JP4968811B2 - 遺伝子発現制御のための一本鎖核酸分子 - Google Patents

遺伝子発現制御のための一本鎖核酸分子 Download PDF

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Publication number
JP4968811B2
JP4968811B2 JP2011537086A JP2011537086A JP4968811B2 JP 4968811 B2 JP4968811 B2 JP 4968811B2 JP 2011537086 A JP2011537086 A JP 2011537086A JP 2011537086 A JP2011537086 A JP 2011537086A JP 4968811 B2 JP4968811 B2 JP 4968811B2
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expression
nucleic acid
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JPWO2012005368A1 (ja
Inventor
忠明 大木
宏剛 林
久男 白水
智洋 濱崎
彰浩 伊藤
鈴木　　寛
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Bonac Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011537086A 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子 Expired - Fee Related JP4968811B2 (ja)

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JP2011537086A JP4968811B2 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子

Applications Claiming Priority (14)

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JP2010156122 2010-07-08
JP2010156122 2010-07-08
JP2010174915 2010-08-03
JP2010174915 2010-08-03
JP2010230808 2010-10-13
JP2010230806 2010-10-13
JP2010230808 2010-10-13
JP2010230806 2010-10-13
JP2010269823 2010-12-02
JP2010269824 2010-12-02
JP2010269824 2010-12-02
JP2010269823 2010-12-02
JP2011537086A JP4968811B2 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子
PCT/JP2011/065737 WO2012005368A1 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子

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JP4968811B2 true JP4968811B2 (ja) 2012-07-04
JPWO2012005368A1 JPWO2012005368A1 (ja) 2013-09-05

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JP2011537086A Expired - Fee Related JP4968811B2 (ja) 2010-07-08 2011-07-08 遺伝子発現制御のための一本鎖核酸分子
JP2012009515A Expired - Fee Related JP5804642B2 (ja) 2010-07-08 2012-01-20 遺伝子発現制御のための一本鎖核酸分子
JP2015150156A Expired - Fee Related JP6162182B2 (ja) 2010-07-08 2015-07-29 遺伝子発現制御のための一本鎖核酸分子

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JP2015150156A Expired - Fee Related JP6162182B2 (ja) 2010-07-08 2015-07-29 遺伝子発現制御のための一本鎖核酸分子

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EP (2) EP2431466B1 (cg-RX-API-DMAC7.html)
JP (3) JP4968811B2 (cg-RX-API-DMAC7.html)
KR (1) KR101849798B1 (cg-RX-API-DMAC7.html)
CN (2) CN104818276B (cg-RX-API-DMAC7.html)
AU (1) AU2011274854B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013000481A2 (cg-RX-API-DMAC7.html)
CA (1) CA2804511C (cg-RX-API-DMAC7.html)
DK (2) DK2933333T3 (cg-RX-API-DMAC7.html)
ES (2) ES2670017T3 (cg-RX-API-DMAC7.html)
HU (2) HUE037500T2 (cg-RX-API-DMAC7.html)
MX (1) MX352568B (cg-RX-API-DMAC7.html)
NZ (2) NZ606232A (cg-RX-API-DMAC7.html)
PT (2) PT2431466E (cg-RX-API-DMAC7.html)
RU (1) RU2628311C2 (cg-RX-API-DMAC7.html)
SG (2) SG186899A1 (cg-RX-API-DMAC7.html)
TW (2) TWI527901B (cg-RX-API-DMAC7.html)
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WO2013133393A1 (ja) * 2012-03-07 2013-09-12 学校法人東京医科大学 Ｖｅｇｆ遺伝子の発現抑制用一本鎖核酸分子
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EP2857513A4 (en) * 2012-05-26 2016-05-25 Bonac Corp Single-stranded nucleic acid molecule controlling the expression of a gene transporter
WO2015099122A1 (ja) 2013-12-26 2015-07-02 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
RU2697094C2 (ru) 2013-12-27 2019-08-12 Бонак Корпорейшн ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ
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CN108064289A (zh) 2015-03-27 2018-05-22 株式会社博纳克 具有递送功能和基因表达调控能力的单链核酸分子
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JPWO2018199338A1 (ja) * 2017-04-27 2020-03-12 国立大学法人広島大学 Ｂ型肝炎治療用核酸分子
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JPWO2019074110A1 (ja) * 2017-10-13 2020-12-24 株式会社ボナック 一本鎖核酸分子およびその製造方法
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
WO2019189722A1 (ja) 2018-03-30 2019-10-03 東レ株式会社 ヘアピン型一本鎖ｒｎａ分子の製造方法
WO2019189591A1 (ja) 2018-03-30 2019-10-03 住友化学株式会社 一本鎖ｒｎａの製造方法
WO2020071407A1 (ja) * 2018-10-02 2020-04-09 東レ株式会社 ヘアピン型一本鎖ｒｎａ分子の製造方法
WO2020152869A1 (ja) 2019-01-25 2020-07-30 杏林製薬株式会社 線維症治療剤
KR20220079832A (ko) 2019-10-11 2022-06-14 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
WO2021153047A1 (ja) 2020-01-29 2021-08-05 住友化学株式会社 核酸オリゴマーの製造方法
KR20220133919A (ko) 2020-01-29 2022-10-05 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
JP7613130B2 (ja) * 2020-03-25 2025-01-15 味の素株式会社 リガーゼ変異体
CN115335387A (zh) 2020-03-27 2022-11-11 住友化学株式会社 核酸寡聚物的制造方法
CN115867559A (zh) 2020-07-09 2023-03-28 住友化学株式会社 核酸寡聚物的制造方法
CN116209668A (zh) 2020-09-24 2023-06-02 住友化学株式会社 核酸寡聚物的制造方法
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JP7201190B1 (ja) 2022-06-03 2023-01-10 株式会社セツロテック 遺伝子改変動物由来の動物繊維
JPWO2024089953A1 (cg-RX-API-DMAC7.html) 2022-10-27 2024-05-02

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JP5804642B2 (ja) 2015-11-04
MX2013000315A (es) 2013-05-01
JP2012130342A (ja) 2012-07-12
TWI573870B (zh) 2017-03-11
NZ704812A (en) 2017-01-27
ES2670017T3 (es) 2018-05-29
EP2431466A4 (en) 2012-04-25
AU2011274854A1 (en) 2013-02-14
TW201217523A (en) 2012-05-01
AU2011274854B2 (en) 2015-04-16
PT2933333T (pt) 2018-04-24
SG196779A1 (en) 2014-02-13
EP2431466B1 (en) 2015-10-07
JP6162182B2 (ja) 2017-07-12
KR20130090792A (ko) 2013-08-14
DK2431466T3 (en) 2016-01-11
KR101849798B1 (ko) 2018-04-17
DK2933333T3 (en) 2018-04-30
JPWO2012005368A1 (ja) 2013-09-05
BR112013000481A2 (pt) 2019-10-15
HK1181423A1 (zh) 2013-11-08
CN102918156A (zh) 2013-02-06
JP2015231381A (ja) 2015-12-24
EP2933333A1 (en) 2015-10-21
HUE037500T2 (hu) 2018-08-28
EP2933333B1 (en) 2018-02-21
CN102918156B (zh) 2015-11-25
ES2550487T3 (es) 2015-11-10
CA2804511A1 (en) 2012-01-12
PT2431466E (pt) 2016-01-08
TWI527901B (zh) 2016-04-01
NZ606232A (en) 2015-06-26
SG186899A1 (en) 2013-02-28
CN104818276A (zh) 2015-08-05
CN104818276B (zh) 2020-12-11
WO2012005368A1 (ja) 2012-01-12
HUE026520T2 (en) 2016-06-28
RU2628311C2 (ru) 2017-08-15
CA2804511C (en) 2021-07-06
MX352568B (es) 2017-11-29
RU2013105329A (ru) 2014-08-20
TW201627500A (zh) 2016-08-01
EP2431466A1 (en) 2012-03-21

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