JP2004509847A5 - - Google Patents
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- JP2004509847A5 JP2004509847A5 JP2002501968A JP2002501968A JP2004509847A5 JP 2004509847 A5 JP2004509847 A5 JP 2004509847A5 JP 2002501968 A JP2002501968 A JP 2002501968A JP 2002501968 A JP2002501968 A JP 2002501968A JP 2004509847 A5 JP2004509847 A5 JP 2004509847A5
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- Prior art keywords
- patient
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- progenitor cells
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- 239000003814 drug Substances 0.000 description 31
- 238000004519 manufacturing process Methods 0.000 description 20
- 210000000130 stem cell Anatomy 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 16
- 230000000302 ischemic effect Effects 0.000 description 15
- 230000003511 endothelial effect Effects 0.000 description 14
- 208000028867 ischemia Diseases 0.000 description 12
- 210000004165 myocardium Anatomy 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 8
- 101710082961 GATA-binding factor 2 Proteins 0.000 description 7
- 201000011510 cancer Diseases 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 208000010125 myocardial infarction Diseases 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000033115 angiogenesis Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 102000019034 Chemokines Human genes 0.000 description 4
- 108010012236 Chemokines Proteins 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- 239000005541 ACE inhibitor Substances 0.000 description 3
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 description 3
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 description 3
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 3
- 101710082513 C-X-C chemokine receptor type 4 Proteins 0.000 description 3
- 206010007558 Cardiac failure chronic Diseases 0.000 description 3
- 206010014498 Embolic stroke Diseases 0.000 description 3
- 208000016988 Hemorrhagic Stroke Diseases 0.000 description 3
- 102000010752 Plasminogen Inactivators Human genes 0.000 description 3
- 108010077971 Plasminogen Inactivators Proteins 0.000 description 3
- 206010043647 Thrombotic Stroke Diseases 0.000 description 3
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 3
- 239000002876 beta blocker Substances 0.000 description 3
- 229940097320 beta blocking agent Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 208000029078 coronary artery disease Diseases 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 230000004217 heart function Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 208000020658 intracerebral hemorrhage Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000010016 myocardial function Effects 0.000 description 3
- 208000031225 myocardial ischemia Diseases 0.000 description 3
- 230000003836 peripheral circulation Effects 0.000 description 3
- 239000002797 plasminogen activator inhibitor Substances 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 102000006573 Chemokine CXCL12 Human genes 0.000 description 2
- 108010008951 Chemokine CXCL12 Proteins 0.000 description 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
- 230000000735 allogeneic effect Effects 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000005240 left ventricle Anatomy 0.000 description 2
- 210000000944 nerve tissue Anatomy 0.000 description 2
- 210000005241 right ventricle Anatomy 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 1
- 102000004890 Interleukin-8 Human genes 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 1
- 229940096397 interleukin-8 Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58744100A | 2000-06-05 | 2000-06-05 | |
| US09/587,441 | 2000-06-05 | ||
| PCT/US2001/018399 WO2001094420A1 (en) | 2000-06-05 | 2001-06-05 | Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012235072A Division JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Division JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004509847A JP2004509847A (ja) | 2004-04-02 |
| JP2004509847A5 true JP2004509847A5 (https=) | 2008-08-07 |
| JP5414958B2 JP5414958B2 (ja) | 2014-02-12 |
Family
ID=24349821
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002501968A Expired - Lifetime JP5414958B2 (ja) | 2000-06-05 | 2001-06-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2012235072A Expired - Lifetime JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Expired - Lifetime JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012235072A Expired - Lifetime JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Expired - Lifetime JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US20040131585A1 (https=) |
| EP (2) | EP2324839B1 (https=) |
| JP (3) | JP5414958B2 (https=) |
| AU (1) | AU2001275339A1 (https=) |
| CA (2) | CA2412436C (https=) |
| MX (1) | MXPA02012067A (https=) |
| WO (1) | WO2001094420A1 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10281478B2 (en) | 2000-04-06 | 2019-05-07 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US20050277576A1 (en) * | 2000-04-06 | 2005-12-15 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US9694038B2 (en) | 2000-04-06 | 2017-07-04 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US20070111935A1 (en) * | 2000-04-06 | 2007-05-17 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US7368425B2 (en) * | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
| CA2412436C (en) | 2000-06-05 | 2013-05-21 | The Trustees Of Columbia University In The City Of New York | Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury |
| AU2001284695A1 (en) | 2000-07-31 | 2002-02-13 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US7862810B2 (en) | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| WO2002022163A1 (en) * | 2000-09-13 | 2002-03-21 | Chugai Seiyaku Kabushiki Kaisha | Remedies for ischemic diseases |
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| ES2380009T3 (es) * | 2001-07-31 | 2012-05-07 | Genzyme Global S.A.R.L. | Métodos para movilizar las células madre/progenitoras |
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| JP2005528362A (ja) | 2002-03-21 | 2005-09-22 | ユニヴァーシティ オヴ フロリダ | 血管新生の調節法 |
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| WO2004052177A2 (en) * | 2002-12-05 | 2004-06-24 | Case Western Reserve University | Cell-based therapies for ischemia |
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| DE10333901A1 (de) * | 2003-07-21 | 2005-03-10 | Transtissue Technologies Gmbh | Verwendung von Chemokinen zur Rekrutierung von humanen mesenchymalen Vorläuferzellen zur Regeneration von Gelenkdefekten |
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| GB0329449D0 (en) * | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
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| US20050265980A1 (en) * | 2004-05-14 | 2005-12-01 | Becton, Dickinson And Company | Cell culture environments for the serum-free expansion of mesenchymal stem cells |
| ATE423842T1 (de) * | 2004-08-13 | 2009-03-15 | Medtronic Inc | Isolation der endothelvorläuferzellen-untermengen und verfahren zu ihrer verwendung |
| EP1827494A4 (en) * | 2004-11-18 | 2010-02-17 | Wayne Franco | COMBINATION GROWTH THERAPY AND CELL THERAPY FOR THE TREATMENT OF ACUTE AND CHRONIC ORGANIC DISEASES |
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- 2001-06-05 EP EP10012752.1A patent/EP2324839B1/en not_active Expired - Lifetime
- 2001-06-05 CA CA2810249A patent/CA2810249A1/en not_active Abandoned
- 2001-06-05 EP EP01942041A patent/EP1290033B1/en not_active Expired - Lifetime
- 2001-06-05 WO PCT/US2001/018399 patent/WO2001094420A1/en not_active Ceased
- 2001-06-05 US US10/220,554 patent/US20040131585A1/en not_active Abandoned
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2005
- 2005-09-22 US US11/234,879 patent/US7662392B2/en not_active Expired - Fee Related
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2007
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