JP5144532B2 - ｃ−Ｍｅｔ阻害剤及び用法 - Google Patents

ｃ−Ｍｅｔ阻害剤及び用法 Download PDF

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Publication number
JP5144532B2
JP5144532B2 JP2008543461A JP2008543461A JP5144532B2 JP 5144532 B2 JP5144532 B2 JP 5144532B2 JP 2008543461 A JP2008543461 A JP 2008543461A JP 2008543461 A JP2008543461 A JP 2008543461A JP 5144532 B2 JP5144532 B2 JP 5144532B2
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aliphatic
compound
ring
optionally substituted
substituted
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JP2008543461A
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Japanese (ja)
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JP2009518296A (ja
JP2009518296A5 (https=
Inventor
デイビッド ラウファー，
アレクサンダー アロノブ，
パン リー，
デイビッド デニンジャー，
キラ マギンティ，
ディーン スタモス，
ジョン カム，
ミシェル スチュワート，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2008543461A 2005-11-30 2006-11-30 ｃ−Ｍｅｔ阻害剤及び用法 Expired - Fee Related JP5144532B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US74085905P 2005-11-30 2005-11-30
US74074105P 2005-11-30 2005-11-30
US74073705P 2005-11-30 2005-11-30
US60/740,741 2005-11-30
US60/740,859 2005-11-30
US60/740,737 2005-11-30
PCT/US2006/045847 WO2007064797A2 (en) 2005-11-30 2006-11-30 Inhibitors of c-met and uses thereof

Publications (3)

Publication Number Publication Date
JP2009518296A JP2009518296A (ja) 2009-05-07
JP2009518296A5 JP2009518296A5 (https=) 2012-11-22
JP5144532B2 true JP5144532B2 (ja) 2013-02-13

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JP2008543461A Expired - Fee Related JP5144532B2 (ja) 2005-11-30 2006-11-30 ｃ−Ｍｅｔ阻害剤及び用法

Country Status (12)

Country Link
US (2) US7728017B2 (https=)
EP (1) EP1963329B1 (https=)
JP (1) JP5144532B2 (https=)
KR (1) KR20080080584A (https=)
AU (1) AU2006320580B2 (https=)
BR (1) BRPI0619252A2 (https=)
CA (1) CA2630884A1 (https=)
IL (1) IL191623A0 (https=)
MX (1) MX2008007049A (https=)
NO (1) NO20082880L (https=)
NZ (1) NZ568666A (https=)
WO (1) WO2007064797A2 (https=)

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TR202010296A1 (tr) 2020-06-30 2022-01-21 Anadolu Ueniversitesi Akt inhibisyonu aracılığıyla a549 hücrelerinde sitotoksik ve apoptotik etki gösteren yeni triazol ve triazolotiyadiazin türevleri
JP2024506858A (ja) 2021-02-02 2024-02-15 リミナル・バイオサイエンシーズ・リミテッド Ｇｐｒ８４アンタゴニストおよびその使用
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US7728017B2 (en) 2010-06-01
CA2630884A1 (en) 2007-06-07
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US7998987B2 (en) 2011-08-16
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KR20080080584A (ko) 2008-09-04
MX2008007049A (es) 2008-10-23
NZ568666A (en) 2011-09-30
EP1963329A2 (en) 2008-09-03
US20100190774A1 (en) 2010-07-29
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