JP5312018B2 - 分解性の移植可能な医療装置 - Google Patents
分解性の移植可能な医療装置 Download PDFInfo
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- JP5312018B2 JP5312018B2 JP2008505501A JP2008505501A JP5312018B2 JP 5312018 B2 JP5312018 B2 JP 5312018B2 JP 2008505501 A JP2008505501 A JP 2008505501A JP 2008505501 A JP2008505501 A JP 2008505501A JP 5312018 B2 JP5312018 B2 JP 5312018B2
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- Prior art keywords
- stent
- poly
- agent
- implant
- metal
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
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- A—HUMAN NECESSITIES
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- A61F2/02—Prostheses implantable into the body
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- A61F2/07—Stent-grafts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/0006—Working by laser beam, e.g. welding, cutting or boring taking account of the properties of the material involved
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
- B23K26/06—Shaping the laser beam, e.g. by masks or multi-focusing
- B23K26/062—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam
- B23K26/0622—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses
- B23K26/0624—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses using ultrashort pulses, i.e. pulses of 1ns or less
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/352—Working by laser beam, e.g. welding, cutting or boring for surface treatment
- B23K26/355—Texturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/36—Removing material
- B23K26/38—Removing material by boring or cutting
- B23K26/382—Removing material by boring or cutting by boring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/36—Removing material
- B23K26/40—Removing material taking account of the properties of the material involved
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
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- A—HUMAN NECESSITIES
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- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
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- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
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- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K2101/00—Articles made by soldering, welding or cutting
- B23K2101/04—Tubular or hollow articles
- B23K2101/06—Tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K2103/00—Materials to be soldered, welded or cut
- B23K2103/02—Iron or ferrous alloys
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
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- B23K2103/12—Copper or alloys thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K2103/00—Materials to be soldered, welded or cut
- B23K2103/50—Inorganic material, e.g. metals, not provided for in B23K2103/02 – B23K2103/26
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Plasma & Fusion (AREA)
- Mechanical Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US66870705P | 2005-04-05 | 2005-04-05 | |
| US60/668,707 | 2005-04-05 | ||
| PCT/US2006/012725 WO2006108065A2 (en) | 2005-04-05 | 2006-04-04 | Degradable implantable medical devices |
Related Child Applications (1)
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| JP2012270170A Division JP5572686B2 (ja) | 2005-04-05 | 2012-12-11 | 分解性の移植可能な医療装置 |
Publications (3)
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| JP2008534232A JP2008534232A (ja) | 2008-08-28 |
| JP2008534232A5 JP2008534232A5 (enExample) | 2009-04-23 |
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| JP2008505501A Expired - Fee Related JP5312018B2 (ja) | 2005-04-05 | 2006-04-04 | 分解性の移植可能な医療装置 |
| JP2012270170A Expired - Fee Related JP5572686B2 (ja) | 2005-04-05 | 2012-12-11 | 分解性の移植可能な医療装置 |
| JP2014104970A Withdrawn JP2014176740A (ja) | 2005-04-05 | 2014-05-21 | 分解性の移植可能な医療装置 |
| JP2015253060A Withdrawn JP2016052602A (ja) | 2005-04-05 | 2015-12-25 | 分解性の移植可能な医療装置 |
| JP2017082664A Withdrawn JP2017159060A (ja) | 2005-04-05 | 2017-04-19 | 分解性の移植可能な医療装置 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012270170A Expired - Fee Related JP5572686B2 (ja) | 2005-04-05 | 2012-12-11 | 分解性の移植可能な医療装置 |
| JP2014104970A Withdrawn JP2014176740A (ja) | 2005-04-05 | 2014-05-21 | 分解性の移植可能な医療装置 |
| JP2015253060A Withdrawn JP2016052602A (ja) | 2005-04-05 | 2015-12-25 | 分解性の移植可能な医療装置 |
| JP2017082664A Withdrawn JP2017159060A (ja) | 2005-04-05 | 2017-04-19 | 分解性の移植可能な医療装置 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20060229711A1 (enExample) |
| EP (3) | EP2796112B2 (enExample) |
| JP (5) | JP5312018B2 (enExample) |
| CN (3) | CN105030390A (enExample) |
| AU (1) | AU2006231652A1 (enExample) |
| BR (1) | BRPI0610519A2 (enExample) |
| CA (2) | CA2604419C (enExample) |
| IL (1) | IL186474A (enExample) |
| NZ (1) | NZ562957A (enExample) |
| WO (1) | WO2006108065A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101844038B1 (ko) * | 2015-03-12 | 2018-04-02 | 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 | 셀 공간에 기능성 물질이 코팅 처리된 스텐트 |
Families Citing this family (278)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
| US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
| US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
| US7713297B2 (en) | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
| US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
| WO2003002243A2 (en) | 2001-06-27 | 2003-01-09 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
| US20060271168A1 (en) * | 2002-10-30 | 2006-11-30 | Klaus Kleine | Degradable medical device |
| US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
| US20080249633A1 (en) * | 2006-08-22 | 2008-10-09 | Tim Wu | Biodegradable Materials and Methods of Use |
| US7901451B2 (en) | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| KR100511618B1 (ko) * | 2005-01-17 | 2005-08-31 | 이경범 | 약물방출 조절형 다층 코팅 스텐트 및 이의 제조방법 |
| AU2006231652A1 (en) | 2005-04-05 | 2006-10-12 | Elixir Medical Corporation | Degradable implantable medical devices |
| CN101193600B (zh) * | 2005-04-29 | 2010-09-08 | 博维医药公司 | 实施内窥镜或关节镜手术的钳子 |
| US20070050009A1 (en) * | 2005-08-30 | 2007-03-01 | Aiden Flanagan | Bioabsorbable stent |
| US8840660B2 (en) * | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
| US20070160672A1 (en) * | 2006-01-06 | 2007-07-12 | Vipul Bhupendra Dave | Methods of making bioabsorbable drug delivery devices comprised of solvent cast films |
| US20070158880A1 (en) * | 2006-01-06 | 2007-07-12 | Vipul Bhupendra Dave | Methods of making bioabsorbable drug delivery devices comprised of solvent cast tubes |
| US20070162110A1 (en) * | 2006-01-06 | 2007-07-12 | Vipul Bhupendra Dave | Bioabsorbable drug delivery devices |
| US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
| US20070224235A1 (en) | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
| US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
| US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
| AU2007249229B2 (en) * | 2006-05-12 | 2013-05-23 | Cardinal Health 529, Llc | Balloon expandable bioabsorbable drug eluting flexible stent |
| US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
| US8771343B2 (en) | 2006-06-29 | 2014-07-08 | Boston Scientific Scimed, Inc. | Medical devices with selective titanium oxide coatings |
| US9265866B2 (en) * | 2006-08-01 | 2016-02-23 | Abbott Cardiovascular Systems Inc. | Composite polymeric and metallic stent with radiopacity |
| US8052743B2 (en) | 2006-08-02 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
| EP1891995A1 (en) * | 2006-08-08 | 2008-02-27 | Debiotech S.A. | Drug loading of porous coating |
| US8900619B2 (en) * | 2006-08-24 | 2014-12-02 | Boston Scientific Scimed, Inc. | Medical devices for the release of therapeutic agents |
| US8088789B2 (en) * | 2006-09-13 | 2012-01-03 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US10695327B2 (en) | 2006-09-13 | 2020-06-30 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| CN101557814B (zh) | 2006-09-13 | 2015-05-20 | 万能医药公司 | 大环内酯化合物及它们的使用方法 |
| ATE508708T1 (de) | 2006-09-14 | 2011-05-15 | Boston Scient Ltd | Medizinprodukte mit wirkstofffreisetzender beschichtung |
| CA2663271A1 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
| JP2010503489A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 生体内分解性内部人工器官およびその製造方法 |
| EP2081614A2 (en) * | 2006-09-15 | 2009-07-29 | Boston Scientific Scimed, Inc. | Magnetized bioerodible endoprosthesis |
| CA2663303A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Endoprosthesis with adjustable surface features |
| CA2663220A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices and methods of making the same |
| EP2399616A1 (en) * | 2006-09-15 | 2011-12-28 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
| EP2068962B1 (en) * | 2006-09-18 | 2013-01-30 | Boston Scientific Limited | Endoprostheses |
| EP2068963B1 (en) * | 2006-09-18 | 2011-10-26 | Boston Scientific Limited | Endoprostheses |
| EP2068781A2 (en) * | 2006-09-18 | 2009-06-17 | Boston Scientific Limited | Medical devices |
| US20100145436A1 (en) * | 2006-09-18 | 2010-06-10 | Boston Scientific Scimed, Inc. | Bio-erodible Stent |
| US9585989B2 (en) * | 2006-09-19 | 2017-03-07 | Boston Scientific Scimed, Inc. | Ureteral stent having variable hardness |
| US20080090097A1 (en) * | 2006-10-11 | 2008-04-17 | The Penn State Research Foundation | Chemically and physically tailored structured thin film assemblies for corrosion prevention or promotion |
| US20080097591A1 (en) * | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
| EP2076211A4 (en) * | 2006-10-20 | 2015-07-22 | Elixir Medical Corp | LUMINOUS PROSTHESES AND METHODS OF COATING THEREOF |
| US8067055B2 (en) | 2006-10-20 | 2011-11-29 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method of use |
| US7981150B2 (en) * | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
| US7832251B2 (en) * | 2006-11-15 | 2010-11-16 | Abbott Laboratories | Patterned mold for medical device |
| CN101652150B (zh) * | 2006-12-01 | 2013-12-11 | 韦克福里斯特大学健康科学院 | 结合胶原抑制剂的医疗装置 |
| US7651527B2 (en) * | 2006-12-15 | 2010-01-26 | Medtronic Vascular, Inc. | Bioresorbable stent |
| DE102006060501A1 (de) * | 2006-12-19 | 2008-06-26 | Biotronik Vi Patent Ag | Verfahren zur Herstellung einer korrosionshemmenden Beschichtung auf einem Implantat aus einer biokorrodierbaren Magnesiumlegierung sowie nach dem Verfahren hergestelltes Implantat |
| US8080055B2 (en) | 2006-12-28 | 2011-12-20 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
| US20130150943A1 (en) | 2007-01-19 | 2013-06-13 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
| US8814930B2 (en) * | 2007-01-19 | 2014-08-26 | Elixir Medical Corporation | Biodegradable endoprosthesis and methods for their fabrication |
| JP2010516403A (ja) * | 2007-01-26 | 2010-05-20 | ボストン サイエンティフィック リミテッド | 植込み型医療用内部人工器官 |
| DE102007004589A1 (de) * | 2007-01-30 | 2008-07-31 | Orlowski, Michael, Dr. | Bioresorbierbarer Metallstent mit kontrollierter Resorption |
| KR20090122202A (ko) * | 2007-01-30 | 2009-11-26 | 헤모텍 아게 | 생분해성 혈관 지지체 |
| CN101636187B (zh) * | 2007-01-30 | 2013-08-28 | 汉莫堤克股份有限公司 | 生物可降解性血管支持器 |
| AT504975B1 (de) * | 2007-02-19 | 2013-12-15 | Arc Austrian Res Centers Gmbh | Gitterteil aus metall und verfahren zur herstellung eines gitterteiles |
| US8273402B2 (en) | 2007-02-26 | 2012-09-25 | Medtronic Vascular, Inc. | Drug coated stent with magnesium topcoat |
| US20080206441A1 (en) * | 2007-02-27 | 2008-08-28 | Medtronic Vascular, Inc. | Ion Beam Etching a Surface of an Implantable Medical Device |
| US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
| US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
| US20080243234A1 (en) * | 2007-03-27 | 2008-10-02 | Medtronic Vascular, Inc. | Magnesium Alloy Stent |
| US20080249608A1 (en) * | 2007-04-04 | 2008-10-09 | Vipul Dave | Bioabsorbable Polymer, Bioabsorbable Composite Stents |
| US8067054B2 (en) * | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
| US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
| US7901452B2 (en) * | 2007-06-27 | 2011-03-08 | Abbott Cardiovascular Systems Inc. | Method to fabricate a stent having selected morphology to reduce restenosis |
| US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US9284409B2 (en) | 2007-07-19 | 2016-03-15 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
| DE102007034363A1 (de) * | 2007-07-24 | 2009-01-29 | Biotronik Vi Patent Ag | Endoprothese |
| US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
| US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
| US8221822B2 (en) | 2007-07-31 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
| US8961589B2 (en) * | 2007-08-01 | 2015-02-24 | Abbott Cardiovascular Systems Inc. | Bioabsorbable coating with tunable hydrophobicity |
| EP2185103B1 (en) | 2007-08-03 | 2014-02-12 | Boston Scientific Scimed, Inc. | Coating for medical device having increased surface area |
| DE102007038799A1 (de) * | 2007-08-17 | 2009-02-19 | Biotronik Vi Patent Ag | Implantat aus einer biokorrodierbaren Magnesiumlegierung und mit einer Beschichtung aus einem biokorrodierbaren Polyphosphazen |
| US8052745B2 (en) * | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
| US8998978B2 (en) * | 2007-09-28 | 2015-04-07 | Abbott Cardiovascular Systems Inc. | Stent formed from bioerodible metal-bioceramic composite |
| US8142490B2 (en) | 2007-10-24 | 2012-03-27 | Cordis Corporation | Stent segments axially connected by thin film |
| US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US20090118812A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
| US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
| US8118857B2 (en) * | 2007-11-29 | 2012-02-21 | Boston Scientific Corporation | Medical articles that stimulate endothelial cell migration |
| CA2709389C (en) * | 2007-12-14 | 2016-07-05 | Micrus Endovascular Corporation | Multistrand coil for interventional therapy |
| US20100008970A1 (en) * | 2007-12-14 | 2010-01-14 | Boston Scientific Scimed, Inc. | Drug-Eluting Endoprosthesis |
| US7972373B2 (en) * | 2007-12-19 | 2011-07-05 | Advanced Technologies And Regenerative Medicine, Llc | Balloon expandable bioabsorbable stent with a single stress concentration region interconnecting adjacent struts |
| KR100942807B1 (ko) * | 2007-12-26 | 2010-02-18 | 재단법인서울대학교산학협력재단 | 폐암의 예방 또는 치료용 유전자 치료제 및 약제 조성물 |
| US20090204203A1 (en) * | 2008-02-07 | 2009-08-13 | Medtronic Vascular, Inc. | Bioabsorbable Stent Having a Radiopaque Marker |
| BRPI0822405A8 (pt) * | 2008-03-11 | 2018-06-05 | Elixir Medical Corp | Método para tratar uma condição ou doença oftálmica, composição farmacêutica, dispositivo para o uso intracorporal, método para inibir a proliferação celular, composto, e, método para fabricar um composto |
| US20090240323A1 (en) * | 2008-03-20 | 2009-09-24 | Medtronic Vascular, Inc. | Controlled Degradation of Magnesium Stents |
| EP2441478B1 (en) * | 2008-04-17 | 2019-04-03 | Dentsply IH AB | Improved medical device with hydrophilic coating |
| JP5581311B2 (ja) | 2008-04-22 | 2014-08-27 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 無機材料のコーティングを有する医療デバイス及びその製造方法 |
| WO2009132176A2 (en) | 2008-04-24 | 2009-10-29 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
| US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
| US8236046B2 (en) * | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
| US10245165B2 (en) | 2009-04-02 | 2019-04-02 | Q3 Medical Devices Limited | Stent |
| EP2296578A4 (en) * | 2008-06-12 | 2014-01-15 | Elixir Medical Corp | INTRAVASCULAR STENT |
| EP2303350A2 (en) | 2008-06-18 | 2011-04-06 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US8206635B2 (en) | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
| US8206636B2 (en) | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
| US10898620B2 (en) | 2008-06-20 | 2021-01-26 | Razmodics Llc | Composite stent having multi-axial flexibility and method of manufacture thereof |
| US8114148B2 (en) | 2008-06-25 | 2012-02-14 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion |
| US8298466B1 (en) | 2008-06-27 | 2012-10-30 | Abbott Cardiovascular Systems Inc. | Method for fabricating medical devices with porous polymeric structures |
| US9820746B2 (en) * | 2008-07-28 | 2017-11-21 | Incube Laboratories LLC | System and method for scaffolding anastomoses |
| US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
| US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
| US8337936B2 (en) * | 2008-10-06 | 2012-12-25 | Biotronik Vi Patent Ag | Implant and method for manufacturing same |
| US20100094407A1 (en) * | 2008-10-10 | 2010-04-15 | Medtronic Vascular, Inc. | Multiple Bioactive Agent Eluting Stents |
| US20100131051A1 (en) * | 2008-11-24 | 2010-05-27 | Medtronic Vascular, Inc. | Systems and Methods for Treatment of Aneurysms Using Zinc Chelator(s) |
| US9283304B2 (en) * | 2008-11-25 | 2016-03-15 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Absorbable stent having a coating for controlling degradation of the stent and maintaining pH neutrality |
| US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
| DE102008054400A1 (de) * | 2008-12-09 | 2010-06-10 | Biotronik Vi Patent Ag | Implantat und Verfahren zur Herstellung desselben |
| US20100217370A1 (en) * | 2009-02-20 | 2010-08-26 | Boston Scientific Scimed, Inc. | Bioerodible Endoprosthesis |
| US8267992B2 (en) | 2009-03-02 | 2012-09-18 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
| US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
| US8551454B2 (en) * | 2009-03-13 | 2013-10-08 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
| US20120010645A1 (en) | 2009-03-20 | 2012-01-12 | Proarc Medical Ltd. | Methods and devices for urethral treatment |
| DE102009001895A1 (de) * | 2009-03-26 | 2010-09-30 | Biotronik Vi Patent Ag | Medizinisches Implantat zur Medikamentenfreisetzung mit poröser Oberfläche |
| US20120089232A1 (en) | 2009-03-27 | 2012-04-12 | Jennifer Hagyoung Kang Choi | Medical devices with galvanic particulates |
| US8435281B2 (en) | 2009-04-10 | 2013-05-07 | Boston Scientific Scimed, Inc. | Bioerodible, implantable medical devices incorporating supersaturated magnesium alloys |
| US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
| US9265633B2 (en) | 2009-05-20 | 2016-02-23 | 480 Biomedical, Inc. | Drug-eluting medical implants |
| EP2260884A1 (de) * | 2009-06-09 | 2010-12-15 | Heller, Jorg | Implantatsystem mit einem temporären Implantat und Verfahren zum Beeinflussung der Korrosionsrate eines Implantates |
| EP3431112A1 (de) * | 2009-06-23 | 2019-01-23 | Biotronik Ag | Implantat und verfahren zur herstellung desselben |
| EP2272547B1 (de) * | 2009-06-23 | 2017-01-11 | Biotronik VI Patent AG | Implantat und Verfahren zur Herstellung desselben |
| US20110022158A1 (en) * | 2009-07-22 | 2011-01-27 | Boston Scientific Scimed, Inc. | Bioerodible Medical Implants |
| CN101987226A (zh) * | 2009-08-03 | 2011-03-23 | 张振 | 可控快速降解的镁及镁合金管连接的放射性粒子链 |
| EP2329853B1 (de) * | 2009-11-10 | 2015-07-22 | Biotronik VI Patent AG | Beschichtete Eisenbasislegierung für medizinische Implantate |
| US10240419B2 (en) | 2009-12-08 | 2019-03-26 | Baker Hughes, A Ge Company, Llc | Downhole flow inhibition tool and method of unplugging a seat |
| US20120318276A1 (en) * | 2009-12-21 | 2012-12-20 | Pat&Co Bvba | Frameless intrauterine devices and systems |
| WO2011119603A1 (en) * | 2010-03-23 | 2011-09-29 | Boston Scientific Scimed, Inc. | Bioerodible medical implants |
| WO2011119573A1 (en) | 2010-03-23 | 2011-09-29 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
| WO2011119430A1 (en) * | 2010-03-26 | 2011-09-29 | Boston Scientific Scimed, Inc. | Endoprosthesis |
| US8685433B2 (en) | 2010-03-31 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Absorbable coating for implantable device |
| US9072618B2 (en) | 2010-05-06 | 2015-07-07 | Biotronik Ag | Biocorrodable implant in which corrosion may be triggered or accelerated after implantation by means of an external stimulus |
| US8679394B2 (en) | 2010-06-10 | 2014-03-25 | Abbott Cardiovascular Systems Inc. | Laser system and processing conditions for manufacturing bioabsorbable stents |
| EP2399620B1 (de) * | 2010-06-28 | 2016-08-10 | Biotronik AG | Implantat und Verfahren zur Herstellung desselben |
| BR112013001691A2 (pt) | 2010-07-23 | 2016-05-24 | Johnson & Johnson Consumer | particulados de metal geradores de corrente de corrosão e uso dos mesmos |
| EP2422826A3 (de) * | 2010-08-27 | 2014-10-29 | Biotronik AG | Implantat und Verfahren zur Herstellung desselben |
| BR112013000997B1 (pt) | 2010-08-31 | 2021-05-04 | Synthes Gmbh | controle da degradação de implantes de metal bioreabsorvíveis |
| EP2433660B1 (de) | 2010-09-28 | 2014-07-30 | Biotronik AG | Beschichtetes Implantat aus einer biokorrodierbaren Magnesiumlegierung |
| JP5636857B2 (ja) * | 2010-10-12 | 2014-12-10 | 国立大学法人茨城大学 | 生体組織接着用柔軟性金属箔テープ及びその接着方法 |
| WO2012063262A2 (en) | 2010-11-08 | 2012-05-18 | Hll Lifecare Limited | A novel intrauterine device with controlled copper release |
| CN103442668B (zh) * | 2011-03-22 | 2016-05-18 | 泰尔茂株式会社 | 支架 |
| US20120259401A1 (en) * | 2011-04-08 | 2012-10-11 | Gerrans Lawrence J | Balloon catheter for launching drug delivery device |
| CN102228721A (zh) * | 2011-06-09 | 2011-11-02 | 中国科学院金属研究所 | 一种可降解冠脉支架及其制备方法 |
| US9492573B2 (en) * | 2011-07-06 | 2016-11-15 | Serene, Llc | Method of treating cholangiocarcinoma and apparatus |
| US9707739B2 (en) * | 2011-07-22 | 2017-07-18 | Baker Hughes Incorporated | Intermetallic metallic composite, method of manufacture thereof and articles comprising the same |
| US9033055B2 (en) | 2011-08-17 | 2015-05-19 | Baker Hughes Incorporated | Selectively degradable passage restriction and method |
| US9090956B2 (en) | 2011-08-30 | 2015-07-28 | Baker Hughes Incorporated | Aluminum alloy powder metal compact |
| US20130138219A1 (en) * | 2011-11-28 | 2013-05-30 | Cook Medical Technologies Llc | Biodegradable stents having one or more coverings |
| US9010416B2 (en) | 2012-01-25 | 2015-04-21 | Baker Hughes Incorporated | Tubular anchoring system and a seat for use in the same |
| WO2013133847A1 (en) * | 2012-03-09 | 2013-09-12 | Eventions, Llc | Biodegradable supporting device |
| US8834902B2 (en) * | 2012-03-09 | 2014-09-16 | Q3 Medical Devices Limited | Biodegradable supporting device |
| US20190269532A1 (en) * | 2012-03-09 | 2019-09-05 | Q3 Medical Devices Limited | Biodegradable supporting device with a radio-opaque marker |
| US9333099B2 (en) | 2012-03-30 | 2016-05-10 | Abbott Cardiovascular Systems Inc. | Magnesium alloy implants with controlled degradation |
| US20160089481A1 (en) * | 2012-03-30 | 2016-03-31 | Dentsply International Inc. | Medical device having a surface comprising gallium oxide |
| EP2863963B1 (en) * | 2012-06-26 | 2019-02-20 | Abbott Cardiovascular Systems Inc. | Implantable prosthesis with hollow struts and passivating coating, and method of making same |
| WO2014028599A1 (en) | 2012-08-14 | 2014-02-20 | Guo Yuebin | A biodegradable medical device having an adjustable degradation rate and methods of making the same |
| US9700441B2 (en) | 2012-10-31 | 2017-07-11 | W. L. Gore & Associates, Inc. | Devices and methods related to deposited support structures |
| US10959715B2 (en) * | 2012-10-31 | 2021-03-30 | W. L. Gore & Associates, Inc. | Devices and methods related to deposited support structures |
| US11744594B2 (en) | 2012-11-16 | 2023-09-05 | W.L. Gore & Associates, Inc. | Space filling devices |
| US20140170600A1 (en) * | 2012-12-14 | 2014-06-19 | Park Istre Ii, Llc | Methods and systems for making colored dental parts |
| EP2956180B1 (en) | 2013-02-15 | 2018-08-01 | Boston Scientific Scimed, Inc. | Bioerodible magnesium alloy microstructures for endoprostheses |
| JP6408556B2 (ja) * | 2013-03-14 | 2018-10-17 | バイオ ディージー インコーポレイテッド | 向上した分解速度を有する生分解性合金を含む埋め込み型医療デバイス |
| WO2014141278A1 (en) | 2013-03-14 | 2014-09-18 | Proarc Medical Ltd. | Methods and devices for urethral treatment |
| EP4257091A3 (en) | 2013-03-15 | 2023-12-06 | Canary Medical Inc. | Devices, systems and methods for monitoring hip replacements |
| DE102013004625A1 (de) * | 2013-03-16 | 2014-09-18 | Universitätsklinikum Freiburg | Bioresorbierbarer Stent |
| WO2014205346A1 (en) | 2013-06-21 | 2014-12-24 | Boston Scientific Scimed, Inc. | Stent with deflecting connector |
| US20160192878A1 (en) | 2013-06-23 | 2016-07-07 | William L. Hunter | Devices, systems and methods for monitoring knee replacements |
| US9816339B2 (en) | 2013-09-03 | 2017-11-14 | Baker Hughes, A Ge Company, Llc | Plug reception assembly and method of reducing restriction in a borehole |
| JP2017501756A (ja) | 2013-10-29 | 2017-01-19 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 体内プロテーゼ用の生侵食性マグネシウム合金マイクロ構造 |
| CN104587534A (zh) * | 2013-10-31 | 2015-05-06 | 先健科技(深圳)有限公司 | 可吸收铁基合金支架 |
| EP3107620B1 (en) * | 2013-12-20 | 2021-09-29 | Neuronano AB | Medical device comprising an electrode and a light source |
| US9364588B2 (en) | 2014-02-04 | 2016-06-14 | Abbott Cardiovascular Systems Inc. | Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating |
| US10865465B2 (en) | 2017-07-27 | 2020-12-15 | Terves, Llc | Degradable metal matrix composite |
| CA2936851A1 (en) | 2014-02-21 | 2015-08-27 | Terves, Inc. | Fluid activated disintegrating metal system |
| US11167343B2 (en) | 2014-02-21 | 2021-11-09 | Terves, Llc | Galvanically-active in situ formed particles for controlled rate dissolving tools |
| US10689740B2 (en) | 2014-04-18 | 2020-06-23 | Terves, LLCq | Galvanically-active in situ formed particles for controlled rate dissolving tools |
| JP6356262B2 (ja) | 2014-04-08 | 2018-07-11 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | ステント |
| WO2015171585A1 (en) * | 2014-05-05 | 2015-11-12 | The University Of Toledo | Biodegradable magnesium alloys and composites |
| JP2016005533A (ja) * | 2014-05-30 | 2016-01-14 | 株式会社日本ステントテクノロジー | ステント |
| US9381280B2 (en) | 2014-06-13 | 2016-07-05 | Abbott Cardiovascular Systems Inc. | Plasticizers for a biodegradable scaffolding and methods of forming same |
| EP4212113A1 (en) | 2014-06-25 | 2023-07-19 | Canary Medical Switzerland AG | Devices monitoring spinal implants |
| CA2990825A1 (en) | 2014-06-25 | 2015-12-30 | William L. Hunter | Devices, systems and methods for using and monitoring orthopedic hardware |
| US10524694B2 (en) | 2014-06-25 | 2020-01-07 | Canaray Medical Inc. | Devices, systems and methods for using and monitoring tubes in body passageways |
| EP3160393A4 (en) | 2014-06-25 | 2018-12-12 | Canary Medical Inc. | Devices, systems and methods for using and monitoring implants |
| US9730819B2 (en) * | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9259339B1 (en) | 2014-08-15 | 2016-02-16 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9855156B2 (en) * | 2014-08-15 | 2018-01-02 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9480588B2 (en) | 2014-08-15 | 2016-11-01 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| CN104189962B (zh) * | 2014-08-29 | 2016-01-20 | 东莞颠覆产品设计有限公司 | 一种表面具有Fe-TiO2涂层的心血管支架及其制备方法 |
| CN104189961B (zh) * | 2014-08-29 | 2016-01-20 | 东莞颠覆产品设计有限公司 | 一种表面具有Ag-TiO2涂层的心血管支架及其制备方法 |
| CN107003984A (zh) | 2014-09-17 | 2017-08-01 | 卡纳里医疗公司 | 用于使用和监测医疗设备的设备、系统和方法 |
| CN104436314A (zh) * | 2014-11-04 | 2015-03-25 | 无锡贺邦金属制品有限公司 | 一种具有抗菌功能的固骨钉用合金材料 |
| US10378303B2 (en) | 2015-03-05 | 2019-08-13 | Baker Hughes, A Ge Company, Llc | Downhole tool and method of forming the same |
| CN107427603A (zh) | 2015-03-11 | 2017-12-01 | 波士顿科学国际有限公司 | 用于内假体的生物溶蚀性镁合金微结构 |
| JP6788796B2 (ja) * | 2015-03-31 | 2020-11-25 | 東レ株式会社 | 抗血栓性金属材料 |
| EP4233873A3 (en) | 2015-06-29 | 2023-10-18 | Lyra Therapeutics, Inc. | Implantable scaffolds for treatment of sinusitis |
| US10232082B2 (en) | 2015-06-29 | 2019-03-19 | 480 Biomedical, Inc. | Implantable scaffolds for treatment of sinusitis |
| CN105056297B (zh) * | 2015-08-06 | 2018-02-23 | 孙培强 | 一种抗菌能力强的医用钛合金棒材 |
| CN105232193A (zh) * | 2015-08-19 | 2016-01-13 | 北京迈迪顶峰医疗科技有限公司 | 一种肺动脉支架 |
| CN106474545B (zh) | 2015-08-28 | 2020-04-10 | 元心科技(深圳)有限公司 | 可吸收铁基合金植入医疗器械 |
| DE102015119539B4 (de) * | 2015-11-12 | 2022-12-22 | Kulzer Gmbh | Hochschlagzähes, transparentes Prothesenmaterial mit niedrigem Rest-MMA Gehalt |
| CN106693043B (zh) * | 2015-11-18 | 2020-06-16 | 先健科技(深圳)有限公司 | 可吸收铁基合金植入医疗器械及其制备方法 |
| CN106806938B (zh) * | 2015-11-27 | 2020-04-14 | 先健科技(深圳)有限公司 | 可吸收铁基合金植入医疗器械 |
| CN106890368A (zh) * | 2015-12-18 | 2017-06-27 | 华东理工大学 | 用于肿瘤定向治疗的输尿管支架及制备方法 |
| CN106902395B (zh) * | 2015-12-22 | 2020-04-07 | 先健科技(深圳)有限公司 | 可吸收铁基合金植入医疗器械 |
| CN105597163B (zh) * | 2015-12-29 | 2019-05-31 | 先健科技(深圳)有限公司 | 铁基合金植入医疗器械及其制备方法 |
| CN106955374B (zh) * | 2016-01-08 | 2019-11-08 | 先健科技(深圳)有限公司 | 植入式器械 |
| CN105457106B (zh) * | 2016-01-11 | 2019-02-01 | 光钰科技股份有限公司 | 适用于热熔植入至骨矫正处或病骨的骨钉 |
| WO2017136624A1 (en) * | 2016-02-03 | 2017-08-10 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Systems and methods for selective coating removal for resorbable metal medical devices |
| WO2017165717A1 (en) | 2016-03-23 | 2017-09-28 | Canary Medical Inc. | Implantable reporting processor for an alert implant |
| TWI604819B (zh) * | 2016-04-13 | 2017-11-11 | Bioabsorbable bone nail capable of developing under x-ray and its making method | |
| CN107376035B (zh) * | 2016-05-16 | 2020-12-01 | 深圳生命谷科技研究院有限公司 | 一种血管支架及其制备方法 |
| ES2873887T3 (es) | 2016-05-16 | 2021-11-04 | Elixir Medical Corp | Liberación de stent |
| US11622872B2 (en) | 2016-05-16 | 2023-04-11 | Elixir Medical Corporation | Uncaging stent |
| ES2991824T3 (es) * | 2016-05-25 | 2024-12-05 | Q3 Medical Devices Ltd | Dispositivo de soporte biodegradable |
| EP3463128B1 (en) * | 2016-06-03 | 2021-11-10 | Q3 Medical Devices Limited | Stent |
| JP7128120B2 (ja) | 2016-06-23 | 2022-08-30 | ポリ-メド インコーポレイテッド | 生分解が管理された医療デバイス |
| CN105903092A (zh) * | 2016-06-23 | 2016-08-31 | 刘芸 | 子宫置入物及子宫置入物的置入系统 |
| CN108261559B (zh) * | 2016-12-30 | 2021-07-30 | 元心科技(深圳)有限公司 | 可吸收铁基器械 |
| WO2018131476A1 (ja) | 2017-01-10 | 2018-07-19 | 不二ライトメタル株式会社 | マグネシウム合金 |
| CN110234366B (zh) * | 2017-01-30 | 2021-11-02 | 株式会社日本医疗机器技研 | 高功能生物可吸收支架 |
| CN106620889A (zh) * | 2017-02-16 | 2017-05-10 | 鼎科医疗技术(苏州)有限公司 | 一种可植入体内的医疗器件及其制作方法 |
| CN109010931B (zh) * | 2017-06-09 | 2022-03-11 | 上海微创医疗器械(集团)有限公司 | 介入医疗器械及阿非迪霉素的应用 |
| US11559612B2 (en) | 2017-07-28 | 2023-01-24 | University of Pittsburgh —of the Commonwealth System of Higher Education | Use of self-assembled alkylsilane coatings for drug delivery applications |
| CN107413287A (zh) * | 2017-08-15 | 2017-12-01 | 泰州希斯曼金属制品有限公司 | 在生物介质中用杀菌金属的纳米级对象的电化学处理方法 |
| CN107607071B (zh) * | 2017-09-26 | 2020-11-06 | 深圳市领先医疗服务有限公司 | 可降解药物涂层支架涂层厚度的测量方法 |
| CN118178739A (zh) * | 2017-09-30 | 2024-06-14 | 元心科技(深圳)有限公司 | 植入式器械 |
| CN107595449A (zh) * | 2017-10-16 | 2018-01-19 | 鼎科医疗技术(苏州)有限公司 | 一种降低电化学腐蚀的可降解金属支架制备方法及其制得的金属支架 |
| GB201718299D0 (en) | 2017-11-03 | 2017-12-20 | Ab Wasstand Dev | Stents |
| CN107899070A (zh) * | 2017-11-13 | 2018-04-13 | 西南大学 | 一种仿松质骨结构与超低弹性模量的人工骨骼及制备方法 |
| TWI645075B (zh) * | 2017-12-13 | 2018-12-21 | 蔡永芳 | 開發單晶異向性氧化物在合金醫療器材上之製備方法 |
| US12016764B2 (en) | 2017-12-22 | 2024-06-25 | Poly-Med, Inc. | Tubular implants with controlled biodegradation |
| CN109966562B (zh) * | 2017-12-27 | 2021-12-17 | 元心科技(深圳)有限公司 | 可吸收金属支架 |
| US20200368008A1 (en) * | 2018-01-16 | 2020-11-26 | Olympus Corporation | Urological Stent |
| US11065136B2 (en) * | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| US11065009B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| WO2019195216A1 (en) * | 2018-04-02 | 2019-10-10 | Battelle Memorial Institute | Coatings for biological interface on implants |
| DE102018110591B4 (de) * | 2018-05-03 | 2022-11-03 | Acandis Gmbh | Medizinische Vorrichtung mit Fibrinbeschichtung, System und Set mit einer derartigen Vorrichtung sowie Herstellverfahren |
| EP3796948A4 (en) | 2018-05-22 | 2022-03-02 | Interface Biologics Inc. | Compositions and methods for delivering drugs to a vessel wall |
| US10441449B1 (en) | 2018-05-30 | 2019-10-15 | Vesper Medical, Inc. | Rotary handle stent delivery system and method |
| CN108962864B (zh) * | 2018-06-14 | 2020-02-14 | 中国电子科技集团公司第二十四研究所 | 一种用于瞬态电路的可水解封装外引线及制作方法 |
| JP6695546B1 (ja) | 2018-07-09 | 2020-05-20 | 不二ライトメタル株式会社 | マグネシウム合金 |
| US12485205B2 (en) * | 2018-08-02 | 2025-12-02 | The Regents Of The University Of California | Biodegradable zinc-based materials including dispersed nanostructures for biomedical applications |
| US10960110B2 (en) * | 2018-08-21 | 2021-03-30 | Jian Xie | Iron-based biodegradable metals for implantable medical devices |
| US10449073B1 (en) | 2018-09-18 | 2019-10-22 | Vesper Medical, Inc. | Rotary handle stent delivery system and method |
| CN111329632B (zh) * | 2018-12-19 | 2021-10-22 | 元心科技(深圳)有限公司 | 可吸收金属支架 |
| CN110859997B (zh) * | 2018-12-20 | 2020-06-23 | 四川大学 | 具有成骨-抗炎-血糖三维响应结构的牙种植体及其制备方法 |
| WO2020150558A1 (en) * | 2019-01-18 | 2020-07-23 | W. L. Gore & Associates, Inc. | Bioabsorbable filament medical devices |
| CA3126019A1 (en) | 2019-01-18 | 2020-07-23 | W. L. Gore & Associates, Inc. | Bioabsorbable medical devices |
| CN109731137B (zh) * | 2019-03-13 | 2021-05-07 | 陕西师范大学 | 具有生物抗污功能的白蛋白涂层的制备方法及具有生物抗污功能的材料 |
| US20210366610A1 (en) | 2019-06-06 | 2021-11-25 | Canary Medical Inc. | Intelligent joint prosthesis |
| MX2021014760A (es) | 2019-06-06 | 2022-01-18 | Canary Medical Inc | Protesis articular inteligente. |
| DE102019121562B4 (de) * | 2019-08-09 | 2024-01-11 | Acandis Gmbh | Medizinische Vorrichtung zur Behandlung von Aneurysmen |
| CN110755177A (zh) * | 2019-10-25 | 2020-02-07 | 上海交通大学医学院附属第九人民医院 | 一种骨缺损植入物及构建方法、制备方法、计算机可读存储介质、设备 |
| CN110859650A (zh) * | 2019-11-27 | 2020-03-06 | 苏州森锋医疗器械有限公司 | 一种吻合钉 |
| US20230001056A1 (en) | 2019-12-03 | 2023-01-05 | Cortronik GmbH | Adaptive chemical post-processing of nonwovens for cardiovascular applications |
| US12408963B2 (en) | 2020-02-20 | 2025-09-09 | Canary Medical Switzerland Ag | Medical device for implanting in boney tissue and characterization of bone fractures |
| US11219541B2 (en) | 2020-05-21 | 2022-01-11 | Vesper Medical, Inc. | Wheel lock for thumbwheel actuated device |
| CN112494189A (zh) * | 2020-11-03 | 2021-03-16 | 北京科技大学 | 一种可降解金属宫腔支架和释放系统及使用方法 |
| DE102020216158B4 (de) * | 2020-12-17 | 2024-08-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Stents für die Anwendung in der interventionellen Behandlung von Gefäßerkrankungen und der Gefäßchirurgie |
| AU2021411660A1 (en) * | 2020-12-28 | 2023-07-13 | Biotyx Medical (Shenzhen) Co., Ltd. | Orthopaedic internal fixation implanted medical device |
| BR112023023389A2 (pt) * | 2021-05-10 | 2024-01-23 | Cilag Gmbh Int | Grampo cirúrgico absorvível que compreende um revestimento |
| US20220354999A1 (en) | 2021-05-10 | 2022-11-10 | Cilag Gmbh International | Bioabsorbable staple comprising mechanisms for slowing the absorption of the staple |
| CN113750297B (zh) * | 2021-09-03 | 2022-04-15 | 东华大学 | 一种结构和功能仿生尿道支架及其制备方法 |
| CN114059146A (zh) * | 2021-11-16 | 2022-02-18 | 湖南华耀百奥医疗科技有限公司 | 一种可降解金属骨结合植入物的表面处理方法 |
| CN113975470B (zh) * | 2021-11-22 | 2023-09-22 | 山东瑞安泰医疗技术有限公司 | 一种可降解金属钼基合金血管内支架制备方法 |
| WO2023096800A1 (en) * | 2021-11-23 | 2023-06-01 | Elixir Medical Corporation | Anticoagulant compounds comprising chelating agents and cationic anti-coagulation enhancers and methods and devices for their use |
| KR102512526B1 (ko) * | 2022-08-18 | 2023-03-21 | 강금용 | 생분해성 마그네슘을 포함하는 관상동맥용 스텐트의 제조방법 및 이의 제조방법으로 제조된 스텐트 |
| DE102022129920B3 (de) | 2022-11-11 | 2023-12-28 | Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden e.V. (IFW Dresden e.V.) | Implantatsystem mit aktiv regulierbarer Degradation und Verfahren zur aktiv regulierbaren Degradation eines Implantatsystems |
| CN116036385B (zh) * | 2023-03-31 | 2023-07-04 | 艾柯医疗器械(北京)股份有限公司 | 一种自膨式编织植入物及其制备方法及包含其的血流导向系统 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2950022C2 (de) * | 1979-12-17 | 1984-01-12 | Vsesojuznyj kardiologičeskij naučnyj centr Akademii medicinskich Nauk SSSR,, Moskva | Elektrischer Leiter zur Implantation in den menschlichen Körper |
| US4645503A (en) * | 1985-08-27 | 1987-02-24 | Orthomatrix Inc. | Moldable bone-implant material |
| US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US4979822A (en) * | 1989-05-30 | 1990-12-25 | Pacific Scientific Company | Particle measuring fluid cell having non-corrodible shims |
| US5496359A (en) * | 1989-07-25 | 1996-03-05 | Smith & Nephew Richards, Inc. | Zirconium oxide and zirconium nitride coated biocompatible leads |
| AU7998091A (en) * | 1990-05-17 | 1991-12-10 | Harbor Medical Devices, Inc. | Medical device polymer |
| CA2060635A1 (en) * | 1991-02-12 | 1992-08-13 | Keith D'alessio | Bioabsorbable medical implants |
| CA2079417C (en) | 1991-10-28 | 2003-01-07 | Lilip Lau | Expandable stents and method of making same |
| FR2689400B1 (fr) * | 1992-04-03 | 1995-06-23 | Inoteb | Materiau pour prothese osseuse contenant des particules de carbonate de calcium dispersees dans une matrice polymere bioresorbable. |
| US5522895A (en) * | 1993-07-23 | 1996-06-04 | Rice University | Biodegradable bone templates |
| US6235061B1 (en) * | 1994-04-04 | 2001-05-22 | The Penn State Research Foundation | Poly(organophosphazene) matrices for bone replacement |
| US5649977A (en) * | 1994-09-22 | 1997-07-22 | Advanced Cardiovascular Systems, Inc. | Metal reinforced polymer stent |
| US5741329A (en) * | 1994-12-21 | 1998-04-21 | Board Of Regents, The University Of Texas System | Method of controlling the pH in the vicinity of biodegradable implants |
| CA2178541C (en) * | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
| CA2252860C (en) * | 1996-05-28 | 2011-03-22 | 1218122 Ontario Inc. | Resorbable implant biomaterial made of condensed calcium phosphate particles |
| US6174329B1 (en) * | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
| US5997517A (en) * | 1997-01-27 | 1999-12-07 | Sts Biopolymers, Inc. | Bonding layers for medical device surface coatings |
| US6240616B1 (en) * | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
| US8172897B2 (en) * | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
| US6610764B1 (en) * | 1997-05-12 | 2003-08-26 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| CN2304419Y (zh) * | 1997-06-13 | 1999-01-20 | 王槐茂 | 血管支架 |
| DE19731021A1 (de) | 1997-07-18 | 1999-01-21 | Meyer Joerg | In vivo abbaubares metallisches Implantat |
| US5980564A (en) * | 1997-08-01 | 1999-11-09 | Schneider (Usa) Inc. | Bioabsorbable implantable endoprosthesis with reservoir |
| US6241771B1 (en) * | 1997-08-13 | 2001-06-05 | Cambridge Scientific, Inc. | Resorbable interbody spinal fusion devices |
| US6626939B1 (en) * | 1997-12-18 | 2003-09-30 | Boston Scientific Scimed, Inc. | Stent-graft with bioabsorbable structural support |
| US20030040790A1 (en) * | 1998-04-15 | 2003-02-27 | Furst Joseph G. | Stent coating |
| US20020099438A1 (en) * | 1998-04-15 | 2002-07-25 | Furst Joseph G. | Irradiated stent coating |
| EP0966979B1 (de) † | 1998-06-25 | 2006-03-08 | Biotronik AG | Implantierbare, bioresorbierbare Gefässwandstütze, insbesondere Koronarstent |
| DE19856983A1 (de) * | 1998-06-25 | 1999-12-30 | Biotronik Mess & Therapieg | Implantierbare, bioresorbierbare Gefäßwandstütze, insbesondere Koronarstent |
| US6325824B2 (en) * | 1998-07-22 | 2001-12-04 | Advanced Cardiovascular Systems, Inc. | Crush resistant stent |
| CN1132636C (zh) * | 1999-01-28 | 2003-12-31 | 蒲忠杰 | 一种医用扩张人体管道支架的制备方法 |
| CN2383533Y (zh) * | 1999-06-09 | 2000-06-21 | 安泰科技股份有限公司 | 医用球囊扩张血管内支架 |
| US20020144757A1 (en) * | 2000-07-07 | 2002-10-10 | Craig Charles Horace | Stainless steel alloy with improved radiopaque characteristics |
| US7402173B2 (en) * | 2000-09-18 | 2008-07-22 | Boston Scientific Scimed, Inc. | Metal stent with surface layer of noble metal oxide and method of fabrication |
| WO2002056790A2 (en) | 2000-12-22 | 2002-07-25 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
| US7077859B2 (en) * | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
| US20030033007A1 (en) * | 2000-12-22 | 2003-02-13 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
| EP1370306B1 (de) * | 2001-01-05 | 2005-10-19 | Jacqueline Yvonne Hausdorf | Durch korrosion abbaubare metallische medizinische implantate |
| EP1416885B1 (en) * | 2001-07-26 | 2007-01-10 | Avantec Vascular Corporation | Devices for delivery of therapeutic agents with variable release profile |
| US6840961B2 (en) * | 2001-12-21 | 2005-01-11 | Etex Corporation | Machinable preformed calcium phosphate bone substitute material implants |
| US7011678B2 (en) * | 2002-01-31 | 2006-03-14 | Radi Medical Systems Ab | Biodegradable stent |
| US20030153971A1 (en) * | 2002-02-14 | 2003-08-14 | Chandru Chandrasekaran | Metal reinforced biodegradable intraluminal stents |
| DE10207161B4 (de) * | 2002-02-20 | 2004-12-30 | Universität Hannover | Verfahren zur Herstellung von Implantaten |
| CN2542279Y (zh) * | 2002-03-21 | 2003-04-02 | 有研亿金新材料股份有限公司 | 一种记忆合金医用内支架 |
| US7261734B2 (en) * | 2002-04-23 | 2007-08-28 | Boston Scientific Scimed, Inc. | Resorption-controllable medical implants |
| US20030204239A1 (en) * | 2002-04-26 | 2003-10-30 | Wenda Carlyle | Endovascular stent with a preservative coating |
| US7122048B2 (en) * | 2002-05-03 | 2006-10-17 | Scimed Life Systems, Inc. | Hypotube endoluminal device |
| CN100435880C (zh) * | 2003-02-28 | 2008-11-26 | 微创医疗器械(上海)有限公司 | 一种药物洗脱介入医疗器械及其制备方法 |
| US20040006380A1 (en) * | 2002-07-05 | 2004-01-08 | Buck Jerrick C. | Stent delivery system |
| US7628696B2 (en) | 2002-07-12 | 2009-12-08 | Atronic International Gmbh | Gaming device with network port for selecting jackpot frequency |
| WO2004010900A1 (en) * | 2002-07-25 | 2004-02-05 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
| DE10237572A1 (de) † | 2002-08-13 | 2004-02-26 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Stent mit polymerer Beschichtung |
| US6638301B1 (en) * | 2002-10-02 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device with radiopacity |
| US7169178B1 (en) * | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
| PT1444993E (pt) * | 2003-02-10 | 2007-01-31 | Heraeus Gmbh W C | Liga metálica melhorada para dispositivos médicos e implantes |
| DE10329260A1 (de) * | 2003-06-23 | 2005-01-13 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Stent mit einem Beschichtungssystem |
| DE10361940A1 (de) * | 2003-12-24 | 2005-07-28 | Restate Patent Ag | Degradationssteuerung biodegradierbarer Implantate durch Beschichtung |
| CN100371032C (zh) * | 2004-01-16 | 2008-02-27 | 东南大学 | 防再狭窄药物缓释型血管支架及其制备方法 |
| CN1314466C (zh) * | 2004-01-16 | 2007-05-09 | 东南大学 | 表面沉积钙磷陶瓷的镍钛非血管腔道支架及其制备方法 |
| DE102004043231A1 (de) † | 2004-09-07 | 2006-03-09 | Biotronik Vi Patent Ag | Endoprothese aus einer Magnesiumlegierung |
| WO2006062518A2 (en) * | 2004-12-08 | 2006-06-15 | Interpore Spine Ltd. | Continuous phase composite for musculoskeletal repair |
| CA2535938C (en) * | 2005-02-10 | 2014-11-25 | Cordis Corporation | Biodegradable medical devices with enhanced mechanical strength and pharmacological functions |
| ES2986867T3 (es) * | 2005-03-03 | 2024-11-12 | Mirus Llc | Aleaciones metálicas mejoradas para dispositivos médicos |
| AU2006231652A1 (en) | 2005-04-05 | 2006-10-12 | Elixir Medical Corporation | Degradable implantable medical devices |
| KR100929133B1 (ko) † | 2006-09-22 | 2009-12-01 | 유앤아이 주식회사 | 생체분해성 금속을 포함하는 임플란트 및 이의 제조방법 |
| US20110022158A1 (en) * | 2009-07-22 | 2011-01-27 | Boston Scientific Scimed, Inc. | Bioerodible Medical Implants |
| CA2817450C (en) * | 2011-02-24 | 2015-12-01 | Biotronik Ag | Biocorrodible magnesium alloy implant |
-
2006
- 2006-04-04 AU AU2006231652A patent/AU2006231652A1/en not_active Abandoned
- 2006-04-04 US US11/398,363 patent/US20060229711A1/en not_active Abandoned
- 2006-04-04 BR BRPI0610519-0A patent/BRPI0610519A2/pt not_active IP Right Cessation
- 2006-04-04 CN CN201510553158.6A patent/CN105030390A/zh active Pending
- 2006-04-04 EP EP14177702.9A patent/EP2796112B2/en not_active Not-in-force
- 2006-04-04 EP EP16198729.2A patent/EP3225216A1/en not_active Withdrawn
- 2006-04-04 WO PCT/US2006/012725 patent/WO2006108065A2/en not_active Ceased
- 2006-04-04 NZ NZ562957A patent/NZ562957A/en not_active IP Right Cessation
- 2006-04-04 CN CN201410378516.XA patent/CN104146795B/zh active Active
- 2006-04-04 JP JP2008505501A patent/JP5312018B2/ja not_active Expired - Fee Related
- 2006-04-04 CA CA 2604419 patent/CA2604419C/en not_active Expired - Fee Related
- 2006-04-04 EP EP20060740576 patent/EP1865882A4/en not_active Withdrawn
- 2006-04-04 CA CA 2885981 patent/CA2885981A1/en not_active Abandoned
- 2006-04-04 CN CN200680018207.5A patent/CN101257860B/zh active Active
-
2007
- 2007-10-07 IL IL186474A patent/IL186474A/en active IP Right Grant
-
2012
- 2012-12-11 JP JP2012270170A patent/JP5572686B2/ja not_active Expired - Fee Related
-
2014
- 2014-05-21 JP JP2014104970A patent/JP2014176740A/ja not_active Withdrawn
-
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- 2015-12-23 US US14/998,288 patent/US10350093B2/en active Active
- 2015-12-25 JP JP2015253060A patent/JP2016052602A/ja not_active Withdrawn
-
2017
- 2017-04-19 JP JP2017082664A patent/JP2017159060A/ja not_active Withdrawn
-
2019
- 2019-06-05 US US16/432,640 patent/US20200188142A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101844038B1 (ko) * | 2015-03-12 | 2018-04-02 | 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 | 셀 공간에 기능성 물질이 코팅 처리된 스텐트 |
| US10441686B2 (en) | 2015-03-12 | 2019-10-15 | Utah-Inha Dds & Advanced Therapeutics Research Center | Stent having functional material coated on cell space thereof |
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| EP2796112B2 (en) | 2023-08-09 |
| CN104146795B (zh) | 2017-11-10 |
| JP2008534232A (ja) | 2008-08-28 |
| CN104146795A (zh) | 2014-11-19 |
| AU2006231652A1 (en) | 2006-10-12 |
| JP2013063319A (ja) | 2013-04-11 |
| CN101257860A (zh) | 2008-09-03 |
| EP3225216A1 (en) | 2017-10-04 |
| CA2604419C (en) | 2015-03-24 |
| IL186474A (en) | 2015-05-31 |
| EP1865882A2 (en) | 2007-12-19 |
| CN101257860B (zh) | 2015-10-21 |
| CN105030390A (zh) | 2015-11-11 |
| JP5572686B2 (ja) | 2014-08-13 |
| BRPI0610519A2 (pt) | 2010-06-22 |
| EP2796112A1 (en) | 2014-10-29 |
| EP1865882A4 (en) | 2013-05-08 |
| JP2014176740A (ja) | 2014-09-25 |
| JP2016052602A (ja) | 2016-04-14 |
| NZ562957A (en) | 2011-03-31 |
| WO2006108065A3 (en) | 2007-06-28 |
| US20160128849A1 (en) | 2016-05-12 |
| US20200188142A1 (en) | 2020-06-18 |
| US10350093B2 (en) | 2019-07-16 |
| US20060229711A1 (en) | 2006-10-12 |
| IL186474A0 (en) | 2008-01-20 |
| CA2604419A1 (en) | 2006-10-12 |
| JP2017159060A (ja) | 2017-09-14 |
| CA2885981A1 (en) | 2006-10-12 |
| WO2006108065A2 (en) | 2006-10-12 |
| EP2796112B1 (en) | 2016-11-16 |
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