JP5414958B2 - ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 - Google Patents
ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 Download PDFInfo
- Publication number
- JP5414958B2 JP5414958B2 JP2002501968A JP2002501968A JP5414958B2 JP 5414958 B2 JP5414958 B2 JP 5414958B2 JP 2002501968 A JP2002501968 A JP 2002501968A JP 2002501968 A JP2002501968 A JP 2002501968A JP 5414958 B2 JP5414958 B2 JP 5414958B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- patient
- human
- bone marrow
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- YYDXWNZZLPCQSL-UHFFFAOYSA-N CC1CC(C)=CC1 Chemical compound CC1CC(C)=CC1 YYDXWNZZLPCQSL-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58744100A | 2000-06-05 | 2000-06-05 | |
| US09/587,441 | 2000-06-05 | ||
| PCT/US2001/018399 WO2001094420A1 (en) | 2000-06-05 | 2001-06-05 | Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012235072A Division JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Division JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004509847A JP2004509847A (ja) | 2004-04-02 |
| JP2004509847A5 JP2004509847A5 (https=) | 2008-08-07 |
| JP5414958B2 true JP5414958B2 (ja) | 2014-02-12 |
Family
ID=24349821
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002501968A Expired - Lifetime JP5414958B2 (ja) | 2000-06-05 | 2001-06-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2012235072A Expired - Lifetime JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Expired - Lifetime JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012235072A Expired - Lifetime JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Expired - Lifetime JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US20040131585A1 (https=) |
| EP (2) | EP2324839B1 (https=) |
| JP (3) | JP5414958B2 (https=) |
| AU (1) | AU2001275339A1 (https=) |
| CA (2) | CA2412436C (https=) |
| MX (1) | MXPA02012067A (https=) |
| WO (1) | WO2001094420A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013063979A (ja) * | 2000-06-05 | 2013-04-11 | Trustees Of Columbia Univ In The City Of New York | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10281478B2 (en) | 2000-04-06 | 2019-05-07 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US20050277576A1 (en) * | 2000-04-06 | 2005-12-15 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US9694038B2 (en) | 2000-04-06 | 2017-07-04 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US20070111935A1 (en) * | 2000-04-06 | 2007-05-17 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US7368425B2 (en) * | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
| AU2001284695A1 (en) | 2000-07-31 | 2002-02-13 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US7862810B2 (en) | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| WO2002022163A1 (en) * | 2000-09-13 | 2002-03-21 | Chugai Seiyaku Kabushiki Kaisha | Remedies for ischemic diseases |
| US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| ES2380009T3 (es) * | 2001-07-31 | 2012-05-07 | Genzyme Global S.A.R.L. | Métodos para movilizar las células madre/progenitoras |
| EP1465983B1 (en) * | 2001-12-21 | 2010-03-31 | Immunex Corporation | Endothelial stem cells, populations, methods of isolation and use thereof |
| JP2005528362A (ja) | 2002-03-21 | 2005-09-22 | ユニヴァーシティ オヴ フロリダ | 血管新生の調節法 |
| US20030199464A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
| WO2004052177A2 (en) * | 2002-12-05 | 2004-06-24 | Case Western Reserve University | Cell-based therapies for ischemia |
| US7470538B2 (en) | 2002-12-05 | 2008-12-30 | Case Western Reserve University | Cell-based therapies for ischemia |
| KR20060008870A (ko) * | 2003-03-20 | 2006-01-27 | 게이이치 후쿠다 | G-csf와 혈관 신생 작용을 갖는 인자의 병용 |
| EP1632241A4 (en) * | 2003-05-16 | 2009-07-22 | Kyowa Hakko Kirin Co Ltd | MEANS FOR THE PREVENTION AND / OR HEALING OF DISEASES IN CONNECTION WITH TISSUE DISORDER |
| DE10333901A1 (de) * | 2003-07-21 | 2005-03-10 | Transtissue Technologies Gmbh | Verwendung von Chemokinen zur Rekrutierung von humanen mesenchymalen Vorläuferzellen zur Regeneration von Gelenkdefekten |
| EP1527785A1 (en) * | 2003-10-27 | 2005-05-04 | Ludwig-Maximilians-Universität München | Use of G-CSF for treating ischemia |
| GB0329449D0 (en) * | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
| EP2946666B1 (en) | 2004-04-30 | 2017-11-15 | OrbusNeich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods of using same |
| US20050265980A1 (en) * | 2004-05-14 | 2005-12-01 | Becton, Dickinson And Company | Cell culture environments for the serum-free expansion of mesenchymal stem cells |
| ATE423842T1 (de) * | 2004-08-13 | 2009-03-15 | Medtronic Inc | Isolation der endothelvorläuferzellen-untermengen und verfahren zu ihrer verwendung |
| EP1827494A4 (en) * | 2004-11-18 | 2010-02-17 | Wayne Franco | COMBINATION GROWTH THERAPY AND CELL THERAPY FOR THE TREATMENT OF ACUTE AND CHRONIC ORGANIC DISEASES |
| US8637005B2 (en) | 2005-11-07 | 2014-01-28 | Amorcyte, Inc. | Compositions and methods of vascular injury repair |
| US20110076255A1 (en) | 2005-11-07 | 2011-03-31 | Pecora Andrew L | Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency |
| MY147516A (en) * | 2005-11-07 | 2012-12-31 | Amorcyte Inc | Compositions and method of vascular injury repair cross-reference to related applications |
| EP1991664B1 (en) | 2006-02-16 | 2018-03-28 | Ospedale San Raffaele S.r.l. | Skeletal muscle periangioblasts and cardiac mesangioblasts, method for isolation and uses thereof |
| TW200734462A (en) | 2006-03-08 | 2007-09-16 | In Motion Invest Ltd | Regulating stem cells |
| RU2388425C2 (ru) * | 2006-08-09 | 2010-05-10 | Федеральное государственное учреждение Новосибирский научно-исследовательский институт патологии кровообращения имени акад. Е.Н. Мешалкина Федерального агентства по высокотехнологичной медицинской помощи | Способ лазерного энграфтинга клеток |
| US20100034794A1 (en) * | 2006-10-03 | 2010-02-11 | Van Der Strate Barry W A | Endothelial progenitor cell compositions and neovascularization |
| US7696309B2 (en) * | 2006-10-23 | 2010-04-13 | The Brigham And Women's Hospital, Inc. | Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
| WO2008085229A2 (en) * | 2006-11-15 | 2008-07-17 | Arteriocyte Inc. | Cell-based therapies for treating liver disease |
| AU2008223817A1 (en) * | 2007-03-02 | 2008-09-12 | National University Of Ireland, Galway | Osteopontin for the prediction and treatment of cardiovascular diseases |
| JP2010523496A (ja) | 2007-03-30 | 2010-07-15 | ザ クリーブランド クリニック ファウンデーション | 虚血障害の治療方法 |
| US8496926B2 (en) | 2007-04-16 | 2013-07-30 | Biocardia, Inc. | Treatment for chronic myocardial infarction |
| US8012474B2 (en) * | 2007-08-02 | 2011-09-06 | Nov Immune S.A. | Anti-RANTES antibodies |
| KR101589442B1 (ko) * | 2007-08-06 | 2016-02-01 | 녹손 파르마 아게 | 에스디에프-1 결합형 핵산 및 이의 용도 |
| KR101666228B1 (ko) | 2007-09-28 | 2016-10-13 | 인트렉손 코포레이션 | 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도 |
| US8247374B2 (en) | 2007-11-09 | 2012-08-21 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium using cytokines and variants thereof |
| US8124071B2 (en) | 2007-11-30 | 2012-02-28 | New York Medical College | Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells |
| WO2009073616A2 (en) | 2007-11-30 | 2009-06-11 | New York Medical College | Compositions comprising vascular and myocyte progenitor cells and methods of their use |
| US8512696B2 (en) | 2007-11-30 | 2013-08-20 | Autologous, Llc | Methods of isolating non-senescent cardiac stem cells and uses thereof |
| WO2009079451A2 (en) | 2007-12-14 | 2009-06-25 | The Cleveland Clinic Foundation | Compositions and methods of promoting wound healing |
| GB0818725D0 (en) | 2008-10-13 | 2008-11-19 | Habib Nagy A | Pharmaceutical composition |
| CN102245189B (zh) * | 2008-12-03 | 2015-06-17 | 阿莫塞特公司 | 改善梗死区灌注的组合物以及血管损伤修复方法 |
| CA2772610C (en) | 2009-08-28 | 2018-01-23 | The Cleveland Clinic Foundation | Sdf-1 delivery for treating ischemic tissue |
| HRP20210334T1 (hr) * | 2009-12-11 | 2021-04-02 | Medregen, Llc | Metode liječenja u kojima se primjenjuju mobilizatori matičnih stanica i imunosupresivna sredstva |
| US10813917B2 (en) | 2009-12-11 | 2020-10-27 | Medregen, Llc | Treatment methods utilizing stem cell mobilizers and immunosuppressive agents |
| WO2011082339A2 (en) * | 2009-12-31 | 2011-07-07 | Cedars-Sinai Medical Center | Regeneration of, reestablishing function in and replacing microvasculature in organs and tissues |
| US9308277B2 (en) | 2010-02-25 | 2016-04-12 | Mesoblast International Sàrl | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
| RU2638802C2 (ru) | 2011-05-16 | 2017-12-15 | Джензим Корпорейшн | Применение антагонистов cxcr4 |
| WO2012170495A1 (en) | 2011-06-07 | 2012-12-13 | Provasculon, Inc. | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 |
| AR087364A1 (es) | 2011-07-29 | 2014-03-19 | Pf Medicament | Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres |
| AR087363A1 (es) | 2011-07-29 | 2014-03-19 | Pf Medicament | Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres |
| US20130231647A1 (en) * | 2012-03-05 | 2013-09-05 | BFM Group International GMBH | Laser therapy for endogenously enhancing ventricular function |
| KR101540698B1 (ko) * | 2012-10-05 | 2015-07-30 | 사회복지법인 삼성생명공익재단 | 허혈혈청을 포함하는 줄기세포 활성화 촉진용 조성물 및 줄기세포의 활성화 촉진 방법 |
| AU2015256383B2 (en) | 2014-05-08 | 2020-05-21 | Wake Forest University Health Sciences | Methods of treating incontinence and other sphincter deficiency disorders |
| WO2017106630A1 (en) | 2015-12-18 | 2017-06-22 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| AU2018244776B2 (en) | 2017-03-30 | 2023-12-14 | Wake Forest University Health Sciences | Methods of treatment for kidney disease |
| MX392743B (es) | 2017-04-12 | 2025-03-12 | Magenta Therapeutics Inc | Antagonistas del receptor de hidrocarburo de arilo y sus usos. |
| WO2019032930A1 (en) | 2017-08-11 | 2019-02-14 | Wake Forest University Health Sciences | USE OF CXCL12 FOR THERAPY AFTER SURGERY OF THE PROSTATE |
| WO2019089833A1 (en) | 2017-10-31 | 2019-05-09 | Magenta Therapeutics Inc. | Compositions and methods for hematopoietic stem and progenitor cell transplant therapy |
| EP3704232A1 (en) | 2017-10-31 | 2020-09-09 | Magenta Therapeutics, Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
| US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
| CN111712262A (zh) | 2017-12-06 | 2020-09-25 | 美真达治疗公司 | 用于动员造血干细胞和祖细胞的给药方案 |
| EP3735412B1 (en) | 2018-01-03 | 2024-02-21 | EdiGene Biotechnology, Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders |
| KR102056447B1 (ko) * | 2018-03-16 | 2019-12-16 | (주)메디노 | 신경줄기세포를 이용한 혈관형성 유도 방법 |
| US20220401481A1 (en) | 2019-11-01 | 2022-12-22 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
| CA3176979A1 (en) | 2020-04-27 | 2021-11-04 | Anthony Boitano | Methods and compositions for transducing hematopoietic stem and progenitor cells in vivo |
| WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
| WO2025224720A1 (en) | 2024-04-24 | 2025-10-30 | Biolinerx Ltd. | Methods of selecting treatment regimen against solid tumors |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US107195A (en) * | 1870-09-06 | Improvement in sawing-machine | ||
| US5008284A (en) | 1989-02-15 | 1991-04-16 | E. R. Squibb & Sons, Inc. | Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation |
| AU651068B2 (en) * | 1989-07-21 | 1994-07-14 | Washington University | Recombinantly produced human membrane cofactor protein (MCP) |
| EP0504257A4 (en) * | 1989-11-29 | 1993-03-03 | Brigham And Women's Hospital | (ala il-8) 77 as a leukocyte adhesion inhibitor |
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| JP2697495B2 (ja) * | 1991-06-19 | 1998-01-14 | 富士レビオ株式会社 | アルデヒド誘導体 |
| US5599703A (en) * | 1993-10-28 | 1997-02-04 | The United States Of America As Represented By The Secretary Of The Navy | In vitro amplification/expansion of CD34+ stem and progenitor cells |
| JPH07166906A (ja) * | 1993-12-14 | 1995-06-27 | Nissan Motor Co Ltd | 燃料カットと点火時期変更による加速スリップ制御装置 |
| DE4442665A1 (de) * | 1994-11-30 | 1996-06-05 | Gruenenthal Gmbh | Chimäre Proteine mit fibrinolytischen und thrombinhemmenden Eigenschaften |
| US6110889A (en) * | 1996-06-14 | 2000-08-29 | Board Of Regents, The University Of Texas System | Peptide tumor cell growth inhibitors |
| JP3866800B2 (ja) | 1996-08-29 | 2007-01-10 | 東菱薬品工業株式会社 | アポトーシス関連疾患の予防及び/又は治療薬 |
| US5980887A (en) * | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
| GB9716656D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| EP0897980A3 (en) * | 1997-08-20 | 2002-04-17 | Smithkline Beecham Corporation | CXCR4B: A human splice variant of CXCR4 chemokine receptor |
| US5880090A (en) * | 1997-09-19 | 1999-03-09 | The Hope Heart Institute | Treatment of vascular graft implants with G-CSF |
| DE69821011T3 (de) * | 1997-10-02 | 2009-01-08 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur Modulierung der Neovaskularisierung und/oder des Wachstums kollateraler Arterien und/oder anderer Arterien aus bestehenden arteriolären Verbindungen |
| EP1021737B1 (en) * | 1997-10-06 | 2008-06-11 | Acculase, Inc. | Apparatus for ablating tissue |
| AU2559799A (en) * | 1998-01-22 | 1999-08-09 | Genentech Inc. | Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies and uses of same |
| CA2311729A1 (en) * | 1998-01-23 | 1999-07-29 | Imclone Systems Incorporated | Purified populations of stem cells |
| IL138075A0 (en) * | 1998-02-27 | 2001-10-31 | Univ Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
| CA2322559C (en) * | 1998-03-09 | 2012-07-17 | St. Elizabeth's Medical Center | Compositions and methods for modulating vascularization |
| WO1999065507A1 (en) * | 1998-06-19 | 1999-12-23 | The General Hospital Corporation | Modulating platelet function |
| US20020107196A1 (en) | 1998-07-21 | 2002-08-08 | Smithkline Beecham Corporation | Method for inducing chemotaxis in endothelial cells by administering stromal cell derived factor-1alpha |
| US20060057722A1 (en) * | 1999-03-30 | 2006-03-16 | Myocardial Therapeutics, Inc. | Conditioned medium of autologous or allogenic progenitor cells for angiogenesis treatment |
| WO2000057922A1 (en) | 1999-03-30 | 2000-10-05 | Ran Kornowski | Intramyocardial injection of autologous bone marrow |
| US20060051334A1 (en) * | 1999-03-30 | 2006-03-09 | Myocardial Therapeutics, Inc. | Injection of bone marrow-derived conditioned medium for angiogenesis |
| JP5704780B2 (ja) | 1999-08-13 | 2015-04-22 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 脈管形成因子の用量および心筋血流を改善するための投与方法 |
| CA2412436C (en) * | 2000-06-05 | 2013-05-21 | The Trustees Of Columbia University In The City Of New York | Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury |
| US7547674B2 (en) | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| EP1311547A2 (en) | 2000-08-22 | 2003-05-21 | The Brigham And Women's Hospital, Inc. | Diagnosis and treatment of cardiovascular conditions |
| WO2002020848A2 (en) * | 2000-09-08 | 2002-03-14 | The Regents Of The University Of California | Gene and sequence variation associated with cancer |
| WO2002022163A1 (en) * | 2000-09-13 | 2002-03-21 | Chugai Seiyaku Kabushiki Kaisha | Remedies for ischemic diseases |
| US20020094327A1 (en) | 2000-11-05 | 2002-07-18 | Petersen Bryon E. | Targeting pluripotent stem cells to tissues |
| IL146970A0 (en) | 2001-12-06 | 2002-08-14 | Yeda Res & Dev | Migration of haematopoietic stem cells and progenitor cells to the liver |
| US20030199464A1 (en) | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| WO2004013158A2 (en) | 2002-08-01 | 2004-02-12 | Northwestern University | MUTANTS OF IgE PROTEINS AND USES THEREOF |
| US7220407B2 (en) * | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
| EP2069262A2 (en) * | 2006-08-29 | 2009-06-17 | Corning Incorporated | High strength substantially non-microcracked cordierite honeycomb body and manufacturing method |
| US7959387B2 (en) | 2007-10-03 | 2011-06-14 | Kennametal Inc. | Shrink fit sleeve for tool holder |
-
2001
- 2001-06-05 CA CA2412436A patent/CA2412436C/en not_active Expired - Lifetime
- 2001-06-05 AU AU2001275339A patent/AU2001275339A1/en not_active Abandoned
- 2001-06-05 JP JP2002501968A patent/JP5414958B2/ja not_active Expired - Lifetime
- 2001-06-05 EP EP10012752.1A patent/EP2324839B1/en not_active Expired - Lifetime
- 2001-06-05 CA CA2810249A patent/CA2810249A1/en not_active Abandoned
- 2001-06-05 EP EP01942041A patent/EP1290033B1/en not_active Expired - Lifetime
- 2001-06-05 WO PCT/US2001/018399 patent/WO2001094420A1/en not_active Ceased
- 2001-06-05 US US10/220,554 patent/US20040131585A1/en not_active Abandoned
- 2001-06-05 MX MXPA02012067A patent/MXPA02012067A/es active IP Right Grant
-
2005
- 2005-09-22 US US11/234,879 patent/US7662392B2/en not_active Expired - Fee Related
-
2007
- 2007-08-20 US US11/894,555 patent/US20080057069A1/en not_active Abandoned
- 2007-08-20 US US11/894,581 patent/US8153113B2/en not_active Expired - Fee Related
-
2010
- 2010-01-15 US US12/657,264 patent/US8486416B2/en not_active Expired - Fee Related
-
2012
- 2012-10-24 JP JP2012235072A patent/JP5710574B2/ja not_active Expired - Lifetime
-
2013
- 2013-07-10 US US13/938,608 patent/US9387234B2/en not_active Expired - Fee Related
- 2013-08-05 JP JP2013162803A patent/JP5710709B2/ja not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013063979A (ja) * | 2000-06-05 | 2013-04-11 | Trustees Of Columbia Univ In The City Of New York | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5710709B2 (ja) | 2015-04-30 |
| US20100209401A1 (en) | 2010-08-19 |
| JP2013063979A (ja) | 2013-04-11 |
| EP1290033B1 (en) | 2012-10-31 |
| US20060111290A1 (en) | 2006-05-25 |
| US7662392B2 (en) | 2010-02-16 |
| WO2001094420B1 (en) | 2002-03-07 |
| EP2324839B1 (en) | 2017-08-09 |
| JP5710574B2 (ja) | 2015-04-30 |
| US20080057069A1 (en) | 2008-03-06 |
| US9387234B2 (en) | 2016-07-12 |
| US8486416B2 (en) | 2013-07-16 |
| EP1290033A4 (en) | 2004-12-08 |
| US20090142296A1 (en) | 2009-06-04 |
| JP2004509847A (ja) | 2004-04-02 |
| WO2001094420A1 (en) | 2001-12-13 |
| CA2810249A1 (en) | 2001-12-13 |
| AU2001275339A1 (en) | 2001-12-17 |
| US8153113B2 (en) | 2012-04-10 |
| US20150150943A1 (en) | 2015-06-04 |
| MXPA02012067A (es) | 2004-08-19 |
| JP2014001221A (ja) | 2014-01-09 |
| US20040131585A1 (en) | 2004-07-08 |
| EP1290033A1 (en) | 2003-03-12 |
| CA2412436C (en) | 2013-05-21 |
| EP2324839A1 (en) | 2011-05-25 |
| CA2412436A1 (en) | 2001-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5414958B2 (ja) | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 | |
| Kocher et al. | Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function | |
| Qin et al. | Functional disruption of α4 integrin mobilizes bone marrow–derived endothelial progenitors and augments ischemic neovascularization | |
| KR102146815B1 (ko) | Hmgb1 단편을 이용한 신규 심근경색의 치료법 | |
| US7135171B2 (en) | Endothelial precursor cells for enhancing and restoring vascular function | |
| JP6682090B2 (ja) | 虚血性疾患治療に適した細胞を含む細胞群の生体外増幅方法 | |
| WO2018139562A1 (ja) | 心筋症、陳旧性心筋梗塞および慢性心不全の治療薬 | |
| Itescu et al. | Myocardial neovascularization by adult bone marrow-derived angioblasts: strategies for improvement of cardiomyocyte function | |
| US7491389B2 (en) | Modulating angiogenesis | |
| CA2559110A1 (en) | Endothelial progenitor cells and methods of use thereof | |
| US20090155220A1 (en) | Use of Bone-Marrow Derived Stem Cells to Treat Ischemia | |
| JP2022503847A (ja) | 治療適用のための骨髄由来ニューロキニン-1受容体陽性(nk1r+)前駆細胞 | |
| Itescu et al. | Adult bone marrow-derived angioblasts for improvement of cardiomyocyte function after myocardial ischemia | |
| Fazel | Cardiac repair and not regeneration after myocardial infarction: the role and therapeutic utility of the c-kitSCF pathway. | |
| Qin et al. | mobilizes bone marrow–derived endothelial progenitors and augments ischemic neovascularization | |
| HK1212887B (en) | Novel method for treating cardiac infarction using hmgb1 fragment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080605 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080605 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110628 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110927 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111004 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111227 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20120420 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120424 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120629 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20120629 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120723 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120730 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121024 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130205 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130507 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130514 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130805 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20131015 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20131113 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5414958 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |