JP5357049B2 - 癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ - Google Patents

癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ Download PDF

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JP5357049B2
JP5357049B2 JP2009544230A JP2009544230A JP5357049B2 JP 5357049 B2 JP5357049 B2 JP 5357049B2 JP 2009544230 A JP2009544230 A JP 2009544230A JP 2009544230 A JP2009544230 A JP 2009544230A JP 5357049 B2 JP5357049 B2 JP 5357049B2
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treatment
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JP2010514787A5 (enExample
JP2010514787A (ja
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スティーブ アモンズ，
チャン−シン デュアン，
ドナルド ユング，
マーク マテウッチ，
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スレッシュオールド ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2009544230A 2006-12-26 2007-12-21 癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ Expired - Fee Related JP5357049B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87186506P 2006-12-26 2006-12-26
US60/871,865 2006-12-26
PCT/US2007/088645 WO2008083101A1 (en) 2006-12-26 2007-12-21 Phosphoramidate alkylator prodrugs for the treatment of cancer

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JP2010514787A JP2010514787A (ja) 2010-05-06
JP2010514787A5 JP2010514787A5 (enExample) 2012-02-02
JP5357049B2 true JP5357049B2 (ja) 2013-12-04

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JP2009544230A Expired - Fee Related JP5357049B2 (ja) 2006-12-26 2007-12-21 癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ

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US (1) US8552048B2 (enExample)
EP (1) EP2114157B1 (enExample)
JP (1) JP5357049B2 (enExample)
ES (1) ES2884044T3 (enExample)
WO (1) WO2008083101A1 (enExample)

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Publication number Publication date
EP2114157B1 (en) 2021-05-26
EP2114157A4 (en) 2013-01-23
ES2884044T3 (es) 2021-12-10
JP2010514787A (ja) 2010-05-06
EP2114157A1 (en) 2009-11-11
US8552048B2 (en) 2013-10-08
US20100183742A1 (en) 2010-07-22
WO2008083101A1 (en) 2008-07-10

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