JP2004509847A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004509847A5 JP2004509847A5 JP2002501968A JP2002501968A JP2004509847A5 JP 2004509847 A5 JP2004509847 A5 JP 2004509847A5 JP 2002501968 A JP2002501968 A JP 2002501968A JP 2002501968 A JP2002501968 A JP 2002501968A JP 2004509847 A5 JP2004509847 A5 JP 2004509847A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- medicament
- manufacture
- progenitor cells
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 description 31
- 238000004519 manufacturing process Methods 0.000 description 20
- 210000000130 stem cell Anatomy 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 16
- 230000000302 ischemic effect Effects 0.000 description 15
- 230000003511 endothelial effect Effects 0.000 description 14
- 208000028867 ischemia Diseases 0.000 description 12
- 210000004165 myocardium Anatomy 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 8
- 101710082961 GATA-binding factor 2 Proteins 0.000 description 7
- 201000011510 cancer Diseases 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 208000010125 myocardial infarction Diseases 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000033115 angiogenesis Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 102000019034 Chemokines Human genes 0.000 description 4
- 108010012236 Chemokines Proteins 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- 239000005541 ACE inhibitor Substances 0.000 description 3
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 description 3
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 description 3
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 3
- 101710082513 C-X-C chemokine receptor type 4 Proteins 0.000 description 3
- 206010007558 Cardiac failure chronic Diseases 0.000 description 3
- 206010014498 Embolic stroke Diseases 0.000 description 3
- 208000016988 Hemorrhagic Stroke Diseases 0.000 description 3
- 102000010752 Plasminogen Inactivators Human genes 0.000 description 3
- 108010077971 Plasminogen Inactivators Proteins 0.000 description 3
- 206010043647 Thrombotic Stroke Diseases 0.000 description 3
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 3
- 239000002876 beta blocker Substances 0.000 description 3
- 229940097320 beta blocking agent Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 208000029078 coronary artery disease Diseases 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 230000004217 heart function Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 208000020658 intracerebral hemorrhage Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000010016 myocardial function Effects 0.000 description 3
- 208000031225 myocardial ischemia Diseases 0.000 description 3
- 230000003836 peripheral circulation Effects 0.000 description 3
- 239000002797 plasminogen activator inhibitor Substances 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 102000006573 Chemokine CXCL12 Human genes 0.000 description 2
- 108010008951 Chemokine CXCL12 Proteins 0.000 description 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
- 230000000735 allogeneic effect Effects 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000005240 left ventricle Anatomy 0.000 description 2
- 210000000944 nerve tissue Anatomy 0.000 description 2
- 210000005241 right ventricle Anatomy 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 1
- 102000004890 Interleukin-8 Human genes 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 1
- 229940096397 interleukin-8 Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58744100A | 2000-06-05 | 2000-06-05 | |
| US09/587,441 | 2000-06-05 | ||
| PCT/US2001/018399 WO2001094420A1 (en) | 2000-06-05 | 2001-06-05 | Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012235072A Division JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Division JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004509847A JP2004509847A (ja) | 2004-04-02 |
| JP2004509847A5 true JP2004509847A5 (https=) | 2008-08-07 |
| JP5414958B2 JP5414958B2 (ja) | 2014-02-12 |
Family
ID=24349821
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002501968A Expired - Lifetime JP5414958B2 (ja) | 2000-06-05 | 2001-06-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2012235072A Expired - Lifetime JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Expired - Lifetime JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012235072A Expired - Lifetime JP5710574B2 (ja) | 2000-06-05 | 2012-10-24 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
| JP2013162803A Expired - Lifetime JP5710709B2 (ja) | 2000-06-05 | 2013-08-05 | ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US20040131585A1 (https=) |
| EP (2) | EP2324839B1 (https=) |
| JP (3) | JP5414958B2 (https=) |
| AU (1) | AU2001275339A1 (https=) |
| CA (2) | CA2810249A1 (https=) |
| MX (1) | MXPA02012067A (https=) |
| WO (1) | WO2001094420A1 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070111935A1 (en) * | 2000-04-06 | 2007-05-17 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US9694038B2 (en) | 2000-04-06 | 2017-07-04 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US20050277576A1 (en) * | 2000-04-06 | 2005-12-15 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US10281478B2 (en) | 2000-04-06 | 2019-05-07 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US7368425B2 (en) * | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
| MXPA02012067A (es) | 2000-06-05 | 2004-08-19 | Univ Columbia | Identificacion y uso de celulas endoteliales precursoras derivadas de medula osea par mejorar la funcion del miocardio despues de dano isquemico. |
| US20020061587A1 (en) | 2000-07-31 | 2002-05-23 | Piero Anversa | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US7862810B2 (en) | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| WO2002022163A1 (en) | 2000-09-13 | 2002-03-21 | Chugai Seiyaku Kabushiki Kaisha | Remedies for ischemic diseases |
| DK1411918T3 (da) * | 2001-07-31 | 2012-04-23 | Genzyme Global S A R L | Fremgangsmåder til at mobilisere progenitor/stamceller |
| US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| MXPA04006154A (es) | 2001-12-21 | 2004-11-01 | Immunex Corp | Celulas madre endoteliales, poblaciones y metodos para el aislamiento y uso de las mismas. |
| EP1490107A4 (en) * | 2002-03-21 | 2005-11-09 | Univ Florida | MODULATION OF ANGIOGENESIS |
| US20030199464A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
| WO2008121719A1 (en) * | 2007-03-30 | 2008-10-09 | The Cleveland Clinic Foundation | Method of treating ischemic disorders |
| US20040258670A1 (en) * | 2002-12-05 | 2004-12-23 | Case Western Reserve University | Cell-based therapies for ischemia |
| US7470538B2 (en) | 2002-12-05 | 2008-12-30 | Case Western Reserve University | Cell-based therapies for ischemia |
| WO2004082703A1 (ja) * | 2003-03-20 | 2004-09-30 | Keiichi Fukuda | Ｇ－ｃｓｆと血管新生作用を有する因子の併用 |
| KR20060018851A (ko) * | 2003-05-16 | 2006-03-02 | 교와 핫꼬 고교 가부시끼가이샤 | 조직 파괴를 수반하는 질환의 예방 및/또는 치료제 |
| DE10333901A1 (de) * | 2003-07-21 | 2005-03-10 | Transtissue Technologies Gmbh | Verwendung von Chemokinen zur Rekrutierung von humanen mesenchymalen Vorläuferzellen zur Regeneration von Gelenkdefekten |
| EP1527785A1 (en) * | 2003-10-27 | 2005-05-04 | Ludwig-Maximilians-Universität München | Use of G-CSF for treating ischemia |
| GB0329449D0 (en) * | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
| TW200605910A (en) | 2004-04-30 | 2006-02-16 | Orbus Medical Technologies Inc | Medical device with coating for capturing genetically-altered cells and methods for using same |
| JP2007536936A (ja) | 2004-05-14 | 2007-12-20 | ベクトン・ディキンソン・アンド・カンパニー | 幹細胞集団および使用方法 |
| CA2574186A1 (en) * | 2004-08-13 | 2006-02-23 | Medtronic, Inc. | Isolation of endothelial progenitor cell subsets and methods for their use |
| WO2006055743A2 (en) * | 2004-11-18 | 2006-05-26 | Franco, Wayne | Compbination growth therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| US20110076255A1 (en) | 2005-11-07 | 2011-03-31 | Pecora Andrew L | Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency |
| US8637005B2 (en) | 2005-11-07 | 2014-01-28 | Amorcyte, Inc. | Compositions and methods of vascular injury repair |
| EP1951864B1 (en) * | 2005-11-07 | 2014-05-07 | Amorcyte, Inc. | Compositions and methods of vascular injury repair |
| EP1991664B1 (en) | 2006-02-16 | 2018-03-28 | Ospedale San Raffaele S.r.l. | Skeletal muscle periangioblasts and cardiac mesangioblasts, method for isolation and uses thereof |
| TW200734462A (en) | 2006-03-08 | 2007-09-16 | In Motion Invest Ltd | Regulating stem cells |
| RU2388425C2 (ru) * | 2006-08-09 | 2010-05-10 | Федеральное государственное учреждение Новосибирский научно-исследовательский институт патологии кровообращения имени акад. Е.Н. Мешалкина Федерального агентства по высокотехнологичной медицинской помощи | Способ лазерного энграфтинга клеток |
| EP2068897A1 (en) * | 2006-10-03 | 2009-06-17 | Medtronic, Inc. | Endothelial progenitor cell compositions and neovascularization |
| US7696309B2 (en) | 2006-10-23 | 2010-04-13 | The Brigham And Women's Hospital, Inc. | Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
| WO2008085229A2 (en) * | 2006-11-15 | 2008-07-17 | Arteriocyte Inc. | Cell-based therapies for treating liver disease |
| EP2114422A1 (en) * | 2007-03-02 | 2009-11-11 | National University of Ireland, Galway | Osteopontin for the prediction and treatment of cardiovascular diseases |
| US8496926B2 (en) | 2007-04-16 | 2013-07-30 | Biocardia, Inc. | Treatment for chronic myocardial infarction |
| ES2453592T3 (es) * | 2007-08-02 | 2014-04-08 | Novimmune Sa | Anticuerpos anti-RANTES y métodos de uso de los mismos |
| US8772257B2 (en) * | 2007-08-06 | 2014-07-08 | Noxxon Pharma Ag | SDF-1 binding nucleic acids and the use thereof |
| MX2010003371A (es) | 2007-09-28 | 2010-05-05 | Intrexon Corp | Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos. |
| WO2009062143A2 (en) | 2007-11-09 | 2009-05-14 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium using cytokines and variants thereof |
| EP2227238A2 (en) | 2007-11-30 | 2010-09-15 | New York Medical College | Compositions comprising vascular and myocyte progenitor cells and methods of their use |
| AU2008334036B2 (en) | 2007-11-30 | 2014-05-29 | New York Medical College | Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells |
| US8512696B2 (en) | 2007-11-30 | 2013-08-20 | Autologous, Llc | Methods of isolating non-senescent cardiac stem cells and uses thereof |
| CA2709398C (en) | 2007-12-14 | 2017-11-07 | The Cleveland Clinic Foundation | Use of stromal cell-derived factor 1 for promoting wound healing |
| GB0818725D0 (en) | 2008-10-13 | 2008-11-19 | Habib Nagy A | Pharmaceutical composition |
| RU2497532C2 (ru) * | 2008-12-03 | 2013-11-10 | Эморсайт, Инк. | Композиции, улучшающие перфузию в области инфаркта и способы восстановления сосудистого повреждения |
| WO2011026041A2 (en) | 2009-08-28 | 2011-03-03 | The Cleveland Clinic Foundation | Sdf-1 delivery for treating ischemic tissue |
| SI2509619T1 (sl) * | 2009-12-11 | 2021-04-30 | Medregen, Llc | Metode zdravljenja z uporabo mobilizatorjev matičnih celic in imunosupresivnih učinkovin |
| US10813917B2 (en) | 2009-12-11 | 2020-10-27 | Medregen, Llc | Treatment methods utilizing stem cell mobilizers and immunosuppressive agents |
| WO2011082339A2 (en) * | 2009-12-31 | 2011-07-07 | Cedars-Sinai Medical Center | Regeneration of, reestablishing function in and replacing microvasculature in organs and tissues |
| WO2011106234A1 (en) | 2010-02-25 | 2011-09-01 | Provasculon, Inc. | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
| KR20140045411A (ko) | 2011-05-16 | 2014-04-16 | 젠자임 코포레이션 | Ｃｘｃｒ４ 길항제의 용도 |
| JP6145089B2 (ja) | 2011-06-07 | 2017-06-07 | メソブラスト インターナショナル エスエイアールエル | ストロマ細胞由来因子−１のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 |
| AR087363A1 (es) | 2011-07-29 | 2014-03-19 | Pf Medicament | Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres |
| AR087364A1 (es) | 2011-07-29 | 2014-03-19 | Pf Medicament | Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres |
| US20130231647A1 (en) * | 2012-03-05 | 2013-09-05 | BFM Group International GMBH | Laser therapy for endogenously enhancing ventricular function |
| US10072247B2 (en) * | 2012-10-05 | 2018-09-11 | Samsung Life Public Welfare Foundation | Composition comprising ischemic serum for promoting activation of stem cell and method for promoting activation of stem cell |
| US10420818B2 (en) | 2014-05-08 | 2019-09-24 | Wake Forest University Health Sciences | Methods of treating incontinence and other sphincter deficiency disorders |
| WO2017106630A1 (en) | 2015-12-18 | 2017-06-22 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| WO2018183625A1 (en) | 2017-03-30 | 2018-10-04 | Wake Forest University Health Sciences | Methods of treatment for kidney disease |
| TW201841916A (zh) | 2017-04-12 | 2018-12-01 | 美商麥珍塔治療學股份有限公司 | 芳香烴受體拮抗劑及其用途 |
| US11654181B2 (en) | 2017-08-11 | 2023-05-23 | Wake Forest University Health Sciences | Use of CXCL12 for therapy after prostate surgery |
| US20190314407A1 (en) | 2017-10-31 | 2019-10-17 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
| EP3703715A1 (en) | 2017-10-31 | 2020-09-09 | Magenta Therapeutics, Inc. | Compositions and methods for hematopoietic stem and progenitor cell transplant therapy |
| US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
| CN111712262A (zh) | 2017-12-06 | 2020-09-25 | 美真达治疗公司 | 用于动员造血干细胞和祖细胞的给药方案 |
| US20200338132A1 (en) | 2018-01-03 | 2020-10-29 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders |
| KR102056447B1 (ko) * | 2018-03-16 | 2019-12-16 | (주)메디노 | 신경줄기세포를 이용한 혈관형성 유도 방법 |
| EP4051298A1 (en) | 2019-11-01 | 2022-09-07 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progentor cells |
| CA3176979A1 (en) | 2020-04-27 | 2021-11-04 | Anthony Boitano | Methods and compositions for transducing hematopoietic stem and progenitor cells in vivo |
| WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
| WO2025224720A1 (en) | 2024-04-24 | 2025-10-30 | Biolinerx Ltd. | Methods of selecting treatment regimen against solid tumors |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US107195A (en) * | 1870-09-06 | Improvement in sawing-machine | ||
| US5008284A (en) * | 1989-02-15 | 1991-04-16 | E. R. Squibb & Sons, Inc. | Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation |
| WO1991002002A1 (en) * | 1989-07-21 | 1991-02-21 | Washington University | Recombinantly produced human membrane cofactor protein (mcp) |
| EP0504257A4 (en) * | 1989-11-29 | 1993-03-03 | Brigham And Women's Hospital | (ala il-8) 77 as a leukocyte adhesion inhibitor |
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| JP2697495B2 (ja) * | 1991-06-19 | 1998-01-14 | 富士レビオ株式会社 | アルデヒド誘導体 |
| US5599703A (en) * | 1993-10-28 | 1997-02-04 | The United States Of America As Represented By The Secretary Of The Navy | In vitro amplification/expansion of CD34+ stem and progenitor cells |
| JPH07166906A (ja) * | 1993-12-14 | 1995-06-27 | Nissan Motor Co Ltd | 燃料カットと点火時期変更による加速スリップ制御装置 |
| DE4442665A1 (de) * | 1994-11-30 | 1996-06-05 | Gruenenthal Gmbh | Chimäre Proteine mit fibrinolytischen und thrombinhemmenden Eigenschaften |
| US6110889A (en) * | 1996-06-14 | 2000-08-29 | Board Of Regents, The University Of Texas System | Peptide tumor cell growth inhibitors |
| JP3866800B2 (ja) * | 1996-08-29 | 2007-01-10 | 東菱薬品工業株式会社 | アポトーシス関連疾患の予防及び／又は治療薬 |
| US5980887A (en) * | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
| GB9716656D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| EP0897980A3 (en) * | 1997-08-20 | 2002-04-17 | Smithkline Beecham Corporation | CXCR4B: A human splice variant of CXCR4 chemokine receptor |
| US5880090A (en) * | 1997-09-19 | 1999-03-09 | The Hope Heart Institute | Treatment of vascular graft implants with G-CSF |
| US7507705B2 (en) * | 1997-10-02 | 2009-03-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Methods for the modulation of neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections |
| EP1021737B1 (en) * | 1997-10-06 | 2008-06-11 | Acculase, Inc. | Apparatus for ablating tissue |
| WO1999037779A1 (en) * | 1998-01-22 | 1999-07-29 | Genentech, Inc. | Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies and uses of same |
| US6852533B1 (en) * | 1998-01-23 | 2005-02-08 | Cornell Research Foundation, Inc. | Purified populations of stem cells |
| ATE512231T1 (de) * | 1998-02-27 | 2011-06-15 | Univ Pennsylvania | Impfstoffe, immuntherapeutika und verfahren zur anwendung derselben |
| WO1999045775A1 (en) * | 1998-03-09 | 1999-09-16 | St. Elizabeth's Medical Center | Compositions and methods for modulating vascularization |
| WO1999065507A1 (en) * | 1998-06-19 | 1999-12-23 | The General Hospital Corporation | Modulating platelet function |
| US20020107195A1 (en) * | 1998-07-21 | 2002-08-08 | Smithkline Beecham Corporation | Method for inducing chemotaxis in endothelial cells by administering stromal cell derived factor-1alpha |
| US20060057722A1 (en) * | 1999-03-30 | 2006-03-16 | Myocardial Therapeutics, Inc. | Conditioned medium of autologous or allogenic progenitor cells for angiogenesis treatment |
| US20060051334A1 (en) * | 1999-03-30 | 2006-03-09 | Myocardial Therapeutics, Inc. | Injection of bone marrow-derived conditioned medium for angiogenesis |
| CA2368677C (en) | 1999-03-30 | 2012-07-10 | Ran Kornowski | Intramyocardial injection of autologous bone marrow |
| JP5704780B2 (ja) * | 1999-08-13 | 2015-04-22 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 脈管形成因子の用量および心筋血流を改善するための投与方法 |
| MXPA02012067A (es) | 2000-06-05 | 2004-08-19 | Univ Columbia | Identificacion y uso de celulas endoteliales precursoras derivadas de medula osea par mejorar la funcion del miocardio despues de dano isquemico. |
| US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| RU2002110275A (ru) | 2000-08-22 | 2004-03-27 | Дзе Брихэм Энд Уимен'З Хоспитал, Инк. (Us) | Диагностика и лечение сердечно-сосудистых состояний |
| WO2002020848A2 (en) * | 2000-09-08 | 2002-03-14 | The Regents Of The University Of California | Gene and sequence variation associated with cancer |
| WO2002022163A1 (en) * | 2000-09-13 | 2002-03-21 | Chugai Seiyaku Kabushiki Kaisha | Remedies for ischemic diseases |
| WO2002036078A2 (en) | 2000-11-05 | 2002-05-10 | University Of Florida | Targeting pluripotent stem cells to tissues |
| IL146970A0 (en) | 2001-12-06 | 2002-08-14 | Yeda Res & Dev | Migration of haematopoietic stem cells and progenitor cells to the liver |
| US20030199464A1 (en) | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| CA2494115A1 (en) | 2002-08-01 | 2004-02-12 | Northwestern University | Mutants of ige proteins and uses thereof |
| US7220407B2 (en) * | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
| EP2069262A2 (en) * | 2006-08-29 | 2009-06-17 | Corning Incorporated | High strength substantially non-microcracked cordierite honeycomb body and manufacturing method |
| US7959387B2 (en) | 2007-10-03 | 2011-06-14 | Kennametal Inc. | Shrink fit sleeve for tool holder |
-
2001
- 2001-06-05 MX MXPA02012067A patent/MXPA02012067A/es active IP Right Grant
- 2001-06-05 JP JP2002501968A patent/JP5414958B2/ja not_active Expired - Lifetime
- 2001-06-05 WO PCT/US2001/018399 patent/WO2001094420A1/en not_active Ceased
- 2001-06-05 AU AU2001275339A patent/AU2001275339A1/en not_active Abandoned
- 2001-06-05 CA CA2810249A patent/CA2810249A1/en not_active Abandoned
- 2001-06-05 CA CA2412436A patent/CA2412436C/en not_active Expired - Lifetime
- 2001-06-05 US US10/220,554 patent/US20040131585A1/en not_active Abandoned
- 2001-06-05 EP EP10012752.1A patent/EP2324839B1/en not_active Expired - Lifetime
- 2001-06-05 EP EP01942041A patent/EP1290033B1/en not_active Expired - Lifetime
-
2005
- 2005-09-22 US US11/234,879 patent/US7662392B2/en not_active Expired - Fee Related
-
2007
- 2007-08-20 US US11/894,555 patent/US20080057069A1/en not_active Abandoned
- 2007-08-20 US US11/894,581 patent/US8153113B2/en not_active Expired - Fee Related
-
2010
- 2010-01-15 US US12/657,264 patent/US8486416B2/en not_active Expired - Fee Related
-
2012
- 2012-10-24 JP JP2012235072A patent/JP5710574B2/ja not_active Expired - Lifetime
-
2013
- 2013-07-10 US US13/938,608 patent/US9387234B2/en not_active Expired - Fee Related
- 2013-08-05 JP JP2013162803A patent/JP5710709B2/ja not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004509847A5 (https=) | ||
| Chavakis et al. | Homing and engraftment of progenitor cells: a prerequisite for cell therapy | |
| JP2012510521A5 (https=) | ||
| US8486416B2 (en) | Use of SDF-1 to improve ischemic myocardial function | |
| Wen et al. | Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction | |
| Wu et al. | Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation | |
| JP2008524331A5 (https=) | ||
| JP2012512910A5 (https=) | ||
| Jiang et al. | Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post‐conditioning | |
| Zhao et al. | SDF‐1/CXCR4‐mediated stem cell mobilization involved in cardioprotective effects of electroacupuncture on mouse with myocardial infarction | |
| KR102678011B1 (ko) | 심부전 및 심장 허혈성 재관류 손상 치료 | |
| Zhou et al. | Therapeutic neovascularization for peripheral arterial diseases: advances and perspectives | |
| Zisa et al. | Intramuscular VEGF activates an SDF1-dependent progenitor cell cascade and an SDF1-independent muscle paracrine cascade for cardiac repair | |
| Wang et al. | Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1α/CXCR4 signaling pathway | |
| Germano et al. | Monocyte chemokine receptors as therapeutic targets in cardiovascular diseases | |
| Louzada et al. | Granulocyte-colony stimulating factor treatment of chronic myocardial infarction | |
| Serpi et al. | Divergent effects of losartan and metoprolol on cardiac remodeling, C‐kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction | |
| CN119564692A (zh) | 利匹韦林在制备治疗心肌梗死药物中的应用 | |
| Bassetti et al. | Son of a lesser god: the case of cell therapy for refractory angina | |
| CN116024172B (zh) | 一种阳离子化合物在制备造血干细胞或祖细胞动员剂中的应用 | |
| Tanaka et al. | Clenbuterol plus granulocyte colony-stimulating factor regulates stem/progenitor cell mobilization and exerts beneficial effect by increasing neovascularization in rats with heart failure | |
| Celik | ST elevation myocardial infarction presenting after use of pseudoephedrine | |
| Rastogi et al. | Darbepoetin-α prevents progressive left ventricular dysfunction and remodeling in nonanemic dogs with heart failure | |
| Pugliatti et al. | Non compaction cardiomyopathy and Antiphospholipid syndrome: a catastrophic thromboembolic association | |
| McDaniel et al. | Intramuscular VEGF activates an SDF1-dependent |