JP5049267B2 - ベンズイソオキサゾールピペラジン化合物およびその使用方法 - Google Patents

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Publication number

JP5049267B2

JP5049267B2 JP2008509129A JP2008509129A JP5049267B2 JP 5049267 B2 JP5049267 B2 JP 5049267B2 JP 2008509129 A JP2008509129 A JP 2008509129A JP 2008509129 A JP2008509129 A JP 2008509129A JP 5049267 B2 JP5049267 B2 JP 5049267B2

Authority

JP

Japan

Prior art keywords

sleep

compound

alkyl

conhs

another embodiment

Prior art date

2005-04-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 238000000034 method Methods 0.000 title abstract description 28
• GAHWPVPYFSNWOU-UHFFFAOYSA-N 1,2-benzoxazole;piperazine Chemical class C1CNCCN1.C1=CC=C2C=NOC2=C1 GAHWPVPYFSNWOU-UHFFFAOYSA-N 0.000 title description 3
• 150000001875 compounds Chemical class 0.000 claims description 265
• 229910052799 carbon Inorganic materials 0.000 claims description 78
• 150000003839 salts Chemical class 0.000 claims description 68
• 208000019116 sleep disease Diseases 0.000 claims description 63
• 229910052739 hydrogen Inorganic materials 0.000 claims description 62
• 238000011282 treatment Methods 0.000 claims description 59
• 239000003814 drug Substances 0.000 claims description 57
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 45
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 39
• 208000020685 sleep-wake disease Diseases 0.000 claims description 31
• 206010022437 insomnia Diseases 0.000 claims description 30
• 229910052794 bromium Inorganic materials 0.000 claims description 26
• 229910052801 chlorine Inorganic materials 0.000 claims description 26
• 229910052731 fluorine Inorganic materials 0.000 claims description 26
• 125000003003 spiro group Chemical group 0.000 claims description 26
• 239000008194 pharmaceutical composition Substances 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 5
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• RRNFVWZCXHFAEE-UHFFFAOYSA-N 1,2-benzoxazole;piperidine Chemical compound C1CCNCC1.C1=CC=C2C=NOC2=C1 RRNFVWZCXHFAEE-UHFFFAOYSA-N 0.000 abstract 1
• 125000000217 alkyl group Chemical group 0.000 description 84
• -1 benzisoxazole compound Chemical class 0.000 description 59
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• 235000021317 phosphate Nutrition 0.000 description 9
• 238000002560 therapeutic procedure Methods 0.000 description 9
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 8
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• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 8
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• 239000002253 acid Substances 0.000 description 8
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• 125000004453 alkoxycarbonyl group Chemical group 0.000 description 8
• 125000005194 alkoxycarbonyloxy group Chemical group 0.000 description 8
• 125000004947 alkyl aryl amino group Chemical group 0.000 description 8
• 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 8
• 125000004691 alkyl thio carbonyl group Chemical group 0.000 description 8
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