JP5357049B2 - 癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ - Google Patents

癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ Download PDF

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JP5357049B2
JP5357049B2 JP2009544230A JP2009544230A JP5357049B2 JP 5357049 B2 JP5357049 B2 JP 5357049B2 JP 2009544230 A JP2009544230 A JP 2009544230A JP 2009544230 A JP2009544230 A JP 2009544230A JP 5357049 B2 JP5357049 B2 JP 5357049B2
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cancer
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treatment
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JP2010514787A5 (enExample
JP2010514787A (ja
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スティーブ アモンズ，
チャン−シン デュアン，
ドナルド ユング，
マーク マテウッチ，
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スレッシュオールド ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2009544230A 2006-12-26 2007-12-21 癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ Expired - Fee Related JP5357049B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87186506P 2006-12-26 2006-12-26
US60/871,865 2006-12-26
PCT/US2007/088645 WO2008083101A1 (en) 2006-12-26 2007-12-21 Phosphoramidate alkylator prodrugs for the treatment of cancer

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JP2010514787A JP2010514787A (ja) 2010-05-06
JP2010514787A5 JP2010514787A5 (enExample) 2012-02-02
JP5357049B2 true JP5357049B2 (ja) 2013-12-04

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JP2009544230A Expired - Fee Related JP5357049B2 (ja) 2006-12-26 2007-12-21 癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ

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US (1) US8552048B2 (enExample)
EP (1) EP2114157B1 (enExample)
JP (1) JP5357049B2 (enExample)
ES (1) ES2884044T3 (enExample)
WO (1) WO2008083101A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200507752B (en) 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
ES2389532T3 (es) 2005-06-29 2012-10-29 Threshold Pharmaceuticals, Inc. Profármacos alquilantes de fosforamidato
ES2884044T3 (es) 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer
US8946275B2 (en) 2008-10-21 2015-02-03 Threshold Pharmaceuticals, Inc. Treatment of cancer using hypoxia activated prodrugs
CA2803113A1 (en) * 2010-06-28 2012-01-12 Threshold Pharmaceuticals, Inc. Treatment of blood cancer
ES2649340T3 (es) * 2010-07-12 2018-01-11 Threshold Pharmaceuticals, Inc. Administración de fármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer
MX2013011199A (es) * 2011-04-01 2013-12-16 Threshold Pharmaceuticals Inc Metodos para tratar el cancer.
CA2832203A1 (en) * 2011-04-15 2012-10-18 Threshold Pharmaceuticals, Inc. Unit dose form for oral administration
EP2793882A4 (en) * 2011-12-22 2015-04-29 Threshold Pharmaceuticals Inc ADMINISTRATION OF HYPOXIA-ACTIVATED PRODRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER
ES2909741T3 (es) * 2012-02-21 2022-05-10 Immunogenesis Inc Tratamiento del cáncer
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
WO2014069063A1 (ja) 2012-10-29 2014-05-08 京セラ株式会社 弾性表面波センサ
US20160158253A1 (en) 2013-07-26 2016-06-09 Threshold Pharmaceuticals, Inc. Treatment of pancreatic cancer with a combination of a hypoxia-activated prodrug and a taxane
US10071109B2 (en) 2013-11-06 2018-09-11 Molecular Templates, Inc. Predictive biomarker for hypoxia-activated prodrug therapy
US10131683B2 (en) 2014-07-17 2018-11-20 Molecular Templates, Inc. TH-302 solid forms and methods related thereto
MY192888A (en) 2015-03-10 2022-09-14 Ascentawits Pharmaceuticals Ltd Dna alkylating agents
EP3277381B1 (en) 2015-04-02 2026-01-07 Obi Pharma, Inc. Nitrobenzyl derivatives of anti-cancer agents
PL412787A1 (pl) 2015-06-22 2017-01-02 Magdalena Król Oparty na makrofagach celowany system dostarczania związków związanych z ferrytyną
AU2016282785A1 (en) 2015-06-24 2018-02-15 Immunogenesis, Inc. Aziridine containing DNA alkylating agents
WO2018026606A1 (en) 2016-08-01 2018-02-08 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with immune modulatory agents for treating cancer
WO2019238886A1 (en) 2018-06-13 2019-12-19 University Of Dundee Bifunctional molecules for targeting usp14
EP3807272A1 (en) 2018-06-13 2021-04-21 Amphista Therapeutics Ltd Bifunctional molecules for targeting rpn11
EP3807263A1 (en) 2018-06-13 2021-04-21 Amphista Therapeutics Ltd Bifunctional molecules for targeting uchl5
WO2020068347A1 (en) * 2018-09-24 2020-04-02 Sierra Oncology, Inc. Methods of treatment of cancer comprising cdc7 inhibitors
EP3650046A1 (en) 2018-11-08 2020-05-13 Cellis AG Mesenchymal stem cell based targeted active ingredient delivery system
WO2022195092A1 (en) 2021-03-18 2022-09-22 Cellis Ag Ferritin variants with increased stability and complexation ability
EP4121446A1 (en) 2020-03-18 2023-01-25 Cellis AG Ferritin variants with increased stability, complexation ability and transferrin receptor affinity
WO2023025291A1 (zh) 2021-08-27 2023-03-02 深圳艾欣达伟医药科技有限公司 冻干制剂溶液及冻干制剂、方法和用途
JP7762796B2 (ja) * 2021-08-27 2025-10-30 アセンタウィッツ ファーマシューティカルズ リミテッド Ｐａｒｐ阻害剤に耐性のある患者のｔｈ－３０２による治療
EP4494643A4 (en) 2022-03-15 2025-09-10 Ascentawits Pharmaceuticals Ltd METHOD OF TREATING A PATIENT WITH BRCA MUTATION CANCER
WO2023198188A1 (zh) 2022-04-15 2023-10-19 深圳艾欣达伟医药科技有限公司 使用th-302单药或联用parp抑制剂治疗癌症的方法
WO2023226959A1 (zh) 2022-05-23 2023-11-30 深圳艾欣达伟医药科技有限公司 烷化剂前药与细胞周期抑制剂联用治疗癌症的方法
WO2024056413A1 (en) 2022-09-13 2024-03-21 Cellis Ag Isolated targeted delivery system for the treatment of glioma
EP4591866A1 (en) 2022-09-22 2025-07-30 Ascentawits Pharmaceuticals, Ltd. Use of hypoxia-activated compound in preparation of medicament for treating cancer patient
WO2024133541A1 (en) 2022-12-20 2024-06-27 Cellis Sp. Z O.O. [Ltd.] Isolated targeted delivery system for the treatment of ovarian cancer
TW202434258A (zh) * 2023-02-27 2024-09-01 大陸商深圳艾欣達偉醫藥科技有限公司 溶液、凍乾製劑、凍乾製劑單位包裝、注射液及注射液配製方法
WO2025083276A1 (en) 2023-10-19 2025-04-24 Cellis Ag Improved isolated targeted delivery system

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652579A (en) 1969-06-26 1972-03-28 Hoffmann La Roche 1-methyl-2-substituted 5-nitroimidazoles
DE2229223C3 (de) 1971-07-30 1975-12-18 Gruppo Lepetit S.P.A., Mailand (Italien) 2-Nitro-S-imidazol-Derivate und Verfahren zu deren Herstellung
US4921963A (en) 1987-04-13 1990-05-01 British Columbia Cancer Foundation Platinum complexes with one radiosensitizing ligand
JPH0819111B2 (ja) 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
US5190929A (en) 1988-05-25 1993-03-02 Research Corporation Technologies, Inc. Cyclophosphamide analogs useful as anti-tumor agents
US5403932A (en) 1988-05-25 1995-04-04 Research Corporation Technologies, Inc. Phosphoramidates useful as antitumor agents
US4908356A (en) 1988-05-25 1990-03-13 Research Corporation Technologies, Inc. Aldophosphamide derivatives useful as antitumor agents
DE3835772A1 (de) 1988-10-20 1990-04-26 Deutsches Krebsforsch Tumorhemmende saccharid-konjugate
KR927003539A (ko) 1990-01-26 1992-12-18 스즈끼 쯔네시 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제
US5233031A (en) 1991-09-23 1993-08-03 University Of Rochester Phosphoramidate analogs of 2'-deoxyuridine
ES2279506T3 (es) 1991-10-23 2007-08-16 Cancer Research Technology Limited Nitrorreductasa bacteriana para la reduccion de cb1954 y analogos del mismo a una forma citotoxica.
US5750782A (en) 1992-11-27 1998-05-12 Cancer Research Campaign Technology Limited Nitroaniline derivatives and their use as anti-tumour agents
US5306727A (en) 1993-04-30 1994-04-26 Research Corporation Technologies, Inc. Phosphoramidates useful as antitumor agents
US5691371A (en) 1993-05-25 1997-11-25 Auckland Uniservices Limited Nitrobenzyl mustard quaternary salts and their use as hypoxia-selective cytotoxic agents
DK0648503T3 (da) 1993-09-22 2000-10-02 Hoechst Ag Pro-prodrugs, deres fremstilling og anvendelse
JPH07309761A (ja) 1994-05-20 1995-11-28 Kyowa Hakko Kogyo Co Ltd デュオカルマイシン誘導体の安定化法
US5659061A (en) 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities
GB9516943D0 (en) 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
US6218519B1 (en) 1996-04-12 2001-04-17 Pro-Neuron, Inc. Compounds and methods for the selective treatment of cancer and bacterial infections
US6130237A (en) 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
US6251933B1 (en) 1996-12-13 2001-06-26 The Cancer Research Campaign Technology Limited Seco precursors of cyclopropylindolines and their use as prodrugs
DE19720312A1 (de) 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
US6240925B1 (en) 1999-03-23 2001-06-05 Cynosure, Inc. Photothermal vascular targeting with bioreductive agents
GB9909612D0 (en) 1999-04-26 1999-06-23 Cancer Res Campaign Tech N-protected amines and their use as prodrugs
JP4629238B2 (ja) 1999-05-24 2011-02-09 サザン・リサーチ・インスティテュート イソホスホアミドマスタード・アナログ及びその使用
WO2001004130A1 (en) 1999-07-14 2001-01-18 Purdue Research Foundation Phosphoramide compounds
EP1268493B1 (en) 2000-03-31 2006-02-15 Purdue Research Foundation Phosphoramidate prodrugs
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
IL154183A0 (en) 2001-05-31 2003-07-31 Medarex Inc Cytotoxins, prodrugs, linkers and stabilizers useful therefor
FR2825926A1 (fr) 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
US7091186B2 (en) 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
KR20030067275A (ko) 2002-02-07 2003-08-14 주식회사 하이폭시 니트로이미다졸 및 위상 이성질화 효소 저해제를유효성분으로 포함하는 항암제
GB0306907D0 (en) 2003-03-26 2003-04-30 Angiogene Pharm Ltd Boireductively-activated prodrugs
GB0306908D0 (en) 2003-03-26 2003-04-30 Angiogene Pharm Ltd Bioreductively activated stilbene prodrugs
ZA200507752B (en) 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
US6855695B2 (en) 2003-06-13 2005-02-15 Vion Pharmaceuticals, Inc. Water-soluble SHPs as novel alkylating agents
US7629332B2 (en) 2003-10-31 2009-12-08 Auckland Uniservices Limited Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents
KR20120117943A (ko) 2004-02-06 2012-10-24 쓰레솔드 파마슈티컬스, 인코포레이티드 항암 치료 방법
US20090042820A1 (en) 2004-11-22 2009-02-12 Threshold Pharmaceuticals, Inc. Tubulin Binding Anti Cancer Agents And Prodrugs Thereof
ES2389532T3 (es) 2005-06-29 2012-10-29 Threshold Pharmaceuticals, Inc. Profármacos alquilantes de fosforamidato
KR100755435B1 (ko) * 2005-10-04 2007-09-04 삼성전자주식회사 디지털 방송 제한 수신 단말기 및 그 방법
WO2008011588A2 (en) 2006-07-20 2008-01-24 Threshold Pharmaceuticals, Inc. Glycoconjugates of phosphoramidate alkylators for treatment of cancer
WO2008076826A1 (en) 2006-12-13 2008-06-26 Threshold Pharmaceuticals, Inc. Pyrophosphoramide alkylators
ES2884044T3 (es) 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer

Also Published As

Publication number Publication date
ES2884044T3 (es) 2021-12-10
EP2114157A1 (en) 2009-11-11
WO2008083101A1 (en) 2008-07-10
EP2114157A4 (en) 2013-01-23
US8552048B2 (en) 2013-10-08
JP2010514787A (ja) 2010-05-06
US20100183742A1 (en) 2010-07-22
EP2114157B1 (en) 2021-05-26

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