JP5060478B2 - Ｒｈｏ−キナーゼ阻害剤としてのピペリジニル置換されたイソキノロン誘導体 - Google Patents

Ｒｈｏ−キナーゼ阻害剤としてのピペリジニル置換されたイソキノロン誘導体 Download PDF

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JP5060478B2
JP5060478B2 JP2008523188A JP2008523188A JP5060478B2 JP 5060478 B2 JP5060478 B2 JP 5060478B2 JP 2008523188 A JP2008523188 A JP 2008523188A JP 2008523188 A JP2008523188 A JP 2008523188A JP 5060478 B2 JP5060478 B2 JP 5060478B2
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alkyl
alkylene
aryl
halogen
heterocyclyl
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JP2009502829A (ja
JP2009502829A5 (enExample
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オリヴァー・プレッテンブルク
アーミン・ホーフマイスター
ディーター・カーデライト
ヨーアヒム・ブレンデル
マティーアス・レーン
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
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  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
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JP2008523188A 2005-07-26 2006-07-20 Ｒｈｏ−キナーゼ阻害剤としてのピペリジニル置換されたイソキノロン誘導体 Expired - Lifetime JP5060478B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05016154.6 2005-07-26
EP05016154 2005-07-26
PCT/EP2006/007139 WO2007012421A1 (en) 2005-07-26 2006-07-20 Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2009502829A JP2009502829A (ja) 2009-01-29
JP2009502829A5 JP2009502829A5 (enExample) 2009-09-03
JP5060478B2 true JP5060478B2 (ja) 2012-10-31

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JP2008523188A Expired - Lifetime JP5060478B2 (ja) 2005-07-26 2006-07-20 Ｒｈｏ−キナーゼ阻害剤としてのピペリジニル置換されたイソキノロン誘導体

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Country Link
US (1) US8188117B2 (enExample)
EP (2) EP2385047B1 (enExample)
JP (1) JP5060478B2 (enExample)
KR (1) KR101373535B1 (enExample)
CN (1) CN101228149B (enExample)
AR (1) AR054868A1 (enExample)
AU (1) AU2006274245B2 (enExample)
BR (1) BRPI0613861B8 (enExample)
CA (1) CA2615577C (enExample)
CR (1) CR9603A (enExample)
DK (1) DK1910333T3 (enExample)
DO (1) DOP2006000178A (enExample)
EC (1) ECSP088135A (enExample)
ES (1) ES2423006T3 (enExample)
GT (1) GT200600328A (enExample)
IL (1) IL188702A (enExample)
MA (1) MA29636B1 (enExample)
MX (1) MX2008001053A (enExample)
MY (1) MY148479A (enExample)
NI (1) NI200800025A (enExample)
NO (1) NO341888B1 (enExample)
NZ (1) NZ565668A (enExample)
PE (1) PE20070217A1 (enExample)
PT (1) PT1910333E (enExample)
RU (1) RU2414467C2 (enExample)
TN (1) TNSN08039A1 (enExample)
TW (1) TWI383979B (enExample)
UA (1) UA93882C2 (enExample)
UY (1) UY29697A1 (enExample)
WO (1) WO2007012421A1 (enExample)
ZA (1) ZA200710951B (enExample)

Cited By (1)

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JP2010516682A (ja) * 2007-01-22 2010-05-20 ジーティーエックス・インコーポレイテッド 核内受容体結合剤

Families Citing this family (38)

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EP1899322B1 (en) 2005-06-28 2009-09-02 Sanofi-Aventis Isoquinoline derivatives as inhibitors of rho-kinase
HRP20110839T1 (hr) 2005-07-26 2011-12-31 Sanofi Derivati cikloheksaminizokinolona kao inhibitori rho-kinaze
TW200738682A (en) * 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives
EP2066640B1 (en) * 2006-09-11 2011-09-07 N.V. Organon 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives
AU2007338410B2 (en) 2006-12-27 2012-08-16 Sanofi-Aventis Cycloalkylamine substituted isoquinoline derivatives
CN101595094B (zh) 2006-12-27 2013-02-20 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮衍生物
KR20090094338A (ko) 2006-12-27 2009-09-04 사노피-아벤티스 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
ATE502027T1 (de) 2006-12-27 2011-04-15 Sanofi Aventis Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren
JP5421783B2 (ja) 2006-12-27 2014-02-19 サノフイ Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体
EP2102164B1 (en) 2006-12-27 2010-12-01 Sanofi-Aventis Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
KR20100103646A (ko) * 2007-12-26 2010-09-27 사노피-아벤티스 ６­치환된­１­（２ｈ）­이소퀴놀리논의 제조 방법
SI2303845T1 (sl) 2008-06-24 2013-12-31 Sanofi Bi- in policiklični substituirani izokinolin in izokinolinski derivati kot inhibitorji rho-kinaze
PL2313374T3 (pl) 2008-06-24 2014-03-31 Sanofi Sa 6-podstawione izochinoliny i izochinolinony
PE20110059A1 (es) 2008-06-24 2011-02-15 Sanofi Aventis Isoquinolinas e isoquinolinonas sustituidas en calidad de inhibidores de la rho-quinasa
US9865233B2 (en) 2008-12-30 2018-01-09 Intel Corporation Hybrid graphics display power management
CN102666540A (zh) * 2009-10-13 2012-09-12 Msd欧斯股份有限公司 用于治疗乙酰胆碱受体相关疾病的稠合吖嗪衍生物
BR112014000267A2 (pt) * 2011-07-04 2016-09-20 Bayer Ip Gmbh utilização de isoquinolinonas, isoquinolinedionas, isoquinolinetrionas e dihidroisoquinolinonas substituídas ou, em cada caso, sais das mesmas como agentes ativos contra o stress abiótico em plantas
DK2729460T3 (en) * 2011-07-08 2016-04-18 Sanofi Sa Crystalline solvates of 6- (piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride
HRP20160358T1 (hr) * 2011-07-08 2016-05-06 Sanofi Polimorfi 6-(piperidin-4-iloksi)-2h-izokinolin-1-on hidroklorida
MY161361A (en) 2011-07-08 2017-04-14 Sanofi Sa Substituted phenyl compounds
EP2740458B1 (en) 2012-12-06 2016-08-03 IP Gesellschaft für Management mbH Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide
EP3290407B1 (en) 2013-10-18 2020-01-01 Celgene Quanticel Research, Inc Bromodomain inhibitors
BR122019007990B1 (pt) 2013-11-18 2021-05-04 Forma Therapeutics, Inc Composto, e, composição farmacêutica
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