JP5538356B2 - １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 - Google Patents

１１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 Download PDF

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JP5538356B2
JP5538356B2 JP2011500805A JP2011500805A JP5538356B2 JP 5538356 B2 JP5538356 B2 JP 5538356B2 JP 2011500805 A JP2011500805 A JP 2011500805A JP 2011500805 A JP2011500805 A JP 2011500805A JP 5538356 B2 JP5538356 B2 JP 5538356B2
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alkyl
halo
cycloalkyl
alkoxy
hydroxy
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JP2011515398A5 (https=
JP2011515398A (ja
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クラレモン，デーヴィッド・エイ
ツァン，リンハン
イエ，ユアンジェ
シン，スレシュ・ビー
タイス，コリン・エム
マクギーハン，ジェラルド
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ヴァイティー ファーマシューティカルズ，インコーポレイテッド
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
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  • Diabetes (AREA)
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JP2011500805A 2008-03-18 2009-03-18 １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 Expired - Fee Related JP5538356B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3764608P 2008-03-18 2008-03-18
US61/037,646 2008-03-18
PCT/US2009/001712 WO2009117109A1 (en) 2008-03-18 2009-03-18 Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

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JP2011515398A JP2011515398A (ja) 2011-05-19
JP2011515398A5 JP2011515398A5 (https=) 2012-05-10
JP5538356B2 true JP5538356B2 (ja) 2014-07-02

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US (1) US20110105504A1 (https=)
EP (1) EP2274287B1 (https=)
JP (1) JP5538356B2 (https=)
CA (1) CA2718264A1 (https=)
WO (1) WO2009117109A1 (https=)

Families Citing this family (40)

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US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
RU2531272C2 (ru) 2008-05-01 2014-10-20 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
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