EA201170209A1 - Производные пиперазина, применяемые в качестве модуляторов кальциевого канала ca2.2 - Google Patents

Производные пиперазина, применяемые в качестве модуляторов кальциевого канала ca2.2

Info

Publication number
EA201170209A1
EA201170209A1 EA201170209A EA201170209A EA201170209A1 EA 201170209 A1 EA201170209 A1 EA 201170209A1 EA 201170209 A EA201170209 A EA 201170209A EA 201170209 A EA201170209 A EA 201170209A EA 201170209 A1 EA201170209 A1 EA 201170209A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
piperazine
models
calcium channel
manufacture
Prior art date
Application number
EA201170209A
Other languages
English (en)
Other versions
EA018621B1 (ru
Inventor
Пол Джон Бесвик
Алистер Кэмпбелл
Эндрю Питер Кридлэнд
Роберт Джеймс Глив
Джаг Пол Хир
Невилль Хьюберт Николсон
Ли Уилльям Пэйдж
Сэйди Вайл
Original Assignee
Конвердженс Фармасьютикалз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Конвердженс Фармасьютикалз Лимитед filed Critical Конвердженс Фармасьютикалз Лимитед
Publication of EA201170209A1 publication Critical patent/EA201170209A1/ru
Publication of EA018621B1 publication Critical patent/EA018621B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым производным пиперазина, к способам их изготовления, к фармацевтическим композициям, содержащим указанные производные, и к применению указанных производных для лечения заболеваний, при которых полезно блокировать кальциевые каналы Ca2.2.
EA201170209A 2008-07-17 2009-07-15 ПРОИЗВОДНЫЕ ПИПЕРАЗИНА, ПРИМЕНЯЕМЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ КАЛЬЦИЕВОГО КАНАЛА Ca2.2 EA018621B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0813142.7A GB0813142D0 (en) 2008-07-17 2008-07-17 Novel compounds
PCT/EP2009/059012 WO2010007073A1 (en) 2008-07-17 2009-07-15 Piperazine derivatives used as cav2.2 calcium channel modulators

Publications (2)

Publication Number Publication Date
EA201170209A1 true EA201170209A1 (ru) 2011-08-30
EA018621B1 EA018621B1 (ru) 2013-09-30

Family

ID=39737239

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170209A EA018621B1 (ru) 2008-07-17 2009-07-15 ПРОИЗВОДНЫЕ ПИПЕРАЗИНА, ПРИМЕНЯЕМЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ КАЛЬЦИЕВОГО КАНАЛА Ca2.2

Country Status (19)

Country Link
US (3) US8530478B2 (ru)
EP (2) EP2346828B1 (ru)
JP (2) JP5543966B2 (ru)
KR (1) KR101599087B1 (ru)
CN (1) CN102099337B (ru)
AR (1) AR072809A1 (ru)
AU (1) AU2009272762B2 (ru)
BR (1) BRPI0916622A2 (ru)
CA (1) CA2730471C (ru)
EA (1) EA018621B1 (ru)
ES (2) ES2396962T3 (ru)
GB (1) GB0813142D0 (ru)
IL (1) IL210446A (ru)
MX (1) MX2011000600A (ru)
PL (1) PL2300432T3 (ru)
TW (1) TW201016677A (ru)
UY (1) UY31990A (ru)
WO (2) WO2010007073A1 (ru)
ZA (1) ZA201100014B (ru)

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Also Published As

Publication number Publication date
JP5688850B2 (ja) 2015-03-25
AU2009272762A1 (en) 2010-01-21
WO2010007073A1 (en) 2010-01-21
US8536183B2 (en) 2013-09-17
IL210446A (en) 2014-01-30
ZA201100014B (en) 2011-09-28
ES2396962T3 (es) 2013-03-01
US8530478B2 (en) 2013-09-10
US20120302746A1 (en) 2012-11-29
CN102099337A (zh) 2011-06-15
KR20110031199A (ko) 2011-03-24
MX2011000600A (es) 2011-05-24
TW201016677A (en) 2010-05-01
JP2011528020A (ja) 2011-11-10
IL210446A0 (en) 2011-03-31
UY31990A (es) 2010-01-05
AR072809A1 (es) 2010-09-22
JP2011528019A (ja) 2011-11-10
US20100022555A1 (en) 2010-01-28
EP2346828A1 (en) 2011-07-27
AU2009272762B2 (en) 2013-08-15
CA2730471A1 (en) 2010-01-21
EP2346828B1 (en) 2012-10-03
KR101599087B1 (ko) 2016-03-02
US8288388B2 (en) 2012-10-16
CA2730471C (en) 2016-12-06
BRPI0916622A2 (pt) 2019-04-09
JP5543966B2 (ja) 2014-07-09
US20110130379A1 (en) 2011-06-02
EA018621B1 (ru) 2013-09-30
ES2396960T3 (es) 2013-03-01
EP2300432A1 (en) 2011-03-30
PL2300432T3 (pl) 2013-03-29
CN102099337B (zh) 2013-08-21
WO2010007072A1 (en) 2010-01-21
GB0813142D0 (en) 2008-08-27
EP2300432B1 (en) 2012-10-03

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