JP5513708B2 - 造影イメージング用の気体封入マイクロベシクル・アセンブリー - Google Patents

造影イメージング用の気体封入マイクロベシクル・アセンブリー Download PDF

Info

Publication number
JP5513708B2
JP5513708B2 JP2006546389A JP2006546389A JP5513708B2 JP 5513708 B2 JP5513708 B2 JP 5513708B2 JP 2006546389 A JP2006546389 A JP 2006546389A JP 2006546389 A JP2006546389 A JP 2006546389A JP 5513708 B2 JP5513708 B2 JP 5513708B2
Authority
JP
Japan
Prior art keywords
assembly
gas
microvesicles
suspension
microvesicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006546389A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007515470A (ja
JP2007515470A5 (https=
Inventor
ミシェル・シュナイダー
フィリップ・ビュサ
フェン・ヤン
アンヌ・セナント
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of JP2007515470A publication Critical patent/JP2007515470A/ja
Publication of JP2007515470A5 publication Critical patent/JP2007515470A5/ja
Application granted granted Critical
Publication of JP5513708B2 publication Critical patent/JP5513708B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Adornments (AREA)
JP2006546389A 2003-12-22 2004-12-21 造影イメージング用の気体封入マイクロベシクル・アセンブリー Expired - Fee Related JP5513708B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03029534.9 2003-12-22
EP03029534 2003-12-22
PCT/IB2004/004230 WO2005063305A1 (en) 2003-12-22 2004-12-21 Gas-filled microvesicle assembly for contrast imaging

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011237685A Division JP2012051932A (ja) 2003-12-22 2011-10-28 造影イメージング用の気体封入マイクロベシクル・アセンブリー

Publications (3)

Publication Number Publication Date
JP2007515470A JP2007515470A (ja) 2007-06-14
JP2007515470A5 JP2007515470A5 (https=) 2007-12-27
JP5513708B2 true JP5513708B2 (ja) 2014-06-04

Family

ID=34717195

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006546389A Expired - Fee Related JP5513708B2 (ja) 2003-12-22 2004-12-21 造影イメージング用の気体封入マイクロベシクル・アセンブリー
JP2011237685A Pending JP2012051932A (ja) 2003-12-22 2011-10-28 造影イメージング用の気体封入マイクロベシクル・アセンブリー

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011237685A Pending JP2012051932A (ja) 2003-12-22 2011-10-28 造影イメージング用の気体封入マイクロベシクル・アセンブリー

Country Status (9)

Country Link
US (1) US9750821B2 (https=)
EP (1) EP1701745B1 (https=)
JP (2) JP5513708B2 (https=)
CN (1) CN100563718C (https=)
AU (1) AU2004308756B2 (https=)
CA (1) CA2547024C (https=)
ES (1) ES2531732T3 (https=)
NO (1) NO338316B1 (https=)
WO (1) WO2005063305A1 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004029010D1 (de) 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
WO2005063306A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Assembly of gas-filled microvesicle with active component for contrast imaging
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
DE602007006968D1 (de) 2006-09-05 2010-07-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden
US20090180967A1 (en) * 2008-01-15 2009-07-16 Eugene Tu Ultrsonically active microparticles and method of use
US20090234231A1 (en) * 2008-03-13 2009-09-17 Knight Jon M Imaging Catheter With Integrated Contrast Agent Injector
CN102202694B (zh) 2008-10-07 2014-03-12 博莱科瑞士股份有限公司 包含抗-聚合物抗体的靶向构建体和结合它们的脂质体或微泡
CN111808084A (zh) 2008-11-10 2020-10-23 阿布特斯生物制药公司 用于递送治疗剂的新型脂质和组合物
CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
WO2011034892A2 (en) * 2009-09-15 2011-03-24 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for microbubbles
CN101773675B (zh) * 2010-03-05 2012-05-30 中山大学 一种负载液态氟碳的聚合物纳米超声显像囊泡及其制备方法
US9844504B2 (en) 2010-04-16 2017-12-19 University of Pittsburgh—of the Commonwealth System of Higher Education Custom designed microbubble contrast agents and techniques of ultrasound delivery optimized for gene therapy
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
WO2012030675A1 (en) * 2010-08-28 2012-03-08 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for plasmid gene transfection using polymer-modified microbubbles
EA029635B1 (ru) 2011-12-16 2018-04-30 Нанобиотикс Применение наночастицы, включающей металлический материал, покрытый материалом оксида гафния, в онкологии и композиция, ее содержащая
WO2013151682A1 (en) 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
EP2842545B1 (en) * 2012-04-24 2020-02-12 Osaka University Method for producing an aqueous dispersion of drug nanoparticles and use thereof
US20150343079A1 (en) * 2012-10-25 2015-12-03 Sogang University Research Foundation Ultrasound contrast agent with nanoparticles including drug and method for preparing the same
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
EP2968825A4 (en) 2013-03-15 2016-09-07 Childrens Medical Center Gas-filled stabilized particles and methods of use
WO2014191569A1 (en) 2013-05-30 2014-12-04 Nanobiotix Pharmaceutical composition, preparation and uses thereof
KR101595795B1 (ko) * 2014-03-19 2016-02-22 (주)아이엠지티 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법
CN104337766A (zh) * 2014-10-09 2015-02-11 唐春林 一种地高辛脂质微泡及其制备方法
EP3229776B1 (en) 2014-11-25 2023-06-28 Curadigm Sas Pharmaceutical composition combining at least two distinct nanoparticles and a pharmaceutical compound, preparation and uses thereof
UA123665C2 (uk) 2014-11-25 2021-05-12 Кюрадігм Сас Фармацевтична композиція, її одержання і застосування
ES2774365T3 (es) 2014-11-25 2020-07-20 Curadigm Sas Composición farmacéutica, preparación y usos de la misma
EP3223796B1 (en) 2014-11-25 2021-07-21 Curadigm Sas Pharmaceutical compositions, preparation and uses thereof
SG11201704143YA (en) 2014-11-25 2017-06-29 Nanobiotix Pharmaceutical composition, preparation and uses thereof
EP4154915A1 (en) 2014-12-31 2023-03-29 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
UA124572C2 (uk) 2015-05-28 2021-10-13 Нанобіотікс Наночастинки для застосування як терапевтичної вакцини
WO2017136475A1 (en) 2016-02-01 2017-08-10 Trust Biosonics Inc. Lipid microbubbles and process of making thereof
KR20180133527A (ko) 2016-05-04 2018-12-14 랜티우스 메디컬 이메징, 인크. 초음파 조영제의 제조 방법 및 장치
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
NO342271B1 (en) * 2016-09-29 2018-04-30 Sintef Tto As A new drug delivery system for treatment of cancer
US11147890B2 (en) 2017-02-28 2021-10-19 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
JP7227694B2 (ja) * 2017-12-08 2023-02-22 大平 猛 正に帯電したナノバブル分散液
WO2020127816A1 (en) * 2018-12-21 2020-06-25 Bracco Suisse Sa Gas-filled microvesicles with ligand
US20200360289A1 (en) * 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
KR20230024922A (ko) * 2020-06-15 2023-02-21 브라코 스위스 에스.에이. 초음파-매개된 요법의 개선

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2647121A (en) * 1951-02-02 1953-07-28 Ruth P Jacoby Diamine-bis-acetamides
US2819718A (en) * 1953-07-16 1958-01-14 Isidore H Goldman Drainage tube
US2844629A (en) * 1956-04-25 1958-07-22 American Home Prod Fatty acid amides and derivatives thereof
US3096560A (en) * 1958-11-21 1963-07-09 William J Liebig Process for synthetic vascular implants
JPS5141663B1 (https=) * 1966-03-12 1976-11-11
NL143127B (nl) * 1969-02-04 1974-09-16 Rhone Poulenc Sa Versterkingsorgaan voor een defecte hartklep.
US3614954A (en) * 1970-02-09 1971-10-26 Medtronic Inc Electronic standby defibrillator
US3614955A (en) * 1970-02-09 1971-10-26 Medtronic Inc Standby defibrillator and method of operation
US3945052A (en) * 1972-05-01 1976-03-23 Meadox Medicals, Inc. Synthetic vascular graft and method for manufacturing the same
US3805301A (en) * 1972-07-28 1974-04-23 Meadox Medicals Inc Tubular grafts having indicia thereon
US4013507A (en) * 1973-09-18 1977-03-22 California Institute Of Technology Ionene polymers for selectively inhibiting the vitro growth of malignant cells
US3995623A (en) * 1974-12-23 1976-12-07 American Hospital Supply Corporation Multipurpose flow-directed catheter
US4281669A (en) * 1975-05-09 1981-08-04 Macgregor David C Pacemaker electrode with porous system
US4096860A (en) * 1975-10-08 1978-06-27 Mclaughlin William F Dual flow encatheter
CA1069652A (en) * 1976-01-09 1980-01-15 Alain F. Carpentier Supported bioprosthetic heart valve with compliant orifice ring
US4134402A (en) * 1976-02-11 1979-01-16 Mahurkar Sakharam D Double lumen hemodialysis catheter
US4072146A (en) * 1976-09-08 1978-02-07 Howes Randolph M Venous catheter device
US4335723A (en) * 1976-11-26 1982-06-22 The Kendall Company Catheter having inflatable retention means
US4099528A (en) * 1977-02-17 1978-07-11 Sorenson Research Co., Inc. Double lumen cannula
US4140126A (en) * 1977-02-18 1979-02-20 Choudhury M Hasan Method for performing aneurysm repair
US4182833A (en) * 1977-12-07 1980-01-08 Celanese Polymer Specialties Company Cationic epoxide-amine reaction products
US4180068A (en) * 1978-04-13 1979-12-25 Motion Control, Incorporated Bi-directional flow catheter with retractable trocar/valve structure
EP0005035B1 (en) * 1978-04-19 1981-09-23 Imperial Chemical Industries Plc A method of preparing a tubular product by electrostatic spinning
US4284459A (en) * 1978-07-03 1981-08-18 The Kendall Company Method for making a molded catheter
US4227533A (en) * 1978-11-03 1980-10-14 Bristol-Myers Company Flushable urinary catheter
US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4339369A (en) * 1981-04-23 1982-07-13 Celanese Corporation Cationic epoxide-amine reaction products
ATE26584T1 (de) 1983-07-01 1987-05-15 Battelle Memorial Institute In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten.
SE463651B (sv) 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
ATE60340T1 (de) 1984-10-19 1991-02-15 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CH667874A5 (fr) 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US20080063603A1 (en) 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (https=) 1990-04-02 1993-05-01 Sint Sa
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
JP2974083B2 (ja) 1990-11-26 1999-11-08 株式会社 小松製作所 静油圧―機械式伝動機の制御装置
CA2112905A1 (en) 1991-07-05 1993-01-21 Michael R. Violante Ultrasmall non-aggregated porous particles entrapping gas-bubbles
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4208527A1 (de) * 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
WO1994001140A1 (de) 1992-07-03 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Echokontrastmittelzubereitung
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
DK0711179T3 (da) 1993-07-30 2005-02-14 Imcor Pharmaceutical Co Stabiliserede sammensætninger med mikrobobler til ultralyd
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
PT682530E (pt) 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
EP0699445A3 (en) 1994-08-04 1996-04-17 Gakko Houjin Toin Gakuen Process for the preparation of an ultrasonic microbubble contrast agent with a surfactant
GB9417941D0 (en) 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
WO1996009037A1 (en) 1994-09-23 1996-03-28 The Liposome Company, Inc. Method of producing a lyophilized liposome product
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
US6165442A (en) 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
NZ331372A (en) 1996-02-19 2000-01-28 Nycomed Imaging As freeze-dried vesicle containing a thermally stabilized ultrasound contrast agent
ES2197986T3 (es) 1996-02-19 2004-01-16 Amersham Health As Mejoras introducidas en o relacionadas con agentes de contraste.
KR100442182B1 (ko) 1996-07-22 2004-07-30 시게이트 테크놀로지 엘엘씨 위상 검출 추정기
NZ334365A (en) 1996-08-02 1999-10-28 Nycomed Imaging As Use of a contrast agent comprising microbubbles of biocompatible gas stabilised by opsonisable amphiphilic material for ultrasound imaging of the liver
JP2001502349A (ja) * 1996-10-21 2001-02-20 ニユコメド・イメージング・アクシエセルカペト 造影剤におけるまたはこれに関する改良
WO1998018501A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
DE69735901T2 (de) 1996-10-28 2007-05-10 Ge Healthcare As Verbesseringen an oder in verbindung mit diagnostischen/therapeutischen mitteln
GB9701237D0 (en) 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
GB9717589D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
JP2001520207A (ja) 1997-10-21 2001-10-30 ニユコメド・イメージング・アクシエセルカペト 微小血管に標的設定された造影剤および血管拡張剤による超音波造影
US20020169138A1 (en) * 1997-10-24 2002-11-14 Southern Research Institute Delivery vehicles for bioactive agents and uses thereof
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
JP4772958B2 (ja) 1998-02-09 2011-09-14 ブラッコ・リサーチ・ソシエテ・アノニム 生物学的に活性な媒質の標的に向けた送達
GB9808599D0 (en) 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
JP2000143550A (ja) * 1998-11-10 2000-05-23 Toin Gakuen 超音波造影剤
DE10013850A1 (de) 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
CA2432474C (en) 2000-12-23 2012-06-26 Dyax Corp. Fibrin binding polypeptides useful inter alia in medical imaging processes
JP2002212108A (ja) 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
US7179449B2 (en) 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
ES2243350T3 (es) 2001-01-31 2005-12-01 Bracco International B.V. Agente de contraste liofizable que comprende microburbujas de gas.
AU2002317095A1 (en) * 2001-07-03 2003-01-21 Governors Of The University Of Alberta Magnetic nanoparticles for bioseparation application and methods for producing same
CA2456988A1 (en) * 2001-08-16 2003-02-27 Alan P. Carpenter, Jr. Gas microsphere liposome composites
ES2398393T3 (es) 2002-03-01 2013-03-15 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia
CA2477935C (en) 2002-03-01 2015-01-06 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1518028B1 (fr) 2002-06-19 2011-11-09 Dimitrios Patsalaridis Dispositif de support ancrable dans le sol
WO2004083902A2 (en) * 2002-10-25 2004-09-30 Georgia Tech Research Corporation Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
DE602004029010D1 (de) 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
JP2007509989A (ja) 2003-10-31 2007-04-19 ポイント バイオメディカル コーポレイション 超音波造影剤として有用な再構成可能なミクロスフィア組成物
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
WO2005063306A1 (en) 2003-12-22 2005-07-14 Bracco Research Sa Assembly of gas-filled microvesicle with active component for contrast imaging
ATE466596T1 (de) 2004-01-20 2010-05-15 Sunnybrook & Womens College Hochfrequenz-ultraschall-darstellung mit kontrastmitteln
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物

Also Published As

Publication number Publication date
CA2547024A1 (en) 2005-07-14
WO2005063305A1 (en) 2005-07-14
CN1897979A (zh) 2007-01-17
AU2004308756B2 (en) 2010-06-24
ES2531732T3 (es) 2015-03-18
JP2012051932A (ja) 2012-03-15
EP1701745A1 (en) 2006-09-20
NO338316B1 (no) 2016-08-08
US20070071685A1 (en) 2007-03-29
CA2547024C (en) 2013-12-17
NO20063419L (no) 2006-09-21
US9750821B2 (en) 2017-09-05
JP2007515470A (ja) 2007-06-14
CN100563718C (zh) 2009-12-02
AU2004308756A1 (en) 2005-07-14
EP1701745B1 (en) 2014-12-10

Similar Documents

Publication Publication Date Title
JP5513708B2 (ja) 造影イメージング用の気体封入マイクロベシクル・アセンブリー
JP2007515471A (ja) 造影イメージング用の活性成分を有する気体封入マイクロベシクルのアセンブリー
US10076580B2 (en) Gas-filled microvesicles composition for contrast imaging
JP5420410B2 (ja) ポリマー修飾脂質を含むガス封入微小胞

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071108

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071108

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101207

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110221

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110607

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110628

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20110721

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111028

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20111207

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20120113

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131008

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131011

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140204

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140328

R150 Certificate of patent or registration of utility model

Ref document number: 5513708

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees