JP5192380B2 - 皮膚老化防止用皮膚外用剤組成物 - Google Patents
皮膚老化防止用皮膚外用剤組成物 Download PDFInfo
- Publication number
- JP5192380B2 JP5192380B2 JP2008529922A JP2008529922A JP5192380B2 JP 5192380 B2 JP5192380 B2 JP 5192380B2 JP 2008529922 A JP2008529922 A JP 2008529922A JP 2008529922 A JP2008529922 A JP 2008529922A JP 5192380 B2 JP5192380 B2 JP 5192380B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- composition
- external preparation
- gallate
- preparation composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims description 57
- 238000002360 preparation method Methods 0.000 title claims description 30
- 230000009759 skin aging Effects 0.000 title claims description 14
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 30
- 235000005487 catechin Nutrition 0.000 claims description 30
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims description 25
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims description 22
- LVJJFMLUMNSUFN-UHFFFAOYSA-N gallocatechin gallate Natural products C1=C(O)C=C2OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C1OC(=O)C1=CC(O)=C(O)C(O)=C1 LVJJFMLUMNSUFN-UHFFFAOYSA-N 0.000 claims description 21
- LSHVYAFMTMFKBA-PZJWPPBQSA-N (+)-catechin-3-O-gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-PZJWPPBQSA-N 0.000 claims description 19
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 claims description 19
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 claims description 17
- 229940030275 epigallocatechin gallate Drugs 0.000 claims description 17
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 16
- 150000001765 catechin Chemical class 0.000 claims description 16
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 claims description 16
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 claims description 15
- 150000002216 flavonol derivatives Chemical class 0.000 claims description 15
- 235000011957 flavonols Nutrition 0.000 claims description 15
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 claims description 14
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 14
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 14
- 239000004480 active ingredient Substances 0.000 claims description 14
- 229950001002 cianidanol Drugs 0.000 claims description 14
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 claims description 14
- 235000007743 myricetin Nutrition 0.000 claims description 14
- 229940116852 myricetin Drugs 0.000 claims description 14
- 230000037303 wrinkles Effects 0.000 claims description 11
- 230000037394 skin elasticity Effects 0.000 claims description 9
- 230000006872 improvement Effects 0.000 claims description 8
- 230000036570 collagen biosynthesis Effects 0.000 claims description 7
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 claims description 7
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 claims description 6
- 206010061218 Inflammation Diseases 0.000 claims description 6
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 6
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims description 5
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 claims description 5
- 230000003712 anti-aging effect Effects 0.000 claims description 5
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims description 4
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims description 4
- 235000012734 epicatechin Nutrition 0.000 claims description 4
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 3
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 3
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 claims description 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 235000005875 quercetin Nutrition 0.000 claims description 3
- 229960001285 quercetin Drugs 0.000 claims description 3
- WMBWREPUVVBILR-GHTZIAJQSA-N (+)-gallocatechin gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-GHTZIAJQSA-N 0.000 claims description 2
- 102000023984 PPAR alpha Human genes 0.000 claims 2
- XMOCLSLCDHWDHP-SWLSCSKDSA-N (+)-Epigallocatechin Natural products C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-SWLSCSKDSA-N 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 42
- 238000012360 testing method Methods 0.000 description 24
- 244000269722 Thea sinensis Species 0.000 description 23
- 235000009569 green tea Nutrition 0.000 description 23
- 230000015572 biosynthetic process Effects 0.000 description 22
- 230000000694 effects Effects 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 20
- 235000020688 green tea extract Nutrition 0.000 description 17
- 239000006210 lotion Substances 0.000 description 15
- 229940094952 green tea extract Drugs 0.000 description 14
- 108010035532 Collagen Proteins 0.000 description 13
- 102000008186 Collagen Human genes 0.000 description 13
- 102000012141 Peroxisome proliferator-activated receptor alpha Human genes 0.000 description 13
- 229920001436 collagen Polymers 0.000 description 13
- 239000000126 substance Substances 0.000 description 13
- 239000006071 cream Substances 0.000 description 12
- 235000016709 nutrition Nutrition 0.000 description 12
- 102000013382 Gelatinases Human genes 0.000 description 11
- 108010026132 Gelatinases Proteins 0.000 description 11
- 210000002615 epidermis Anatomy 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 239000000284 extract Substances 0.000 description 10
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 9
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- WMBWREPUVVBILR-NQIIRXRSSA-N (-)-gallocatechin gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-NQIIRXRSSA-N 0.000 description 8
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 8
- 101710151806 72 kDa type IV collagenase Proteins 0.000 description 8
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 description 7
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 210000004207 dermis Anatomy 0.000 description 7
- 239000006228 supernatant Substances 0.000 description 7
- 238000002965 ELISA Methods 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 6
- 210000004927 skin cell Anatomy 0.000 description 6
- 102000029816 Collagenase Human genes 0.000 description 5
- 108060005980 Collagenase Proteins 0.000 description 5
- 229960002424 collagenase Drugs 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 210000002510 keratinocyte Anatomy 0.000 description 5
- 108010038862 laminin 10 Proteins 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000032683 aging Effects 0.000 description 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- -1 deobromine Natural products 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000001678 irradiating effect Effects 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 230000037373 wrinkle formation Effects 0.000 description 4
- 230000004913 activation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000005550 inflammation mediator Substances 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 229920001076 Cutan Polymers 0.000 description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- 239000005089 Luciferase Substances 0.000 description 2
- 206010051246 Photodermatosis Diseases 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000037356 lipid metabolism Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000002824 peroxisome Anatomy 0.000 description 2
- 230000008845 photoaging Effects 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 229930002330 retinoic acid Natural products 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- 229930013915 (+)-catechin Natural products 0.000 description 1
- 235000007219 (+)-catechin Nutrition 0.000 description 1
- 235000007246 (+)-epicatechin Nutrition 0.000 description 1
- 229930013799 (-)-catechin Natural products 0.000 description 1
- 235000007331 (-)-catechin Nutrition 0.000 description 1
- PFTAWBLQPZVEMU-HIFRSBDPSA-N (-)-catechin Chemical compound C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-HIFRSBDPSA-N 0.000 description 1
- 235000007355 (-)-epicatechin Nutrition 0.000 description 1
- 229930013783 (-)-epicatechin Natural products 0.000 description 1
- XMOCLSLCDHWDHP-DOMZBBRYSA-N (-)-gallocatechin Chemical compound C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-DOMZBBRYSA-N 0.000 description 1
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 description 1
- YIWGJFPJRAEKMK-UHFFFAOYSA-N 1-(2H-benzotriazol-5-yl)-3-methyl-8-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Chemical compound CN1C(=O)N(c2ccc3n[nH]nc3c2)C2(CCN(CC2)C(=O)c2cnc(NCc3cccc(OC(F)(F)F)c3)nc2)C1=O YIWGJFPJRAEKMK-UHFFFAOYSA-N 0.000 description 1
- GMVPRGQOIOIIMI-DODZYUBVSA-N 7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DODZYUBVSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108090000331 Firefly luciferases Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 1
- 102000001776 Matrix metalloproteinase-9 Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000007399 Nuclear hormone receptor Human genes 0.000 description 1
- 108020005497 Nuclear hormone receptor Proteins 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 108010050808 Procollagen Proteins 0.000 description 1
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 description 1
- 108010052090 Renilla Luciferases Proteins 0.000 description 1
- 108091027981 Response element Proteins 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000000270 basal cell Anatomy 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000008687 biosynthesis inhibition Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- CXQWRCVTCMQVQX-UHFFFAOYSA-N cis-dihydroquercetin Natural products O1C2=CC(O)=CC(O)=C2C(=O)C(O)C1C1=CC=C(O)C(O)=C1 CXQWRCVTCMQVQX-UHFFFAOYSA-N 0.000 description 1
- 230000011382 collagen catabolic process Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 230000006355 external stress Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 238000007804 gelatin zymography Methods 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 1
- 108010028309 kalinin Proteins 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 210000001985 kidney epithelial cell Anatomy 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000003818 metabolic dysfunction Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 230000009703 regulation of cell differentiation Effects 0.000 description 1
- 230000025053 regulation of cell proliferation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000007805 zymography Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050083665A KR101219293B1 (ko) | 2005-09-08 | 2005-09-08 | 최적 농도의 카테킨과 데아닌을 함유하는 피부 외용제조성물 |
| KR1020050083667A KR101219296B1 (ko) | 2005-09-08 | 2005-09-08 | 표피-진피 경계부 보호용 피부 외용제 조성물 |
| KR10-2005-0083665 | 2005-09-08 | ||
| KR10-2005-0083667 | 2005-09-08 | ||
| KR1020060021797A KR20070091964A (ko) | 2006-03-08 | 2006-03-08 | 퍼옥시좀 증식체 활성화 수용체 알파 활성화용 피부 외용제조성물 |
| KR10-2006-0021797 | 2006-03-08 | ||
| PCT/KR2006/003571 WO2007029982A1 (en) | 2005-09-08 | 2006-09-08 | Composition of skin external application for anti-aging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009507826A JP2009507826A (ja) | 2009-02-26 |
| JP2009507826A5 JP2009507826A5 (OSRAM) | 2012-07-19 |
| JP5192380B2 true JP5192380B2 (ja) | 2013-05-08 |
Family
ID=37836058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529922A Expired - Fee Related JP5192380B2 (ja) | 2005-09-08 | 2006-09-08 | 皮膚老化防止用皮膚外用剤組成物 |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US20090012155A1 (OSRAM) |
| JP (1) | JP5192380B2 (OSRAM) |
| WO (1) | WO2007029982A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11938163B2 (en) | 2020-06-09 | 2024-03-26 | Amorepacific Corporation | Composition for improving respiratory health continuously exposed to particulate matter atmosphere |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101404398B1 (ko) * | 2007-06-20 | 2014-06-09 | (주)뉴트리 | 주름개선 화장료 조성물 |
| IT1393841B1 (it) | 2009-04-30 | 2012-05-11 | Giuliani Spa | Composizione farmaceutica o dermatologica o nutrizionale o cosmetica per combattere l'azione di immunosoppressione provocata sulla pelle da agenti aggressivi |
| FR2956977A1 (fr) * | 2010-03-03 | 2011-09-09 | Emulscience | Composition cosmetique anti-age, utilisation et procede d'application correspondant |
| EP2558436B1 (en) * | 2010-04-12 | 2017-06-07 | Berkem S.A. | Process for the manufacture of stabilised polyphenol derivatives |
| US8815265B2 (en) * | 2010-06-30 | 2014-08-26 | Avon Products, Inc. | Cosmetic use of N-substituted sulfonyloxybenzylamines and related compounds |
| MX2012013787A (es) | 2010-06-30 | 2012-12-17 | Avon Prod Inc | Composiciones y metodos para estimular magp-1 y mejorar la apariencia de la piel. |
| US8455518B2 (en) * | 2010-12-28 | 2013-06-04 | Avon Products, Inc. | Method of treating skin with microRNA modulators |
| KR101914157B1 (ko) * | 2011-08-24 | 2018-12-31 | (주)아모레퍼시픽 | 녹차 성분을 함유하는 화장료 조성물 |
| WO2013083431A1 (en) * | 2011-12-06 | 2013-06-13 | Unilever Plc | Skin anti-ageing composition |
| WO2013089533A1 (ko) * | 2011-12-16 | 2013-06-20 | 주식회사 아모레퍼시픽 | 텐저레틴을 함유하는 피부 외용제 조성물 |
| KR102142311B1 (ko) * | 2011-12-16 | 2020-08-10 | (주)아모레퍼시픽 | 텐저레틴을 함유하는 피부 외용제 조성물 |
| DE102012210384A1 (de) * | 2012-06-20 | 2014-05-22 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitung enthaltend eine oder mehrere Substanz(en), die das Gen / Protein für den Rezeptor Endo180 modulieren |
| FR2997855B1 (fr) * | 2012-11-15 | 2015-02-13 | Rocher Yves Biolog Vegetale | Utilisation d'un extrait de saba senegalensis dans une composition cosmetique apaisante et/ou uniformisant la couleur de la peau |
| JP2015040230A (ja) * | 2013-08-20 | 2015-03-02 | 学校法人東京理科大学 | 抗酸化組成物およびこれを含む化粧品製剤 |
| US20160324764A1 (en) * | 2014-02-18 | 2016-11-10 | Micdermco, L.L.C. | Particle-Free Microdermabrasion Formulations |
| US9415243B2 (en) * | 2014-02-18 | 2016-08-16 | Micdermco, L.L.C. | Particle-free microdermabrasion formulations |
| JP2014240431A (ja) * | 2014-09-17 | 2014-12-25 | 富士フイルム株式会社 | 腸内有害菌低減剤、それを含む食品または医薬品 |
| KR101656682B1 (ko) * | 2015-06-01 | 2016-09-12 | (주)아모레퍼시픽 | (-)카테친, (-)에피카테친 갈레이트 및 (-)갈로카테친을 함유하는 피부 미용, 성형용, 및 당뇨병 예방 또는 치료용 조성물 |
| WO2017201596A1 (pt) * | 2016-05-24 | 2017-11-30 | Natura Cosméticos S.A. | Composição cosmética antissinais, sistema de composições e método para tratamento cosmético da pele |
| US10376566B2 (en) * | 2016-07-20 | 2019-08-13 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Composition and method for improving sleep duration and quality |
| KR102224355B1 (ko) | 2016-09-30 | 2021-03-09 | (주)아모레퍼시픽 | 극차광 재배 녹차 추출물을 함유하는 피부 외용제 조성물 |
| EP3682865A1 (en) * | 2019-01-15 | 2020-07-22 | Amorepacific Corporation | Composition for skin-whitening or preventing or improving skin wrinkles comprising green tea extract which has modified amounts of ingredients |
| FR3125426B1 (fr) * | 2021-07-22 | 2024-10-25 | Lvmh Rech | Utilisation cosmétique d’un extrait de thé noir en provenance de l’île Maurice |
| WO2023212371A2 (en) * | 2022-04-28 | 2023-11-02 | L'oreal | Compositions suitable as setters |
| WO2023208807A1 (en) * | 2022-04-28 | 2023-11-02 | L'oreal | Makeup composition comprising a polyphenol, a polyoxyalkylenated hydrocarbon-based compound and a monoalcohol, and processes using same |
| WO2023212375A1 (en) * | 2022-04-28 | 2023-11-02 | L'oreal | Compositions comprising a polyphenol and a nonionic compound y |
| FR3137571B1 (fr) * | 2022-07-05 | 2025-07-25 | Oreal | Compositions comprenant un polyphénol et un composé glycérolé |
| FR3137567B1 (fr) * | 2022-07-05 | 2025-05-02 | Oreal | Compositions d’émulsion comprenant un polyphénol et un composé non ionique a hlb faible |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5389677B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of treating wrinkles using glycalic acid |
| DE19824727A1 (de) * | 1998-06-03 | 1999-12-09 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Catechinen oder einem Gehalt an Extrakt von grünem Tee |
| GB9918028D0 (en) | 1999-07-30 | 1999-09-29 | Unilever Plc | Skin care composition |
| GB9918030D0 (en) * | 1999-07-30 | 1999-09-29 | Unilever Plc | Skin care composition |
| JP2001139484A (ja) * | 1999-11-16 | 2001-05-22 | Lion Corp | 皮膚外用剤 |
| FI20000004A0 (fi) * | 2000-01-03 | 2000-01-03 | Slk Foundation | Flavonoidilääke... |
| US6248341B1 (en) * | 2000-01-14 | 2001-06-19 | Color Access, Inc. | Method of treating topical angiogenesis-related disorders |
| JP2002265359A (ja) * | 2001-03-07 | 2002-09-18 | Ito En Ltd | カイニン酸型グルタミン酸受容体遮蔽剤、ａｍｐａ型グルタミン酸受容体遮蔽剤、脳保護剤及び脳保護機能を備えた飲食物 |
| JP2002293736A (ja) * | 2001-03-30 | 2002-10-09 | Sunstar Inc | メーラード反応阻害剤およびそれを含有する組成物 |
| KR100439627B1 (ko) | 2001-06-18 | 2004-07-12 | 주식회사 엘지생활건강 | 피부주름 예방 및 치료용 조성물 |
| JP2003137727A (ja) * | 2001-11-01 | 2003-05-14 | Noevir Co Ltd | 皮膚外用剤 |
| US7314634B2 (en) * | 2002-02-22 | 2008-01-01 | Steven Hernandez | Use of polyphenols to treat skin conditions |
| JP2003252745A (ja) * | 2002-02-28 | 2003-09-10 | Shiseido Co Ltd | マトリックスメタロプロテアーゼ（ＭＭＰｓ）阻害剤 |
| JP2003300824A (ja) * | 2002-04-09 | 2003-10-21 | Inabata Koryo Kk | 老化防止用皮膚外用剤 |
| US20030229030A1 (en) * | 2002-06-11 | 2003-12-11 | Theoharides Theoharis C. | Method of treating interleukin-6-mediated inflammatory diseases |
| US20040180102A1 (en) * | 2002-07-31 | 2004-09-16 | Procyte Corporation | Compositions containing peptide copper complexes and phytochemical compounds, and methods related thereto |
| JP2004067551A (ja) * | 2002-08-05 | 2004-03-04 | Naris Cosmetics Co Ltd | コラーゲン産生促進剤、及びこれを含有する老化防止用皮膚外用剤 |
| JP3926711B2 (ja) * | 2002-08-30 | 2007-06-06 | 株式会社ファンケル | 表皮の偏平化を予防、防止、改善する皮膚老化防止用組成物 |
| US7270840B2 (en) * | 2002-11-22 | 2007-09-18 | New Sun Nutrition Llc | Antioxidative compositions |
| JP4109564B2 (ja) | 2003-03-24 | 2008-07-02 | 株式会社コーセー | 皮膚障害抑制剤、皮膚障害改善剤並びにそれらを含有する皮膚外用剤 |
| JP2006524236A (ja) * | 2003-04-24 | 2006-10-26 | アモレパシフィック コーポレーション | スリミング用組成物 |
| KR100955236B1 (ko) | 2003-06-25 | 2010-04-29 | (주)아모레퍼시픽 | 데아닌의 경피흡수 촉진 방법 및 이를 함유하는피부외용제 조성물 |
| KR101172058B1 (ko) | 2004-04-14 | 2012-08-10 | (주)아모레퍼시픽 | 피부주름 개선 및 탄력 증진용 피부 외용제 조성물 |
| US7351745B2 (en) * | 2004-12-22 | 2008-04-01 | Avon Products, Inc | Compositions and methods of their use for improving the condition and appearance of skin |
-
2006
- 2006-09-08 JP JP2008529922A patent/JP5192380B2/ja not_active Expired - Fee Related
- 2006-09-08 WO PCT/KR2006/003571 patent/WO2007029982A1/en not_active Ceased
- 2006-09-08 US US12/064,887 patent/US20090012155A1/en not_active Abandoned
-
2016
- 2016-03-02 US US15/058,681 patent/US10092493B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11938163B2 (en) | 2020-06-09 | 2024-03-26 | Amorepacific Corporation | Composition for improving respiratory health continuously exposed to particulate matter atmosphere |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007029982A1 (en) | 2007-03-15 |
| US10092493B2 (en) | 2018-10-09 |
| JP2009507826A (ja) | 2009-02-26 |
| US20160175217A1 (en) | 2016-06-23 |
| US20090012155A1 (en) | 2009-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5192380B2 (ja) | 皮膚老化防止用皮膚外用剤組成物 | |
| US10849840B2 (en) | Compositions and methods for stimulation MAGP-1 to improve the appearance of skin | |
| CN113874044B (zh) | 皮肤组合物 | |
| KR101517950B1 (ko) | 철갑상어로부터 수득한 점액을 함유하는 화장료 조성물 | |
| CN103989589A (zh) | 含有香豆雌酚或包含香豆雌酚的豆提取物的、用于皮肤护理的化妆品组合物 | |
| CN102370591A (zh) | 石榴皮提取方法及其提取物的应用 | |
| JP2018538256A (ja) | Ｐａｌｍａｒｉａ ｐａｌｍａｔａとジャスミンとの相乗作用的抽出物、それを含む組成物およびそれらの使用 | |
| KR20140012456A (ko) | 아케비아 사포닌-디를 포함하는 피부 상태 개선용 조성물 | |
| KR20170141432A (ko) | 알파-망고스틴, 베타-망고스틴, 감마-망고스틴 또는 가르탄닌 화합물을 유효성분으로 함유하는 피부 주름 개선 또는 피부 보습용 조성물 | |
| US20090170788A1 (en) | Novel use of 1, 2, 3, 4, 6-penta-o-galloyl-beta-d-glucose | |
| JP2012162487A (ja) | 美白剤、抗老化剤及び皮膚化粧料 | |
| AU2021275500B2 (en) | Protein hydrolysate of Moringa Peregrina Seed Cake for Its Application as a Medicament, Process for Obtaining Same and Pharmaceutical and Dermatological Compositions | |
| EP4003282B1 (en) | Treatment of aging or uv-damaged skin | |
| KR20140079571A (ko) | 얌빈 추출물을 이용한 피부 외용제 조성물 | |
| US20240091294A1 (en) | Extract of Top Growth of Holy Basil, and Cosmetic or Dermatological Compositions Containing Same | |
| KR20180108255A (ko) | 파리신 비를 포함하는 화장료 조성물 | |
| KR20090052096A (ko) | 이끼 추출물 또는 그 유효 성분인 뎁시돈 또는 뎁시돈유도체를 함유하는 항노화 피부 외용제 조성물 | |
| KR101219296B1 (ko) | 표피-진피 경계부 보호용 피부 외용제 조성물 | |
| TWI865434B (zh) | 感覺刺激低減劑之評估或選擇方法 | |
| KR20070091964A (ko) | 퍼옥시좀 증식체 활성화 수용체 알파 활성화용 피부 외용제조성물 | |
| KR102083405B1 (ko) | 스티풀레아노사이드 r1을 유효성분으로 함유하는 피부 노화 방지 및 주름 개선용 조성물 | |
| KR102109829B1 (ko) | 화장료 조성물 | |
| KR20180108254A (ko) | 파리신 a를 포함하는 화장료 조성물 | |
| KR20190020361A (ko) | 헤파리노이드를 포함하는 피부 노화방지 또는 주름개선용 화장료 조성물 및 약학 조성물 | |
| FR3019988A1 (fr) | Utilisation cosmetique d'un extrait de chicorium intybus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090713 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20120125 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120228 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120528 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20120528 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130115 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130131 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5192380 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160208 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |