KR101373535B1 - Ｒｈｏ-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체 - Google Patents

Ｒｈｏ-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체 Download PDF

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KR101373535B1
KR101373535B1 KR1020087002168A KR20087002168A KR101373535B1 KR 101373535 B1 KR101373535 B1 KR 101373535B1 KR 1020087002168 A KR1020087002168 A KR 1020087002168A KR 20087002168 A KR20087002168 A KR 20087002168A KR 101373535 B1 KR101373535 B1 KR 101373535B1
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alkyl
alkylene
aryl
compound
halogen
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KR20080028971A (ko
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올리버 플레텐부르크
아르민 호프마이슈터
디터 카데라이트
요아힘 브렌델
마티아스 뢴
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사노피
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
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  • Pain & Pain Management (AREA)
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  • Gynecology & Obstetrics (AREA)
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KR1020087002168A 2005-07-26 2006-07-20 Ｒｈｏ-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체 Active KR101373535B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05016154 2005-07-26
EP05016154.6 2005-07-26
PCT/EP2006/007139 WO2007012421A1 (en) 2005-07-26 2006-07-20 Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20080028971A KR20080028971A (ko) 2008-04-02
KR101373535B1 true KR101373535B1 (ko) 2014-03-12

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KR1020087002168A Active KR101373535B1 (ko) 2005-07-26 2006-07-20 Ｒｈｏ-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체

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Country Link
US (1) US8188117B2 (enExample)
EP (2) EP1910333B1 (enExample)
JP (1) JP5060478B2 (enExample)
KR (1) KR101373535B1 (enExample)
CN (1) CN101228149B (enExample)
AR (1) AR054868A1 (enExample)
AU (1) AU2006274245B2 (enExample)
BR (1) BRPI0613861B8 (enExample)
CA (1) CA2615577C (enExample)
CR (1) CR9603A (enExample)
DK (1) DK1910333T3 (enExample)
DO (1) DOP2006000178A (enExample)
EC (1) ECSP088135A (enExample)
ES (1) ES2423006T3 (enExample)
GT (1) GT200600328A (enExample)
IL (1) IL188702A (enExample)
MA (1) MA29636B1 (enExample)
MX (1) MX2008001053A (enExample)
MY (1) MY148479A (enExample)
NI (1) NI200800025A (enExample)
NO (1) NO341888B1 (enExample)
NZ (1) NZ565668A (enExample)
PE (1) PE20070217A1 (enExample)
PT (1) PT1910333E (enExample)
RU (1) RU2414467C2 (enExample)
TN (1) TNSN08039A1 (enExample)
TW (1) TWI383979B (enExample)
UA (1) UA93882C2 (enExample)
UY (1) UY29697A1 (enExample)
WO (1) WO2007012421A1 (enExample)
ZA (1) ZA200710951B (enExample)

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TW200738682A (en) * 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives
ATE523493T1 (de) * 2006-09-11 2011-09-15 Organon Nv 2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate
KR101517154B1 (ko) * 2006-12-27 2015-04-30 사노피 Ｒｈｏ-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
CN101595094B (zh) 2006-12-27 2013-02-20 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮衍生物
ATE502027T1 (de) 2006-12-27 2011-04-15 Sanofi Aventis Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren
CA2673920C (en) 2006-12-27 2015-03-24 Sanofi-Aventis Cycloalkylamine substituted isoquinoline derivatives
RU2009128693A (ru) 2006-12-27 2011-02-10 Санофи-Авентис (Fr) Замещенные производные изохинолина и изохинолинона
HRP20100705T1 (hr) 2006-12-27 2011-01-31 Sanofi-Aventis Cikloalkilaminski supstituirani izokinolinski i izokinolinonski derivati
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
BRPI0806371A2 (pt) * 2007-01-22 2011-09-13 Gtx Inc agentes ligação de receptor nuclear
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BRPI0821837A2 (pt) * 2007-12-26 2015-06-16 Sanofi Aventis Processo para a preparação de 6-substituídas-1-(2h)-isoquinolinonas
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AU2009262509B2 (en) 2008-06-24 2014-01-30 Sanofi Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors
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WO2013004652A1 (de) * 2011-07-04 2013-01-10 Bayer Intellectual Property Gmbh Verwendung substituierter isochinolinone, isochinolindione, isochinolintrione und dihydroisochinolinone oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress
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PE20161065A1 (es) 2013-10-18 2016-11-19 Celgene Quanticel Res Inc Inhibidores de bromodominio
DK3071203T3 (da) 2013-11-18 2021-03-15 Forma Therapeutics Inc Tetrahydroquinolinsammensætninger som bet-bromdomæne-inhibitorer
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI770552B (zh) 2014-12-24 2022-07-11 美商基利科學股份有限公司 喹唑啉化合物
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