JP5026633B2 - 細胞増殖の阻害のための置換ビスインドリルマレイミド類 - Google Patents

細胞増殖の阻害のための置換ビスインドリルマレイミド類 Download PDF

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Publication number
JP5026633B2
JP5026633B2 JP2000536713A JP2000536713A JP5026633B2 JP 5026633 B2 JP5026633 B2 JP 5026633B2 JP 2000536713 A JP2000536713 A JP 2000536713A JP 2000536713 A JP2000536713 A JP 2000536713A JP 5026633 B2 JP5026633 B2 JP 5026633B2
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JP
Japan
Prior art keywords
indol
methyl
nitro
mmol
compound
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JP2000536713A
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English (en)
Japanese (ja)
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JP2002506864A5 (https=
JP2002506864A (ja
Inventor
ディングラ，ウルヴァシ・ホーダ
フリン，ドナ・メアリー
ケ，ジューン
ウェーバー，ジュセッペ・フェデリコ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2000536713A 1998-03-17 1999-03-10 細胞増殖の阻害のための置換ビスインドリルマレイミド類 Expired - Lifetime JP5026633B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7833198P 1998-03-17 1998-03-17
US60/078,331 1998-03-17
PCT/EP1999/001534 WO1999047518A1 (en) 1998-03-17 1999-03-10 Substituted bisindolymaleimides for the inhibition of cell proliferation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010126632A Division JP2010222366A (ja) 1998-03-17 2010-06-02 細胞増殖の阻害のための置換ビスインドリルマレイミド類

Publications (3)

Publication Number Publication Date
JP2002506864A JP2002506864A (ja) 2002-03-05
JP2002506864A5 JP2002506864A5 (https=) 2006-04-27
JP5026633B2 true JP5026633B2 (ja) 2012-09-12

Family

ID=22143350

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000536713A Expired - Lifetime JP5026633B2 (ja) 1998-03-17 1999-03-10 細胞増殖の阻害のための置換ビスインドリルマレイミド類
JP2010126632A Pending JP2010222366A (ja) 1998-03-17 2010-06-02 細胞増殖の阻害のための置換ビスインドリルマレイミド類

Family Applications After (1)

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JP2010126632A Pending JP2010222366A (ja) 1998-03-17 2010-06-02 細胞増殖の阻害のための置換ビスインドリルマレイミド類

Country Status (33)

Country Link
US (1) US6048887A (https=)
EP (1) EP1064279B1 (https=)
JP (2) JP5026633B2 (https=)
KR (1) KR100659411B1 (https=)
CN (1) CN1127500C (https=)
AR (1) AR018162A1 (https=)
AT (1) ATE243693T1 (https=)
AU (1) AU755673B2 (https=)
BR (1) BR9908882A (https=)
CA (1) CA2322689C (https=)
CO (1) CO5070675A1 (https=)
CZ (1) CZ299068B6 (https=)
DE (1) DE69909068T2 (https=)
DK (1) DK1064279T3 (https=)
ES (1) ES2203111T3 (https=)
HR (1) HRP20000585B1 (https=)
HU (1) HU228831B1 (https=)
ID (1) ID26353A (https=)
IL (1) IL138247A (https=)
MA (1) MA26613A1 (https=)
MY (1) MY121046A (https=)
NO (1) NO320306B1 (https=)
NZ (1) NZ506476A (https=)
PE (1) PE20000340A1 (https=)
PL (1) PL195323B1 (https=)
PT (1) PT1064279E (https=)
RS (1) RS49965B (https=)
RU (1) RU2208612C2 (https=)
SA (1) SA99191295B1 (https=)
TR (1) TR200002580T2 (https=)
TW (1) TW539676B (https=)
WO (1) WO1999047518A1 (https=)
ZA (1) ZA992072B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010222366A (ja) * 1998-03-17 2010-10-07 F Hoffmann La Roche Ag 細胞増殖の阻害のための置換ビスインドリルマレイミド類

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
TR200200987T2 (tr) * 1999-10-12 2002-09-23 F.Hoffmann-La Roche Ag Kanser tedavisine yönelik,ornatılmış pirroller
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
US6482847B2 (en) 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6469179B1 (en) 2000-10-03 2002-10-22 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6548531B2 (en) 2001-02-09 2003-04-15 Hoffmann-La Roche Inc. Method for cancer therapy
WO2002102373A1 (en) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Method for administration of cancer therapeutic
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
WO2008117935A1 (en) * 2007-03-28 2008-10-02 Industry-Academic Cooperation Foundation, Yonsei University Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same
CN102924437B (zh) * 2012-11-19 2014-07-02 东华大学 3-哌嗪基-4-吲哚马来酰亚胺化合物及其制备和应用
WO2019000224A1 (zh) * 2017-06-27 2019-01-03 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
ES2236702T3 (es) * 1993-12-23 2005-07-16 Eli Lilly And Company Inhibidores de la proteina quinasa c.
PE91598A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PE91698A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
ES2203111T3 (es) * 1998-03-17 2004-04-01 F. Hoffmann-La Roche Ag Maleimidas bisindol sustituidas para la inhibicion de proloferacion celular.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010222366A (ja) * 1998-03-17 2010-10-07 F Hoffmann La Roche Ag 細胞増殖の阻害のための置換ビスインドリルマレイミド類

Also Published As

Publication number Publication date
AR018162A1 (es) 2001-10-31
CA2322689C (en) 2008-11-25
YU55200A (sh) 2002-11-15
HUP0101258A3 (en) 2002-08-28
ATE243693T1 (de) 2003-07-15
WO1999047518A1 (en) 1999-09-23
DK1064279T3 (da) 2003-10-06
CN1293671A (zh) 2001-05-02
CZ20003384A3 (cs) 2000-12-13
EP1064279B1 (en) 2003-06-25
IL138247A (en) 2005-08-31
NO20004579L (no) 2000-09-14
KR100659411B1 (ko) 2006-12-18
PL342964A1 (en) 2001-07-16
NZ506476A (en) 2003-12-19
NO20004579D0 (no) 2000-09-14
HUP0101258A2 (hu) 2001-10-28
EP1064279A1 (en) 2001-01-03
ES2203111T3 (es) 2004-04-01
CZ299068B6 (cs) 2008-04-16
HK1036452A1 (en) 2002-01-04
CN1127500C (zh) 2003-11-12
HRP20000585B1 (en) 2009-02-28
JP2002506864A (ja) 2002-03-05
MA26613A1 (fr) 2004-12-20
SA99191295B1 (ar) 2006-04-26
RU2208612C2 (ru) 2003-07-20
AU3409999A (en) 1999-10-11
JP2010222366A (ja) 2010-10-07
HRP20000585A2 (en) 2001-08-31
IL138247A0 (en) 2001-10-31
ZA992072B (en) 1999-09-22
RS49965B (sr) 2008-09-29
AU755673B2 (en) 2002-12-19
CO5070675A1 (es) 2001-08-28
TR200002580T2 (tr) 2000-11-21
DE69909068D1 (de) 2003-07-31
US6048887A (en) 2000-04-11
PT1064279E (pt) 2003-10-31
BR9908882A (pt) 2000-11-21
CA2322689A1 (en) 1999-09-23
ID26353A (id) 2000-12-14
KR20010041995A (ko) 2001-05-25
TW539676B (en) 2003-07-01
MY121046A (en) 2005-12-30
HU228831B1 (en) 2013-05-28
DE69909068T2 (de) 2004-05-06
PL195323B1 (pl) 2007-09-28
PE20000340A1 (es) 2000-05-13
NO320306B1 (no) 2005-11-21

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