JP5355424B2 - 肥満の治療において有用である、シーナラ・スコリムスおよびフェセオラス・ブルガリスの抽出物を含む組成物 - Google Patents
肥満の治療において有用である、シーナラ・スコリムスおよびフェセオラス・ブルガリスの抽出物を含む組成物 Download PDFInfo
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- JP5355424B2 JP5355424B2 JP2009552122A JP2009552122A JP5355424B2 JP 5355424 B2 JP5355424 B2 JP 5355424B2 JP 2009552122 A JP2009552122 A JP 2009552122A JP 2009552122 A JP2009552122 A JP 2009552122A JP 5355424 B2 JP5355424 B2 JP 5355424B2
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- scolimus
- vulgaris
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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Description
b)合わせた抽出物を濾過または遠心分離し、遠心分離後の出発抽出物のバイオマスの重量の約10%に相当する体積まで濃縮する;
c)濃縮された水性抽出物を、希エタノールを用いて、60〜70体積%の最終濃度となるまで、分別沈殿させる;
d)沈殿を分離し、60%エタノールを用いて脱塩水から再沈殿させる、または10000Daカットオフの膜上でダイアフィルトレーションし、沈殿残渣を乾燥する。
シーナラ・スコリムス有刺種の抽出物の調製
収穫時に刻み凍結したシーナラ・スコリムス頭部(サルジニア有刺種)2kgを、加熱ジャケットを備えたパーコレーターに仕込み、95℃のEtOHの4760mlで覆い、アルコール含量を約70%とした(植物中の水含量は85%と推定される)。70℃で3時間接触させ、次に、取り出した。その後の抽出において、70℃でEtOH70体積%で抽出し、植物を覆い、最短接触時間3時間とした。溶媒約15リッターを用いて、合計5回抽出した。
(実施例2)
シーナラ・スコリムスおよびフェセオラス・ブルガリス抽出物をソフトゼラチンカプセル用の油性懸濁液として調製
(単位組成):
シーナラ・スコリムス抽出物 100mg
フェセオラス・ブルガリス抽出物 100mg
モノステアリン酸グリセリル 30mg
大豆レクチン 10mg
オエノセラ・ビエニス油適量 700mg
(製造プロセス)
・オエノセラ・ビエニス油を約70℃に加熱し、撹拌下にモノステアリン酸グリセリルをその中に溶融する;
・得られた溶液に大豆レシチンを加える;
・得られた溶液にシーナラ・スコリムスおよびフェセオラス・ブルガリス抽出物を分散させて、均一分布を確保する;
・得られた溶液を、撹拌しつつ、徐々に冷却する。
シーナラ・スコリムスおよびフェセオラス・ブルガリス抽出物をハードゼラチンカプセルとして調製
(単位組成):
シーナラ・スコリムス抽出物 150mg
フェセオラス・ブルガリス抽出物 50mg
微結晶性セルロース 200mg
ラクトース 95mg
二酸化ケイ素 5mg
(製造プロセス)
・抽出物、微結晶性セルロース、ラクトースおよび二酸化ケイ素を混合する;
・得られた混合物を、ハードゼラチンカプセル間に分ける;
(実施例4)
シーナラ・スコリムスおよびフェセオラス・ブルガリス抽出物を放出調節顆粒として調製
(単位組成):
シーナラ・スコリムス抽出物 100mg
フェセオラス・ブルガリス抽出物 50mg
微結晶性セルロース 100mg
ポビドン 10mg
カルボキシメチルセルロースナトリウム 8mg
メタクリル酸コポリマー 50mg
クエン酸トリエチル 3.2mg
タルク 8mg
シメチコン 0.3mg
(製造プロセス)
・抽出物、微結晶性セルロースおよびカルボキシメチルセルロースナトリウムを、ポビドンの水溶液を用いて顆粒化する;
・得られた顆粒を乾燥し、測定する;
・メタクリル酸コポリマー、クエン酸トリエチル、タルクおよびシメチコンの水性懸濁液を用いて、顆粒を被覆する。
シーナラ・スコリムスおよびフェセオラス・ブルガリス抽出物を即効型顆粒として調製
(単位組成):
シーナラ・スコリムス抽出物 100mg
フェセオラス・ブルガリス抽出物 50mg
微結晶性セルロース 100mg
ポビドン 10mg
カルボキシメチルセルロースナトリウム 8mg
(製造プロセス)
・抽出物、微結晶性セルロースおよびカルボキシメチルセルロースナトリウムを、ポビドンの水溶液を用いて顆粒化する;
・得られた顆粒を乾燥し、測定する;
(実施例6)
異なる放出プロフィールを有するシーナラ・スコリムスおよびフェセオラス・ブルガリス抽出物顆粒の混合物
(製造プロセス)
・実施例4に記載の顆粒の50%と、実施例5に記載の顆粒の50%とを混合する;
・得られた混合物を、ハードゼラチンカプセル間に分ける。
Claims (4)
- シーナラ・スコリムス(Cynara scolymus)の抽出物と、ファセオラス・ブルガリス(Phaseolus vulgaris)の抽出物とを1:0.25〜1:1の比で含む組成物を含む、糖尿病治療用又は肥満治療用の医薬。
- 前記シーナラ・スコリムス抽出物は、カフェオイルキナ酸含量が30〜60%であり、ルテオリングリコシド含量が2〜5%の範囲である、請求項1に記載の糖尿病治療用又は肥満治療用の医薬。
- 前記フェセオラス・ブルガリス抽出物は、α−アミラーゼ阻害剤含量が1200〜1600USP/mg(HPLC滴定量7〜14重量%)であり、フィトヘマグルチニン含量が12000〜30000HAU/gであることを特徴とする、請求項1または2に記載の糖尿病治療用又は肥満治療用の医薬。
- 前記組成物が、さらにオエノセラ・ビエニス油を含む、請求項1〜3のいずれかに記載の糖尿病治療用又は肥満治療用の医薬。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90532007P | 2007-03-07 | 2007-03-07 | |
EP07425132A EP1967198B1 (en) | 2007-03-07 | 2007-03-07 | Formulations containing cynara scolymus and phaseolus vulgaris extracts which are useful in the treatment of obesity |
US60/905,320 | 2007-03-07 | ||
EP07425132.3 | 2007-03-07 | ||
PCT/EP2008/001787 WO2008107184A1 (en) | 2007-03-07 | 2008-03-06 | Formulations containing cynara scolymus and phaseolus vulgaris extracts which are useful in the treatment of obesity |
Publications (3)
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JP2010520246A JP2010520246A (ja) | 2010-06-10 |
JP2010520246A5 JP2010520246A5 (ja) | 2011-04-21 |
JP5355424B2 true JP5355424B2 (ja) | 2013-11-27 |
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JP2009552122A Expired - Fee Related JP5355424B2 (ja) | 2007-03-07 | 2008-03-06 | 肥満の治療において有用である、シーナラ・スコリムスおよびフェセオラス・ブルガリスの抽出物を含む組成物 |
Country Status (20)
Country | Link |
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US (2) | US7887854B2 (ja) |
EP (1) | EP1967198B1 (ja) |
JP (1) | JP5355424B2 (ja) |
KR (1) | KR101456555B1 (ja) |
CN (1) | CN101641111B (ja) |
AT (1) | ATE431155T1 (ja) |
AU (1) | AU2008224057B2 (ja) |
BR (1) | BRPI0808563B1 (ja) |
CA (1) | CA2680078C (ja) |
DE (1) | DE602007001128D1 (ja) |
DK (1) | DK1967198T3 (ja) |
ES (1) | ES2323815T3 (ja) |
HK (1) | HK1121694A1 (ja) |
IL (1) | IL200709A (ja) |
NO (1) | NO339322B1 (ja) |
PL (1) | PL1967198T3 (ja) |
PT (1) | PT1967198E (ja) |
RU (1) | RU2453323C2 (ja) |
SI (1) | SI1967198T1 (ja) |
WO (1) | WO2008107184A1 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20052450A1 (it) | 2005-12-22 | 2007-06-23 | Indena Spa | Estratti di phaseolus vulgaris loro uso e formulazioni che li contengono |
CN101874822A (zh) | 2009-04-27 | 2010-11-03 | 玫琳凯有限公司 | 植物性抗痤疮制剂 |
EP2345646A1 (en) * | 2010-01-14 | 2011-07-20 | InterMed Discovery GmbH | Use of tricyclic sesquiterpene lactones in the treatment of obesity and related diseases and non-therapeutic treatable conditions |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
KR101330190B1 (ko) | 2011-09-20 | 2013-11-15 | (주)그린솔루션스 | 하고초 추출물의 헴 옥시게나아제-1 발현 조절을 통한 지방 생성 억제용 화장료 조성물 |
KR102245069B1 (ko) | 2011-12-19 | 2021-04-26 | 마리 케이 인코포레이티드 | 피부톤 향상을 위한 식물 추출물의 조합물 |
ITMI20121570A1 (it) * | 2012-09-20 | 2014-03-21 | Indena Spa | Nuovi estratti di cynara scolimus, coffea spp. e olea europaea per il trattamento della sindrome metabolica |
ITMI20121727A1 (it) * | 2012-10-12 | 2014-04-13 | Indena Spa | Formulazioni per il trattamento e la prevenzione dell'obesita' |
ITMI20121749A1 (it) * | 2012-10-16 | 2014-04-17 | Indena Spa | Estratti di helianthus annuus utili nel trattamento della sindrome metabolica e nella diminuzione dell'indice glicemico di alimenti e procedimento per la loro preparazione e composizioni che li contengono |
KR102323049B1 (ko) | 2014-03-10 | 2021-11-05 | 마리 케이 인코포레이티드 | 피부 라이트닝 조성물 |
DE202014005450U1 (de) * | 2014-07-04 | 2015-10-06 | Ursapharm Arzneimittel Gmbh | Lactosefreies Arzneimittel |
US20160302451A1 (en) * | 2015-04-16 | 2016-10-20 | Michael Hudnall | Medical Food for Patients with Chronic Liver Disease |
FR3075570B1 (fr) * | 2017-12-22 | 2020-01-03 | Agro Innovation International | Stimulation de la nitrification d'un sol avec des compositions comprenant un extrait de plante |
IT201900000367A1 (it) * | 2019-01-10 | 2020-07-10 | Altergon Sa | Composizioni comprendenti un peptide in grado di stimolare la via del segnale gprc6a-dipendente |
CN110433280A (zh) * | 2019-09-11 | 2019-11-12 | 周口师范学院 | 植物血凝素在制备预防或治疗肥胖药物中的应用 |
Family Cites Families (6)
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GB8524275D0 (en) * | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
DE19627376A1 (de) * | 1996-07-06 | 1998-01-08 | Aar Pharma Adler Apotheke | Verwendung von Artischocken-(Cynara)-Extrakten |
HRP990080B1 (en) * | 1999-03-12 | 2003-04-30 | Vladimir Leko | Plant mixture and a medical preparation for the treatment of diabetes mellitus, type ii, obtained therefrom |
US6818234B1 (en) * | 1999-08-27 | 2004-11-16 | Access Business Group International Llc | Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation |
ITMI20051347A1 (it) | 2005-07-14 | 2007-01-15 | Indena Spa | Estratti di cynara scolimus loro uso e formulazioni che li contengono |
ITMI20052450A1 (it) | 2005-12-22 | 2007-06-23 | Indena Spa | Estratti di phaseolus vulgaris loro uso e formulazioni che li contengono |
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2007
- 2007-03-07 ES ES07425132T patent/ES2323815T3/es active Active
- 2007-03-07 PL PL07425132T patent/PL1967198T3/pl unknown
- 2007-03-07 AT AT07425132T patent/ATE431155T1/de active
- 2007-03-07 DE DE602007001128T patent/DE602007001128D1/de active Active
- 2007-03-07 SI SI200730037T patent/SI1967198T1/sl unknown
- 2007-03-07 DK DK07425132T patent/DK1967198T3/da active
- 2007-03-07 EP EP07425132A patent/EP1967198B1/en active Active
- 2007-03-07 PT PT07425132T patent/PT1967198E/pt unknown
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- 2008-03-05 US US12/042,354 patent/US7887854B2/en active Active
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- 2008-03-06 BR BRPI0808563-3A patent/BRPI0808563B1/pt not_active IP Right Cessation
- 2008-03-06 RU RU2009133338/15A patent/RU2453323C2/ru active
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- 2008-03-06 AU AU2008224057A patent/AU2008224057B2/en not_active Ceased
- 2008-03-06 WO PCT/EP2008/001787 patent/WO2008107184A1/en active Application Filing
- 2008-03-06 CN CN200880007206XA patent/CN101641111B/zh not_active Expired - Fee Related
- 2008-03-06 KR KR1020097018545A patent/KR101456555B1/ko active IP Right Grant
- 2008-03-06 JP JP2009552122A patent/JP5355424B2/ja not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
US20080220097A1 (en) | 2008-09-11 |
WO2008107184A1 (en) | 2008-09-12 |
AU2008224057B2 (en) | 2012-07-19 |
PT1967198E (pt) | 2009-06-15 |
NO339322B1 (no) | 2016-11-28 |
EP1967198A1 (en) | 2008-09-10 |
EP1967198B1 (en) | 2009-05-13 |
US20100136145A1 (en) | 2010-06-03 |
DK1967198T3 (da) | 2009-08-10 |
IL200709A (en) | 2013-07-31 |
RU2009133338A (ru) | 2011-03-10 |
US7887854B2 (en) | 2011-02-15 |
RU2453323C2 (ru) | 2012-06-20 |
DE602007001128D1 (de) | 2009-06-25 |
CN101641111A (zh) | 2010-02-03 |
KR20090118051A (ko) | 2009-11-17 |
CN101641111B (zh) | 2012-05-23 |
JP2010520246A (ja) | 2010-06-10 |
US7887855B2 (en) | 2011-02-15 |
HK1121694A1 (en) | 2009-04-30 |
KR101456555B1 (ko) | 2014-10-31 |
BRPI0808563A2 (pt) | 2014-09-02 |
PL1967198T3 (pl) | 2009-10-30 |
ES2323815T3 (es) | 2009-07-24 |
IL200709A0 (en) | 2010-05-17 |
CA2680078A1 (en) | 2008-09-12 |
BRPI0808563B1 (pt) | 2018-02-14 |
SI1967198T1 (sl) | 2009-08-31 |
NO20100527A1 (no) | 2010-05-19 |
ATE431155T1 (de) | 2009-05-15 |
AU2008224057A1 (en) | 2008-09-12 |
CA2680078C (en) | 2016-12-06 |
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