) * | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
| US8933132B2 (en) * | 2011-01-19 | 2015-01-13 | Convergence Pharmaceuticals Limited | Tricyclic substituted benzenesulfonamide piperazine derivatives as CAV2.2 calcium channel blockers |
| CN103781759B (zh) | 2011-06-27 | 2016-01-13 | 纽朗制药有限公司 | 氟化的芳基烷基氨基甲酰胺衍生物 |
| EA032638B1 (ru) * | 2014-04-14 | 2019-06-28 | Грюненталь Гмбх | Арилзамещенные гетероциклилсульфоны |
| US9879000B2 (en) * | 2014-04-14 | 2018-01-30 | Grünenthal GmbH | Heteroaryl substituted heterocyclyl sulfones |
| GB201516183D0 (en) * | 2015-09-14 | 2015-10-28 | Calchan Ltd | Novel pharmaceutical composition |
| TW201718557A (zh) | 2015-10-08 | 2017-06-01 | 歌林達有限公司 | 經吡唑基取代之四氫吡喃基碸 |
| TW201726128A (zh) | 2015-10-08 | 2017-08-01 | 歌林達有限公司 | 經吡唑基取代之四氫哌喃基碸 |
| EP3615521A4 (en) * | 2017-04-26 | 2021-02-17 | Cavion, Inc. | METHODS FOR IMPROVING MEMORY AND COGNITION AND TREATING MEMORY AND COGNITIVE DISORDERS |
| CN118085389B (zh) * | 2024-03-11 | 2024-11-05 | 伟建实业(苏州)有限公司 | 一种环保型抗菌海绵及其制备方法 |
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