BRPI0916622A2 - derivados de piperazina usados como moduladores de canal de cálcio cav2,2 - Google Patents
derivados de piperazina usados como moduladores de canal de cálcio cav2,2Info
- Publication number
- BRPI0916622A2 BRPI0916622A2 BRPI0916622-0A BRPI0916622A BRPI0916622A2 BR PI0916622 A2 BRPI0916622 A2 BR PI0916622A2 BR PI0916622 A BRPI0916622 A BR PI0916622A BR PI0916622 A2 BRPI0916622 A2 BR PI0916622A2
- Authority
- BR
- Brazil
- Prior art keywords
- cav2
- calcium channel
- piperazine derivatives
- channel modulators
- derivatives used
- Prior art date
Links
- 108090000312 Calcium Channels Proteins 0.000 title abstract 3
- 102000003922 Calcium Channels Human genes 0.000 title abstract 3
- 150000004885 piperazines Chemical class 0.000 title abstract 3
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0813142.7 | 2008-07-17 | ||
| GBGB0813142.7A GB0813142D0 (en) | 2008-07-17 | 2008-07-17 | Novel compounds |
| PCT/EP2009/059012 WO2010007073A1 (en) | 2008-07-17 | 2009-07-15 | Piperazine derivatives used as cav2.2 calcium channel modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0916622A2 true BRPI0916622A2 (pt) | 2019-04-09 |
Family
ID=39737239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0916622-0A BRPI0916622A2 (pt) | 2008-07-17 | 2009-07-15 | derivados de piperazina usados como moduladores de canal de cálcio cav2,2 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8530478B2 (enExample) |
| EP (2) | EP2300432B1 (enExample) |
| JP (2) | JP5688850B2 (enExample) |
| KR (1) | KR101599087B1 (enExample) |
| CN (1) | CN102099337B (enExample) |
| AR (1) | AR072809A1 (enExample) |
| AU (1) | AU2009272762B2 (enExample) |
| BR (1) | BRPI0916622A2 (enExample) |
| CA (1) | CA2730471C (enExample) |
| EA (1) | EA018621B1 (enExample) |
| ES (2) | ES2396962T3 (enExample) |
| GB (1) | GB0813142D0 (enExample) |
| IL (1) | IL210446A (enExample) |
| MX (1) | MX2011000600A (enExample) |
| PL (1) | PL2300432T3 (enExample) |
| TW (1) | TW201016677A (enExample) |
| UY (1) | UY31990A (enExample) |
| WO (2) | WO2010007072A1 (enExample) |
| ZA (1) | ZA201100014B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0813142D0 (en) * | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| GB201000685D0 (en) | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
| EP2665729B1 (en) * | 2011-01-19 | 2015-04-01 | Convergence Pharmaceuticals Limited | Piperazine derivatives as cav2.2 calcium channel blockers |
| CN103781759B (zh) | 2011-06-27 | 2016-01-13 | 纽朗制药有限公司 | 氟化的芳基烷基氨基甲酰胺衍生物 |
| EP3495360A1 (en) * | 2014-04-14 | 2019-06-12 | Grünenthal GmbH | Heteroaryl substituted heterocyclyl sulfones |
| US9896440B2 (en) | 2014-04-14 | 2018-02-20 | Grünenthal GmbH | Aryl substituted heterocyclyl sulfones |
| GB201516183D0 (en) * | 2015-09-14 | 2015-10-28 | Calchan Ltd | Novel pharmaceutical composition |
| TW201718557A (zh) | 2015-10-08 | 2017-06-01 | 歌林達有限公司 | 經吡唑基取代之四氫吡喃基碸 |
| TW201726128A (zh) | 2015-10-08 | 2017-08-01 | 歌林達有限公司 | 經吡唑基取代之四氫哌喃基碸 |
| MX2019012818A (es) * | 2017-04-26 | 2020-07-14 | Cavion Inc | Metodos para mejorar la memoria y la cognicion y para el tratamiento de trastornos de la memoria y cognitivos. |
| CN118085389B (zh) * | 2024-03-11 | 2024-11-05 | 伟建实业(苏州)有限公司 | 一种环保型抗菌海绵及其制备方法 |
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-
2008
- 2008-07-17 GB GBGB0813142.7A patent/GB0813142D0/en not_active Ceased
-
2009
- 2009-07-15 TW TW098123842A patent/TW201016677A/zh unknown
- 2009-07-15 US US13/054,265 patent/US8530478B2/en not_active Expired - Fee Related
- 2009-07-15 MX MX2011000600A patent/MX2011000600A/es active IP Right Grant
- 2009-07-15 AU AU2009272762A patent/AU2009272762B2/en not_active Ceased
- 2009-07-15 CN CN200980127788XA patent/CN102099337B/zh not_active Expired - Fee Related
- 2009-07-15 WO PCT/EP2009/059011 patent/WO2010007072A1/en not_active Ceased
- 2009-07-15 ES ES09780587T patent/ES2396962T3/es active Active
- 2009-07-15 WO PCT/EP2009/059012 patent/WO2010007073A1/en not_active Ceased
- 2009-07-15 BR BRPI0916622-0A patent/BRPI0916622A2/pt not_active IP Right Cessation
- 2009-07-15 EA EA201170209A patent/EA018621B1/ru not_active IP Right Cessation
- 2009-07-15 CA CA2730471A patent/CA2730471C/en not_active Expired - Fee Related
- 2009-07-15 UY UY0001031990A patent/UY31990A/es unknown
- 2009-07-15 JP JP2011517910A patent/JP5688850B2/ja not_active Expired - Fee Related
- 2009-07-15 PL PL09780587T patent/PL2300432T3/pl unknown
- 2009-07-15 EP EP09780587A patent/EP2300432B1/en not_active Not-in-force
- 2009-07-15 ES ES09780586T patent/ES2396960T3/es active Active
- 2009-07-15 EP EP09780586A patent/EP2346828B1/en not_active Not-in-force
- 2009-07-15 KR KR1020117001109A patent/KR101599087B1/ko not_active Expired - Fee Related
- 2009-07-15 JP JP2011517911A patent/JP5543966B2/ja not_active Expired - Fee Related
- 2009-07-15 AR ARP090102692A patent/AR072809A1/es unknown
- 2009-07-15 US US12/503,125 patent/US8288388B2/en not_active Expired - Fee Related
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2011
- 2011-01-03 ZA ZA2011/00014A patent/ZA201100014B/en unknown
- 2011-01-03 IL IL210446A patent/IL210446A/en not_active IP Right Cessation
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2012
- 2012-08-07 US US13/568,211 patent/US8536183B2/en not_active Expired - Fee Related
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