JP4950896B2 - ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体およびその使用 - Google Patents

ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体およびその使用 Download PDF

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Publication number
JP4950896B2
JP4950896B2 JP2007538352A JP2007538352A JP4950896B2 JP 4950896 B2 JP4950896 B2 JP 4950896B2 JP 2007538352 A JP2007538352 A JP 2007538352A JP 2007538352 A JP2007538352 A JP 2007538352A JP 4950896 B2 JP4950896 B2 JP 4950896B2
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Prior art keywords
hydroxy
bicyclo
azonia
acetoxy
ylcarbamoylmethyl
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Expired - Fee Related
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JP2007538352A
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Japanese (ja)
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JP2008518890A5 (OSRAM
JP2008518890A (ja
Inventor
ニール・ジョン・プレス
スティーブン・ポール・コリングウッド
アース・ベッティグ
ブライアン・コックス
スダカール・デヴィダスラオ・ガラド
キム・ヒュンチュル
ディミトリス・パプートサキス
サイモン・ジェイムズ・ワトソン
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2007538352A 2004-11-02 2005-10-31 ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体およびその使用 Expired - Fee Related JP4950896B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0424284.8 2004-11-02
GBGB0424284.8A GB0424284D0 (en) 2004-11-02 2004-11-02 Organic compounds
PCT/EP2005/011662 WO2006048225A1 (en) 2004-11-02 2005-10-31 Quinuclidine derivatives and their use as muscarinic m3 receptor antagonists

Publications (3)

Publication Number Publication Date
JP2008518890A JP2008518890A (ja) 2008-06-05
JP2008518890A5 JP2008518890A5 (OSRAM) 2012-03-15
JP4950896B2 true JP4950896B2 (ja) 2012-06-13

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ID=33515948

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JP2007538352A Expired - Fee Related JP4950896B2 (ja) 2004-11-02 2005-10-31 ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体およびその使用

Country Status (33)

Country Link
US (2) US7723356B2 (OSRAM)
EP (2) EP1811999B1 (OSRAM)
JP (1) JP4950896B2 (OSRAM)
KR (1) KR101252307B1 (OSRAM)
CN (1) CN101056634B (OSRAM)
AR (1) AR054090A1 (OSRAM)
AT (1) ATE481099T1 (OSRAM)
AU (1) AU2005300710B2 (OSRAM)
BR (1) BRPI0517945A (OSRAM)
CA (1) CA2583237C (OSRAM)
CY (1) CY1110952T1 (OSRAM)
DE (1) DE602005023639D1 (OSRAM)
DK (1) DK1811999T3 (OSRAM)
EC (1) ECSP077424A (OSRAM)
ES (1) ES2353142T3 (OSRAM)
GB (1) GB0424284D0 (OSRAM)
HR (1) HRP20100693T1 (OSRAM)
IL (1) IL182695A0 (OSRAM)
JO (1) JO2613B1 (OSRAM)
MA (1) MA29080B1 (OSRAM)
MX (1) MX2007005189A (OSRAM)
MY (1) MY145207A (OSRAM)
NO (1) NO20072371L (OSRAM)
NZ (1) NZ554302A (OSRAM)
PE (1) PE20060609A1 (OSRAM)
PL (1) PL1811999T3 (OSRAM)
PT (1) PT1811999E (OSRAM)
RU (1) RU2399620C2 (OSRAM)
SI (1) SI1811999T1 (OSRAM)
TN (1) TNSN07164A1 (OSRAM)
TW (1) TW200628154A (OSRAM)
WO (1) WO2006048225A1 (OSRAM)
ZA (1) ZA200702772B (OSRAM)

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UA107499C2 (uk) * 2010-06-22 2015-01-12 Chiesi Farm Spa Склад сухого порошку, який містить антимускариновий засіб
RU2569846C2 (ru) * 2010-06-22 2015-11-27 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Алкалоидные производные сложных аминоэфиров и включающие их лекарственные композиции
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
CA2828219A1 (en) 2011-02-25 2012-08-30 Irm Llc Pyrazolo [1,5-a] pyridines as trk inhibitors
JP2011195593A (ja) * 2011-06-30 2011-10-06 Astrazeneca Ab ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体
HK1212348A1 (en) 2012-12-19 2016-06-10 Novartis Ag Autotaxin inhibitors
WO2015162558A1 (en) 2014-04-24 2015-10-29 Novartis Ag Autotaxin inhibitors
WO2015171753A1 (en) * 2014-05-06 2015-11-12 Visco Anthony G Methods of treating or preventing preterm labor
CN109851615B (zh) * 2019-04-22 2021-06-08 上海旭东海普药业有限公司 纯化戊乙奎醚的方法

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EP1811999B1 (en) 2010-09-15
RU2007120454A (ru) 2008-12-10
KR101252307B1 (ko) 2013-04-08
PE20060609A1 (es) 2006-08-21
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