AR054868A1 - Derivados de isoquinolona sustituidos con piperidinilo - Google Patents

Derivados de isoquinolona sustituidos con piperidinilo

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Publication number
AR054868A1
AR054868A1 ARP060103199A ARP060103199A AR054868A1 AR 054868 A1 AR054868 A1 AR 054868A1 AR P060103199 A ARP060103199 A AR P060103199A AR P060103199 A ARP060103199 A AR P060103199A AR 054868 A1 AR054868 A1 AR 054868A1
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Argentina
Prior art keywords
alkylene
alkyl
heterocyclyl
aryl
cycloalkyl
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ARP060103199A
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English (en)
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Sanofi Aventis Deutschland
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Publication of AR054868A1 publication Critical patent/AR054868A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Compuestos utiles para el tratamiento y/o prevencion de enfermedades asociadas con la Rho-quinasa y/o la fosforilacion mediada por la Rho-quinasa de la fosfatasa de la cadena ligera de miosina, y a composiciones que contienen tales compuestos. Reivindicacion 1: Un compuesto de formula (1) o de formula (2) donde R1 es H, alquilo (C1-6), alquenilo (C2-6), alquinilo (C2-6), [alquileno (C1-6)]0-1-cicloalquilo (C3-8), [alquileno (C1 -6)]0-1-heterociclilo (C5-10), [alquileno (C1- 6)]0-1-arilo (C6-10), C(O)-alquilo (C1-6), C(O)-alquenilo (C2-6), C(O)-alquinilo (C2-6), C(O)-[alquileno (C1-6)]0-1-cicloalquilo (C3-8), C(O)-[alquileno (C1-6)]0-1-heterociclilo (C5-10) o C(O)-[alquileno (C1-6)]0-1-arilo (C6-10, R2 es H, alquilo (C1- 6), [alquileno (C1-6]0-1-R', [alquileno (C1-6)]0-1-O-alquilo (C1-6), [alquiIeno (C1-6)]0-1-O-R', [alquileno (C1-6)]0-1-NH2, [alquileno (C1-6)]0-1-NH-alquilo (C1-6), [alquileno (C1-6)]0-1-N[alquilo (C1-6)]2, [alquileno (C1-6)]0-1-CH[R']2, [alquileno (C1-6)]0-1-C(O)-R', [alquileno (C1-6]0-1-C(O)NH2, [alquileno (C1-6)]0-1-C(O)NH-R' o [alquileno (C1-6)]0-1-C(O)N[R']2; R3 es H, halogeno, CN, alquilo (C1-6), alquileno (C1-6)-R', OH, O-Rö, NH2, NHRö, NRöRö o NH-C(O)-Rö,R4 es H, halogeno, hidroxi, CN, alquilo C1-6, cicloalquilo C3-8, alquileno C1-6-R'; R5 es H, halogeno, CN, NO2, alquilo (C1-6), alquenilo (C2-6), R', alquileno (C1-6)-arilo (C6-10), alquenileno (C2-6)-arilo (C6-C10), alquileno (C1-6)-heterociclilo (C5-10), NH2, NH-R', NH-SO2H, NH- SO2-alquilo (C1-6), NHSO2-R', NH-C(O)-alquilo (C1-6), NH-C(O)-R', C(O)N[alquilo (C1-6)]2, C(O)OH o C(O)O-alquilo (C1-6); R6 es H, R', alquilo (C1-8), alquileno (C1-6)-R', alquileno (C1-6)-O-alquilo (C1-6), alquileno (C1-6)-O-R', alquileno (C1-6)- CH[R']2, alquileno (C1-6)-C(O)-R', alquileno (C1-6)-C(O)NH2, alquileno (C1-6)-C(O)NH-R' o alquileno (C1-6)-C(O)N[R']2; R7 y R8 son independientemente entre sí H, halogeno, CN, NO2, alquilo (C1-6), O-alquilo (C1-6), O-[alquileno (C1-6)]0-1-R', alquenilo (C2-6), R', alquenileno (C2-6)-arilo (C6-10), alquileno (C1-6)-R', NH2, NH-R', NH-SO2H, NHSO2-alquilo (C1-6), NH-SO2-R', SO2-NH2, SO2-NHR', NH-C(O)-alquilo (C1-6), NH-C(O)-R', C(O)N[alquilo (C1-6)]2, C(O)OH o C(O)O-alquilo (C1-6); R9 es halogeno o alquilo (C1-6); n es 0, 1,2,3 o 4; y L es O o O-alquileno (C1-6); donde R' es cicloalquilo (C3-8), heterociclilo (C5-10) o arilo (C6-10); y Rö es cicloalquilo (C3-8), heterociclilo (C5-10), arilo (C6-10), alquilo (C1-6), alquileno (C1-6)- R', alquileno (C1-6)-O-alquilo (C1-6), alquileno (C1-6)-O-R' o alquileno (C1-6)NRxRy; y donde Rx y Ry son independientemente entre sí alquilo (C1-6), heterociclilo (C5-10), arilo (C6-10), alquileno (C1-4)-heterociclilo (C5-10), alquileno (C1-4)- arilo (C6-10), alquiIeno (C1-4)-NH-alquilo (C1-6), alquileno (C1-4)-N[alquilo (C1-6)]2, alquileno (C1-4)-N[arilo (C6-10)]2 o alquileno (C1-4)-N[heterociclilo (C5-10)]2; y donde en los restos R4, R5, R7 y R8 un átomo de hidrogeno del grupo alquilo o alquileno puede estar opcionalmente sustituido con OH, OCH3, COOH, COOCH3, NH2, NHCH3, N(CH3)2, CONH2, CONHCH3 o CON(CH3)2 o un grupo alquilo o alquileno puede estar halogenado una o más veces; y/o sus sales farmacéuticamente aceptables y/o formas estereoisoméricas y/o derivados fisiologicamente funcionales.
ARP060103199A 2005-07-26 2006-07-25 Derivados de isoquinolona sustituidos con piperidinilo AR054868A1 (es)

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US (1) US8188117B2 (es)
EP (2) EP2385047B1 (es)
JP (1) JP5060478B2 (es)
KR (1) KR101373535B1 (es)
CN (1) CN101228149B (es)
AR (1) AR054868A1 (es)
AU (1) AU2006274245B2 (es)
BR (1) BRPI0613861B8 (es)
CA (1) CA2615577C (es)
CR (1) CR9603A (es)
DK (1) DK1910333T3 (es)
DO (1) DOP2006000178A (es)
EC (1) ECSP088135A (es)
ES (1) ES2423006T3 (es)
GT (1) GT200600328A (es)
HK (1) HK1123035A1 (es)
IL (1) IL188702A (es)
MA (1) MA29636B1 (es)
MX (1) MX2008001053A (es)
MY (1) MY148479A (es)
NI (1) NI200800025A (es)
NO (1) NO341888B1 (es)
NZ (1) NZ565668A (es)
PE (1) PE20070217A1 (es)
PT (1) PT1910333E (es)
RU (1) RU2414467C2 (es)
TN (1) TNSN08039A1 (es)
TW (1) TWI383979B (es)
UA (1) UA93882C2 (es)
UY (1) UY29697A1 (es)
WO (1) WO2007012421A1 (es)
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MY155009A (en) 2006-12-27 2015-08-28 Sanofi Aventis Cycloalkylamine substituted isoquinolone derivatives
BRPI0720862A2 (pt) 2006-12-27 2014-02-25 Sanofi Aventis Derivados de isoquinolina e isoquinolinona substituídos como inibidores de rho-cinase
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