JP5518893B2 - 肺ならびに肺の疾患および障害の治療 - Google Patents
肺ならびに肺の疾患および障害の治療 Download PDFInfo
- Publication number
- JP5518893B2 JP5518893B2 JP2011542520A JP2011542520A JP5518893B2 JP 5518893 B2 JP5518893 B2 JP 5518893B2 JP 2011542520 A JP2011542520 A JP 2011542520A JP 2011542520 A JP2011542520 A JP 2011542520A JP 5518893 B2 JP5518893 B2 JP 5518893B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- tissue
- derived
- lung
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Pregnancy & Childbirth (AREA)
- Botany (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13942508P | 2008-12-19 | 2008-12-19 | |
| US61/139,425 | 2008-12-19 | ||
| PCT/US2009/068881 WO2010071864A1 (en) | 2008-12-19 | 2009-12-19 | Treatment of lung and pulmonary diseases and disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512911A JP2012512911A (ja) | 2012-06-07 |
| JP2012512911A5 JP2012512911A5 (cg-RX-API-DMAC7.html) | 2013-05-02 |
| JP5518893B2 true JP5518893B2 (ja) | 2014-06-11 |
Family
ID=41816472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542520A Expired - Fee Related JP5518893B2 (ja) | 2008-12-19 | 2009-12-19 | 肺ならびに肺の疾患および障害の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10557116B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2379088B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5518893B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN107028983A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009327384B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0923068B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2747794C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2665883T3 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2379088T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010071864A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| PL1641916T3 (pl) | 2003-06-27 | 2016-08-31 | Depuy Synthes Products Inc | Regeneracja i naprawa tkanki nerwowej z wykorzystaniem komórek poporodowych |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| CN102036688B (zh) * | 2007-10-05 | 2014-07-02 | 伊西康公司 | 使用人脐带组织来源的细胞进行肾脏组织的修复和再生 |
| US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
| EP2237789B1 (en) * | 2007-12-27 | 2017-01-25 | DePuy Synthes Products, Inc. | Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells |
| AU2009327384B2 (en) | 2008-12-19 | 2014-07-10 | DePuy Synthes Products, LLC | Treatment of lung and pulmonary diseases and disorders |
| US20130302283A1 (en) * | 2012-05-14 | 2013-11-14 | Advanced Technologies And Regenerative Medicine, Llc | hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| EP2411504B1 (en) | 2009-03-26 | 2017-05-10 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells as therapy for alzheimer's disease |
| EP2723357A4 (en) | 2011-06-21 | 2015-04-01 | Bvw Holding Ag | MEDICAL DEVICE COMPRISING BOSWELLIC ACID |
| AU2012358810B2 (en) | 2011-12-23 | 2018-03-15 | DePuy Synthes Products, Inc. | Detection of human umbilical cord tissue-derived cells |
| US9888680B2 (en) | 2013-04-04 | 2018-02-13 | The Trustees Of Columbia University In The City Of New York | Functional recovery of human lungs for transplantation |
| CA2943088A1 (en) * | 2014-03-20 | 2015-10-01 | Patrick J. Casey | Method for the treatment of damaged tissue |
| US20190153386A1 (en) * | 2017-11-17 | 2019-05-23 | James R. Musick | Stem cell line for treatment of various medical conditions |
| EP4108084A4 (en) * | 2020-02-17 | 2023-11-08 | Nippon Becton Dickinson Company, Ltd. | Sample preservation composition |
| JP7589052B2 (ja) * | 2021-01-28 | 2024-11-25 | キヤノンメディカルシステムズ株式会社 | 医用情報処理装置、医用情報処理システム、医用情報処理方法、及び医用情報処理プログラム |
| CN116036229A (zh) * | 2023-01-05 | 2023-05-02 | 安徽科门生物科技有限公司 | 一种含干细胞外泌体的雾化剂及其用于治疗肺部疾病的应用 |
Family Cites Families (249)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3665061A (en) * | 1969-07-16 | 1972-05-23 | United States Banknote Corp | Process for producing collagen sponges |
| JPS5651747B2 (cg-RX-API-DMAC7.html) * | 1973-05-31 | 1981-12-08 | ||
| CH635748A5 (fr) | 1977-08-16 | 1983-04-29 | Cellorgan Laboratoires Sa | Procede d'obtention de cellules placentaires de brebis. |
| US4216144A (en) | 1977-10-20 | 1980-08-05 | Ashmead H H | Soluble iron proteinates |
| JPS6040439B2 (ja) * | 1978-03-29 | 1985-09-11 | 大正製薬株式会社 | ヒドロコルチゾン誘導体 |
| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4487865A (en) * | 1983-12-15 | 1984-12-11 | Biomatrix, Inc. | Polymeric articles modified with hyaluronate |
| US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| US4925667A (en) * | 1986-05-27 | 1990-05-15 | Qmax Technology Group, Inc. | Substrate with particulate cosmetic |
| JPS642643A (en) | 1987-06-26 | 1989-01-06 | Bio Material Yunibaasu:Kk | Artificial skin |
| NZ226750A (en) | 1987-10-29 | 1990-09-26 | Amrad Corp Ltd | Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| US20030032178A1 (en) | 1988-08-04 | 2003-02-13 | Williams Robert Lindsay | In vitro propagation of embryonic stem cells |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5574205A (en) | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5840580A (en) | 1990-05-01 | 1998-11-24 | Becton Dickinson And Company | Phenotypic characterization of the hematopoietic stem cell |
| AU664976B2 (en) | 1990-08-29 | 1995-12-14 | Gene Pharming Europe Bv | Homologous recombination in mammalian cells |
| US5342761A (en) | 1990-10-01 | 1994-08-30 | Research Development Foundation | Oncofetal gene, gene product and uses therefor |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5286632A (en) | 1991-01-09 | 1994-02-15 | Jones Douglas H | Method for in vivo recombination and mutagenesis |
| NL9100038A (nl) * | 1991-01-11 | 1992-08-03 | Stamicarbon | Enzym-gekatalyseerde bereiding van optisch aktieve carbonzuren. |
| US6399369B1 (en) | 1991-07-08 | 2002-06-04 | Neurospheres Holdings Ltd. | Multipotent neural stem cell cDNA libraries |
| AU2515992A (en) | 1991-08-20 | 1993-03-16 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| US5320962A (en) | 1992-07-22 | 1994-06-14 | Duke University | DNA encoding the human A1 adenosine receptor |
| US5589376A (en) | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
| US20040224409A1 (en) | 1992-09-25 | 2004-11-11 | Laurent Pradier | Recombinant adenoviruses coding for brain-derived neurotrophic factor (BDNF) |
| US5677181A (en) | 1992-10-29 | 1997-10-14 | The Australian National University | Angiogenesis inhibitory antibodies |
| US5670483A (en) | 1992-12-28 | 1997-09-23 | Massachusetts Insititute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US5955343A (en) | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US5707643A (en) | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
| WO1994025584A1 (en) | 1993-04-28 | 1994-11-10 | Johns Hopkins University School Of Medicine | Chronic endothelial cell culture under flow |
| IL110589A0 (en) | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| JP3680114B2 (ja) | 1993-09-17 | 2005-08-10 | 敏一 中村 | 脳神経障害治療剤 |
| US6686198B1 (en) | 1993-10-14 | 2004-02-03 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
| US6432711B1 (en) | 1993-11-03 | 2002-08-13 | Diacrin, Inc. | Embryonic stem cells capable of differentiating into desired cell lines |
| US5456835A (en) * | 1993-11-08 | 1995-10-10 | Hemasure, Inc. | Device and process for removing free hemoglobin from blood |
| DE4406073A1 (de) | 1994-02-24 | 1995-08-31 | Univ Ludwigs Albert | Verfahren zur Herstellung von humanen, klonogenen Fibroblasten, Verfahren zur Gentransfizierung von Fibroblasten und so erhaltene Fibroblasten |
| US5698518A (en) | 1994-03-30 | 1997-12-16 | Oklahoma Medical Research Foundation | Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists |
| US6001647A (en) | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
| US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| US5834308A (en) | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
| EP0952792B1 (en) * | 1994-06-06 | 2003-08-27 | Case Western Reserve University | Biomatrix for tissue regeneration |
| IL114397A0 (en) | 1994-07-01 | 1995-10-31 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF-beta-family |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
| US5725493A (en) | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
| US5684032A (en) | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US5641750A (en) | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
| US6200606B1 (en) | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US5842477A (en) | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
| WO1997033995A2 (en) | 1996-03-15 | 1997-09-18 | Munin Corporation | Extracellular matrix signalling molecules |
| EP0953040A4 (en) | 1996-04-26 | 2001-12-12 | Univ Case Western Reserve | REGENERATION OF THE SKIN USING MESENCHYMAL STEM CELLS |
| US6787355B1 (en) | 1996-08-26 | 2004-09-07 | Mcgill University | Multipotent neural stem cells from peripheral tissues and uses thereof |
| US5919702A (en) | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
| EP0989855A4 (en) | 1997-05-13 | 2002-06-12 | Osiris Therapeutics Inc | REGENERATION OF CARTILAGE IN OSTEOARTHRITIS BY MEANS OF HUMAN MESENCHYMAL STEM CELLS |
| CA2290381A1 (en) * | 1997-05-21 | 1998-11-26 | Sloan-Kettering Institute For Cancer Research | Method for increasing the concentration of ascorbic acid in brain tissues of a subject |
| AU738334B2 (en) | 1997-05-30 | 2001-09-13 | Osteobiologics, Inc. | Fiber-reinforced, porous, biodegradable implant device |
| ATE307195T1 (de) | 1997-07-14 | 2005-11-15 | Osiris Therapeutics Inc | Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen |
| US5902598A (en) | 1997-08-28 | 1999-05-11 | Control Delivery Systems, Inc. | Sustained release drug delivery devices |
| AU1615599A (en) | 1997-12-02 | 1999-06-16 | Zen Bio, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
| US6291240B1 (en) | 1998-01-29 | 2001-09-18 | Advanced Tissue Sciences, Inc. | Cells or tissues with increased protein factors and methods of making and using same |
| AU749675B2 (en) | 1998-03-13 | 2002-07-04 | Mesoblast International Sarl | Uses for human non-autologous mesenchymal stem cells |
| US9585916B2 (en) * | 1999-03-26 | 2017-03-07 | Northern Therapeutics Inc. | Cell based therapy for the pulmonary system |
| US6171610B1 (en) | 1998-04-24 | 2001-01-09 | University Of Massachusetts | Guided development and support of hydrogel-cell compositions |
| WO1999056759A1 (en) | 1998-05-07 | 1999-11-11 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| US6387367B1 (en) | 1998-05-29 | 2002-05-14 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US6323188B1 (en) | 1998-07-01 | 2001-11-27 | Donald L. Weissman | Treatment and prevention of cardiovascular diseases, heart attack, and stroke, primary and subsequent, with help of aspirin and certain vitamins |
| US20040037818A1 (en) | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
| ES2553108T3 (es) | 1998-08-10 | 2015-12-04 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Diferenciación de células no productoras de insulina en células productoras de insulina mediante GLP-1 o exendina-4 y utilizaciones de las mismas |
| US5958767A (en) | 1998-08-14 | 1999-09-28 | The Children's Medical Center Corp. | Engraftable human neural stem cells |
| US6284245B1 (en) | 1998-08-25 | 2001-09-04 | Diacrin, Inc. | Neural retinal cells and retinal pigment epithelium cells and their use in treatment of retinal disorders |
| US6444205B2 (en) | 1998-09-30 | 2002-09-03 | Diacrin, Inc. | Transplantation of neural cells for the treatment of chronic pain or spasticity |
| US6610540B1 (en) | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| JP2002535982A (ja) | 1999-02-04 | 2002-10-29 | マックギル ユニヴァーシティー | 細胞分化のためのプラットホーム |
| US6326201B1 (en) | 1999-02-10 | 2001-12-04 | Curis, Inc. | Pancreatic progenitor cells, methods and uses related thereto |
| BR0008552A (pt) | 1999-03-10 | 2002-05-07 | Univ Pittsburgh | Células tronco e redes derivadas de tecido adiposo |
| US20030007954A1 (en) | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
| CA2370330C (en) | 1999-04-16 | 2009-01-20 | Wm. Marsh Rice University | Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers |
| US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US6287340B1 (en) | 1999-05-14 | 2001-09-11 | Trustees Of Tufts College | Bioengineered anterior cruciate ligament |
| WO2000073421A2 (en) | 1999-06-02 | 2000-12-07 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
| AU5886000A (en) | 1999-06-25 | 2001-01-31 | Northwestern University | Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells |
| US6355699B1 (en) * | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| DK1226233T3 (da) | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
| EP1216049A2 (en) | 1999-09-14 | 2002-06-26 | Children's Medical Center Corporation | Methods for treating muscular dystrophy with bone marrow cells |
| US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| US20030129745A1 (en) | 1999-10-28 | 2003-07-10 | Robl James M. | Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues |
| EP1099754A1 (en) | 1999-11-10 | 2001-05-16 | Universiteit Leiden | Mesenchymal stem cells and/or progenitor cells, their isolation and use |
| US20020164307A1 (en) | 1999-12-06 | 2002-11-07 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| JP2003523323A (ja) | 1999-12-06 | 2003-08-05 | ザ ジェネラル ホスピタル コーポレーション | 膵臓幹細胞および移植におけるその使用 |
| US7785882B2 (en) | 2000-01-18 | 2010-08-31 | Cornell Research Foundation, Inc. | Neuronal progenitor cells from hippocampal tissue and a method for isolating and purifying them |
| US7544509B2 (en) | 2000-01-24 | 2009-06-09 | Mcgill University | Method for preparing stem cell preparations |
| US6610535B1 (en) | 2000-02-10 | 2003-08-26 | Es Cell International Pte Ltd. | Progenitor cells and methods and uses related thereto |
| WO2001059072A1 (en) | 2000-02-11 | 2001-08-16 | Philadelphia Health And Education Corporation | Differentiation of bone marrow cells into neuronal cells and uses therefor |
| US7514259B2 (en) | 2000-02-11 | 2009-04-07 | Schepens Eye Research Institute | Isolation and transplantation of retinal stem cells |
| AU2001243464B2 (en) | 2000-03-09 | 2006-04-13 | Saneron Ccel Therapeutics, Inc. | Human cord blood as a source of neural tissue for repair of the brain and spinal cord |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US6673606B1 (en) | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US20030212024A1 (en) | 2000-05-12 | 2003-11-13 | Keating Mark T | Compositions and methods for cell dedifferentiation and tissue regeneration |
| US8273570B2 (en) | 2000-05-16 | 2012-09-25 | Riken | Process of inducing differentiation of embryonic cell to cell expressing neural surface marker using OP9 or PA6 cells |
| US7049072B2 (en) | 2000-06-05 | 2006-05-23 | University Of South Florida | Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state |
| US6759039B2 (en) | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| AU2001293586A1 (en) | 2000-09-29 | 2002-04-08 | Vincent Tropepe | Primitive neural stem cells and method for differentiation of stem cells to neural cells |
| US20020098584A1 (en) | 2000-11-06 | 2002-07-25 | Palmer Theo D. | Postmortem stem cells |
| CA2430627A1 (en) | 2000-11-30 | 2002-12-27 | Stemron, Inc. | Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| KR100915482B1 (ko) | 2000-12-06 | 2009-09-03 | 하리리 로버트 제이 | 태반 줄기 세포의 회수 방법 |
| US6599323B2 (en) | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
| CA2435826A1 (en) | 2001-01-24 | 2002-08-01 | The Government Of The United States Of America | Differentiation of stem cells to pancreatic endocrine cells |
| ATE419333T1 (de) | 2001-02-06 | 2009-01-15 | Massachusetts Inst Technology | Peptidgerüstverkapselung von gewebszellen und verwendungen davon |
| US7449180B2 (en) | 2001-02-06 | 2008-11-11 | John Kisiday | Macroscopic scaffold containing amphiphilic peptides encapsulating cells |
| EP2336299A1 (en) | 2001-02-14 | 2011-06-22 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| ES2548591T3 (es) | 2001-02-14 | 2015-10-19 | Anthrogenesis Corporation | Placenta post-parto de mamífero, su uso y células madre placentarias de la misma |
| EP1491093B1 (en) | 2001-02-14 | 2013-07-31 | ABT Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US7838292B1 (en) | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
| EP1385935A4 (en) | 2001-03-29 | 2004-09-15 | Ixion Biotechnology Inc | METHOD FOR TRANSDIFFERENTIATION OF NON-PANCREATIC STEM CELLS IN THE PANCREAS DIFFERENTIATION PATHWAY |
| EP1379626A2 (en) | 2001-04-19 | 2004-01-14 | DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung | A method for differentiating stem cells into insulin-producing cells |
| US20030211605A1 (en) | 2001-05-01 | 2003-11-13 | Lee Sang-Hun | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
| US20030022369A1 (en) | 2001-05-18 | 2003-01-30 | Helen Fillmore | Differentiation of specialized dermal and epidermal cells into neuronal cells |
| JP2005515753A (ja) | 2001-05-25 | 2005-06-02 | サイセラ,インコーポレイテッド | 幹細胞分化 |
| DE60233805D1 (de) | 2001-08-08 | 2009-11-05 | Levesque Biosciences Inc | Zusammensetzungen und verfahren zur isolierung, vermehrung und differenzierung nicht-embryonale menschlicher stammzellen und deren verwendungen |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| WO2003018767A2 (en) | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| US20030104997A1 (en) | 2001-09-05 | 2003-06-05 | Black Ira B. | Multi-lineage directed induction of bone marrow stromal cell differentiation |
| CN1195055C (zh) | 2001-09-06 | 2005-03-30 | 周胜利 | 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法 |
| US20050064587A1 (en) | 2001-09-07 | 2005-03-24 | Lawrence Rosenberg | Pancreatic small cells and uses thereof |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
| GB2396623B (en) | 2001-09-28 | 2006-04-05 | Es Cell Int Pte Ltd | Methods of derivation and propagation of undifferentiated human embryonic stem (hes) cells on feeder-free matrices and human feeder layers |
| JP2005506074A (ja) | 2001-10-18 | 2005-03-03 | イクシオン・バイオテクノロジー・インコーポレーテッド | 肝臓の幹細胞および前駆細胞の膵臓機能細胞への転換 |
| US7129034B2 (en) | 2001-10-25 | 2006-10-31 | Cedars-Sinai Medical Center | Differentiation of whole bone marrow |
| EP1453954A4 (en) | 2001-11-09 | 2004-12-15 | Artecel Sciences Inc | Endocrine pancreas differentiation of adipose tissue-derived stromal cells and uses thereof |
| US8021876B2 (en) * | 2001-11-15 | 2011-09-20 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
| JP3728750B2 (ja) | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
| WO2003045439A1 (en) | 2001-11-28 | 2003-06-05 | Anges Mg, Inc. | Genetic remedies for neurodegenerative diseases |
| ATE532854T1 (de) | 2001-12-04 | 2011-11-15 | Organogenesis Inc | Kultivierte zellen aus den langerhansschen inseln |
| WO2003054171A1 (en) | 2001-12-06 | 2003-07-03 | The Regents Of The University Of California | Method for differentiating islet precursor cells into beta cells |
| CN1602351B (zh) | 2001-12-07 | 2011-03-30 | 杰龙公司 | 源自人胚胎干细胞的胰岛细胞 |
| JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
| US20030113910A1 (en) | 2001-12-18 | 2003-06-19 | Mike Levanduski | Pluripotent stem cells derived without the use of embryos or fetal tissue |
| US7101546B2 (en) | 2001-12-21 | 2006-09-05 | Amcyte, Inc. | In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development |
| EP1458854B1 (en) | 2001-12-21 | 2010-04-14 | Mount Sinai Hospital | Cellular compositions and methods of making and using them |
| CN1671835A (zh) | 2001-12-28 | 2005-09-21 | 塞拉提斯股份公司 | 一种建立多能人胚泡衍生的干细胞的方法 |
| AU2003202988A1 (en) | 2002-01-14 | 2003-07-30 | The Board Of Trustees Of The University Of Illinois | Use of modified pyrimidine compounds to promote stem cell migration and proliferation |
| US20030162290A1 (en) | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
| AU2003217357A1 (en) | 2002-02-07 | 2003-09-02 | The Research Foundation Of The State University Of New York | Generation of new insulin cells from progenitor cells present in adult pancreatic islets |
| NZ534643A (en) | 2002-02-13 | 2010-06-25 | Anthrogenesis Corp | Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells |
| WO2003070189A2 (en) | 2002-02-15 | 2003-08-28 | Cornell Research Foundation, Inc. | Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein |
| US20050118714A1 (en) | 2002-02-19 | 2005-06-02 | Chul-Won Ha | Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood and differentation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues |
| WO2003072728A2 (en) | 2002-02-22 | 2003-09-04 | University Of Florida | Cellular trans-differentiation |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US20030161818A1 (en) | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7150990B2 (en) | 2002-03-06 | 2006-12-19 | Reprocell, Inc. | Self-renewing pluripotent hepatic stem cells |
| AU2003221173A1 (en) | 2002-03-27 | 2003-10-08 | Asahi Kasei Kabushiki Kaisha | Placenta-origin mesenchymal cells and medicinal use thereof |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US20050118715A1 (en) | 2002-04-12 | 2005-06-02 | Hariri Robert J. | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| JP4136434B2 (ja) | 2002-04-17 | 2008-08-20 | 進 清野 | インスリン産生細胞の誘導 |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| JP2005523328A (ja) | 2002-04-19 | 2005-08-04 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 胎盤由来の幹細胞及びその使用 |
| AU2003239176A1 (en) | 2002-04-25 | 2003-11-10 | Wisconsin Alumni Research Foundation | Neurodegenerative disorder treatment using gdnf secreting neural cells |
| US20040029269A1 (en) | 2002-05-07 | 2004-02-12 | Goldman Steven A | Promoter-based isolation, purification, expansion, and transplantation of neuronal progenitor cells, oligodendrocyte progenitor cells, or neural stem cells from a population of embryonic stem cells |
| AU2003233119A1 (en) | 2002-05-08 | 2003-11-11 | Neuronova Ab | Modulation of neural stem cells with s1p or lpa receptor agonists |
| WO2003102134A2 (en) | 2002-05-28 | 2003-12-11 | Becton, Dickinson And Company | Pancreatic acinar cells into insulin producing cells |
| KR20050008757A (ko) | 2002-05-30 | 2005-01-21 | 셀진 코포레이션 | 세포 분화를 조절하고 골수증식성 질환 및 골수형성이상증후군을 치료하기 위하여 jnk 또는 mkk 저해제를사용하는 방법 |
| GB2405642B (en) | 2002-06-07 | 2007-03-28 | Es Cell Int Pte Ltd | Methods of regulating differentiation in stem cells |
| US7410797B2 (en) | 2002-06-11 | 2008-08-12 | Ogle Roy C | Meningeal-derived stem cells |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| EP1551955A4 (en) | 2002-07-16 | 2006-11-29 | Yissum Res Dev Co | METHOD FOR IMPLANTING MESENCHYMAL STEM CELLS FOR TISSUE PAIRING AND FORMATION |
| US7390659B2 (en) | 2002-07-16 | 2008-06-24 | The Trustees Of Columbia University In The City Of New York | Methods for inducing differentiation of embryonic stem cells and uses thereof |
| AU2003250666A1 (en) | 2002-07-29 | 2004-02-16 | Asahi Kasei Kabushiki Kaisha | Stem cells for treating pancreatic damage |
| JP2005534345A (ja) | 2002-07-29 | 2005-11-17 | エス セル インターナショナル ピーティーイー リミテッド | インスリン陽性、グルコース応答性細胞の分化のための多段階方法 |
| AU2003262628A1 (en) | 2002-08-14 | 2004-03-03 | University Of Florida | Bone marrow cell differentiation |
| WO2004018655A2 (en) * | 2002-08-26 | 2004-03-04 | Neuronova Ab | Method for culturing stem cells |
| EP1543111A4 (en) | 2002-08-28 | 2006-09-13 | Univ Florida | NEUROGENESIS FROM HEPATIC STEM CELLS |
| US7371576B2 (en) | 2002-09-06 | 2008-05-13 | Reneuron, Inc. | CD56 positive human adult pancreatic endocrine progenitor cells |
| US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| JP4571387B2 (ja) | 2003-02-07 | 2010-10-27 | 宣男 櫻川 | ヒト羊膜由来サイドポピュレーション細胞及びその用途 |
| EP2277992A3 (en) | 2003-02-11 | 2011-03-02 | John E. Davies | Progenitor cells from Wharton's jelly of human umbilical cord |
| WO2004111207A1 (en) | 2003-06-09 | 2004-12-23 | Centelion | Multicellular in vitro model of angiogenesis and methods for using the same |
| PL1641916T3 (pl) * | 2003-06-27 | 2016-08-31 | Depuy Synthes Products Inc | Regeneracja i naprawa tkanki nerwowej z wykorzystaniem komórek poporodowych |
| US9572840B2 (en) * | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US8518390B2 (en) * | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| AU2004269409A1 (en) | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
| US20050089513A1 (en) | 2003-10-28 | 2005-04-28 | Norio Sakuragawa | Side population cells originated from human amnion and their uses |
| GB0404656D0 (en) | 2004-03-02 | 2004-04-07 | Univ Manchester | Treatment of spinal conditions |
| US8039258B2 (en) | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
| IN2014CN03629A (cg-RX-API-DMAC7.html) | 2004-11-17 | 2015-09-04 | Neuralstem Inc | |
| WO2006101548A2 (en) | 2004-12-21 | 2006-09-28 | Ethicon, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| US20060153815A1 (en) | 2004-12-21 | 2006-07-13 | Agnieszka Seyda | Tissue engineering devices for the repair and regeneration of tissue |
| WO2006083394A2 (en) | 2004-12-21 | 2006-08-10 | Ethicon, Inc. | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| EP1831355A2 (en) | 2004-12-23 | 2007-09-12 | Ethicon, Inc. | Soft tissue repair and regeneration using postpartum-derived cells and cell products |
| ES2621847T3 (es) | 2004-12-23 | 2017-07-05 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas |
| WO2006071773A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incoporated | Treatment of osteochondral diseases using postpartum-derived cells and products thereof |
| WO2006071778A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| US7741311B2 (en) | 2005-01-03 | 2010-06-22 | Shaker Mousa | Composition and method for treating occlusive vascular diseases, nerve regeneration, and wound healing |
| CN101589137B (zh) | 2005-03-31 | 2013-06-05 | 斯丹姆涅恩有限公司 | 羊膜来源的细胞组合物及其制备方法和用途 |
| GB2440089B8 (en) | 2005-05-05 | 2012-09-05 | Univ Goettingen Georg August | Regeneration system, its production and use |
| US7923007B2 (en) | 2005-08-08 | 2011-04-12 | Academia Sinica | Brain tissue damage therapies |
| US20100034779A1 (en) | 2005-11-02 | 2010-02-11 | Kaomei Guan | Compositions and methods for producing pluripotent cells from adult testis |
| US9175261B2 (en) | 2005-12-16 | 2015-11-03 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
| JP5179376B2 (ja) | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
| JP5599568B2 (ja) | 2005-12-28 | 2014-10-01 | エシコン・インコーポレイテッド | 分娩後由来細胞を用いた末梢血管疾患の治療 |
| US9125906B2 (en) * | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| EP2471903B1 (en) | 2005-12-29 | 2018-02-14 | Anthrogenesis Corporation | Placental stem cell populations |
| EP1976978A2 (en) | 2005-12-29 | 2008-10-08 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| US20070178073A1 (en) * | 2006-02-01 | 2007-08-02 | Samsung Life Public Welfare Foundation | Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease |
| PL2366775T3 (pl) | 2006-03-23 | 2015-08-31 | Pluristem Ltd | Sposoby namnażania komórek oraz zastosowania komórek i pożywek kondycjonowanych wytworzonych w ten sposób do terapii |
| CA2705450A1 (en) | 2006-04-27 | 2007-11-08 | Cell Therapy Technologies, Inc. Et Al | Stem cells for treating lung diseases |
| WO2007142651A1 (en) | 2006-06-09 | 2007-12-13 | Caritas St. Elizabeth Medical Center Of Boston, Inc. | Methods and compositions for the treatment of neuropathy |
| WO2008002250A1 (en) | 2006-06-30 | 2008-01-03 | Elena Kozlova | Improved stem cells for transplantation and methods for production thereof |
| TW200817019A (en) | 2006-07-10 | 2008-04-16 | Univ Columbia | De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells |
| US7993918B2 (en) * | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| GB0619500D0 (en) * | 2006-10-03 | 2006-11-08 | Univ Keele | Treatment of fibrosis |
| DK2078073T3 (da) | 2006-10-12 | 2013-10-28 | Ethicon Inc | Nyreafledte celler og fremgangsmåder til anvendelse deraf til vævsreparation og -regenerering |
| WO2008085221A2 (en) | 2006-10-27 | 2008-07-17 | Caritas St. Elizabeth Medical Center Of Boston, Inc. | Therapeutic use of cd31 expressing cells |
| CN101611139B (zh) | 2006-11-13 | 2012-07-04 | 伊西康公司 | 利用微载体的产后来源的细胞的体外扩增 |
| CN101657206B (zh) * | 2007-02-12 | 2013-07-03 | 人类起源公司 | 利用胎盘干细胞治疗炎性疾病 |
| US20080305148A1 (en) | 2007-03-19 | 2008-12-11 | National Yang Ming University | Treatment of spinal injuries using human umbilical mesenchymal stem cells |
| CN102036688B (zh) | 2007-10-05 | 2014-07-02 | 伊西康公司 | 使用人脐带组织来源的细胞进行肾脏组织的修复和再生 |
| US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
| EP2237789B1 (en) | 2007-12-27 | 2017-01-25 | DePuy Synthes Products, Inc. | Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells |
| MX2011005230A (es) * | 2008-11-21 | 2011-06-16 | Anthrogenesis Corp | Tratamiento de enfermedades, desordenes o condiciones del pulmon usando celulas de placenta. |
| US20130302283A1 (en) | 2012-05-14 | 2013-11-14 | Advanced Technologies And Regenerative Medicine, Llc | hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS |
| JP5646502B2 (ja) | 2008-12-19 | 2014-12-24 | デピュイ・シンセス・プロダクツ・エルエルシーDePuy Synthes Products, LLC | 神経因性疼痛を治療するための臍帯組織由来細胞 |
| AU2009327384B2 (en) | 2008-12-19 | 2014-07-10 | DePuy Synthes Products, LLC | Treatment of lung and pulmonary diseases and disorders |
| JP6095893B2 (ja) | 2008-12-19 | 2017-03-15 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | 傷害後の神経組織の再生および修復 |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| EP2411504B1 (en) | 2009-03-26 | 2017-05-10 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells as therapy for alzheimer's disease |
| EP2624847B1 (en) * | 2010-10-05 | 2017-09-13 | AAL Scientifics, Inc. | Human lung stem cells and uses thereof |
-
2009
- 2009-12-19 AU AU2009327384A patent/AU2009327384B2/en not_active Ceased
- 2009-12-19 CN CN201710139929.6A patent/CN107028983A/zh active Pending
- 2009-12-19 ES ES09796901.8T patent/ES2665883T3/es active Active
- 2009-12-19 CA CA2747794A patent/CA2747794C/en active Active
- 2009-12-19 JP JP2011542520A patent/JP5518893B2/ja not_active Expired - Fee Related
- 2009-12-19 CN CN2009801573949A patent/CN102387807A/zh active Pending
- 2009-12-19 WO PCT/US2009/068881 patent/WO2010071864A1/en not_active Ceased
- 2009-12-19 US US12/642,774 patent/US10557116B2/en not_active Expired - Fee Related
- 2009-12-19 PL PL09796901T patent/PL2379088T3/pl unknown
- 2009-12-19 BR BRPI0923068-8A patent/BRPI0923068B1/pt not_active IP Right Cessation
- 2009-12-19 EP EP09796901.8A patent/EP2379088B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012512911A (ja) | 2012-06-07 |
| US20100158877A1 (en) | 2010-06-24 |
| PL2379088T3 (pl) | 2018-07-31 |
| EP2379088B1 (en) | 2018-02-28 |
| BRPI0923068B1 (pt) | 2021-05-25 |
| CN107028983A (zh) | 2017-08-11 |
| AU2009327384B2 (en) | 2014-07-10 |
| EP2379088A1 (en) | 2011-10-26 |
| BRPI0923068A2 (pt) | 2019-10-01 |
| CN102387807A (zh) | 2012-03-21 |
| WO2010071864A1 (en) | 2010-06-24 |
| CA2747794A1 (en) | 2010-06-24 |
| US10557116B2 (en) | 2020-02-11 |
| CA2747794C (en) | 2018-10-30 |
| ES2665883T3 (es) | 2018-04-30 |
| AU2009327384A1 (en) | 2011-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5518893B2 (ja) | 肺ならびに肺の疾患および障害の治療 | |
| JP6779931B2 (ja) | 肺疾患及び肺障害の炎症促進性メディエータのhUTC調節 | |
| EP2379089B1 (en) | Regeneration and repair of neural tissue following injury | |
| JP5646502B2 (ja) | 神経因性疼痛を治療するための臍帯組織由来細胞 | |
| US9585918B2 (en) | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells | |
| AU2011374879C1 (en) | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells | |
| US9592258B2 (en) | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells | |
| US20190054125A1 (en) | hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS | |
| HK1208381B (en) | Hutc modulation of pro-inflammatory mediators of lung and pulmonary diseases and disorders |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120330 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120330 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130308 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130813 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140304 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140402 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5518893 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |