JP5124464B2 - ２−［［６−［（３ｒ）−３−アミノ−１−ピペリジニル］−３，４−ジヒドロ−３−メチル−２，４−ジオキソ−１（２ｈ）−ピリミジニル］メチル］−ベンゾニトリルの安息香酸塩の多形及びそれらの使用方法 - Google Patents
２−［［６−［（３ｒ）−３−アミノ−１−ピペリジニル］−３，４−ジヒドロ−３−メチル−２，４−ジオキソ−１（２ｈ）−ピリミジニル］メチル］−ベンゾニトリルの安息香酸塩の多形及びそれらの使用方法 Download PDFInfo
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- JP5124464B2 JP5124464B2 JP2008531290A JP2008531290A JP5124464B2 JP 5124464 B2 JP5124464 B2 JP 5124464B2 JP 2008531290 A JP2008531290 A JP 2008531290A JP 2008531290 A JP2008531290 A JP 2008531290A JP 5124464 B2 JP5124464 B2 JP 5124464B2
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
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Applications Claiming Priority (3)
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| US71813305P | 2005-09-16 | 2005-09-16 | |
| US60/718,133 | 2005-09-16 | ||
| PCT/US2006/035701 WO2007035372A2 (en) | 2005-09-16 | 2006-09-13 | Polymorphs of benzoate salt of 2-[[6-[(3r)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2h)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
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| JP2009514798A JP2009514798A (ja) | 2009-04-09 |
| JP2009514798A5 JP2009514798A5 (OSRAM) | 2009-11-05 |
| JP5124464B2 true JP5124464B2 (ja) | 2013-01-23 |
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| WO (1) | WO2007035372A2 (OSRAM) |
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| US7550590B2 (en) | 2003-03-25 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005016911A1 (en) * | 2003-08-13 | 2005-02-24 | Takeda Pharmaceutical Company Limited | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
| EP1699777B1 (en) * | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| JP2007513058A (ja) * | 2003-09-08 | 2007-05-24 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
| UA85871C2 (uk) | 2004-03-15 | 2009-03-10 | Такеда Фармасьютікал Компані Лімітед | Інгібітори дипептидилпептидази |
| US7931661B2 (en) * | 2004-06-14 | 2011-04-26 | Usgi Medical, Inc. | Apparatus and methods for performing transluminal gastrointestinal procedures |
| JP2008524331A (ja) | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
| WO2007033350A1 (en) | 2005-09-14 | 2007-03-22 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
| EP1924567B1 (en) * | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| JP2009531456A (ja) * | 2006-03-28 | 2009-09-03 | 武田薬品工業株式会社 | （ｒ）−３−アミノピペリジン二塩酸塩の調製 |
| TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| MY147596A (en) | 2007-02-01 | 2012-12-31 | Takeda Pharmaceutical | Solid preparation comprising alogliptin and pioglitazone |
| JP5284967B2 (ja) * | 2007-02-01 | 2013-09-11 | 武田薬品工業株式会社 | 打錠障害を生じない錠剤製剤 |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| TWI421102B (zh) * | 2007-07-19 | 2014-01-01 | Takeda Pharmaceutical | 固態製劑 |
| PE20090938A1 (es) | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR101657960B1 (ko) | 2008-08-15 | 2016-09-20 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｆａｂ-관련 질환의 치료에 사용하기 위한 푸린 유도체 |
| ES2671069T3 (es) | 2008-12-23 | 2018-06-04 | Sandoz Ag | Forma cristalina de la alogliptina |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| AR075204A1 (es) | 2009-01-29 | 2011-03-16 | Boehringer Ingelheim Int | Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2 |
| LT2395983T (lt) | 2009-02-13 | 2020-07-10 | Boehringer Ingelheim International Gmbh | Farmacinė kompozicija, apimanti sglt2 inhibitorių, dpp-iv inhibitorių ir, pasirinktinai, papildomą priešdiabetinį agentą, bei jos panaudojimas |
| NZ594044A (en) | 2009-02-13 | 2014-08-29 | Boehringer Ingelheim Int | Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics |
| CN102361557A (zh) | 2009-03-26 | 2012-02-22 | Mapi医药公司 | 制备阿格列汀的方法 |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| EA034869B1 (ru) | 2009-11-27 | 2020-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин |
| JP2013522279A (ja) | 2010-03-18 | 2013-06-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病及び関連状態の治療で用いるｇｐｒ１１９作動薬とｄｄｐ−ｉｖ阻害薬リナグリプチンの組合せ |
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| KR101819609B1 (ko) | 2010-05-05 | 2018-01-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법 |
| MX2012013069A (es) * | 2010-05-12 | 2013-01-24 | Mapi Pharma Ltd | Polimorfos de benzoato de alogliptina. |
| KR20230051307A (ko) | 2010-06-24 | 2023-04-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
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| WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012145603A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
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-
2006
- 2006-08-31 TW TW095132161A patent/TW200745079A/zh unknown
- 2006-09-13 EP EP06803516A patent/EP1934198B1/en active Active
- 2006-09-13 KR KR1020087007908A patent/KR20080056183A/ko not_active Withdrawn
- 2006-09-13 WO PCT/US2006/035701 patent/WO2007035372A2/en not_active Ceased
- 2006-09-13 US US11/531,595 patent/US20070066635A1/en not_active Abandoned
- 2006-09-13 AU AU2006292637A patent/AU2006292637A1/en not_active Abandoned
- 2006-09-13 CN CNA200680043022XA patent/CN101360735A/zh active Pending
- 2006-09-13 ZA ZA200802856A patent/ZA200802856B/xx unknown
- 2006-09-13 BR BRPI0616215-0A patent/BRPI0616215A2/pt not_active IP Right Cessation
- 2006-09-13 AT AT06803516T patent/ATE518851T1/de not_active IP Right Cessation
- 2006-09-13 CA CA002622698A patent/CA2622698A1/en not_active Abandoned
- 2006-09-13 GE GEAP200610610A patent/GEP20115171B/en unknown
- 2006-09-13 NZ NZ566798A patent/NZ566798A/en unknown
- 2006-09-13 EA EA200800728A patent/EA015359B1/ru not_active IP Right Cessation
- 2006-09-13 JP JP2008531290A patent/JP5124464B2/ja not_active Expired - Fee Related
- 2006-09-15 AR ARP060104064A patent/AR056518A1/es not_active Application Discontinuation
- 2006-09-15 PE PE2006001122A patent/PE20070766A1/es not_active Application Discontinuation
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2008
- 2008-03-13 IL IL190170A patent/IL190170A0/en unknown
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- 2008-03-31 NO NO20081581A patent/NO20081581L/no not_active Application Discontinuation
- 2008-04-11 CR CR9881A patent/CR9881A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CR9881A (es) | 2008-07-29 |
| JP2009514798A (ja) | 2009-04-09 |
| PE20070766A1 (es) | 2007-09-22 |
| MA29800B1 (fr) | 2008-09-01 |
| CA2622698A1 (en) | 2007-03-29 |
| CN101360735A (zh) | 2009-02-04 |
| EP1934198A2 (en) | 2008-06-25 |
| ATE518851T1 (de) | 2011-08-15 |
| WO2007035372A3 (en) | 2007-06-14 |
| EA015359B1 (ru) | 2011-06-30 |
| TW200745079A (en) | 2007-12-16 |
| AR056518A1 (es) | 2007-10-10 |
| WO2007035372A2 (en) | 2007-03-29 |
| IL190170A0 (en) | 2008-08-07 |
| GEP20115171B (en) | 2011-03-10 |
| US20070066635A1 (en) | 2007-03-22 |
| EP1934198B1 (en) | 2011-08-03 |
| NO20081581L (no) | 2008-05-23 |
| EA200800728A1 (ru) | 2008-12-30 |
| BRPI0616215A2 (pt) | 2011-06-14 |
| NZ566798A (en) | 2011-03-31 |
| ZA200802856B (en) | 2009-09-30 |
| AU2006292637A1 (en) | 2007-03-29 |
| KR20080056183A (ko) | 2008-06-20 |
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