JP2009502829A5 - - Google Patents
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- Publication number
- JP2009502829A5 JP2009502829A5 JP2008523188A JP2008523188A JP2009502829A5 JP 2009502829 A5 JP2009502829 A5 JP 2009502829A5 JP 2008523188 A JP2008523188 A JP 2008523188A JP 2008523188 A JP2008523188 A JP 2008523188A JP 2009502829 A5 JP2009502829 A5 JP 2009502829A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- halogen
- aryl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05016154 | 2005-07-26 | ||
| EP05016154.6 | 2005-07-26 | ||
| PCT/EP2006/007139 WO2007012421A1 (en) | 2005-07-26 | 2006-07-20 | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502829A JP2009502829A (ja) | 2009-01-29 |
| JP2009502829A5 true JP2009502829A5 (enExample) | 2009-09-03 |
| JP5060478B2 JP5060478B2 (ja) | 2012-10-31 |
Family
ID=34979095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008523188A Active JP5060478B2 (ja) | 2005-07-26 | 2006-07-20 | Ｒｈｏ−キナーゼ阻害剤としてのピペリジニル置換されたイソキノロン誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8188117B2 (enExample) |
| EP (2) | EP1910333B1 (enExample) |
| JP (1) | JP5060478B2 (enExample) |
| KR (1) | KR101373535B1 (enExample) |
| CN (1) | CN101228149B (enExample) |
| AR (1) | AR054868A1 (enExample) |
| AU (1) | AU2006274245B2 (enExample) |
| BR (1) | BRPI0613861B8 (enExample) |
| CA (1) | CA2615577C (enExample) |
| CR (1) | CR9603A (enExample) |
| DK (1) | DK1910333T3 (enExample) |
| DO (1) | DOP2006000178A (enExample) |
| EC (1) | ECSP088135A (enExample) |
| ES (1) | ES2423006T3 (enExample) |
| GT (1) | GT200600328A (enExample) |
| IL (1) | IL188702A (enExample) |
| MA (1) | MA29636B1 (enExample) |
| MX (1) | MX2008001053A (enExample) |
| MY (1) | MY148479A (enExample) |
| NI (1) | NI200800025A (enExample) |
| NO (1) | NO341888B1 (enExample) |
| NZ (1) | NZ565668A (enExample) |
| PE (1) | PE20070217A1 (enExample) |
| PT (1) | PT1910333E (enExample) |
| RU (1) | RU2414467C2 (enExample) |
| TN (1) | TNSN08039A1 (enExample) |
| TW (1) | TWI383979B (enExample) |
| UA (1) | UA93882C2 (enExample) |
| UY (1) | UY29697A1 (enExample) |
| WO (1) | WO2007012421A1 (enExample) |
| ZA (1) | ZA200710951B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1899322T1 (sl) | 2005-06-28 | 2010-01-29 | Sanofi Aventis | Izokinolinski derivati kot inhibitorji Rho-kinaze |
| AU2006274246B2 (en) | 2005-07-26 | 2012-07-12 | Sanofi-Aventis | Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors |
| TW200738682A (en) * | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| CN101528703B (zh) * | 2006-09-11 | 2011-09-07 | 欧加农股份有限公司 | 2-（1-氧代-1h-异喹啉-2-基）乙酰胺衍生物 |
| AU2007338408B2 (en) | 2006-12-27 | 2012-07-26 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
| RU2455302C2 (ru) | 2006-12-27 | 2012-07-10 | Санофи-Авентис | ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| ATE502027T1 (de) | 2006-12-27 | 2011-04-15 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
| EP2125745B1 (en) | 2006-12-27 | 2017-02-22 | Sanofi | Cycloalkylamine substituted isoquinolone derivatives |
| CN101611012B (zh) | 2006-12-27 | 2012-11-14 | 塞诺菲-安万特股份有限公司 | 环烷基胺取代的异喹啉衍生物 |
| BRPI0720859A2 (pt) | 2006-12-27 | 2014-03-25 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona substituídos com cicloalquilamina |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| WO2008091555A2 (en) * | 2007-01-22 | 2008-07-31 | Gtx, Inc. | Nuclear receptor binding agents |
| CA2710447A1 (en) * | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Process for the preparation of 6-substituted-1-(2h)-isoquinolinones |
| MX2010013974A (es) | 2008-06-24 | 2011-01-14 | Sanofi Aventis | Isoquinolinas e isoquinolinonas 6-sustituidas. |
| PL2303845T3 (pl) | 2008-06-24 | 2014-03-31 | Sanofi Sa | Bi- i policykliczne podstawione pochodne izochinoliny i izochinolinonu jako inhibitory kinazy Rho |
| BRPI0914696A2 (pt) | 2008-06-24 | 2016-10-18 | Sanofi Aventis | isoquinolinas e isoquinolinonas substituídas como inibidores da rho-quinase |
| US9865233B2 (en) | 2008-12-30 | 2018-01-09 | Intel Corporation | Hybrid graphics display power management |
| IN2012DN02968A (enExample) * | 2009-10-13 | 2015-07-31 | Msd Oss Bv | |
| EP2729007A1 (de) * | 2011-07-04 | 2014-05-14 | Bayer Intellectual Property GmbH | Verwendung substituierter isochinolinone, isochinolindione, isochinolintrione und dihydroisochinolinone oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress |
| ES2567317T3 (es) * | 2011-07-08 | 2016-04-21 | Sanofi | Polimorfos de hidrocloruro de 6-(piperidin-4-iloxi)-2H-isoquinolin-1-ona |
| PL2729460T3 (pl) * | 2011-07-08 | 2016-07-29 | Sanofi Sa | Krystaliczne solwaty chlorowodorku 6-(piperydyn-4-ylooksy)-2H-izochinolin-1-onu |
| BR112014000279B1 (pt) * | 2011-07-08 | 2020-11-24 | Sanofi | composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i) |
| EP3141235A1 (en) | 2012-12-06 | 2017-03-15 | IP Gesellschaft für Management mbH | N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3-methylazetidine-l -sulfonamide |
| HRP20221389T1 (hr) | 2013-10-18 | 2023-01-06 | Celgene Quanticel Research, Inc. | Inhibitori bromodomena |
| ES2860695T3 (es) | 2013-11-18 | 2021-10-05 | Forma Therapeutics Inc | Composiciones de tetrahidroquinolina como inhibidores de bromodominio BET |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| TW202237569A (zh) | 2014-12-24 | 2022-10-01 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| SG11201705184PA (en) | 2014-12-24 | 2017-07-28 | Gilead Sciences Inc | Isoquinoline compounds for the treatment of hiv |
| EA032430B1 (ru) | 2014-12-24 | 2019-05-31 | Джилид Сайэнс, Инк. | Конденсированные пиримидины для лечения вич |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| US9957267B2 (en) | 2015-07-01 | 2018-05-01 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| EP3440052B1 (en) * | 2016-04-06 | 2023-10-25 | University Of Oulu | Compounds for use in the treatment of cancer |
| JP2019513804A (ja) | 2016-04-18 | 2019-05-30 | セルジーン クオンティセル リサーチ，インク． | 治療用化合物 |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| CN106632258B (zh) * | 2016-12-15 | 2019-04-02 | 三峡大学 | 四氢异喹啉-2-基芳氧基苯氧基烷基酮化合物及其应用 |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| WO2023076812A1 (en) | 2021-10-30 | 2023-05-04 | Aneuryst, Inc. | Treatments for disturbed cerebral homeostasis |
| WO2024030854A1 (en) * | 2022-08-01 | 2024-02-08 | Valo Health, Inc. | Process for preparing 6-substituted-1-(2h)-isoquinolinones and intermediate compound |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| WO1992002476A1 (en) | 1990-07-31 | 1992-02-20 | E.I. Du Pont De Nemours And Company | Catalytic equilibration of selected halocarbons |
| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| HUP9900926A3 (en) * | 1995-09-07 | 2002-12-28 | Hoffmann La Roche | New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| ES2286834T5 (es) | 1996-08-12 | 2011-01-31 | Mitsubishi Tanabe Pharma Corporation | Medicamentos que comprenden un inhibidor de la rho quinasa. |
| JPH1087629A (ja) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
| EP1007525A1 (en) | 1997-08-29 | 2000-06-14 | Zeneca Limited | Aminometyl oxooxazolidinyl benzene derivatives |
| TW575567B (en) | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
| GB9912701D0 (en) | 1999-06-01 | 1999-08-04 | Smithkline Beecham Plc | Novel compounds |
| US6541456B1 (en) | 1999-12-01 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
| MXPA02007036A (es) | 2000-01-20 | 2002-12-13 | Eisai Co Ltd | Compuesto de piperidina novedoso y composicion farmaceutica del mismo. |
| US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| WO2001064238A2 (en) | 2000-02-29 | 2001-09-07 | Curis, Inc. | Methods and compositions for regulating adipocytes |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| AU2001296008A1 (en) | 2000-10-27 | 2002-05-06 | Takeda Chemical Industries Ltd. | Process for preparing substituted aromatic compounds and intermediates therefor |
| JP2004520347A (ja) | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
| SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
| WO2002088101A2 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| EP1403255A4 (en) * | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | RHO KINASE INHIBITORS |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| WO2003024450A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| EP1541559A4 (en) * | 2002-07-22 | 2007-08-22 | Asahi Kasei Pharma Corp | 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE |
| EP1550660A1 (en) | 2002-09-12 | 2005-07-06 | Kirin Beer Kabushiki Kaisha | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same |
| US20050014783A1 (en) | 2003-05-29 | 2005-01-20 | Schering Aktiengesellschaft | Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy |
| EP1638939A2 (en) | 2003-06-24 | 2006-03-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US7691879B2 (en) | 2003-09-23 | 2010-04-06 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
| JP4718467B2 (ja) | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
| US20050067037A1 (en) | 2003-09-30 | 2005-03-31 | Conocophillips Company | Collapse resistant composite riser |
| EP1671962A1 (en) | 2003-10-10 | 2006-06-21 | Ono Pharmaceutical Co., Ltd. | Novel fused heterocyclic compound and use thereof |
| JP2007008816A (ja) * | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
| WO2005054202A1 (en) | 2003-11-25 | 2005-06-16 | Eli Lilly And Company | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b) |
| WO2005074535A2 (en) | 2004-01-30 | 2005-08-18 | Eisai Co., Ltd. | Cholinesterase inhibitors for spinal cord disorders |
| EP1729761A4 (en) | 2004-03-05 | 2008-09-03 | Eisai Co Ltd | TREATMENT OF CADASIL WITH CHOLINESTERASE INHIBITORS |
| SE0400850D0 (sv) | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| US7517991B2 (en) | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| AU2006274246B2 (en) | 2005-07-26 | 2012-07-12 | Sanofi-Aventis | Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors |
| TW200745101A (en) | 2005-09-30 | 2007-12-16 | Organon Nv | 9-Azabicyclo[3.3.1]nonane derivatives |
| US7618985B2 (en) | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
| TW200738682A (en) * | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| US7893088B2 (en) | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| ATE502027T1 (de) | 2006-12-27 | 2011-04-15 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
| BRPI0720859A2 (pt) | 2006-12-27 | 2014-03-25 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona substituídos com cicloalquilamina |
-
2006
- 2006-07-20 ES ES06776306T patent/ES2423006T3/es active Active
- 2006-07-20 AU AU2006274245A patent/AU2006274245B2/en active Active
- 2006-07-20 JP JP2008523188A patent/JP5060478B2/ja active Active
- 2006-07-20 EP EP06776306.0A patent/EP1910333B1/en active Active
- 2006-07-20 PT PT67763060T patent/PT1910333E/pt unknown
- 2006-07-20 DK DK06776306.0T patent/DK1910333T3/da active
- 2006-07-20 NI NI200800025A patent/NI200800025A/es unknown
- 2006-07-20 EP EP11176273.8A patent/EP2385047B1/en active Active
- 2006-07-20 UA UAA200802430A patent/UA93882C2/ru unknown
- 2006-07-20 WO PCT/EP2006/007139 patent/WO2007012421A1/en not_active Ceased
- 2006-07-20 BR BRPI0613861A patent/BRPI0613861B8/pt active IP Right Grant
- 2006-07-20 MX MX2008001053A patent/MX2008001053A/es active IP Right Grant
- 2006-07-20 KR KR1020087002168A patent/KR101373535B1/ko active Active
- 2006-07-20 NZ NZ565668A patent/NZ565668A/en not_active IP Right Cessation
- 2006-07-20 CA CA2615577A patent/CA2615577C/en active Active
- 2006-07-20 RU RU2008106950/04A patent/RU2414467C2/ru active
- 2006-07-20 CN CN2006800271613A patent/CN101228149B/zh active Active
- 2006-07-24 GT GT200600328A patent/GT200600328A/es unknown
- 2006-07-24 TW TW095126882A patent/TWI383979B/zh active
- 2006-07-24 MY MYPI20063515A patent/MY148479A/en unknown
- 2006-07-25 DO DO2006000178A patent/DOP2006000178A/es unknown
- 2006-07-25 AR ARP060103199A patent/AR054868A1/es active IP Right Grant
- 2006-07-25 PE PE2006000896A patent/PE20070217A1/es not_active Application Discontinuation
- 2006-07-26 UY UY29697A patent/UY29697A1/es not_active Application Discontinuation
-
2007
- 2007-12-18 CR CR9603A patent/CR9603A/es not_active Application Discontinuation
- 2007-12-18 ZA ZA200701095A patent/ZA200710951B/xx unknown
-
2008
- 2008-01-10 IL IL188702A patent/IL188702A/en active IP Right Grant
- 2008-01-18 MA MA30583A patent/MA29636B1/fr unknown
- 2008-01-25 US US12/019,866 patent/US8188117B2/en active Active
- 2008-01-25 EC EC2008008135A patent/ECSP088135A/es unknown
- 2008-01-25 TN TNP2008000039A patent/TNSN08039A1/en unknown
- 2008-02-22 NO NO20080963A patent/NO341888B1/no unknown
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