JP4999679B2 - 検体分析装置 - Google Patents
検体分析装置 Download PDFInfo
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Description
まず、図1〜図10を参照して、本発明の第1実施形態による検体分析装置1の全体構成について説明する。
目の「PT」(プロトロンビン時間)および「APTT」(活性化部分トロンボプラスチン時間)は、凝固時間法を用いて測定を行う項目である。測定項目の「ATIII」(アンチトロンビンIII)は、合成基質法を用いて測定を行う項
目である。測定項目の「FDP」(フィブリン分解生成物)は、免疫比濁法を用いて測定を行う項目である。
そして、ステップS32において、430nmの波長の光に対する検体の吸光度が1.5よりも大きいか否かが判断される。そして、ステップS32において、430nmの波長の光に対する検体の吸光度が1.5以下であると判断された場合には、ステップS33において、検体分析一覧表中のオン状態で二次分注の対象であることを示す二次分注フラグの項目がオフ(表中では「0」)からオン(表中では「1」)に変更されて、図13のステップS16に戻る。一方、ステップS32において、430nmの波長の光に対する検体の吸光度が1.5よりも大きいと判断された場合には、ステップS34において、「P」の値が10よりも大きいか否かが判断される。ここで、「P」は、「−(565nmの波長の光に対する検体の吸光度−430nmの波長の光に対する検体の吸光度)/(565−430)」により求められる値である。そして、ステップS34において、「P」の値が10よりも大きいと判断された場合には、図15のステップS35において、検体の測定項目が合成基質法を用いる測定項目であるか否かが判断される。
図17〜図27を参照して、この第2実施形態では、上記第1実施形態と異なり、第1光学的情報取得部240と第2光学的情報取得部270とに共通に用いられるランプユニット250を備えた検体分析装置201について説明する。なお、第2実施形態で用いる凝固時間法は、検体が凝固する過程を透過光の変化として検出する測定方法である。そして、凝固時間法を用いて測定を行う測定項目としては、PT(プロトロンビン時間)、APTT(活性化部分トロンボプラスチン時間)やFbg(フィブリノーゲン量)などがある。
Claims (9)
- 検体を収容した検体容器を搬送するための搬送部と、
第1キュベットを保持するための第1保持部を含み、前記第1保持部を移動可能な第1容器保持機構と、
第2キュベットを保持するための第2保持部を含み、前記第2保持部を移動可能な第2容器保持機構と、
前記第1容器保持機構の第1保持部および前記第2容器保持機構の第2保持部のそれぞれに前記第1キュベットおよび前記第2キュベットを供給するキュベット供給部と、
前記搬送部によって搬送された検体容器に収容されている検体を吸引し、前記第1容器保持機構の第1保持部に保持されている第1キュベットに分取する第1分取部と、
前記第1保持部に保持されている第1キュベットに光を照射可能な位置に配置された光照射部と、前記光照射部から照射された光を、前記第1保持部に保持されている前記第1キュベットを介して受光可能な位置に配置された受光部と、を含み、前記第1分取部によって分取された検体のみを収容し、前記第1保持部に保持されている前記第1キュベットに光を照射することにより当該第1キュベット内の前記検体に対して光学測定を行う光学測定部と、
前記光学測定が行われ、前記第1保持部に保持されている前記第1キュベット中の前記検体を、前記第2容器保持機構の第2保持部に保持されている第2キュベットに分取する第2分取部と、
前記第2キュベットにて検体と試薬とを混和して測定用試料を調製する試料調製部と、
前記測定用試料を分析する分析部と、
少なくとも前記第1容器保持機構、前記第2容器保持機構、前記キュベット供給部、前記第1分取部、前記第2分取部、および、前記試料調製部の動作を制御するように構成された制御部と、を備え、
前記制御部は、前記光学測定部による前記検体の光学測定の結果に応じて、前記第2キュベットへの前記検体の分取を実行させるか否かを判断し、前記第2キュベットへの前記検体の分取を実行すると判断した場合に、前記光学測定が行われた前記第1キュベット中の検体を前記第2キュベットに分取するよう前記第2分取部を制御する、検体分析装置。 - 検体を収容した検体容器を搬送するための搬送部と、
第1キュベットを保持するための第1保持部を含み、前記第1保持部を移動可能な第1容器保持機構と、
第2キュベットを保持するための第2保持部を含み、前記第2保持部を移動可能な第2容器保持機構と、
前記第1容器保持機構の第1保持部および前記第2容器保持機構の第2保持部のそれぞれに前記第1キュベットおよび前記第2キュベットを供給するキュベット供給部と、
前記搬送部によって搬送された検体容器に収容されている検体を吸引し、前記第1容器保持機構の第1保持部に保持された第1キュベットに分取する第1分取部と、
前記第1保持部に保持されている第1キュベットに光を照射可能な位置に配置された光照射部と、前記光照射部から照射された光を、前記第1保持部に保持されている前記第1キュベットを介して受光可能な位置に配置された受光部とを含み、前記第1分取部によって分取された検体のみを収容し、前記第1保持部に保持されている前記第1キュベットに光を照射することにより当該第1キュベット内の前記検体に対して光学測定を行う光学測定部と、
前記光学測定が行われ、前記第1保持部に保持されている前記第1キュベット中の前記検体を、前記第2容器保持機構の第2保持部に保持されている第2キュベットに分取する第2分取部と、
前記第2キュベットにて検体と試薬とを混和して測定用試料を調製する試料調製部と、
前記測定用試料を分析する分析部と、
少なくとも前記第1容器保持機構、前記第2容器保持機構、前記キュベット供給部、前記第1分取部、前記第2分取部、および、前記試料調製部の動作を制御するように構成された制御部と、を備え、
前記制御部は、前記光学測定部による前記検体の光学測定の結果に応じて、前記分析部に前記測定用試料の分析を実行させるか否かを判断し、前記分析部に前記測定用試料の分析を実行させると判断した場合に、前記試料調製部によって調製された前記測定用試料の分析を実行するよう前記分析部を制御する、検体分析装置。 - 前記制御部は、前記検体容器内の検体が前記第1保持部に保持されている前記第1キュベットに分取されると、前記第1保持部を所定位置に移動させるように前記第1容器保持機構を制御し、
前記光学測定部は、前記所定位置に移動された前記第1保持部に保持されている前記第1キュベットに光を照射することにより、当該第1キュベット内の前記検体に対して光学測定を行う、請求項1または2に記載の検体分析装置。 - 前記光照射部は、前記所定位置にある前記第1保持部に保持されている前記第1キュベットに光を照射可能な位置に配置され、
前記受光部は、前記光照射部から照射された光を、前記第1保持部に保持されている前記第1キュベットを介して受光可能な位置に配置されている、請求項3に記載の検体分析装置。 - 前記第1分取部は、前記検体容器に挿入して前記検体を吸引するための管を含み、
前記検体容器は、前記検体容器の開口部を閉鎖するための蓋を含み、
前記第1分取部は、前記管を前記蓋に貫通させることにより前記検体容器内の前記検体を吸引する、請求項1〜4のいずれか1項に記載の検体分析装置。 - 前記分析部は、前記測定用試料に対して光を照射するための光源を含み、前記光源から前記測定用試料に光を照射して前記測定用試料から光学的情報を取得するとともに、前記光学的情報を分析することにより分析結果を得る、請求項1〜5のいずれか1項に記載の検体分析装置。
- 前記光学測定部は、前記分析部の光源を使用して光学測定を行う、請求項6に記載の検体分析装置。
- 前記光学測定部は、前記検体に対して光学測定を行うことにより、前記検体中の干渉物質の有無に関する情報を取得する、請求項1〜7のいずれか1項に記載の検体分析装置。
- 前記分析部は、検体が凝固する過程を透過光または散乱光の変化として検出する、請求項1〜8のいずれか1項に記載の検体分析装置。
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Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2645086A3 (en) * | 2006-03-16 | 2014-03-12 | Sysmex Corporation | Sample analyzer |
JP4875391B2 (ja) * | 2006-03-30 | 2012-02-15 | シスメックス株式会社 | 検体分析装置 |
EP2259069B1 (en) * | 2008-03-31 | 2018-09-12 | Sysmex Corporation | Blood coagulation analyzer and method of analyzing blood coagulation |
CN105181407B (zh) * | 2008-03-31 | 2020-06-30 | 希森美康株式会社 | 制样装置与制样方法以及细胞分析装置与细胞分析方法 |
AU2009201799A1 (en) * | 2008-05-23 | 2009-12-10 | Aristocrat Technologies Australia Pty Limited | A method of gaming, a game controller and a gaming system |
JP5319696B2 (ja) * | 2008-11-17 | 2013-10-16 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
JP5021010B2 (ja) * | 2009-08-18 | 2012-09-05 | あおい精機株式会社 | 検体処理装置及び検体処理方法 |
JP5608871B2 (ja) * | 2010-03-09 | 2014-10-15 | 学校法人慶應義塾 | レーザカテーテル出射部の血液焦げ付き防止システム |
JP5478360B2 (ja) * | 2010-05-20 | 2014-04-23 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
US20130183769A1 (en) * | 2010-09-17 | 2013-07-18 | Universal Bio Research Co., Ltd. | Cartridge and automatic analysis device |
JP5822534B2 (ja) * | 2011-05-13 | 2015-11-24 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
JP5474903B2 (ja) * | 2011-09-28 | 2014-04-16 | あおい精機株式会社 | 検査前処理装置、検査前処理方法、及び検体処理装置 |
EP2885643B1 (en) * | 2012-08-20 | 2019-02-27 | Siemens Healthcare Diagnostics Inc. | Methods and apparatus for ascertaining specimen and/or sample container characteristics while in transit |
JP6180745B2 (ja) * | 2013-01-30 | 2017-08-16 | 株式会社日立ハイテクノロジーズ | 核酸分析装置 |
WO2014149118A2 (en) | 2013-03-15 | 2014-09-25 | Abbott Laboratories | Diagnostic analyzers with pretreatment carousels and related methods |
US20140271369A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Laboratories | System and Method for Processing Both Clinical Chemistry and Immunoassay Tests |
US10094842B2 (en) * | 2014-10-17 | 2018-10-09 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Automatic biochemical analyzer |
US10006857B2 (en) * | 2015-01-26 | 2018-06-26 | Bacterioscan Ltd. | Laser-scatter measurement instrument having carousel-based fluid sample arrangement |
WO2016130962A1 (en) | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
CN107430058A (zh) | 2015-02-27 | 2017-12-01 | Hycor生物医学有限责任公司 | 用于悬浮和洗涤多个试杯的内容物的装置和方法 |
CN108027379B (zh) | 2015-06-26 | 2021-07-23 | 雅培实验室 | 用于诊断分析设备的反应容器交换装置 |
EP3314224A4 (en) | 2015-06-26 | 2019-05-15 | Abbott Laboratories | MOVABLE REACTION VESSEL FOR MOVING REACTION VESSES FROM A PROCESSING RAIL TO A ROTATING DEVICE IN A DIAGNOSTIC ANALYZER |
US11815446B2 (en) | 2016-01-28 | 2023-11-14 | Siemens Healthcare Diagnostics Inc. | Methods and apparatus for characterizing a specimen container and specimen |
AU2017220028B2 (en) | 2016-02-17 | 2022-04-28 | Becton, Dickinson And Company | Automated sample preparation system for diagnostic testing of same |
CA3019765A1 (en) | 2016-04-22 | 2017-10-26 | Becton, Dickinson And Company | Automated diagnostic analyzer and method for its operation |
EP3446132B1 (en) | 2016-04-22 | 2023-06-14 | Becton, Dickinson and Company | Automated analyzer piercing stoppers for aspiration |
CN117253055A (zh) | 2016-10-28 | 2023-12-19 | 贝克曼库尔特有限公司 | 物质准备评估系统 |
US11073472B2 (en) | 2016-11-14 | 2021-07-27 | Siemens Healthcare Diagnostics Inc. | Methods and apparatus for characterizing a specimen using pattern illumination |
WO2019018313A1 (en) | 2017-07-19 | 2019-01-24 | Siemens Healthcare Diagnostics Inc. | METHODS FOR COMPENSATION OF PARASITE LIGHT AND APPARATUS FOR CHARACTERIZING A SPECIMEN |
CN107315094B (zh) * | 2017-07-27 | 2023-12-01 | 深圳传世生物医疗有限公司 | 凝血分析仪及凝血分析方法 |
EP3737930A4 (en) * | 2018-01-10 | 2021-03-10 | Siemens Healthcare Diagnostics, Inc. | METHOD AND DEVICE FOR CHARACTERIZATION OF A BIOLOGICAL SAMPLE USING A NEURAL NETWORK WITH REDUCED TRAINING |
EP3578971B1 (en) * | 2018-06-05 | 2021-12-15 | Fenwal, Inc. | Determination of cause of redness in biological fluid |
WO2020103051A1 (zh) * | 2018-11-21 | 2020-05-28 | 北京普利生仪器有限公司 | 样本吸光度差的测量方法、样本分析仪和存储介质 |
CN109900539B (zh) * | 2019-03-15 | 2021-07-20 | 遵义医学院附属医院 | 一种hpv检测实验用仿生型试剂批量添加及混匀装置 |
WO2021207897A1 (zh) * | 2020-04-13 | 2021-10-21 | 深圳迈瑞生物医疗电子股份有限公司 | 一种样本分析方法和装置 |
WO2021207898A1 (zh) * | 2020-04-13 | 2021-10-21 | 深圳迈瑞生物医疗电子股份有限公司 | 一种样本分析装置及方法 |
CN113237852B (zh) * | 2021-06-03 | 2024-04-19 | 高洪亮 | 血标本状态识别装置 |
US20230306614A1 (en) * | 2022-03-28 | 2023-09-28 | Darvis Inc. | System and method for tracking surgical kit |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6182272U (ja) * | 1984-11-02 | 1986-05-31 | ||
JPS6234095B2 (ja) * | 1979-04-28 | 1987-07-24 | Nippon Electron Optics Lab | |
JPH01287466A (ja) * | 1988-05-16 | 1989-11-20 | Toshiba Corp | 自動化学分析装置 |
JPH04130248A (ja) * | 1990-09-21 | 1992-05-01 | Hitachi Ltd | 自動分析装置 |
JPH06347466A (ja) * | 1993-03-22 | 1994-12-22 | Nittec Co Ltd | 容器の移送方法 |
JPH07280814A (ja) * | 1994-04-14 | 1995-10-27 | Hitachi Ltd | 検体検査自動化システム |
JPH0894636A (ja) * | 1994-09-21 | 1996-04-12 | Toa Medical Electronics Co Ltd | 検体の自動分析方法および装置 |
JPH08114600A (ja) * | 1994-10-19 | 1996-05-07 | Hitachi Ltd | 生体試料分析システム |
JP2001027643A (ja) * | 1999-05-11 | 2001-01-30 | Sysmex Corp | 自動分析装置 |
JP2003098185A (ja) * | 2001-07-20 | 2003-04-03 | Ortho-Clinical Diagnostics Inc | 臨床分析器のための補助試料供給器 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3609042A (en) | 1968-05-13 | 1971-09-28 | Hitachi Ltd | Optical measuring apparatus for sampling material, making a flame test, and comparing the light from an unknown concentration with that from two known concentrations |
GB1603821A (en) | 1977-04-15 | 1981-12-02 | Johnson Matthey Co Ltd | Catalysts for the production of formaldehyde |
JPS5630650A (en) | 1979-08-22 | 1981-03-27 | Hitachi Ltd | Automatic chemical analyzer |
EP0041366B1 (en) | 1980-05-30 | 1986-09-10 | Hitachi, Ltd. | Method for operating an apparatus for analysing samples optically |
JPS5782769A (en) | 1980-11-10 | 1982-05-24 | Hitachi Ltd | Automatic analyzing device |
AU553772B2 (en) | 1981-07-20 | 1986-07-24 | American Hospital Supply Corp. | Cuvette system for automated chemical analyzer |
JPS5970946A (ja) | 1982-10-15 | 1984-04-21 | Toshiba Corp | 吸光度測定装置 |
JPS59100862A (ja) | 1982-12-01 | 1984-06-11 | Hitachi Ltd | 自動分析装置 |
JPS6182272A (ja) | 1984-09-29 | 1986-04-25 | Hitachi Ltd | ベクトル処理装置 |
JPS61241639A (ja) | 1985-04-19 | 1986-10-27 | Hitachi Ltd | 反応試料分析装置 |
DE3683573D1 (de) | 1985-06-26 | 1992-03-05 | Japan Tectron Instr Corp | Automatischer analysenapparat. |
EP0231430B1 (en) * | 1986-01-31 | 1991-07-17 | Kabushiki Kaisha Nittec | Automatic analysis apparatus |
US4919887A (en) * | 1986-09-16 | 1990-04-24 | Nittec Co., Ltd. | Automatic analyzer |
US5698450A (en) | 1986-10-14 | 1997-12-16 | Ringrose; Anthony | Method for measuring antigens or antibodies in biological fluids |
JPH01145552A (ja) | 1987-12-02 | 1989-06-07 | Olympus Optical Co Ltd | 自動分析装置 |
JPH0758263B2 (ja) | 1988-08-26 | 1995-06-21 | 株式会社日立製作所 | 自動蛍光光度計を用いる分析方法 |
JPH02223859A (ja) | 1989-02-25 | 1990-09-06 | Shimadzu Corp | 生化学分析方法 |
JP2649409B2 (ja) * | 1989-03-14 | 1997-09-03 | 株式会社日立製作所 | 臨床検査用の自動分析方法 |
US5646046A (en) * | 1989-12-01 | 1997-07-08 | Akzo Nobel N.V. | Method and instrument for automatically performing analysis relating to thrombosis and hemostasis |
JPH04348258A (ja) * | 1991-05-27 | 1992-12-03 | Kowa Co | 多チャンネル光学測定装置 |
US5376313A (en) * | 1992-03-27 | 1994-12-27 | Abbott Laboratories | Injection molding a plastic assay cuvette having low birefringence |
JPH06265554A (ja) * | 1993-03-11 | 1994-09-22 | Daikin Ind Ltd | 血液生化学成分の分析方法およびその装置 |
US5734468A (en) * | 1995-08-18 | 1998-03-31 | Beckman Instruments, Inc. | Probe and method for determining serum indices of a serum sample |
US6353471B1 (en) | 1995-10-10 | 2002-03-05 | Cme Telemetrix Inc. | Method and apparatus for non-destructive screening of specimen integrity |
JP3994143B2 (ja) * | 1995-11-21 | 2007-10-17 | エヌアイアール ダイアグナスティック インク. | 血液分析器のための検体の迅速な分光光度法の予備検査鑑別方法及び装置 |
US5745243A (en) | 1996-11-15 | 1998-04-28 | Optical Solutions, Inc. | Photometer apparatus |
JPH10170444A (ja) | 1996-12-06 | 1998-06-26 | Hamamatsu Photonics Kk | 光測定装置 |
JPH10274656A (ja) | 1997-03-28 | 1998-10-13 | Kdk Corp | グルコース濃度の測定方法 |
EP1930078A1 (en) * | 1998-05-01 | 2008-06-11 | Gen-Probe Incorporated | Method for agitating the contents of a container |
JP3558898B2 (ja) | 1998-11-05 | 2004-08-25 | 株式会社日立製作所 | 自動分析装置及び自動分析方法 |
US6388750B1 (en) | 1998-12-17 | 2002-05-14 | Beckman Coulter, Inc. | Device and method for preliminary testing a neat serum sample in a primary collection tube |
US6797518B1 (en) | 2000-09-11 | 2004-09-28 | Ortho-Clinical Diagnostics, Inc. | Analysis method with sample quality measurement |
US20030026773A1 (en) | 2001-06-26 | 2003-02-06 | The Procter & Gamble Company | Anhydrous liquid antiperspirant emulsions |
JP4234393B2 (ja) * | 2002-10-31 | 2009-03-04 | 株式会社東芝 | 生体情報計測装置 |
US8326388B2 (en) | 2002-10-31 | 2012-12-04 | Toshiba Medical Systems Corporation | Method and apparatus for non-invasive measurement of living body characteristics by photoacoustics |
JP4491277B2 (ja) | 2004-05-21 | 2010-06-30 | 株式会社日立ハイテクノロジーズ | 試料分析装置 |
WO2006040387A1 (en) * | 2004-10-11 | 2006-04-20 | Thermo Fisher Scientific Oy | Method for automatically detecting factors that disturb analysis by a photometer |
EP2605020B1 (en) | 2005-03-29 | 2017-05-17 | Sysmex Corporation | Method of specimen analysis and specimen analyzer |
EP2645086A3 (en) | 2006-03-16 | 2014-03-12 | Sysmex Corporation | Sample analyzer |
JP6234095B2 (ja) | 2013-07-16 | 2017-11-22 | キヤノン株式会社 | 液体吐出ヘッド及びその製造方法 |
-
2006
- 2006-03-23 JP JP2007510430A patent/JP4999679B2/ja active Active
- 2006-03-23 WO PCT/JP2006/305813 patent/WO2006104006A1/ja active Application Filing
- 2006-03-23 CN CNA200680010576XA patent/CN101151534A/zh active Pending
- 2006-03-23 CN CN201410195085.3A patent/CN103941027B/zh active Active
- 2006-03-23 EP EP06729780.4A patent/EP1867997B1/en active Active
-
2007
- 2007-09-28 US US11/905,328 patent/US8545760B2/en active Active
-
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- 2013-08-30 US US14/015,358 patent/US9028756B2/en active Active
-
2015
- 2015-04-02 US US14/677,170 patent/US9316583B2/en active Active
-
2016
- 2016-03-15 US US15/070,597 patent/US10261016B2/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6234095B2 (ja) * | 1979-04-28 | 1987-07-24 | Nippon Electron Optics Lab | |
JPS6182272U (ja) * | 1984-11-02 | 1986-05-31 | ||
JPH01287466A (ja) * | 1988-05-16 | 1989-11-20 | Toshiba Corp | 自動化学分析装置 |
JPH04130248A (ja) * | 1990-09-21 | 1992-05-01 | Hitachi Ltd | 自動分析装置 |
JPH06347466A (ja) * | 1993-03-22 | 1994-12-22 | Nittec Co Ltd | 容器の移送方法 |
JPH07280814A (ja) * | 1994-04-14 | 1995-10-27 | Hitachi Ltd | 検体検査自動化システム |
JPH0894636A (ja) * | 1994-09-21 | 1996-04-12 | Toa Medical Electronics Co Ltd | 検体の自動分析方法および装置 |
JPH08114600A (ja) * | 1994-10-19 | 1996-05-07 | Hitachi Ltd | 生体試料分析システム |
JP2001027643A (ja) * | 1999-05-11 | 2001-01-30 | Sysmex Corp | 自動分析装置 |
JP2003098185A (ja) * | 2001-07-20 | 2003-04-03 | Ortho-Clinical Diagnostics Inc | 臨床分析器のための補助試料供給器 |
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US20160195560A1 (en) | 2016-07-07 |
EP1867997B1 (en) | 2015-04-29 |
CN103941027A (zh) | 2014-07-23 |
US20080020481A1 (en) | 2008-01-24 |
US9028756B2 (en) | 2015-05-12 |
US9316583B2 (en) | 2016-04-19 |
US10261016B2 (en) | 2019-04-16 |
WO2006104006A1 (ja) | 2006-10-05 |
EP1867997A4 (en) | 2014-01-01 |
CN101151534A (zh) | 2008-03-26 |
US8545760B2 (en) | 2013-10-01 |
EP1867997A1 (en) | 2007-12-19 |
US20140004612A1 (en) | 2014-01-02 |
JPWO2006104006A1 (ja) | 2008-09-04 |
CN103941027B (zh) | 2016-09-07 |
US20150211995A1 (en) | 2015-07-30 |
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