JP5517919B2 - 即時血管内グルコース測定のための平衡非消費蛍光センサー - Google Patents
即時血管内グルコース測定のための平衡非消費蛍光センサー Download PDFInfo
- Publication number
- JP5517919B2 JP5517919B2 JP2010507711A JP2010507711A JP5517919B2 JP 5517919 B2 JP5517919 B2 JP 5517919B2 JP 2010507711 A JP2010507711 A JP 2010507711A JP 2010507711 A JP2010507711 A JP 2010507711A JP 5517919 B2 JP5517919 B2 JP 5517919B2
- Authority
- JP
- Japan
- Prior art keywords
- analyte
- glucose
- sensor system
- sensor
- dye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims description 127
- 239000008103 glucose Substances 0.000 title claims description 127
- 238000005259 measurement Methods 0.000 title description 14
- 239000012491 analyte Substances 0.000 claims description 114
- 230000005284 excitation Effects 0.000 claims description 93
- 239000007850 fluorescent dye Substances 0.000 claims description 67
- 230000027455 binding Effects 0.000 claims description 50
- 239000000017 hydrogel Substances 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 35
- 239000013307 optical fiber Substances 0.000 claims description 14
- 238000004020 luminiscence type Methods 0.000 claims description 10
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 3
- HBWDWGMBZIFBQE-UHFFFAOYSA-N benzylboronic acid Chemical group OB(O)CC1=CC=CC=C1 HBWDWGMBZIFBQE-UHFFFAOYSA-N 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000000504 luminescence detection Methods 0.000 claims 1
- 239000000975 dye Substances 0.000 description 93
- 229920000642 polymer Polymers 0.000 description 72
- 239000011159 matrix material Substances 0.000 description 47
- 150000001875 compounds Chemical class 0.000 description 44
- KXXXUIKPSVVSAW-UHFFFAOYSA-K pyranine Chemical compound [Na+].[Na+].[Na+].C1=C2C(O)=CC(S([O-])(=O)=O)=C(C=C3)C2=C2C3=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C2=C1 KXXXUIKPSVVSAW-UHFFFAOYSA-K 0.000 description 38
- 238000010521 absorption reaction Methods 0.000 description 27
- 239000002253 acid Substances 0.000 description 27
- 230000003287 optical effect Effects 0.000 description 25
- 238000001514 detection method Methods 0.000 description 24
- 229910052757 nitrogen Inorganic materials 0.000 description 24
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 21
- 239000000243 solution Substances 0.000 description 20
- 125000005620 boronic acid group Chemical group 0.000 description 18
- 238000002866 fluorescence resonance energy transfer Methods 0.000 description 18
- 230000004044 response Effects 0.000 description 16
- 238000010791 quenching Methods 0.000 description 15
- 230000000171 quenching effect Effects 0.000 description 15
- 239000008280 blood Substances 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 14
- 230000008859 change Effects 0.000 description 14
- 239000000835 fiber Substances 0.000 description 14
- 239000000523 sample Substances 0.000 description 14
- -1 O 2 Chemical class 0.000 description 13
- 125000003118 aryl group Chemical group 0.000 description 13
- 150000002303 glucose derivatives Chemical class 0.000 description 13
- 108020003175 receptors Proteins 0.000 description 12
- 102000005962 receptors Human genes 0.000 description 12
- 230000002378 acidificating effect Effects 0.000 description 11
- 238000001727 in vivo Methods 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 239000000178 monomer Substances 0.000 description 11
- 239000011230 binding agent Substances 0.000 description 10
- 230000007423 decrease Effects 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 238000000862 absorption spectrum Methods 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 238000012544 monitoring process Methods 0.000 description 9
- 238000001139 pH measurement Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 210000004204 blood vessel Anatomy 0.000 description 8
- 230000008878 coupling Effects 0.000 description 8
- 238000010168 coupling process Methods 0.000 description 8
- 238000005859 coupling reaction Methods 0.000 description 8
- 230000010363 phase shift Effects 0.000 description 8
- 230000000875 corresponding effect Effects 0.000 description 7
- 230000036961 partial effect Effects 0.000 description 7
- GNWBLLYJQXKPIP-ZOGIJGBBSA-N (1s,3as,3bs,5ar,9ar,9bs,11as)-n,n-diethyl-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1h-indeno[5,4-f]quinoline-1-carboxamide Chemical compound CN([C@@H]1CC2)C(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)N(CC)CC)[C@@]2(C)CC1 GNWBLLYJQXKPIP-ZOGIJGBBSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 125000005647 linker group Chemical group 0.000 description 6
- 102100026735 Coagulation factor VIII Human genes 0.000 description 5
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 5
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- 125000002947 alkylene group Chemical group 0.000 description 5
- 125000000129 anionic group Chemical group 0.000 description 5
- 239000012736 aqueous medium Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 5
- 238000006116 polymerization reaction Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 229940124530 sulfonamide Drugs 0.000 description 5
- 150000003456 sulfonamides Chemical group 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
- 230000009977 dual effect Effects 0.000 description 4
- 239000003269 fluorescent indicator Substances 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical class [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 4
- 239000007793 ph indicator Substances 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- DYPYMMHZGRPOCK-UHFFFAOYSA-N seminaphtharhodafluor Chemical compound O1C(=O)C2=CC=CC=C2C21C(C=CC=1C3=CC=C(O)C=1)=C3OC1=CC(N)=CC=C21 DYPYMMHZGRPOCK-UHFFFAOYSA-N 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 229920003176 water-insoluble polymer Polymers 0.000 description 4
- 229920003169 water-soluble polymer Polymers 0.000 description 4
- MWVTWFVJZLCBMC-UHFFFAOYSA-N 4,4'-bipyridine Chemical group C1=NC=CC(C=2C=CN=CC=2)=C1 MWVTWFVJZLCBMC-UHFFFAOYSA-N 0.000 description 3
- KYARBIJYVGJZLB-UHFFFAOYSA-N 7-amino-4-hydroxy-2-naphthalenesulfonic acid Chemical compound OC1=CC(S(O)(=O)=O)=CC2=CC(N)=CC=C21 KYARBIJYVGJZLB-UHFFFAOYSA-N 0.000 description 3
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 3
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 3
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 238000007334 copolymerization reaction Methods 0.000 description 3
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229920001477 hydrophilic polymer Polymers 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 230000001678 irradiating effect Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 3
- 229920000867 polyelectrolyte Polymers 0.000 description 3
- 125000006239 protecting group Chemical group 0.000 description 3
- 238000000159 protein binding assay Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 150000003457 sulfones Chemical class 0.000 description 3
- 125000000542 sulfonic acid group Chemical group 0.000 description 3
- 229920001169 thermoplastic Polymers 0.000 description 3
- 239000004416 thermosoftening plastic Substances 0.000 description 3
- 239000010409 thin film Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- OFDVABAUFQJWEZ-UHFFFAOYSA-N 3-pyridin-3-ylpyridine Chemical group C1=CN=CC(C=2C=NC=CC=2)=C1 OFDVABAUFQJWEZ-UHFFFAOYSA-N 0.000 description 2
- ABVCMDMBWDRVAG-UHFFFAOYSA-N 4-hydroxypyrene-1,2,3-trisulfonamide Chemical class C1=CC=C2C=C(O)C3=C(S(N)(=O)=O)C(S(=O)(=O)N)=C(S(N)(=O)=O)C4=CC=C1C2=C43 ABVCMDMBWDRVAG-UHFFFAOYSA-N 0.000 description 2
- MTYHUTYJKFVTJJ-UHFFFAOYSA-N 4-hydroxypyrene-1,2,3-trisulfonic acid Chemical class OS(=O)(=O)C1=C(S(O)(=O)=O)C(S(O)(=O)=O)=C2C(O)=CC3=CC=CC4=CC=C1C2=C34 MTYHUTYJKFVTJJ-UHFFFAOYSA-N 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- 0 C*c(cc1)ccc1C(C(C=C1)=NC1=C(C1=CC[C@](C(c(cc2)ccc2S(O)(=O)=O)=C2N=C3C=C2)N1)c1ccc([*-])cc1)=C(C=C1)NC1=C3c1ccc([*-])cc1 Chemical compound C*c(cc1)ccc1C(C(C=C1)=NC1=C(C1=CC[C@](C(c(cc2)ccc2S(O)(=O)=O)=C2N=C3C=C2)N1)c1ccc([*-])cc1)=C(C=C1)NC1=C3c1ccc([*-])cc1 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- GAIQIDITLZQBHB-UHFFFAOYSA-N [3,6,8-tris(chlorosulfonyl)pyren-1-yl] acetate Chemical compound C1=C2C(OC(=O)C)=CC(S(Cl)(=O)=O)=C(C=C3)C2=C2C3=C(S(Cl)(=O)=O)C=C(S(Cl)(=O)=O)C2=C1 GAIQIDITLZQBHB-UHFFFAOYSA-N 0.000 description 2
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000002820 assay format Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000560 biocompatible material Substances 0.000 description 2
- 229920000249 biocompatible polymer Polymers 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 150000001642 boronic acid derivatives Chemical class 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 238000012875 competitive assay Methods 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 150000004985 diamines Chemical class 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 238000000295 emission spectrum Methods 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000012982 microporous membrane Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000003068 molecular probe Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 229920000620 organic polymer Polymers 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 2
- 238000012643 polycondensation polymerization Methods 0.000 description 2
- 150000004032 porphyrins Chemical class 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000012048 reactive intermediate Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000008279 sol Substances 0.000 description 2
- 125000000565 sulfonamide group Chemical group 0.000 description 2
- 229920001187 thermosetting polymer Polymers 0.000 description 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
- 150000000185 1,3-diols Chemical class 0.000 description 1
- HBOMLICNUCNMMY-KJFJCRTCSA-N 1-[(4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1C1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-KJFJCRTCSA-N 0.000 description 1
- YEBQUUKDSJCPIX-UHFFFAOYSA-N 12h-benzo[a]thioxanthene Chemical class C1=CC=CC2=C3CC4=CC=CC=C4SC3=CC=C21 YEBQUUKDSJCPIX-UHFFFAOYSA-N 0.000 description 1
- VXXRMBQHVJKWIC-UHFFFAOYSA-N 2-(1-pyridin-2-ylethenyl)pyridine Chemical group C=1C=CC=NC=1C(=C)C1=CC=CC=N1 VXXRMBQHVJKWIC-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical group CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 1
- OLYBTQCLJOBELT-UHFFFAOYSA-N 2-bromoethanamine;hydrochloride Chemical compound Cl.NCCBr OLYBTQCLJOBELT-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- WFOTVGYJMFZMTD-UHFFFAOYSA-N 3',10'-dihydroxyspiro[2-benzofuran-3,7'-benzo[c]xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C(C=CC=1C3=CC=C(O)C=1)=C3OC1=CC(O)=CC=C21 WFOTVGYJMFZMTD-UHFFFAOYSA-N 0.000 description 1
- MSQCQZMTRWHMFQ-UHFFFAOYSA-N 3-(2-methylprop-2-enoyloxy)propane-1-sulfonic acid;sodium Chemical compound [Na].CC(=C)C(=O)OCCCS(O)(=O)=O MSQCQZMTRWHMFQ-UHFFFAOYSA-N 0.000 description 1
- DATYUTWESAKQQM-UHFFFAOYSA-N 4,7-phenanthroline Chemical compound C1=CC=C2C3=CC=CN=C3C=CC2=N1 DATYUTWESAKQQM-UHFFFAOYSA-N 0.000 description 1
- OMPGKWICGUBROA-UHFFFAOYSA-N 4-sulfamoylbutanoic acid Chemical compound NS(=O)(=O)CCCC(O)=O OMPGKWICGUBROA-UHFFFAOYSA-N 0.000 description 1
- NIXVAPHNPNMUIX-UHFFFAOYSA-N 6-amino-2-methylhex-2-enamide Chemical compound NC(=O)C(C)=CCCCN NIXVAPHNPNMUIX-UHFFFAOYSA-N 0.000 description 1
- OBJOZRVSMLPASY-UHFFFAOYSA-N 8-hydroxypyrene-1,3,6-trisulfonic acid Chemical compound C1=C2C(O)=CC(S(O)(=O)=O)=C(C=C3)C2=C2C3=C(S(O)(=O)=O)C=C(S(O)(=O)=O)C2=C1 OBJOZRVSMLPASY-UHFFFAOYSA-N 0.000 description 1
- STGMORHGPQLXMT-UHFFFAOYSA-N 9h-indeno[2,1-c]pyridazine Chemical compound C1=NN=C2CC3=CC=CC=C3C2=C1 STGMORHGPQLXMT-UHFFFAOYSA-N 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- GWWFKWJMIKQILK-UHFFFAOYSA-N B(C1=CC(=C(C(=C1CBr)CBr)C)C)(O)O Chemical compound B(C1=CC(=C(C(=C1CBr)CBr)C)C)(O)O GWWFKWJMIKQILK-UHFFFAOYSA-N 0.000 description 1
- 208000031872 Body Remains Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108010062580 Concanavalin A Proteins 0.000 description 1
- 108010065556 Drug Receptors Proteins 0.000 description 1
- 102000013138 Drug Receptors Human genes 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- JPBQBCTYPHBRIE-UHFFFAOYSA-N NC1=CC=C2N=CC=CC2=C1.OBO Chemical compound NC1=CC=C2N=CC=CC2=C1.OBO JPBQBCTYPHBRIE-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- DAKWPKUUDNSNPN-UHFFFAOYSA-N Trimethylolpropane triacrylate Chemical compound C=CC(=O)OCC(CC)(COC(=O)C=C)COC(=O)C=C DAKWPKUUDNSNPN-UHFFFAOYSA-N 0.000 description 1
- NJSSICCENMLTKO-HRCBOCMUSA-N [(1r,2s,4r,5r)-3-hydroxy-4-(4-methylphenyl)sulfonyloxy-6,8-dioxabicyclo[3.2.1]octan-2-yl] 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)O[C@H]1C(O)[C@@H](OS(=O)(=O)C=2C=CC(C)=CC=2)[C@@H]2OC[C@H]1O2 NJSSICCENMLTKO-HRCBOCMUSA-N 0.000 description 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
- BSLYIJNTYFJXKX-UHFFFAOYSA-N [1,2,3-tris(chlorosulfonyl)pyren-4-yl] acetate Chemical compound ClS(=O)(=O)C1=C(S(Cl)(=O)=O)C(S(Cl)(=O)=O)=C2C(OC(=O)C)=CC3=CC=CC4=CC=C1C2=C34 BSLYIJNTYFJXKX-UHFFFAOYSA-N 0.000 description 1
- MIHJMMKHEDKTNX-UHFFFAOYSA-N [6,7,8-tris(chlorosulfonyl)pyren-1-yl] acetate Chemical compound C1=C2C(OC(=O)C)=CC=C(C=C3)C2=C2C3=C(S(Cl)(=O)=O)C(S(Cl)(=O)=O)=C(S(Cl)(=O)=O)C2=C1 MIHJMMKHEDKTNX-UHFFFAOYSA-N 0.000 description 1
- 239000000980 acid dye Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000012644 addition polymerization Methods 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940124277 aminobutyric acid Drugs 0.000 description 1
- 239000003011 anion exchange membrane Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical class 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- UWCPYKQBIPYOLX-UHFFFAOYSA-N benzene-1,3,5-tricarbonyl chloride Chemical compound ClC(=O)C1=CC(C(Cl)=O)=CC(C(Cl)=O)=C1 UWCPYKQBIPYOLX-UHFFFAOYSA-N 0.000 description 1
- XFOZBWSTIQRFQW-UHFFFAOYSA-M benzyl-dimethyl-prop-2-enylazanium;chloride Chemical compound [Cl-].C=CC[N+](C)(C)CC1=CC=CC=C1 XFOZBWSTIQRFQW-UHFFFAOYSA-M 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000010364 biochemical engineering Methods 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 210000001736 capillary Anatomy 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- PBHVCRIXMXQXPD-UHFFFAOYSA-N chembl2369102 Chemical group C1=CC(S(=O)(=O)O)=CC=C1C(C1=CC=C(N1)C(C=1C=CC(=CC=1)S(O)(=O)=O)=C1C=CC(=N1)C(C=1C=CC(=CC=1)S(O)(=O)=O)=C1C=CC(N1)=C1C=2C=CC(=CC=2)S(O)(=O)=O)=C2N=C1C=C2 PBHVCRIXMXQXPD-UHFFFAOYSA-N 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229920000547 conjugated polymer Polymers 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000009146 cooperative binding Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- 230000005595 deprotonation Effects 0.000 description 1
- 238000010537 deprotonation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- WQZGKKKJIJFFOK-UKLRSMCWSA-N dextrose-2-13c Chemical class OC[C@H]1OC(O)[13C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-UKLRSMCWSA-N 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical compound CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 238000000695 excitation spectrum Methods 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000002875 fluorescence polarization Methods 0.000 description 1
- 238000002189 fluorescence spectrum Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- BICAGYDGRXJYGD-UHFFFAOYSA-N hydrobromide;hydrochloride Chemical compound Cl.Br BICAGYDGRXJYGD-UHFFFAOYSA-N 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000010324 immunological assay Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000012633 leachable Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- VHRYZQNGTZXDNX-UHFFFAOYSA-N methacryloyl chloride Chemical compound CC(=C)C(Cl)=O VHRYZQNGTZXDNX-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 229920000344 molecularly imprinted polymer Polymers 0.000 description 1
- 230000002794 monomerizing effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- WFKDPJRCBCBQNT-UHFFFAOYSA-N n,2-dimethylprop-2-enamide Chemical compound CNC(=O)C(C)=C WFKDPJRCBCBQNT-UHFFFAOYSA-N 0.000 description 1
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 description 1
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- HUMMCEUVDBVXTQ-UHFFFAOYSA-N naphthalen-1-ylboronic acid Chemical compound C1=CC=C2C(B(O)O)=CC=CC2=C1 HUMMCEUVDBVXTQ-UHFFFAOYSA-N 0.000 description 1
- 150000002902 organometallic compounds Chemical class 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 150000005041 phenanthrolines Chemical class 0.000 description 1
- 238000007539 photo-oxidation reaction Methods 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001228 polyisocyanate Polymers 0.000 description 1
- 239000005056 polyisocyanate Substances 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- OBJOZRVSMLPASY-UHFFFAOYSA-K pyranine(3-) Chemical compound C1=C2C(O)=CC(S([O-])(=O)=O)=C(C=C3)C2=C2C3=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C2=C1 OBJOZRVSMLPASY-UHFFFAOYSA-K 0.000 description 1
- 150000003220 pyrenes Chemical class 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- RJSRSRITMWVIQT-UHFFFAOYSA-N quinolin-6-amine Chemical compound N1=CC=CC2=CC(N)=CC=C21 RJSRSRITMWVIQT-UHFFFAOYSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000005504 styryl group Chemical group 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UZNHKBFIBYXPDV-UHFFFAOYSA-N trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)NCCC[N+](C)(C)C UZNHKBFIBYXPDV-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
- A61B5/14735—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter comprising an immobilised reagent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91730707P | 2007-05-10 | 2007-05-10 | |
| US60/917,307 | 2007-05-10 | ||
| PCT/US2008/063330 WO2008141241A1 (en) | 2007-05-10 | 2008-05-09 | Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010526599A JP2010526599A (ja) | 2010-08-05 |
| JP2010526599A5 JP2010526599A5 (enExample) | 2011-06-23 |
| JP5517919B2 true JP5517919B2 (ja) | 2014-06-11 |
Family
ID=39689412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507711A Expired - Fee Related JP5517919B2 (ja) | 2007-05-10 | 2008-05-09 | 即時血管内グルコース測定のための平衡非消費蛍光センサー |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8738107B2 (enExample) |
| EP (1) | EP2162057A1 (enExample) |
| JP (1) | JP5517919B2 (enExample) |
| CA (1) | CA2686065A1 (enExample) |
| WO (1) | WO2008141241A1 (enExample) |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
| US7657297B2 (en) * | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
| US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US7899511B2 (en) * | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US6862465B2 (en) | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
| US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6175752B1 (en) * | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6949816B2 (en) * | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US9282925B2 (en) * | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US7828728B2 (en) * | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
| US8260393B2 (en) * | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
| US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US7134999B2 (en) | 2003-04-04 | 2006-11-14 | Dexcom, Inc. | Optimized sensor geometry for an implantable glucose sensor |
| US8423113B2 (en) * | 2003-07-25 | 2013-04-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
| JP4708342B2 (ja) | 2003-07-25 | 2011-06-22 | デックスコム・インコーポレーテッド | 埋設可能な装置に用いる酸素増大膜システム |
| US20100168657A1 (en) * | 2003-08-01 | 2010-07-01 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US7519408B2 (en) | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
| US7494465B2 (en) * | 2004-07-13 | 2009-02-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8060173B2 (en) * | 2003-08-01 | 2011-11-15 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8886273B2 (en) * | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US8369919B2 (en) * | 2003-08-01 | 2013-02-05 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| US7920906B2 (en) * | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US8615282B2 (en) * | 2004-07-13 | 2013-12-24 | Dexcom, Inc. | Analyte sensor |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8287453B2 (en) | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
| US8774886B2 (en) | 2006-10-04 | 2014-07-08 | Dexcom, Inc. | Analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
| EP2239566B1 (en) | 2003-12-05 | 2014-04-23 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
| EP2301428B1 (en) | 2003-12-09 | 2016-11-30 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
| US7637868B2 (en) * | 2004-01-12 | 2009-12-29 | Dexcom, Inc. | Composite material for implantable device |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8277713B2 (en) * | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
| US20050245799A1 (en) * | 2004-05-03 | 2005-11-03 | Dexcom, Inc. | Implantable analyte sensor |
| US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US9414777B2 (en) | 2004-07-13 | 2016-08-16 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7783333B2 (en) * | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
| US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
| US8565848B2 (en) | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8133178B2 (en) * | 2006-02-22 | 2012-03-13 | Dexcom, Inc. | Analyte sensor |
| US8744546B2 (en) * | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| US8060174B2 (en) | 2005-04-15 | 2011-11-15 | Dexcom, Inc. | Analyte sensing biointerface |
| US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| EP1991110B1 (en) | 2006-03-09 | 2018-11-07 | DexCom, Inc. | Systems and methods for processing analyte sensor data |
| US7831287B2 (en) | 2006-10-04 | 2010-11-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7751863B2 (en) | 2007-02-06 | 2010-07-06 | Glumetrics, Inc. | Optical determination of ph and glucose |
| AU2008213677A1 (en) | 2007-02-06 | 2008-08-14 | Glumetrics, Inc. | Optical systems and methods for rationmetric measurement of blood glucose concentration |
| US7824918B2 (en) * | 2007-08-06 | 2010-11-02 | Glumetrics, Inc. | HPTS-Mono and BIS Cys-Ma polymerizable fluorescent dyes for use in analyte sensors |
| JP2010527010A (ja) * | 2007-05-10 | 2010-08-05 | グルメトリクス、 インク. | 被分析物センサーを較正する装置および方法 |
| EP2162057A1 (en) | 2007-05-10 | 2010-03-17 | Glumetrics, Inc. | Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement |
| CA2688184A1 (en) | 2007-06-08 | 2008-12-18 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8202731B2 (en) * | 2007-08-06 | 2012-06-19 | Glumetrics, Inc. | HPTS-mono and bis Cys-MA polymerizable fluorescent dyes for use in analyte sensors |
| EP4098177A1 (en) | 2007-10-09 | 2022-12-07 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
| WO2009067626A1 (en) | 2007-11-21 | 2009-05-28 | Glumetrics, Inc. | Use of an equilibrium intravascular sensor to achieve tight glycemic control |
| US20090242399A1 (en) * | 2008-03-25 | 2009-10-01 | Dexcom, Inc. | Analyte sensor |
| EP3387993A3 (en) * | 2008-03-28 | 2018-11-14 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| WO2009129186A2 (en) | 2008-04-17 | 2009-10-22 | Glumetrics, Inc. | Sensor for percutaneous intravascular deployment without an indwelling cannula |
| JP2011521237A (ja) | 2008-05-20 | 2011-07-21 | ユニバーシティー ヘルス ネットワーク | 螢光に基づく画像化およびモニタリング用装置ならびにその方法 |
| EP2299904B1 (en) * | 2008-06-06 | 2019-09-11 | Intuity Medical, Inc. | Medical measurement method |
| US8560039B2 (en) | 2008-09-19 | 2013-10-15 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
| WO2010111660A1 (en) | 2009-03-27 | 2010-09-30 | Dexcom, Inc. | Methods and systems for promoting glucose management |
| US8746031B2 (en) | 2009-05-18 | 2014-06-10 | Lightship Medical Limited | Glucose sensor calibration |
| US9517023B2 (en) | 2009-06-01 | 2016-12-13 | Profusa, Inc. | Method and system for directing a localized biological response to an implant |
| US20110077477A1 (en) * | 2009-09-30 | 2011-03-31 | Glumetrics, Inc. | Sensors with thromboresistant coating |
| US8467843B2 (en) | 2009-11-04 | 2013-06-18 | Glumetrics, Inc. | Optical sensor configuration for ratiometric correction of blood glucose measurement |
| JP2013519101A (ja) * | 2010-02-08 | 2013-05-23 | グルメトリクス, インコーポレイテッド | 化学センサーの抗酸化剤保護 |
| US9151764B2 (en) | 2010-02-16 | 2015-10-06 | Lightship Medical Limited | Barrier layer for glucose sensor |
| CA2789932A1 (en) * | 2010-02-19 | 2011-08-25 | Glysure Ltd | Intravascular glucose sensor |
| AU2011217067A1 (en) * | 2010-02-19 | 2012-09-06 | Lightship Medical Limited | Subcutaneous glucose sensor |
| EP2545373B1 (en) * | 2010-03-11 | 2022-08-24 | Medtronic Minimed, Inc. | Measuring analyte concentration incorporating temperature and ph correction |
| US10010272B2 (en) | 2010-05-27 | 2018-07-03 | Profusa, Inc. | Tissue-integrating electronic apparatus |
| US20120006100A1 (en) | 2010-07-06 | 2012-01-12 | Medtronic Minimed, Inc. | Method and/or system for determining blood glucose reference sample times |
| US20120053427A1 (en) * | 2010-08-31 | 2012-03-01 | Glumetrics, Inc. | Optical sensor configuration and methods for monitoring glucose activity in interstitial fluid |
| WO2012048150A1 (en) | 2010-10-06 | 2012-04-12 | Profusa, Inc. | Tissue-integrating sensors |
| US8919180B2 (en) | 2010-10-28 | 2014-12-30 | Medtronic Minimed, Inc. | Determination and application of glucose sensor reliability indicator and/or metric |
| US9033878B2 (en) | 2010-10-28 | 2015-05-19 | Medtronic Minimed, Inc. | Glucose sensor signal reliability analysis |
| CN103370623B (zh) * | 2010-12-17 | 2016-05-04 | 视觉股份公司 | 水凝胶在具有提高的灵敏度的生物传感器中的用途 |
| US10429380B2 (en) | 2010-12-17 | 2019-10-01 | Eyesense Ag | Device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein |
| JP6084172B2 (ja) * | 2011-03-15 | 2017-02-22 | センセオニクス,インコーポレーテッド | 酸化感受性材料の統合的な触媒による保護 |
| ES2847578T3 (es) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Calibración avanzada de sensor de analito y detección de errores |
| GB201113435D0 (en) | 2011-08-03 | 2011-09-21 | Glysure Ltd | Sensor calibration |
| US9250246B2 (en) | 2011-06-29 | 2016-02-02 | Portland State University | Near-infrared fluorescent dyes with large stokes shifts |
| RU2014102629A (ru) * | 2011-06-29 | 2015-08-10 | Зе Орегон Стейт Боард Оф Хайе Эдьюкейшн Он Бехалф Оф Портланд Стейт Юниверсити | Выявление аналита с использованием флуорофоров ближней инфракрасной области |
| US9642568B2 (en) * | 2011-09-06 | 2017-05-09 | Medtronic Minimed, Inc. | Orthogonally redundant sensor systems and methods |
| US10352941B2 (en) | 2011-09-27 | 2019-07-16 | Medtronic Minimed, Inc. | Method for functionalizing a porous membrane covering of an optical sensor to facilitate coupling of an antithrom-bogenic agent |
| EP2797509A1 (en) * | 2011-12-29 | 2014-11-05 | Wellsense, Inc. | Analyte sensor with extended range of detection |
| WO2013102161A1 (en) * | 2011-12-29 | 2013-07-04 | Wellsense, Inc. | Analyte sensor |
| CA3095821C (en) | 2012-03-15 | 2023-03-14 | Baxter International Inc. | Sensor |
| US9017622B2 (en) | 2012-04-10 | 2015-04-28 | Lightship Medical Limited | Calibrator for a sensor |
| US20130344619A1 (en) | 2012-06-21 | 2013-12-26 | Lightship Medical Limited | Glucose sensor |
| CN103712927B (zh) * | 2012-09-29 | 2016-12-21 | 埃科莱布美国股份有限公司 | 检测系统和方法以及水处理系统和方法 |
| US8803090B2 (en) * | 2012-11-09 | 2014-08-12 | Fenwal, Inc. | Citrate detector for blood processing system |
| US11320418B2 (en) | 2012-12-12 | 2022-05-03 | Iassay, Inc. | Modular hand-held point of care testing system |
| GB201317746D0 (en) | 2013-10-08 | 2013-11-20 | Smith & Nephew | PH indicator |
| WO2014137993A1 (en) * | 2013-03-04 | 2014-09-12 | David Reed Markle | METHODS FOR USE IN A CALIBRATION-FREE ABSORBANCE SENSOR FOR MEASURING pH AND pCO2 |
| CA2904031A1 (en) | 2013-03-14 | 2014-10-02 | Profusa, Inc. | Method and device for correcting optical signals |
| EP3003131B1 (en) | 2013-06-06 | 2020-05-27 | Profusa, Inc. | Apparatus for detecting optical signals from implanted sensors |
| US9662050B2 (en) | 2013-06-21 | 2017-05-30 | Verify Life Sciences LLC | Physiological measurement using wearable device |
| US9963556B2 (en) | 2013-09-18 | 2018-05-08 | Senseonics, Incorporated | Critical point drying of hydrogels in analyte sensors |
| US10379125B2 (en) * | 2013-12-27 | 2019-08-13 | Becton, Dickinson And Company | System and method for dynamically calibrating and measuring analyte concentration in diabetes management monitors |
| US10039491B2 (en) * | 2014-06-30 | 2018-08-07 | Verily Life Sciences Llc | Methods for reducing noise in optical biological sensors |
| CA2954465A1 (en) | 2014-07-10 | 2016-01-14 | Smith & Nephew Plc | Improvements in and relating to polymer materials |
| CN115989999A (zh) | 2014-07-24 | 2023-04-21 | 大学健康网络 | 用于诊断目的的数据的收集和分析 |
| US10488418B2 (en) * | 2014-09-02 | 2019-11-26 | The Regents Of The University Of California | Fluorescence assay for intestinal permeability |
| EP3206567A1 (en) | 2014-10-13 | 2017-08-23 | Glusense, Ltd. | Analyte-sensing device |
| GB201600746D0 (en) * | 2016-01-14 | 2016-03-02 | Smith & Nephew | Improvements in and relating to polymer materials |
| GB201600747D0 (en) | 2016-01-14 | 2016-03-02 | Smith & Nephew | Improvements in and relating to devices |
| US10871487B2 (en) | 2016-04-20 | 2020-12-22 | Glusense Ltd. | FRET-based glucose-detection molecules |
| AU2017298463B2 (en) * | 2016-07-20 | 2022-09-01 | University Of Maryland, Baltimore | Silicone hydrogel based fluorescent assay and contact lens |
| US11331018B2 (en) | 2016-12-22 | 2022-05-17 | Profusa, Inc. | System and single-channel biosensor for and method of determining analyte value |
| US10555693B2 (en) * | 2017-02-12 | 2020-02-11 | Hoon Kim | Portable apparatus for noninvasively measuring blood glucose level and operating method thereof |
| CA3077720A1 (en) | 2017-10-24 | 2019-05-02 | Dexcom, Inc. | Pre-connected analyte sensors |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| DE102017128290B4 (de) * | 2017-11-29 | 2020-07-09 | Bundesrepublik Deutschland, vertreten durch die Bundesministerin für Wirtschaft und Energie, diese vertreten durch den Präsidenten der Bundesanstalt für Materialforschung und-prüfung (BAM) | Messvorrichtung und Messsystem zur Bestimmung des pH-Wertes und Verfahren zum Bestimmen des pH-Wertes |
| CN113711017A (zh) * | 2019-07-03 | 2021-11-26 | 松下知识产权经营株式会社 | 检测装置和检测方法 |
| US12042281B2 (en) | 2019-07-17 | 2024-07-23 | Terumo Cardiovascular Systems Corporation | Fluorescent nanomaterial sensors and related methods |
| US12186076B2 (en) * | 2021-02-09 | 2025-01-07 | Medtronic, Inc. | Optical based glucose sensor |
Family Cites Families (460)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338157B1 (en) | 1992-09-09 | 1999-11-02 | Sims Deltec Inc | Systems and methods for communicating with ambulat |
| US1120700A (en) | 1914-02-02 | 1914-12-15 | Hoechst Ag | Arseno-azo compounds and process of making same. |
| US1334901A (en) | 1918-12-10 | 1920-03-23 | Higdon Emma | Turning-sheet and pad |
| US2112244A (en) | 1933-08-26 | 1938-03-29 | Squibb & Sons Inc | Amino azobenzene arsonic acids |
| US2018792A (en) | 1933-10-17 | 1935-10-29 | Soc Of Chemical Ind | Process for the manufacture of hydroxypyrene |
| US2094224A (en) | 1934-05-25 | 1937-09-28 | Gen Aniline Works Inc | Pyrene 3, 5, 8, 10-tetra-sulphonic acid and derivatives thereof |
| US2274551A (en) | 1939-06-30 | 1942-02-24 | Eastman Kodak Co | Derivatives of resins and their preparation |
| US2496151A (en) | 1946-08-14 | 1950-01-31 | Harvel Corp | Azo dyestuffs |
| US3011293A (en) | 1953-03-24 | 1961-12-05 | Pickering Dorothy Frances | Collapsible container |
| US2812524A (en) | 1955-03-25 | 1957-11-12 | Lawrence C Pruitt | Patient turner |
| AT267017B (de) | 1965-04-02 | 1968-12-10 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung von neuen, substituierten 2,7-Bisphenylazoderivaten der Chromotropsäure |
| US3302219A (en) | 1966-01-14 | 1967-02-07 | Joe F Harris | Hospital bed and lifting and turning device |
| US3488098A (en) | 1968-03-26 | 1970-01-06 | Teletype Corp | Motion translating device |
| US3659586A (en) | 1969-05-20 | 1972-05-02 | Univ Johns Hopkins | Percutaneous carbon dioxide sensor and process for measuring pulmonary efficiency |
| US3846353A (en) | 1970-06-08 | 1974-11-05 | Department Of Health Education | Nonthrombogenic plastic material and method for making the same |
| US3685059A (en) | 1970-07-28 | 1972-08-22 | Gulf General Atomic Inc | Prosthetic blood circulation device having a pyrolytic carbon coated blood contacting surface |
| CH530006A (de) | 1970-10-01 | 1972-10-31 | Hoffmann La Roche | Elektrodenanordnung |
| US3827089A (en) | 1971-09-16 | 1974-08-06 | W Grow | Turnover bed assembly |
| US3808615A (en) | 1972-05-22 | 1974-05-07 | W Geary | Bed and pillow assembly |
| US3865548A (en) | 1972-06-13 | 1975-02-11 | Einstein Coll Med | Analytical apparatus and process |
| CH564771A5 (enExample) | 1973-05-10 | 1975-07-31 | Hoffmann La Roche | |
| US3884225A (en) | 1973-06-01 | 1975-05-20 | Evelyn Ruth Witter | Bed patient turn and hold device |
| SE428596B (sv) | 1975-04-09 | 1983-07-11 | Raychem Corp | Anordning for hopkoppling av substrat exv ror omfattande ett organ av minnesmetall |
| US3930580A (en) | 1973-10-19 | 1976-01-06 | Medical Products Corporation | Sterilizable, peelable pouch or tray assembly |
| US3909504A (en) | 1973-11-05 | 1975-09-30 | Carrier Tel Corp America Inc | Ruggedized package for electronic components and the like |
| GB1447163A (en) | 1974-03-13 | 1976-08-25 | Gibbs J R | Beds |
| US3895403A (en) | 1974-04-05 | 1975-07-22 | Sanford Davis | Patient orienting device |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4041932A (en) | 1975-02-06 | 1977-08-16 | Fostick Moshe A | Method for monitoring blood gas tension and pH from outside the body |
| DE2508637C3 (de) | 1975-02-28 | 1979-11-22 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Anordnung zur optischen Messung von Blutgasen |
| SE400173B (sv) | 1975-03-20 | 1978-03-20 | Aminkemi Ab | Forfarande vid stabilisering av en hepariniserad yta innehallande vid blodkontakt utlosbart heparin |
| IT1057223B (it) | 1976-02-19 | 1982-03-10 | Cselt Centro Studi Lab Telecom | Equalizzatore ottico per trasmissione di segnali di guide ottiche multimodo |
| FR2350831A1 (fr) | 1976-05-13 | 1977-12-09 | Caneva Moutinho Mario | Dispositif permettant de faciliter les mouvements des personnes devant garder le lit et ayant des difficultes motrices |
| SU621624A2 (ru) | 1977-04-28 | 1978-08-30 | Ленинградский Ордена Ленина Ордена Октябрьской Революции И Ордена Трудового Красного Знамени Горный Институт Им.Г.В.Плеханова | Стенд дл изучени условий загр знени и очистки конвейерных лент |
| GB2005418B (en) | 1977-07-26 | 1982-04-21 | Searle & Co | Electrochemical sensor system |
| FR2403098A1 (fr) | 1977-09-19 | 1979-04-13 | Merieux Inst | Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application |
| CA1065969A (fr) | 1977-09-28 | 1979-11-06 | Gratien Bouillon | Sonde cerebrale auto-bloquante |
| US4200110A (en) | 1977-11-28 | 1980-04-29 | United States Of America | Fiber optic pH probe |
| US4345606A (en) | 1977-12-13 | 1982-08-24 | Littleford Philip O | Split sleeve introducers for pacemaker electrodes and the like |
| NO141592C (no) | 1978-06-22 | 1980-04-23 | Kjell Roeisaeth | Innretning til haandtering av en person paa et underlag |
| US4269605A (en) | 1978-06-28 | 1981-05-26 | Amicon Corporation | Method and kit for separation of glycoproteins |
| US4344438A (en) | 1978-08-02 | 1982-08-17 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Optical sensor of plasma constituents |
| US4180879A (en) | 1978-08-04 | 1980-01-01 | Mann Rose A | Body positioner |
| US4240438A (en) | 1978-10-02 | 1980-12-23 | Wisconsin Alumni Research Foundation | Method for monitoring blood glucose levels and elements |
| US4306562A (en) | 1978-12-01 | 1981-12-22 | Cook, Inc. | Tear apart cannula |
| GB2038017B (en) | 1978-12-20 | 1982-11-24 | Standard Telephones Cables Ltd | Optical fibre directional coupler |
| JPS5618342Y2 (enExample) | 1979-04-26 | 1981-04-30 | ||
| US4307933A (en) | 1980-02-20 | 1981-12-29 | General Dynamics, Pomona Division | Optical fiber launch coupler |
| US4358851A (en) | 1980-02-28 | 1982-11-09 | Xerox Corporation | Fiber optic laser device and light emitter utilizing the device |
| DE3036868A1 (de) | 1980-09-30 | 1982-05-13 | Siemens AG, 1000 Berlin und 8000 München | Verfahren zum herstellen von koppel-verzweigung- und mischerelementen aus mindestens zwei lichtleitfasern |
| US4371374A (en) | 1980-11-17 | 1983-02-01 | The Rockefeller University | Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine |
| EP0061884A1 (en) | 1981-03-30 | 1982-10-06 | Imperial Chemical Industries Plc | Optical fibre sensor |
| US4659817A (en) | 1981-05-01 | 1987-04-21 | The Children's Medical Center Corporation | Reporter compounds containing boron |
| US4459712A (en) | 1981-06-11 | 1984-07-17 | Pathan Rajendra K | Hospital bed |
| SE448059B (sv) | 1981-07-27 | 1987-01-19 | Torsten Persson | Anordning for sidvendning av sengliggande personer |
| GB2103786A (en) | 1981-08-14 | 1983-02-23 | Ici Plc | Fibre optic sensor |
| EP0073558A3 (en) | 1981-08-25 | 1984-09-26 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Fiber optic ph probe for tissue measurements |
| US4476870A (en) | 1982-03-30 | 1984-10-16 | The United States Of America As Represented By The Department Of Health And Human Services | Fiber optic PO.sbsb.2 probe |
| US4654327A (en) | 1982-04-21 | 1987-03-31 | Research Corp. | Quaternary ammonium complexes of heparin |
| DE3216516A1 (de) | 1982-05-03 | 1983-11-03 | Siemens AG, 1000 Berlin und 8000 München | Optischer wellenlaengendemultiplexer nach dem beugungsgitterprinzip |
| USRE32514E (en) | 1982-06-14 | 1987-10-06 | Eastman Kodak Company | Polymer compositions having a low coefficient of friction |
| US4515584A (en) | 1982-07-06 | 1985-05-07 | Fujisawa Pharmaceutical Co., Ltd. | Artificial pancreas |
| US4557900A (en) | 1982-09-28 | 1985-12-10 | Cardiovascular Devices, Inc. | Optical sensor with beads |
| US4465335A (en) | 1982-10-12 | 1984-08-14 | The United States Of America As Represented By The Secretary Of The Army | Concentric core optical fiber coupler |
| US4490867A (en) | 1982-12-21 | 1985-01-01 | Lycksele Nya Platprodukter Ab | Bed rocking mechanism |
| US5030420A (en) | 1982-12-23 | 1991-07-09 | University Of Virginia Alumni Patents Foundation | Apparatus for oxygen determination |
| US4495293A (en) | 1983-02-24 | 1985-01-22 | Abbott Laboratories | Fluorometric assay |
| US4528616A (en) | 1983-03-28 | 1985-07-09 | Gte Automatic Electric Inc. | Printed wiring board enclosure |
| US4548907A (en) | 1983-09-14 | 1985-10-22 | Allied Corporation | Fluorescent fluid determination method and apparatus |
| US5007704A (en) | 1983-10-28 | 1991-04-16 | Baxter International Inc. | Oximeter |
| US4754538A (en) | 1983-11-15 | 1988-07-05 | Raychem Corporation | Annular tube-like driver |
| AU559681B2 (en) | 1983-12-19 | 1987-03-19 | Litton Systems, Incorporated | Three port coupler |
| SE441128B (sv) | 1984-01-25 | 1985-09-09 | Asea Ab | Fiberoptisk givare for metning av dynamisk acceleration |
| US4654127A (en) | 1984-04-11 | 1987-03-31 | Sentech Medical Corporation | Self-calibrating single-use sensing device for clinical chemistry and method of use |
| JPS60231156A (ja) | 1984-04-30 | 1985-11-16 | Kuraray Co Ltd | 液絡式の比較電極 |
| US4846543A (en) | 1984-05-02 | 1989-07-11 | Kaptron, Inc. | Star coupler for optical fibers |
| JPS6114562A (ja) | 1984-06-30 | 1986-01-22 | Terumo Corp | pH測定装置 |
| US4621049A (en) | 1984-11-19 | 1986-11-04 | Miles Laboratories, Inc. | Enzymatic high range glucose test |
| US5217691A (en) | 1984-11-19 | 1993-06-08 | Miles Inc. | Nonenzymatic glucose test |
| US4803049A (en) | 1984-12-12 | 1989-02-07 | The Regents Of The University Of California | pH-sensitive optrode |
| DE3446726A1 (de) | 1984-12-21 | 1986-06-26 | Fa. Carl Zeiss, 7920 Heidenheim | Optische anordnung mit einem konkavspiegel oder konkavgitter |
| GB8504521D0 (en) | 1985-02-21 | 1985-03-27 | Genetics Int Inc | Electrochemical assay |
| DE3509262A1 (de) | 1985-03-12 | 1985-10-10 | Heinrich Dipl.-Ing. 1000 Berlin Ranke | Behindertenbett mit hebevorrichtung und badewanne |
| US4654031A (en) | 1985-04-15 | 1987-03-31 | Warner-Lambert Company | Flash chamber |
| US4776047A (en) | 1985-05-07 | 1988-10-11 | Med Bed Technologies, Inc. | Multiple function invalid bed arrangement |
| US4750795A (en) | 1985-06-13 | 1988-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Optical fiber coupler |
| US4943364A (en) | 1985-06-21 | 1990-07-24 | Spectramed, Inc. | Fiber optic CO2 sensor |
| US4796633A (en) | 1985-06-25 | 1989-01-10 | American Hospital Supply Corporation | Method and apparatus for in vitro calibration of oxygen saturation monitor |
| US4810655A (en) | 1985-07-03 | 1989-03-07 | Abbott Laboratories | Method for measuring oxygen concentration |
| US4650472A (en) | 1985-08-30 | 1987-03-17 | Cook, Incorporated | Apparatus and method for effecting percutaneous catheterization of a blood vessel using a small gauge introducer needle |
| US4629451A (en) | 1985-09-23 | 1986-12-16 | Victory Engineering Corp. | Stereotaxic array plug |
| FR2588471B1 (fr) | 1985-10-15 | 1990-06-08 | Bernard Jean Marc | Lit anti-escarres |
| US4792689A (en) | 1985-11-12 | 1988-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Method for obtaining a ratio measurement for correcting common path variations in intensity in fiber optic sensors |
| CN1003110B (zh) | 1985-11-15 | 1989-01-25 | 李鸿柱 | 程序控制复康床 |
| JPH025799Y2 (enExample) | 1986-02-07 | 1990-02-13 | ||
| US4684538A (en) | 1986-02-21 | 1987-08-04 | Loctite Corporation | Polysiloxane urethane compounds and adhesive compositions, and method of making and using the same |
| US4755173A (en) | 1986-02-25 | 1988-07-05 | Pacesetter Infusion, Ltd. | Soft cannula subcutaneous injection set |
| US4710623A (en) | 1986-02-27 | 1987-12-01 | Eli Lilly And Company | Optical fiber catheter with fiber-contained reactive element |
| US4675925A (en) | 1986-04-03 | 1987-06-30 | Henrietta Littleton | Device for manipulating bedridden patients |
| US4798738A (en) | 1986-10-10 | 1989-01-17 | Cardiovascular Devices, Inc. | Micro sensor |
| US4801187A (en) | 1986-04-30 | 1989-01-31 | Baxter Travenol Laboratories, Inc. | Liquid light tube end cap assembly |
| US4689308A (en) | 1986-05-01 | 1987-08-25 | International Biomedics, Inc. | Article for preparing a chemical sensor for use |
| US4703756A (en) | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
| AT385755B (de) | 1986-06-13 | 1988-05-10 | Koller Ernst | Verfahren zur herstellung von neuen pyrensulfonsaeurederivaten |
| US4927222A (en) | 1986-06-16 | 1990-05-22 | Shiley Incorporated | Dual optical fiber device |
| US4822127A (en) | 1986-06-16 | 1989-04-18 | Shiley Incorporated | Multi-channel optical transmission system |
| US4854321A (en) | 1986-06-18 | 1989-08-08 | Medex, Inc. | Integrated optic system for monitoring blood gases |
| US4727730A (en) | 1986-07-10 | 1988-03-01 | Medex, Inc. | Integrated optic system for monitoring blood pressure |
| US4886338A (en) | 1986-10-10 | 1989-12-12 | Minnesota Mining And Manufacturing Company | Optical fiber event sensor |
| US5012809A (en) | 1986-10-10 | 1991-05-07 | Shulze John E | Fiber optic catheter system with fluorometric sensor and integral flexure compensation |
| EP0269453B1 (en) | 1986-11-28 | 1993-03-17 | Takeda Chemical Industries, Ltd. | A process for producing carboxylic acid esters |
| US4794619A (en) | 1986-12-05 | 1988-12-27 | Conax Buffalo Corporation | Optical fiber temperature sensor |
| US5162130A (en) | 1986-12-17 | 1992-11-10 | Mclaughlin Gerald G | Light activated coloration of dental restorations |
| US4833091A (en) | 1987-02-06 | 1989-05-23 | Shiley Incorporated | Sensor system |
| US5093266A (en) | 1987-02-06 | 1992-03-03 | Shiley Inc. | Sensor system |
| US4746751A (en) | 1987-05-07 | 1988-05-24 | Baxter Travenol Laboratories, Inc. | Silicone reactive/fluorescent silane dye compositions |
| DE3720736A1 (de) | 1987-06-23 | 1989-01-05 | Erwin Dr Schleicher | Verfahren, reagenzien und ausruestung zur einfachen bestimmung von nicht-enzymatisch glykosylierten proteinen in koerperfluessigkeiten |
| US4816130A (en) | 1987-07-02 | 1989-03-28 | Becton, Dickinson And Company | Blood electrolyte sensors including crosslinked polyetherurethane membranes |
| ATE73935T1 (de) | 1987-07-07 | 1992-04-15 | Siemens Ag | Sensor fuer gase oder ionen. |
| US4861728A (en) | 1987-07-24 | 1989-08-29 | Becton, Dickinson And Company | Immunoassay of glycosylated hemoglobin using a labeled boron reagent |
| US4785814A (en) | 1987-08-11 | 1988-11-22 | Cordis Corporation | Optical probe for measuring pH and oxygen in blood and employing a composite membrane |
| US4851195A (en) | 1987-08-17 | 1989-07-25 | Pfizer Hospital Products Group, Inc. | Carbon dioxide sensor |
| US5047020A (en) | 1987-09-14 | 1991-09-10 | Baxter International Inc. | Ionic heparin coating |
| US4923273A (en) | 1987-10-13 | 1990-05-08 | Texas A&M University System | Method for producing reflective taps in optical fibers and applications thereof |
| US5185263A (en) | 1987-10-23 | 1993-02-09 | Avl Medical Instruments Ag | Method for calibration of a measurement apparatus |
| US4821738A (en) | 1987-11-19 | 1989-04-18 | Marquest Medical Products, Inc. | Arterial blood gas syringe |
| FR2624007A1 (fr) | 1987-12-02 | 1989-06-09 | Perdu Jean Francois | Lit sanitaire a rouleaux special pour soins aux malades grabataires |
| US4906232A (en) | 1988-03-01 | 1990-03-06 | Abbott Laboratories | Intravascular delivery device |
| US4838269A (en) | 1988-03-24 | 1989-06-13 | Scimed Life Systems, Inc. | Manifold for angioplasty balloon catheter |
| EP0336985B1 (en) | 1988-04-09 | 1993-01-27 | Hewlett-Packard GmbH | Method for manufacturing an optical probe |
| US4960412A (en) | 1988-04-15 | 1990-10-02 | Universal Medical Instrument Corp. | Catheter introducing system |
| US4903707A (en) | 1988-04-22 | 1990-02-27 | Camino Laboratories | Ventricular catheter assembly |
| US4872226A (en) | 1988-06-06 | 1989-10-10 | Robert Lonardo | Means for positioning bedfast patients |
| US5361758A (en) | 1988-06-09 | 1994-11-08 | Cme Telemetrix Inc. | Method and device for measuring concentration levels of blood constituents non-invasively |
| US5000901A (en) | 1988-07-25 | 1991-03-19 | Abbott Laboratories | Fiber-optic physiological probes |
| US4941308A (en) | 1988-07-25 | 1990-07-17 | Abbott Laboratories | Method of packaging for a sterilizable calibratable medical device |
| AT390517B (de) | 1988-08-04 | 1990-05-25 | Avl Verbrennungskraft Messtech | Optischer sensor und verfahren zu dessen herstellung |
| US4966597A (en) | 1988-11-04 | 1990-10-30 | Cosman Eric R | Thermometric cardiac tissue ablation electrode with ultra-sensitive temperature detection |
| US4937901A (en) | 1988-11-04 | 1990-07-03 | Brennan Louis G | Apparatus for turning a patient from a supine to a prone position and vice-versa |
| US4985022A (en) | 1988-11-23 | 1991-01-15 | Med Institute, Inc. | Catheter having durable and flexible segments |
| US5188803A (en) | 1988-12-01 | 1993-02-23 | Abbott Laboratories | Device for preparing a medical sensor for use |
| US4889407A (en) | 1988-12-02 | 1989-12-26 | Biomedical Sensors Limited | Optical waveguide sensor and method of making same |
| US4939801A (en) | 1988-12-22 | 1990-07-10 | Schaal Gary A | Patient transporting and turning gurney |
| IT1225494B (it) | 1988-12-23 | 1990-11-20 | Italpres Snc Di Fregni & C | Apparecchiatura per prevenire la formazione e curare le piaghe da decubito in pazienti lungodegenti |
| US5153827A (en) | 1989-01-30 | 1992-10-06 | Omni-Flow, Inc. | An infusion management and pumping system having an alarm handling system |
| US5047208A (en) | 1989-02-23 | 1991-09-10 | Medtronic, Inc. | Blood gas monitoring sensors |
| US4955862A (en) | 1989-05-22 | 1990-09-11 | Target Therapeutics, Inc. | Catheter and catheter/guide wire device |
| US5141497A (en) | 1989-06-06 | 1992-08-25 | Becton, Dickinson And Company | Apparatus and method for an introducer |
| US5182353A (en) | 1989-08-16 | 1993-01-26 | Puritan-Bennett Corporation | Method for bonding an analyte-sensitive dye compound to an addition-cure silicone |
| US5330718A (en) * | 1989-08-16 | 1994-07-19 | Puritan-Bennett Corporation | Sensor element and method for making the same |
| US5129906A (en) | 1989-09-08 | 1992-07-14 | Linvatec Corporation | Bioabsorbable tack for joining bodily tissue and in vivo method and apparatus for deploying same |
| US5512246A (en) | 1989-09-21 | 1996-04-30 | Anthony P. Russell | Method and means for detecting polyhydroxyl compounds |
| US5137833A (en) | 1989-09-21 | 1992-08-11 | Russell Anthony P | Method for detecting polyhydroxyl compounds |
| US5132432A (en) | 1989-09-22 | 1992-07-21 | Molecular Probes, Inc. | Chemically reactive pyrenyloxy sulfonic acid dyes |
| EP0543797B1 (en) | 1989-11-16 | 1995-06-21 | N.E. Chemcat Corporation | Method and apparatus for holding an article |
| US5342789A (en) * | 1989-12-14 | 1994-08-30 | Sensor Technologies, Inc. | Method and device for detecting and quantifying glucose in body fluids |
| US4946038A (en) | 1989-12-20 | 1990-08-07 | Rolland Eaton | Medicine container and cover therefor |
| US5054497A (en) | 1990-02-21 | 1991-10-08 | Biomedical Monitors And Implants, Inc. | Cranial sensor attaching device and method for its use |
| US5098618A (en) | 1990-03-14 | 1992-03-24 | Joseph Zelez | Surface modification of plastic substrates |
| EP0447196A1 (en) | 1990-03-16 | 1991-09-18 | Hewlett-Packard Company | Boronic acid dyes |
| US5175016A (en) | 1990-03-20 | 1992-12-29 | Minnesota Mining And Manufacturing Company | Method for making gas sensing element |
| US5180376A (en) | 1990-05-01 | 1993-01-19 | Cathco, Inc. | Non-buckling thin-walled sheath for the percutaneous insertion of intraluminal catheters |
| US5104388A (en) | 1990-05-08 | 1992-04-14 | Fbk International Corporation | Membrane splittable tubing |
| US5047627A (en) | 1990-05-18 | 1991-09-10 | Abbott Laboratories | Configuration fiber-optic blood gas sensor bundle and method of making |
| US5109452A (en) | 1990-07-16 | 1992-04-28 | Puritan-Bennett Corporation | Electrical-optical hybrid connector |
| US5279596A (en) | 1990-07-27 | 1994-01-18 | Cordis Corporation | Intravascular catheter with kink resistant tip |
| US5166990A (en) | 1990-08-10 | 1992-11-24 | Puritan-Bennett Corporation | Multiple optical fiber event sensor and method of manufacture |
| US5176882A (en) | 1990-12-06 | 1993-01-05 | Hewlett-Packard Company | Dual fiberoptic cell for multiple serum measurements |
| US5178267A (en) | 1990-12-20 | 1993-01-12 | Abbott Laboratories | Packaging system for a sterilizable calbratable medical device |
| US5082112A (en) | 1991-02-05 | 1992-01-21 | United States Surgical Corporation | Package for endoscopic ligating instrument |
| AR245376A1 (es) | 1991-02-25 | 1994-01-31 | Liliana Rosa Grinfeld Y Robert | Canula de perfusion arterial, para circulacion extracorporea y otros usos. |
| US5167715A (en) | 1991-03-04 | 1992-12-01 | General Electric Company | Apparatus and method for impregnating superconductor windings |
| US5119463A (en) | 1991-04-09 | 1992-06-02 | Abbott Laboratories | Compound optical probe employing single optical waveguide |
| JP2948678B2 (ja) | 1991-04-24 | 1999-09-13 | 玄々化学工業株式会社 | 減圧塗装装置 |
| US5068931A (en) | 1991-06-21 | 1991-12-03 | Smith Gene A | Apparatus for lifting and turning a patient confined to a bed |
| US5137033A (en) | 1991-07-15 | 1992-08-11 | Norton John L | Patient monitoring device |
| US5380304A (en) | 1991-08-07 | 1995-01-10 | Cook Incorporated | Flexible, kink-resistant, introducer sheath and method of manufacture |
| US5305740A (en) | 1991-09-12 | 1994-04-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Sealing means for endotracheal tubes |
| US5335305A (en) | 1991-12-19 | 1994-08-02 | Optex Biomedical, Inc. | Optical sensor for fluid parameters |
| US5261887A (en) | 1992-01-22 | 1993-11-16 | Baxter International Inc. | Easy-to-handle, self-guiding catheter stripper |
| US5168587A (en) | 1992-05-18 | 1992-12-08 | Shutes Robert S | Patient positioning device |
| US5280130A (en) | 1992-05-22 | 1994-01-18 | Biomedical Sensors, Ltd. | Assembly of a tube and a part and apparatus and method of manufacture |
| US5354448A (en) | 1992-05-22 | 1994-10-11 | Biomedical Sensors Ltd. | Electrochemical sensor |
| US5230031A (en) | 1992-05-22 | 1993-07-20 | Biomedical Sensors, Ltd. | Barrier for a connector |
| US5246109A (en) | 1992-05-22 | 1993-09-21 | Biomedical Sensors, Ltd. | Package for an active medical device |
| US5262037A (en) | 1992-05-22 | 1993-11-16 | Biomedical Sensors, Ltd. | Electrochemical sensor |
| US5257338A (en) | 1992-05-22 | 1993-10-26 | Biomedical Sensors, Ltd. | Device for transmitting and returning light and apparatus and method of manufacture |
| US5302731A (en) | 1992-07-13 | 1994-04-12 | Becton, Dickinson And Company | Fluorescent pH indicators |
| JP2599994Y2 (ja) | 1992-07-30 | 1999-09-27 | 株式会社堀場製作所 | 実験室用イオン濃度計の自動校正装置 |
| US5290266A (en) | 1992-08-14 | 1994-03-01 | General Electric Company | Flexible coating for magnetic resonance imaging compatible invasive devices |
| AU4850793A (en) | 1992-09-14 | 1994-04-12 | Purdue Research Foundation | Electrophoretically mediated chemical analysis |
| WO1994010553A1 (en) | 1992-10-23 | 1994-05-11 | Optex Biomedical, Inc. | Fibre-optic probe for the measurement of fluid parameters |
| EP0596700A1 (en) | 1992-11-03 | 1994-05-11 | Hewlett-Packard Company | Cis-diol detection method and solid supports |
| US5956501A (en) | 1997-01-10 | 1999-09-21 | Health Hero Network, Inc. | Disease simulation system and method |
| US5832448A (en) | 1996-10-16 | 1998-11-03 | Health Hero Network | Multiple patient monitoring system for proactive health management |
| US5307263A (en) | 1992-11-17 | 1994-04-26 | Raya Systems, Inc. | Modular microprocessor-based health monitoring system |
| US5545143A (en) | 1993-01-21 | 1996-08-13 | T. S. I. Medical | Device for subcutaneous medication delivery |
| DK25793A (da) | 1993-03-09 | 1994-09-10 | Pharma Plast Int As | Infusionssæt til intermitterende eller kontinuerlig indgivelse af et terapeutisk middel |
| US5280548A (en) | 1993-03-11 | 1994-01-18 | Boc Health Care, Inc. | Emission based fiber optic sensors for pH and carbon dioxide analysis |
| US5607644A (en) | 1993-06-10 | 1997-03-04 | Optical Sensors Incorporated | Optical sensor for the measurement of pH in a fluid, and related sensing compositions and methods |
| KR0180315B1 (ko) | 1993-06-30 | 1999-03-20 | 알렌 제이. 스피겔 | 환자혈액중의 다수 변수들의 생체내 측정을 위한 다-변수 카테터 |
| US5527325A (en) | 1993-07-09 | 1996-06-18 | Device For Vascular Intervention, Inc. | Atherectomy catheter and method |
| US5954651A (en) | 1993-08-18 | 1999-09-21 | Scimed Life Systems, Inc. | Catheter having a high tensile strength braid wire constraint |
| US5334157A (en) | 1993-09-09 | 1994-08-02 | Gesco International, Inc. | Catheter introducer |
| US5409469A (en) | 1993-11-04 | 1995-04-25 | Medtronic, Inc. | Introducer system having kink resistant splittable sheath |
| GB2284809B (en) | 1993-11-07 | 1998-04-29 | Japan Res Dev Corp | A fluorescent phenylboronic acid suitable for use in the detection of saccharides |
| US5514710A (en) | 1994-01-11 | 1996-05-07 | Molecular Probes, Inc. | Photocleavable derivatives of hydroxyprenesulfonic acids |
| US5511547A (en) | 1994-02-16 | 1996-04-30 | Biomedical Sensors, Ltd. | Solid state sensors |
| US5536249A (en) | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
| US5391250A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Method of fabricating thin film sensors |
| US5569186A (en) | 1994-04-25 | 1996-10-29 | Minimed Inc. | Closed loop infusion pump system with removable glucose sensor |
| US5389217A (en) | 1994-04-28 | 1995-02-14 | Biomedical Sensors Ltd. | Measurement of bladder oxygen |
| PL316940A1 (en) | 1994-05-02 | 1997-02-17 | Ciba Geigy Ag | System of optical sensing elements for determining ph values and ionic strength |
| US5605152A (en) * | 1994-07-18 | 1997-02-25 | Minimed Inc. | Optical glucose sensor |
| IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US5658264A (en) | 1994-11-10 | 1997-08-19 | Target Therapeutics, Inc. | High performance spiral-wound catheter |
| DE19502183C1 (de) | 1995-01-25 | 1996-08-14 | Wolfgang Dr Fleckenstein | Halterungsvorrichtung für Gehirnmeßsonden |
| JP2799837B2 (ja) | 1995-03-03 | 1998-09-21 | 科学技術振興事業団 | ビナフチル基を有するボロン酸化合物 |
| US5676784A (en) | 1995-03-15 | 1997-10-14 | Abbott Laboratories | Method of fabricating a heater coil for a catheter used to monitor cardiac output |
| US5702373A (en) | 1995-08-31 | 1997-12-30 | Target Therapeutics, Inc. | Composite super-elastic alloy braid reinforced catheter |
| US5634911A (en) | 1995-05-19 | 1997-06-03 | General Surgical Innovations, Inc. | Screw-type skin seal with inflatable membrane |
| US5665065A (en) | 1995-05-26 | 1997-09-09 | Minimed Inc. | Medication infusion device with blood glucose data input |
| US5622259A (en) | 1995-06-07 | 1997-04-22 | Church; Jonathan M. | Reduction of discoloration in plastic materials |
| US5545179A (en) | 1995-07-21 | 1996-08-13 | Ethicon Endo-Surgery, Inc. | Endoscopic access assembly |
| JP3183390B2 (ja) | 1995-09-05 | 2001-07-09 | キヤノン株式会社 | 光電変換装置及びそれを用いた撮像装置 |
| US6019736A (en) | 1995-11-06 | 2000-02-01 | Francisco J. Avellanet | Guidewire for catheter |
| US6174424B1 (en) | 1995-11-20 | 2001-01-16 | Cirrex Corp. | Couplers for optical fibers |
| US6766183B2 (en) | 1995-11-22 | 2004-07-20 | Medtronic Minimed, Inc. | Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers |
| US6002954A (en) | 1995-11-22 | 1999-12-14 | The Regents Of The University Of California | Detection of biological molecules using boronate-based chemical amplification and optical sensors |
| DE69633573T2 (de) | 1995-11-22 | 2005-10-06 | Medtronic MiniMed, Inc., Northridge | Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor |
| US5797876A (en) | 1995-11-27 | 1998-08-25 | Therox, Inc. | High pressure perfusion device |
| US5951929A (en) | 1995-12-12 | 1999-09-14 | Medi-Dyne Inc. | Method for forming a catheter having overlapping welds |
| USD388418S (en) | 1996-03-18 | 1997-12-30 | Iomega Corporation | Computer screen with an icon |
| US5827242A (en) | 1996-06-21 | 1998-10-27 | Medtronic, Inc. | Reinforced catheter body and method for its fabrication |
| DE19624753A1 (de) | 1996-06-21 | 1998-01-02 | Teves Gmbh Alfred | Hydraulische Kraftfahrzeugbremsanlage mit Radschlupfregelung |
| US5755704A (en) | 1996-10-29 | 1998-05-26 | Medtronic, Inc. | Thinwall guide catheter |
| US6607509B2 (en) | 1997-12-31 | 2003-08-19 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
| US6741877B1 (en) | 1997-03-04 | 2004-05-25 | Dexcom, Inc. | Device and method for determining analyte levels |
| US7899511B2 (en) | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US5747666A (en) | 1997-03-26 | 1998-05-05 | Willis; John P. | Point-of-care analyzer module |
| DE19717107B4 (de) | 1997-04-23 | 2005-06-23 | Disetronic Licensing Ag | System aus Behältnis und Antriebsvorrichtung für einen Kolben, der in dem ein Medikamentfluid enthaltenden Behältnis gehalten ist |
| US6186982B1 (en) | 1998-05-05 | 2001-02-13 | Elan Corporation, Plc | Subcutaneous drug delivery device with improved filling system |
| US5954643A (en) | 1997-06-09 | 1999-09-21 | Minimid Inc. | Insertion set for a transcutaneous sensor |
| US6558351B1 (en) | 1999-06-03 | 2003-05-06 | Medtronic Minimed, Inc. | Closed loop system for controlling insulin infusion |
| AU8150498A (en) | 1997-06-17 | 1999-01-04 | Injectimed, Inc. | Method and apparatus for introducing an intravenous catheter |
| US5947940A (en) | 1997-06-23 | 1999-09-07 | Beisel; Robert F. | Catheter reinforced to prevent luminal collapse and tensile failure thereof |
| US6584335B1 (en) | 1997-08-09 | 2003-06-24 | Roche Diagnostics Gmbh | Analytical device for in vivo analysis in the body of a patient |
| DE19738942A1 (de) | 1997-09-05 | 1999-03-25 | Pulsion Verwaltungs Gmbh & Co | Verfahren und Vorrichtung zur Injektionszeitpunkt- und Injektionsdauerbestimmung bei Thermodilutionsmessungen |
| US6117290A (en) | 1997-09-26 | 2000-09-12 | Pepex Biomedical, Llc | System and method for measuring a bioanalyte such as lactate |
| US5891114A (en) | 1997-09-30 | 1999-04-06 | Target Therapeutics, Inc. | Soft-tip high performance braided catheter |
| AT409306B (de) | 1997-10-03 | 2002-07-25 | Hoffmann La Roche | Optisch chemischer sensor |
| US6119028A (en) | 1997-10-20 | 2000-09-12 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces |
| AU6325798A (en) | 1997-11-12 | 1999-05-31 | Stereotaxis, Inc. | Intracranial bolt and method of placing and using an intracranial bolt to position a medical device |
| US20010008766A1 (en) | 1998-03-17 | 2001-07-19 | Sylvia Daunert | Quantitative binding assays using green fluorescent protein as a label |
| US7647237B2 (en) | 1998-04-29 | 2010-01-12 | Minimed, Inc. | Communication station and software for interfacing with an infusion pump, analyte monitor, analyte meter, or the like |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| DE19820808C2 (de) | 1998-05-09 | 2000-11-02 | Wolfgang Fleckenstein | Einführungsvorrichtung für Gehirnsonden |
| CA2311487C (en) | 1998-05-13 | 2004-02-10 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
| US6702972B1 (en) | 1998-06-09 | 2004-03-09 | Diametrics Medical Limited | Method of making a kink-resistant catheter |
| US6736797B1 (en) | 1998-06-19 | 2004-05-18 | Unomedical A/S | Subcutaneous infusion set |
| US6355021B1 (en) | 1998-07-14 | 2002-03-12 | Maersk Medical A/S | Medical puncturing device |
| CA2336985C (en) | 1998-07-17 | 2011-01-04 | University Of Maryland, Baltimore | Method of glucose or galactose detection with glucose/galactose binding protein |
| JP2002522103A (ja) | 1998-08-07 | 2002-07-23 | インフィニット バイオメディカル テクノロジーズ インコーポレイテッド | 埋め込み式の心筋虚血の検出、指示、および動作方法 |
| US6558320B1 (en) | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
| US6248067B1 (en) | 1999-02-05 | 2001-06-19 | Minimed Inc. | Analyte sensor and holter-type monitor system and method of using the same |
| US6554798B1 (en) | 1998-08-18 | 2003-04-29 | Medtronic Minimed, Inc. | External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities |
| US6248127B1 (en) | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
| US6304766B1 (en) | 1998-08-26 | 2001-10-16 | Sensors For Medicine And Science | Optical-based sensing devices, especially for in-situ sensing in humans |
| US6330464B1 (en) | 1998-08-26 | 2001-12-11 | Sensors For Medicine & Science | Optical-based sensing devices |
| GB9821575D0 (en) | 1998-10-02 | 1998-11-25 | Diametrics Medical Limited | Cranial bolt |
| GB2342863B (en) | 1998-10-02 | 2003-02-19 | Diametrics Medical Ltd | Probe |
| EP1413245B1 (en) | 1998-10-08 | 2011-06-29 | Medtronic MiniMed, Inc. | Telemetered characteristic monitor system |
| DE29817986U1 (de) | 1998-10-08 | 1998-12-24 | Homedica AG, Cham | Meßsondenhalterung |
| DK1716884T3 (en) | 1998-10-29 | 2014-03-10 | Medtronic Minimed Inc | reservoir Connection |
| US7193521B2 (en) | 1998-10-29 | 2007-03-20 | Medtronic Minimed, Inc. | Method and apparatus for detecting errors, fluid pressure, and occlusions in an ambulatory infusion pump |
| US6248093B1 (en) | 1998-10-29 | 2001-06-19 | Minimed Inc. | Compact pump drive system |
| US7563267B2 (en) | 1999-04-09 | 2009-07-21 | Evalve, Inc. | Fixation device and methods for engaging tissue |
| US6187130B1 (en) | 1999-05-26 | 2001-02-13 | Scimed Life Systems, Inc. | Method of creating a tip on a catheter |
| US7806886B2 (en) | 1999-06-03 | 2010-10-05 | Medtronic Minimed, Inc. | Apparatus and method for controlling insulin infusion with state variable feedback |
| EP1204859B1 (en) | 1999-07-16 | 2006-11-22 | The Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| US6273874B1 (en) | 1999-08-18 | 2001-08-14 | Becton, Dickinson And Company | Protected peelable U-wing introducer |
| US6682938B1 (en) | 1999-09-15 | 2004-01-27 | The Regents Of The University Of California | Glucose sensing molecules having selected fluorescent properties |
| US6464849B1 (en) | 1999-10-07 | 2002-10-15 | Pepex Biomedical, L.L.C. | Sensor for measuring a bioanalyte such as lactate |
| US6453956B2 (en) | 1999-11-05 | 2002-09-24 | Medtronic Minimed, Inc. | Needle safe transfer guard |
| US6363273B1 (en) | 1999-12-22 | 2002-03-26 | Codman & Shurtleff, Inc. | Introducer element and method of using same |
| US6454744B1 (en) | 1999-12-23 | 2002-09-24 | Tfx Medical, Inc. | Peelable PTFE sheaths and methods for manufacture of same |
| US7003336B2 (en) | 2000-02-10 | 2006-02-21 | Medtronic Minimed, Inc. | Analyte sensor method of making the same |
| US6895263B2 (en) | 2000-02-23 | 2005-05-17 | Medtronic Minimed, Inc. | Real time self-adjusting calibration algorithm |
| US7890295B2 (en) | 2000-02-23 | 2011-02-15 | Medtronic Minimed, Inc. | Real time self-adjusting calibration algorithm |
| US6375627B1 (en) * | 2000-03-02 | 2002-04-23 | Agilent Technologies, Inc. | Physiological fluid extraction with rapid analysis |
| US20010041869A1 (en) | 2000-03-23 | 2001-11-15 | Causey James D. | Control tabs for infusion devices and methods of using the same |
| AU2001254621A1 (en) | 2000-05-05 | 2001-11-20 | K.U. Leuven R And D | Critical illness neuropathy |
| US6442413B1 (en) | 2000-05-15 | 2002-08-27 | James H. Silver | Implantable sensor |
| US7181261B2 (en) | 2000-05-15 | 2007-02-20 | Silver James H | Implantable, retrievable, thrombus minimizing sensors |
| US7769420B2 (en) | 2000-05-15 | 2010-08-03 | Silver James H | Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction |
| WO2001088534A2 (en) | 2000-05-16 | 2001-11-22 | Cygnus, Inc. | Methods for improving performance and reliability of biosensors |
| CN1446222A (zh) | 2000-08-04 | 2003-10-01 | 医药及科学传感器公司 | 水环境中分析物的检测 |
| ES2287156T3 (es) | 2000-09-08 | 2007-12-16 | Insulet Corporation | Dispositivos y sistemas para la infusion de un paciente. |
| US7807210B1 (en) | 2000-10-31 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Hemocompatible polymers on hydrophobic porous polymers |
| US6387672B1 (en) | 2000-12-04 | 2002-05-14 | Beckman Coulter, Inc. | Photo-induced electron transfer fluorescent sensor molecules |
| US6627177B2 (en) | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| US7470420B2 (en) * | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
| US6653141B2 (en) | 2000-12-05 | 2003-11-25 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing method and device |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US6800451B2 (en) | 2001-01-05 | 2004-10-05 | Sensors For Medicine And Science, Inc. | Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone |
| US6432695B1 (en) | 2001-02-16 | 2002-08-13 | Institute Of Microelectronics | Miniaturized thermal cycler |
| CA2434731C (en) | 2001-02-22 | 2010-01-26 | Insulet Corporation | Modular infusion device and method |
| EP1383560B2 (de) | 2001-04-06 | 2023-04-26 | F. Hoffmann-La Roche AG | Infusionsset |
| US20020071225A1 (en) | 2001-04-19 | 2002-06-13 | Minimed Inc. | Direct current motor safety circuits for fluid delivery systems |
| US7682669B1 (en) | 2001-07-30 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device |
| US6544212B2 (en) | 2001-07-31 | 2003-04-08 | Roche Diagnostics Corporation | Diabetes management system |
| US20070136825A1 (en) | 2001-09-18 | 2007-06-14 | Wolf-Bernd Frommer | Fusion proteins useful for detecting analytes |
| US20050267326A1 (en) | 2001-10-02 | 2005-12-01 | Alfred E. Mann Institute For Biomedical Eng. At The University Of Southern California | Percutaneous chemical sensor based on fluorescence resonant energy transfer (FRET) |
| US7096053B2 (en) | 2001-10-02 | 2006-08-22 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Internal biochemical sensing device |
| US20030232383A1 (en) | 2001-11-02 | 2003-12-18 | Sylvia Daunert | Novel reagentless sensing system for measuring carbohydrates based on the galactose/glucose binding protein |
| AU2002360487A1 (en) | 2001-12-04 | 2003-06-17 | Ashim K. Mitra | Acyclovir-peptide analogs |
| US7399277B2 (en) | 2001-12-27 | 2008-07-15 | Medtronic Minimed, Inc. | System for monitoring physiological characteristics |
| US7064103B2 (en) | 2002-01-04 | 2006-06-20 | Becton, Dickinson And Company | Binding protein as biosensors |
| US6855556B2 (en) | 2002-01-04 | 2005-02-15 | Becton, Dickinson And Company | Binding protein as biosensors |
| US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| JP4624678B2 (ja) | 2002-02-21 | 2011-02-02 | パイオニア・サージカル・オーソバイオロジックス,インコーポレイテッド | 架橋生物活性ヒドロゲルマトリックス |
| US7041082B2 (en) | 2002-02-28 | 2006-05-09 | Smiths Medical Md, Inc. | Syringe pump control systems and methods |
| JP4014897B2 (ja) | 2002-03-08 | 2007-11-28 | 株式会社堀場製作所 | 自動イオン濃度測定装置 |
| EP1482840B1 (en) | 2002-03-11 | 2008-12-10 | PAWLISZYN, Janusz B. | Micro-devices for investigation of biological systems |
| US6960192B1 (en) | 2002-04-23 | 2005-11-01 | Insulet Corporation | Transcutaneous fluid delivery system |
| US20040087842A1 (en) * | 2002-05-30 | 2004-05-06 | Lakowicz Joseph R. | Fluorescent probes for saccharrides |
| US7278983B2 (en) | 2002-07-24 | 2007-10-09 | Medtronic Minimed, Inc. | Physiological monitoring device for controlling a medication infusion device |
| US20040068230A1 (en) | 2002-07-24 | 2004-04-08 | Medtronic Minimed, Inc. | System for providing blood glucose measurements to an infusion device |
| US20050118726A1 (en) | 2002-08-26 | 2005-06-02 | Schultz Jerome S. | System and method for detecting bioanalytes and method for producing a bioanalyte sensor |
| AU2003272680A1 (en) | 2002-09-23 | 2004-04-08 | Chromagen, Inc. | Novel green and orange fluorescent labels and their uses |
| US6819951B2 (en) | 2002-09-24 | 2004-11-16 | Mayo Foundation For Medical Education And Research | Peripherally inserted central catheter with continuous central venous oximetry and proximal high flow port |
| US7226414B2 (en) | 2002-10-09 | 2007-06-05 | Biotex, Inc. | Method and apparatus for analyte sensing |
| WO2004039487A1 (en) | 2002-11-01 | 2004-05-13 | Mcmaster University | Multicomponent protein microarrays |
| US7381184B2 (en) | 2002-11-05 | 2008-06-03 | Abbott Diabetes Care Inc. | Sensor inserter assembly |
| AU2003287735A1 (en) * | 2002-11-12 | 2004-06-03 | Argose, Inc. | Non-invasive measurement of analytes |
| WO2004047643A1 (en) | 2002-11-27 | 2004-06-10 | Z-Tech (Canada) Inc. | Bioimpedance measurement using controller-switched current injection and multiplexer selected electrode connection |
| US7390462B2 (en) | 2002-12-17 | 2008-06-24 | The University Of Maryland Baltimore County | Ratiometric fluorescent pH sensor for non-invasive monitoring |
| US6669929B1 (en) | 2002-12-30 | 2003-12-30 | Colgate Palmolive Company | Dentifrice containing functional film flakes |
| US7229450B1 (en) | 2003-02-11 | 2007-06-12 | Pacesetter, Inc. | Kink resistant introducer with mapping capabilities |
| DE10311452B4 (de) | 2003-03-15 | 2006-04-13 | Roche Diagnostics Gmbh | Analysesystem zur reagenzienfreien Bestimmung der Konzentration eines Analyten im lebenden Gewebe |
| US7358094B2 (en) | 2003-05-01 | 2008-04-15 | Bell Michael L | Sensor system for saccharides |
| EP1623227A4 (en) | 2003-05-09 | 2009-03-04 | Univ Maryland | PROTEINS, SENSORS AND METHODS FOR CHARACTERIZING SUBSTANCES TO BE ANALYZED USING THESE PROTEINS AND THESE SENSORS |
| US20080009687A1 (en) | 2003-06-06 | 2008-01-10 | Smith Joseph T | Coiled circuit bio-sensor |
| NO317911B1 (no) | 2003-06-10 | 2004-12-27 | Lifecare As | Sensor for in-vivo malinger av osmotiske forandringer |
| US7353055B2 (en) | 2003-06-18 | 2008-04-01 | Hogan Josh N | Non-invasive analysis system |
| US7488601B2 (en) | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
| US20040267203A1 (en) | 2003-06-26 | 2004-12-30 | Potter Daniel J. | Splittable cannula having radiopaque marker |
| US7879024B2 (en) | 2003-06-26 | 2011-02-01 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Splittable cannula having radiopaque marker |
| US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US8060173B2 (en) | 2003-08-01 | 2011-11-15 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20050124896A1 (en) | 2003-08-25 | 2005-06-09 | Jacob Richter | Method for protecting implantable sensors and protected implantable sensors |
| US7559894B2 (en) | 2003-09-18 | 2009-07-14 | New Paradigm Concepts, LLC | Multiparameter whole blood monitor and method |
| US7699807B2 (en) | 2003-11-10 | 2010-04-20 | Smiths Medical Asd, Inc. | Device and method for insertion of a cannula of an infusion device |
| US7181260B2 (en) | 2003-11-14 | 2007-02-20 | Guillermo Gutierrez | Apparatus and method for measuring myocardial oxygen consumption |
| US7787923B2 (en) * | 2003-11-26 | 2010-08-31 | Becton, Dickinson And Company | Fiber optic device for sensing analytes and method of making same |
| US7496392B2 (en) | 2003-11-26 | 2009-02-24 | Becton, Dickinson And Company | Fiber optic device for sensing analytes |
| US8287453B2 (en) | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
| US8774886B2 (en) | 2006-10-04 | 2014-07-08 | Dexcom, Inc. | Analyte sensor |
| AU2003296419A1 (en) | 2003-12-09 | 2005-07-21 | Molecular Probes, Inc. | Pyrenyloxysulfonic acid fluorescent agents |
| EP2301428B1 (en) | 2003-12-09 | 2016-11-30 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
| GB0329161D0 (en) | 2003-12-16 | 2004-01-21 | Precisense As | Reagant for detecting an analyte |
| GB0329849D0 (en) | 2003-12-23 | 2004-01-28 | Precisense As | Fluorometers |
| EP1718753A4 (en) | 2004-01-28 | 2009-01-21 | Univ Johns Hopkins | Methods for making and using molecular switches involving circular permutation |
| US7499746B2 (en) | 2004-01-30 | 2009-03-03 | Encore Medical Asset Corporation | Automated adaptive muscle stimulation method and apparatus |
| GB2410793B (en) | 2004-02-05 | 2006-05-17 | Elan Vital | Fluid analyser systems |
| US7345160B2 (en) | 2004-03-29 | 2008-03-18 | University Of Kentucky Research Foundation | Aequorin and obelin mutants with differing wavelengths and bioluminescence |
| WO2005119223A1 (en) | 2004-04-14 | 2005-12-15 | Bioprocessors Corp. | Compositions of matter useful as ph indicators and related methods |
| US20050241959A1 (en) | 2004-04-30 | 2005-11-03 | Kenneth Ward | Chemical-sensing devices |
| US20080319286A1 (en) | 2004-05-24 | 2008-12-25 | Trent Ridder | Optical Probes for Non-Invasive Analyte Measurements |
| FI118951B (fi) | 2004-06-04 | 2008-05-30 | Newtest Oy | Anturiyksikkö, laitejärjestely ja laitejärjestelyä hyödyntävä menetelmä luumassan kehitysarvion muodostamiseksi ja esittämiseksi |
| US8696564B2 (en) | 2004-07-09 | 2014-04-15 | Cardiac Pacemakers, Inc. | Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth |
| USD525632S1 (en) | 2004-07-12 | 2006-07-25 | Sevic System Ag | Set of icons for a portion of an automotive windshield display |
| US7344500B2 (en) | 2004-07-27 | 2008-03-18 | Medtronic Minimed, Inc. | Sensing system with auxiliary display |
| US8313433B2 (en) | 2004-08-06 | 2012-11-20 | Medtronic Minimed, Inc. | Medical data management system and process |
| US7608460B2 (en) | 2004-08-19 | 2009-10-27 | Blood Cell Storage, Inc. | Fluorescent pH detector system and related methods |
| US7468033B2 (en) | 2004-09-08 | 2008-12-23 | Medtronic Minimed, Inc. | Blood contacting sensor |
| US20090171381A1 (en) | 2007-12-28 | 2009-07-02 | Schmitz Gregory P | Devices, methods and systems for neural localization |
| JP2006115948A (ja) | 2004-10-19 | 2006-05-11 | Hitachi Ltd | 血糖値測定装置 |
| US20060105174A1 (en) | 2004-10-25 | 2006-05-18 | The Research Foundation Of State University Of New York | Optical pH sensor |
| US20060088722A1 (en) | 2004-10-25 | 2006-04-27 | Aller Robert C | Optical pH sensor |
| US7306621B1 (en) | 2004-11-19 | 2007-12-11 | National Semiconductor Corporation | Heat transfer control for a prosthetic retinal device |
| WO2006063181A1 (en) | 2004-12-06 | 2006-06-15 | Surmodics, Inc. | Multifunctional medical articles |
| WO2006078432A2 (en) | 2005-01-18 | 2006-07-27 | Cyberkinetics Neurotechnology Systems, Inc. | Biological interface system with automated configuration |
| US20060189926A1 (en) | 2005-02-14 | 2006-08-24 | Hall W D | Apparatus and methods for analyzing body fluid samples |
| US7625372B2 (en) | 2005-02-23 | 2009-12-01 | Vnus Medical Technologies, Inc. | Methods and apparatus for coagulating and/or constricting hollow anatomical structures |
| US20070207498A1 (en) | 2005-02-24 | 2007-09-06 | Lifescan, Inc. | Design and construction of dimeric concanavalin a mutants |
| CN101180093B (zh) | 2005-03-21 | 2012-07-18 | 雅培糖尿病护理公司 | 用于提供结合的药剂输液以及分析物监测系统的方法和系统 |
| WO2006108809A1 (en) | 2005-04-13 | 2006-10-19 | Novo Nordisk A/S | Medical skin mountable device and system |
| US8137314B2 (en) | 2006-08-23 | 2012-03-20 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with compressible or curved reservoir or conduit |
| US20080097291A1 (en) | 2006-08-23 | 2008-04-24 | Hanson Ian B | Infusion pumps and methods and delivery devices and methods with same |
| US8277415B2 (en) | 2006-08-23 | 2012-10-02 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
| US7641649B2 (en) | 2005-05-06 | 2010-01-05 | Medtronic Minimed, Inc. | Reservoir support and method for infusion device |
| US7713240B2 (en) | 2005-09-13 | 2010-05-11 | Medtronic Minimed, Inc. | Modular external infusion device |
| CA2621993A1 (en) | 2005-09-16 | 2007-03-29 | Bg Implant, Inc. | Glaucoma treatment devices and methods |
| US20090196864A1 (en) | 2005-10-20 | 2009-08-06 | Bulla Lee A | Insecticides that target protein kinase a (pka) |
| US20090048430A1 (en) | 2005-11-02 | 2009-02-19 | Duke University | Site specific protein modification |
| US8475408B2 (en) | 2005-11-08 | 2013-07-02 | Asante Solutions, Inc. | Infusion pump system |
| USD550245S1 (en) | 2005-11-10 | 2007-09-04 | Sony Corporation | Computer generated image for a display panel or screen |
| USD550242S1 (en) | 2005-11-10 | 2007-09-04 | Sony Corporation | Computer generated image for a display panel or screen |
| USD559264S1 (en) | 2005-11-10 | 2008-01-08 | Sony Corporation | Computer generated image for a display panel or screen |
| DE102005056310B4 (de) | 2005-11-25 | 2017-02-02 | Drägerwerk AG & Co. KGaA | Verfahren und Vorrichtung zur Überwachung von Infusionen |
| USD544871S1 (en) | 2005-12-02 | 2007-06-19 | Samsung Electronics Co., Ltd. | Generated image for a portable telephone |
| US8114268B2 (en) | 2005-12-30 | 2012-02-14 | Medtronic Minimed, Inc. | Method and system for remedying sensor malfunctions detected by electrochemical impedance spectroscopy |
| US7985330B2 (en) | 2005-12-30 | 2011-07-26 | Medtronic Minimed, Inc. | Method and system for detecting age, hydration, and functional states of sensors using electrochemical impedance spectroscopy |
| US8114269B2 (en) | 2005-12-30 | 2012-02-14 | Medtronic Minimed, Inc. | System and method for determining the point of hydration and proper time to apply potential to a glucose sensor |
| DE502006009203D1 (de) | 2006-01-30 | 2011-05-12 | Pulsion Medical Sys Ag | System zum Einrichten einer Dilutionsmessstelle |
| US7367942B2 (en) | 2006-02-02 | 2008-05-06 | Palco Labs, Inc. | Method and apparatus for testing blood glucose in a reversible infusion line |
| US20080154107A1 (en) | 2006-12-20 | 2008-06-26 | Jina Arvind N | Device, systems, methods and tools for continuous glucose monitoring |
| JP2009533101A (ja) | 2006-04-10 | 2009-09-17 | エルンスト,アルネボルグ | 携帯用バランス取りプロテーゼ |
| USD560224S1 (en) | 2006-04-17 | 2008-01-22 | Samsung Electronics Co., Ltd. | Telephone with video display |
| US7942844B2 (en) | 2006-04-28 | 2011-05-17 | Medtronic Minimed, Inc. | Remote monitoring for networked fluid infusion systems |
| ATE514755T1 (de) | 2006-07-25 | 2011-07-15 | Glumetrics Inc | Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung |
| US7682338B2 (en) | 2006-08-23 | 2010-03-23 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
| US7828764B2 (en) | 2006-08-23 | 2010-11-09 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir filling and infusion medium delivery |
| USD592223S1 (en) | 2006-10-12 | 2009-05-12 | Bystronic Laser Ag | Printed material and icon for computer display, electronic screen |
| USD582427S1 (en) | 2006-10-12 | 2008-12-09 | Bystronic Laser Ag | Printed material and icon for computer display, electronic screen |
| US9725549B2 (en) | 2006-10-27 | 2017-08-08 | Basf Se | Radiation-curable mixture containing low-molecular, ethylenically unsaturated compounds having non-aromatic ring systems |
| US20080125700A1 (en) | 2006-11-29 | 2008-05-29 | Moberg Sheldon B | Methods and apparatuses for detecting medical device acceleration, temperature, and humidity conditions |
| US7946985B2 (en) | 2006-12-29 | 2011-05-24 | Medtronic Minimed, Inc. | Method and system for providing sensor redundancy |
| US8075499B2 (en) | 2007-05-18 | 2011-12-13 | Vaidhi Nathan | Abnormal motion detector and monitor |
| US8110251B2 (en) | 2007-02-06 | 2012-02-07 | Glumetrics, Inc. | Method for polymerizing a monomer solution within a cavity to generate a smooth polymer surface |
| US7824918B2 (en) | 2007-08-06 | 2010-11-02 | Glumetrics, Inc. | HPTS-Mono and BIS Cys-Ma polymerizable fluorescent dyes for use in analyte sensors |
| AU2008213677A1 (en) | 2007-02-06 | 2008-08-14 | Glumetrics, Inc. | Optical systems and methods for rationmetric measurement of blood glucose concentration |
| USD626143S1 (en) | 2007-02-06 | 2010-10-26 | Glumetrics, Inc. | Computer-generated icon for a blood glucose display |
| US7751863B2 (en) | 2007-02-06 | 2010-07-06 | Glumetrics, Inc. | Optical determination of ph and glucose |
| US20080269714A1 (en) | 2007-04-25 | 2008-10-30 | Medtronic Minimed, Inc. | Closed loop/semi-closed loop therapy modification system |
| US8323250B2 (en) | 2007-04-30 | 2012-12-04 | Medtronic Minimed, Inc. | Adhesive patch systems and methods |
| US7963954B2 (en) | 2007-04-30 | 2011-06-21 | Medtronic Minimed, Inc. | Automated filling systems and methods |
| ATE506368T1 (de) | 2007-05-01 | 2011-05-15 | Glumetrics Inc | Pyridin-boronsäure-quencher zur verwendung in analytsensoren |
| JP2010527010A (ja) | 2007-05-10 | 2010-08-05 | グルメトリクス、 インク. | 被分析物センサーを較正する装置および方法 |
| EP2162057A1 (en) | 2007-05-10 | 2010-03-17 | Glumetrics, Inc. | Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement |
| US8600681B2 (en) | 2007-05-14 | 2013-12-03 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
| WO2008147805A2 (en) | 2007-05-22 | 2008-12-04 | Becton, Dickinson And Company | Dyes having ratiometric fluorescence response for detecting metabolites |
| USD580950S1 (en) | 2007-06-15 | 2008-11-18 | Microsoft Corporation | Icon for a portion of a display screen |
| DK2222686T3 (en) | 2007-07-11 | 2015-09-21 | Medtronic Minimed Inc | Polyviologenboronsyredeaktivatorer for use in analytsensorer |
| JP2010534085A (ja) | 2007-07-20 | 2010-11-04 | メディンゴ・リミテッド | 手動操作可能な携帯式注入装置 |
| US8202731B2 (en) | 2007-08-06 | 2012-06-19 | Glumetrics, Inc. | HPTS-mono and bis Cys-MA polymerizable fluorescent dyes for use in analyte sensors |
| EP2194858B1 (en) | 2007-09-14 | 2017-11-22 | Corventis, Inc. | Medical device automatic start-up upon contact to patient tissue |
| US9023661B2 (en) | 2007-10-18 | 2015-05-05 | Becton, Dickinson And Company | Visual glucose sensor and methods of use thereof |
| EP2055369A1 (en) | 2007-10-30 | 2009-05-06 | Sensile Pat AG | Sensitively permeable coated membrane |
| WO2009067626A1 (en) | 2007-11-21 | 2009-05-28 | Glumetrics, Inc. | Use of an equilibrium intravascular sensor to achieve tight glycemic control |
| US7888754B2 (en) | 2007-12-28 | 2011-02-15 | Yamaha Corporation | MEMS transducer |
| WO2009129186A2 (en) | 2008-04-17 | 2009-10-22 | Glumetrics, Inc. | Sensor for percutaneous intravascular deployment without an indwelling cannula |
| US8207859B2 (en) | 2008-04-28 | 2012-06-26 | Medtronic Minimed, Inc. | Automobile physiological monitoring system and method for using the same |
| USD610065S1 (en) | 2008-12-19 | 2010-02-16 | Dr. Ing. H.C. F. Porsche Aktiengesellschaft | Automobile wheel |
| US8181849B2 (en) | 2008-12-30 | 2012-05-22 | Medtronic Minimed, Inc. | Color detection system for detecting reservoir presence and content in device |
| US8376968B2 (en) | 2009-05-15 | 2013-02-19 | The Hong Kong Polytechnic University | Method and system for quantifying an intention of movement of a user |
| EP2438152A4 (en) | 2009-06-05 | 2012-12-12 | Glumetrics Inc | ALGORITHMS FOR CALIBRATING A SENSOR OF SUBSTANCES TO BE ANALYZED |
| US8308679B2 (en) | 2009-12-30 | 2012-11-13 | Medtronic Minimed, Inc. | Alignment systems and methods |
| US20110077477A1 (en) | 2009-09-30 | 2011-03-31 | Glumetrics, Inc. | Sensors with thromboresistant coating |
| JP5368249B2 (ja) | 2009-10-20 | 2013-12-18 | 日東電工株式会社 | 両面粘着シート |
| US8467843B2 (en) | 2009-11-04 | 2013-06-18 | Glumetrics, Inc. | Optical sensor configuration for ratiometric correction of blood glucose measurement |
| US20110152658A1 (en) | 2009-12-17 | 2011-06-23 | Glumetrics, Inc. | Identification of aberrant measurements of in vivo glucose concentration using temperature |
| JP2013519101A (ja) | 2010-02-08 | 2013-05-23 | グルメトリクス, インコーポレイテッド | 化学センサーの抗酸化剤保護 |
| EP2545373B1 (en) | 2010-03-11 | 2022-08-24 | Medtronic Minimed, Inc. | Measuring analyte concentration incorporating temperature and ph correction |
| US20110263953A1 (en) | 2010-04-27 | 2011-10-27 | Glumetrics, Inc. | Deployment system and method for optical analyte sensor |
| US20120053427A1 (en) | 2010-08-31 | 2012-03-01 | Glumetrics, Inc. | Optical sensor configuration and methods for monitoring glucose activity in interstitial fluid |
| JP5413347B2 (ja) | 2010-09-29 | 2014-02-12 | ブラザー工業株式会社 | 端末装置、表示制御方法および表示制御プログラム |
-
2008
- 2008-05-09 EP EP08769426A patent/EP2162057A1/en not_active Withdrawn
- 2008-05-09 CA CA002686065A patent/CA2686065A1/en not_active Abandoned
- 2008-05-09 JP JP2010507711A patent/JP5517919B2/ja not_active Expired - Fee Related
- 2008-05-09 WO PCT/US2008/063330 patent/WO2008141241A1/en not_active Ceased
- 2008-05-09 US US12/118,401 patent/US8738107B2/en active Active
-
2014
- 2014-04-17 US US14/255,482 patent/US9693720B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20090018418A1 (en) | 2009-01-15 |
| JP2010526599A (ja) | 2010-08-05 |
| WO2008141241A1 (en) | 2008-11-20 |
| EP2162057A1 (en) | 2010-03-17 |
| CA2686065A1 (en) | 2008-11-20 |
| US9693720B2 (en) | 2017-07-04 |
| US20150080685A1 (en) | 2015-03-19 |
| US8738107B2 (en) | 2014-05-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5517919B2 (ja) | 即時血管内グルコース測定のための平衡非消費蛍光センサー | |
| JP5017377B2 (ja) | pH及びグルコースの光学的決定 | |
| DK2989975T3 (en) | OPTICAL SYSTEMS AND PROCEDURES FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION | |
| JP5631215B2 (ja) | 血糖管理維持システム | |
| EP2545373A1 (en) | Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction | |
| JP6534616B2 (ja) | 光検体センサの乾燥挿入および1点invivo較正 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110506 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110506 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20130228 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130625 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130924 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20131001 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131024 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131025 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140304 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140401 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5517919 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |