JP5213704B2 - (r)−n−メチルナルトレキソン、その合成方法およびその医薬用途 - Google Patents
(r)−n−メチルナルトレキソン、その合成方法およびその医薬用途 Download PDFInfo
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- JP5213704B2 JP5213704B2 JP2008513707A JP2008513707A JP5213704B2 JP 5213704 B2 JP5213704 B2 JP 5213704B2 JP 2008513707 A JP2008513707 A JP 2008513707A JP 2008513707 A JP2008513707 A JP 2008513707A JP 5213704 B2 JP5213704 B2 JP 5213704B2
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- Prior art keywords
- mntx
- ion
- methylnaltrexone
- acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
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| RU2469038C2 (ru) | 2006-05-26 | 2012-12-10 | Фармакофор, Инк. | Контролируемое высвобождение фенольных опиатов |
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| TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
| JP2010504325A (ja) | 2006-09-20 | 2010-02-12 | マリンクロット インコーポレイテッド | 置換モルフィナン−6−オン、並びにその塩および中間体の調製 |
| CA2670303A1 (en) * | 2006-11-22 | 2008-11-13 | Progenics Pharmaceuticals, Inc. | (s)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs |
| MX2009005462A (es) * | 2006-11-22 | 2009-08-28 | Progenics Pharm Inc | Analogos de 7,8-saturados-4,5-epoxi-morfinano. |
| PL2137189T3 (pl) | 2007-03-06 | 2015-12-31 | SpecGx LLC | Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego |
| US9040726B2 (en) | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| AU2014201056B2 (en) * | 2007-03-29 | 2016-06-09 | Progenics Pharmaceuticals, Inc. | Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof |
| WO2008129846A1 (ja) | 2007-03-29 | 2008-10-30 | Daiichi Sankyo Company, Limited | 医薬組成物 |
| PL2565195T3 (pl) | 2007-03-29 | 2015-10-30 | Wyeth Llc | Obwodowy receptor opioidowy i jego antagoniści oraz ich zastosowania |
| ES2765811T5 (es) | 2007-03-29 | 2024-02-27 | Progenics Pharm Inc | Forma cristalina de bromuro de (R)-n-metilnaltrexona y sus usos |
| WO2008121348A2 (en) | 2007-03-29 | 2008-10-09 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
| WO2008138383A1 (de) * | 2007-05-16 | 2008-11-20 | Cilag Ag | Verfahren zur herstellung von n-methylnaltrexonbromid |
| US8383649B2 (en) | 2007-07-11 | 2013-02-26 | Mallinckrodt Llc | Crystalline forms of naltrexone methobromide |
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| WO2009099410A1 (en) * | 2008-02-06 | 2009-08-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r)-8-keto-methylnaltrexone |
| EP2730578A1 (en) | 2008-02-06 | 2014-05-14 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnal trexone |
| AU2009225434B2 (en) | 2008-03-21 | 2014-05-22 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
| PL2285780T3 (pl) | 2008-05-27 | 2016-02-29 | SpecGx LLC | Sposoby i związki do wytwarzania normorfinanów |
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| EP2331508B1 (en) | 2008-09-03 | 2014-11-12 | Mallinckrodt LLC | Substituted berbines and processes for their synthesis |
| CN101685084B (zh) * | 2008-09-22 | 2013-09-25 | 重庆医药工业研究院有限责任公司 | 一种采用液相色谱法测定溴甲纳曲酮及其杂质的方法 |
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| JP5784507B2 (ja) * | 2009-02-23 | 2015-09-24 | マリンクロッド エルエルシー | (+)−モルフィナニウム第四級塩およびその生成方法 |
| CN102348688B (zh) | 2009-03-10 | 2014-07-09 | 第一三共株式会社 | 用于制备二胺衍生物的方法 |
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| WO2011115067A1 (ja) | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 抗凝固剤の溶出改善方法 |
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