FR2929613B1 - Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole,leur preparation,comme medicaments et utilisation notamment comme inhibiteurs de met - Google Patents

Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole,leur preparation,comme medicaments et utilisation notamment comme inhibiteurs de met

Info

Publication number
FR2929613B1
FR2929613B1 FR0801819A FR0801819A FR2929613B1 FR 2929613 B1 FR2929613 B1 FR 2929613B1 FR 0801819 A FR0801819 A FR 0801819A FR 0801819 A FR0801819 A FR 0801819A FR 2929613 B1 FR2929613 B1 FR 2929613B1
Authority
FR
France
Prior art keywords
triazolopyridazine
medicaments
novel
preparation
benzimidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0801819A
Other languages
English (en)
Other versions
FR2929613A1 (fr
Inventor
Conception Nemecek
Sylvie Wentzler
Antonio Ugolini
Eric Bacque
Eva Albert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0801819A priority Critical patent/FR2929613B1/fr
Priority to PA8792501A priority patent/PA8792501A1/es
Priority to KR1020107005087A priority patent/KR101654376B1/ko
Priority to UAA201002523A priority patent/UA101328C2/uk
Priority to BRPI0815606 priority patent/BRPI0815606A2/pt
Priority to PL08845285T priority patent/PL2178881T3/pl
Priority to EA201070235A priority patent/EA023465B1/ru
Priority to CN200880106250.6A priority patent/CN101801973B/zh
Priority to SG2012055091A priority patent/SG183077A1/en
Priority to ES08845285T priority patent/ES2436657T3/es
Priority to JP2010519489A priority patent/JP5694767B2/ja
Priority to NZ583177A priority patent/NZ583177A/en
Priority to MEP-2010-7A priority patent/ME00972B/me
Priority to RSP20130542 priority patent/RS53078B/en
Priority to SI200831106T priority patent/SI2178881T1/sl
Priority to DK08845285T priority patent/DK2178881T3/da
Priority to CA2884102A priority patent/CA2884102A1/fr
Priority to PT08845285T priority patent/PT2178881E/pt
Priority to MX2010001593A priority patent/MX2010001593A/es
Priority to MX2014000226A priority patent/MX340060B/es
Priority to CA2695628A priority patent/CA2695628C/fr
Priority to MYPI2010000582A priority patent/MY152535A/en
Priority to EP08845285.9A priority patent/EP2178881B1/fr
Priority to AU2008320791A priority patent/AU2008320791B2/en
Priority to PCT/FR2008/001172 priority patent/WO2009056692A2/fr
Priority to JO2008361A priority patent/JO2935B1/en
Priority to TW97130120A priority patent/TWI429649B/zh
Priority to PE2008001322A priority patent/PE20090900A1/es
Priority to ARP080103452 priority patent/AR068055A1/es
Priority to UY31277A priority patent/UY31277A1/es
Priority to CL2008002351A priority patent/CL2008002351A1/es
Publication of FR2929613A1 publication Critical patent/FR2929613A1/fr
Priority to TNP2010000026A priority patent/TN2010000026A1/fr
Priority to US12/693,736 priority patent/US8546393B2/en
Priority to DO2010000040A priority patent/DOP2010000040A/es
Priority to GT201000023A priority patent/GT201000023A/es
Priority to CO10009506A priority patent/CO6251270A2/es
Priority to CR11252A priority patent/CR11252A/es
Priority to NI201000022A priority patent/NI201000022A/es
Priority to IL20373410A priority patent/IL203734A/en
Priority to ZA2010/00912A priority patent/ZA201000912B/en
Priority to ECSP109944 priority patent/ECSP109944A/es
Priority to MA32659A priority patent/MA31685B1/fr
Application granted granted Critical
Publication of FR2929613B1 publication Critical patent/FR2929613B1/fr
Priority to US14/011,110 priority patent/US9115134B2/en
Priority to HRP20131182AT priority patent/HRP20131182T1/hr
Priority to CY20131101130T priority patent/CY1114906T1/el
Priority to US14/731,246 priority patent/US9321777B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0801819A 2007-08-09 2008-04-02 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole,leur preparation,comme medicaments et utilisation notamment comme inhibiteurs de met Expired - Fee Related FR2929613B1 (fr)

Priority Applications (46)

Application Number Priority Date Filing Date Title
FR0801819A FR2929613B1 (fr) 2008-04-02 2008-04-02 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole,leur preparation,comme medicaments et utilisation notamment comme inhibiteurs de met
PA8792501A PA8792501A1 (es) 2007-08-09 2008-08-05 Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.
KR1020107005087A KR101654376B1 (ko) 2007-08-09 2008-08-06 신규 6-트리아졸로피리다진술파닐 벤조티아졸 및 벤즈이미다졸 유도체, 이들의 제조 방법, 의약 및 제약 조성물로서의 용도, 및 ｍｅｔ 억제제로서의 신규 용도
UAA201002523A UA101328C2 (uk) 2007-08-09 2008-08-06 Похідні 6-триазолпіридинсульфанілбензотіазолу і -бензімідазолу, спосіб їх одержання (варіанти), застосування їх як лікарських засобів, фармацевтична композиціїя та застосування як інгібіторів met
BRPI0815606 BRPI0815606A2 (pt) 2007-08-09 2008-08-06 Derivados de 6-triazol piridazina - sulfanil benzotiazol e benzimidazol, o respectivo processo de preparo, a respectiva aplicação a título de medicamentos, composições farmacêuticas e utilização, notadamente como inibidores de met.
PL08845285T PL2178881T3 (pl) 2007-08-09 2008-08-06 Nowe pochodne 6-triazolopirydazynosulfanylobenzotiazolu i benzimidazolu, sposób ich wytwarzania, ich zastosowanie jako leków, kompozycje farmaceutyczne i nowe zastosowanie zwłaszcza jako inhibitorów MET
EA201070235A EA023465B1 (ru) 2007-08-09 2008-08-06 Новые производные 6-триазолпиридинсульфанил-бензотиазола или -бензимидазола, способ их получения, применение их в качестве лекарственных средств, фармацевтические композиции и новое применение в качестве ингибиторов мет
CN200880106250.6A CN101801973B (zh) 2007-08-09 2008-08-06 6-三唑并哒嗪硫基苯并噻唑和苯并咪唑衍生物、其制备方法和作为药物和药物组合物的应用和作为met抑制剂的用途
SG2012055091A SG183077A1 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
ES08845285T ES2436657T3 (es) 2007-08-09 2008-08-06 Nuevos derivados de 6-triazolopiridazin-sulfanil benzotiazol y bencimidazol, su procedimiento de preparación, su aplicación como medicamentos, composiciones farmacéuticas y nueva utilización como inhibidores de Met
JP2010519489A JP5694767B2 (ja) 2007-08-09 2008-08-06 新規な６−トリアゾロピリダジンスルファニルベンゾチアゾールおよびベンゾイミダゾールの誘導体、これらの製造方法、薬剤および医薬組成物としての適用ならびにｍｅｔ阻害剤としての新規な使用
NZ583177A NZ583177A (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
MEP-2010-7A ME00972B (me) 2007-08-09 2008-08-06 NOVI DERIVATI 6-TRIAZOLOPIRIDAZINSULFANIL BENZOTIAZOLA I BENZIMIDAZOLA, POSTUPAK ZA NJIHOVO DOBIJANJE l UPOTREBA KAO LJEKOVA l FARMACEUTSKIH KOMPOZICIJA l NOVA UPOTREBA KAO INHIBITORA MET-a
RSP20130542 RS53078B (en) 2007-08-09 2008-08-06 NEW 6-TRIAZOLOPYRIDASINSULPHANYL BENZOTHIAZOLE AND BENZIMIDAZOL DERIVATIVES, A PROCEDURE FOR THEIR PRODUCTION AND USE AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS AND NEW USE AS MET INHIBITORS
SI200831106T SI2178881T1 (sl) 2007-08-09 2008-08-06 Novi derivati 6-triazolopiridazin-sulfanil benzotiazola in benzimidazola, postopek za njihovo pripravo, njihova uporaba kot zdravila, farmacevtski sestavki in nova uporaba, zlasti kot Met inhibitorji
DK08845285T DK2178881T3 (da) 2007-08-09 2008-08-06 Hidtil ukendte 6-triazolopyridazin-sulfanyl-benzothiazol- og -benzimidazolderivater, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemidler og farmaceutiske sammensætninger og hidtil ukendt anvendelse som met-hæmmere
CA2884102A CA2884102A1 (fr) 2007-08-09 2008-08-06 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
PT08845285T PT2178881E (pt) 2007-08-09 2008-08-06 Novos derivados de 6-triazolopiridazina-sulfanil benzotiazole e benzimidazole, seu método de preparação, sua aplicação como medicamentos, composições farmacêuticas e nova utilização como inibidores de met
MX2010001593A MX2010001593A (es) 2007-08-09 2008-08-06 Nuevos derivados de 6-triazolopiridazina-sulfanil benzotiazol y bencimidazol, su proceso de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nuevo uso principalmente como inhibidores de met.
MX2014000226A MX340060B (es) 2007-08-09 2008-08-06 Nuevos derivados de 6-triazolopiridazina-sulfanil benzotiazol y bencimidazol, su proceso de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nuevo uso principalmente como inhibidores de met.
CA2695628A CA2695628C (fr) 2007-08-09 2008-08-06 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
MYPI2010000582A MY152535A (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
EP08845285.9A EP2178881B1 (fr) 2007-08-09 2008-08-06 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
AU2008320791A AU2008320791B2 (en) 2007-08-09 2008-08-06 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as MET inhibitors
PCT/FR2008/001172 WO2009056692A2 (fr) 2007-08-09 2008-08-06 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
JO2008361A JO2935B1 (en) 2007-08-09 2008-08-07 6- Tertiary azulo pyridazine sulfanil benzothiazole and benzimidazole derivatives, method of preparation, use as pharmaceutical products, pharmaceutical compositions and new use in particular as met inhibitors (methionine)
TW97130120A TWI429649B (zh) 2007-08-09 2008-08-07 新穎６－三唑并嗒硫烷基苯并噻唑及苯并咪唑衍生物，其製備方法，其作為醫藥品之用途，醫藥組合物及尤其是作為ｍｅｔ抑制劑之新穎用途
PE2008001322A PE20090900A1 (es) 2007-08-09 2008-08-07 Derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol como inhibidores del receptor del factor de creciemiento de hepatocitos (met), su procedimiento de preparacion y una composicion farmaceutica que los contiene
ARP080103452 AR068055A1 (es) 2007-08-09 2008-08-07 Derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol su procedimiento de preparacion su aplicacion como medicamentos composiciones farmaceuticas y su utilizacion principalmente como inhibidores de met
UY31277A UY31277A1 (es) 2007-08-09 2008-08-08 Nuevos derivados de 6-triazolopiridacina -sulfanil benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmacéuticas y nueva utilizacion principalmente como inhibidores de met
CL2008002351A CL2008002351A1 (es) 2007-08-09 2008-08-08 Compuestos derivados de 6-triazolopiridazina-sulfanil benzotiazol y bencimidazol; procedimiento de preparacion; compuestos intermediarios; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento del cancer.
TNP2010000026A TN2010000026A1 (fr) 2007-08-09 2010-01-13 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
US12/693,736 US8546393B2 (en) 2007-08-09 2010-01-26 6-triazolopyridazine sulfanyl benzothiazole derivatives as MET inhibitors
DO2010000040A DOP2010000040A (es) 2007-08-09 2010-01-28 Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol, su procedimiento de preparación, su aplicación como medicamentos, composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met
GT201000023A GT201000023A (es) 2007-08-09 2010-01-28 Nuevos derivados de 6-trialzolopiridacina-sulfanil benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion principalmente como inhibidores de met.
CO10009506A CO6251270A2 (es) 2007-08-09 2010-01-29 Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol su procedimiento de preparacion su aplicacion como medicamentos composiciones farmaceuticas y nueva utilizacion principalmente como inhibidores de met
CR11252A CR11252A (es) 2007-08-09 2010-02-03 Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion principalmente como inhibidores de met
NI201000022A NI201000022A (es) 2007-08-09 2010-02-03 Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol, su procedimiento de preparación, su aplicación como medicamentos, composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.
IL20373410A IL203734A (en) 2007-08-09 2010-02-04 Annotations of 6 - Triazolopyridazinesulfonyl Benzothiazole and Benzimidazole, a Method for their Preparation and Use as Medicines and Preparations
ZA2010/00912A ZA201000912B (en) 2007-08-09 2010-02-08 Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives,method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors
ECSP109944 ECSP109944A (es) 2007-08-09 2010-02-08 Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol, su procedimiento de preparación, su aplicación como medicamentos, composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met
MA32659A MA31685B1 (fr) 2007-08-09 2010-03-01 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
US14/011,110 US9115134B2 (en) 2007-08-09 2013-08-27 6-triazolopyridazine sulfanyl benzothiazole derivatives as MET inhibitors
HRP20131182AT HRP20131182T1 (hr) 2007-08-09 2013-12-12 Novi derivati 6-triazolopiridazinsulfanilbenzotiazola i -benzimidazola, postupak njihovog dobivanja i primjena kao medikamenata i farmaceutskih pripravaka, te nova upotreba kao inhibitora met
CY20131101130T CY1114906T1 (el) 2007-08-09 2013-12-13 Νεα παραγωγα 6-τριαζολοπυριδαζινο-σουλφανυλο βενζοθειαζολης και βενζιμιδαζολης, η διαδικασια της παρασκευης τους, η εφαρμογη τους ως φαρμακα, φαρμακευτικες συνθεσεις και νεα χρηση κυριως ως αναστολεις του μετ
US14/731,246 US9321777B2 (en) 2007-08-09 2015-06-04 6-triazolopyridazine sulfanyl benzothiazole derivatives as MET inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0801819A FR2929613B1 (fr) 2008-04-02 2008-04-02 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole,leur preparation,comme medicaments et utilisation notamment comme inhibiteurs de met

Publications (2)

Publication Number Publication Date
FR2929613A1 FR2929613A1 (fr) 2009-10-09
FR2929613B1 true FR2929613B1 (fr) 2010-12-31

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FR0801819A Expired - Fee Related FR2929613B1 (fr) 2007-08-09 2008-04-02 Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole,leur preparation,comme medicaments et utilisation notamment comme inhibiteurs de met

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FR (1) FR2929613B1 (fr)

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WO2007064797A2 (fr) * 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibiteurs de c-met et leurs utilisations
KR101412675B1 (ko) * 2005-12-21 2014-07-03 얀센 파마슈티카 엔.브이. 티로신 키나제 모듈레이터로서의 트리아졸로피리다진

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