JP4926061B2 - イソプレノイド化合物の産生を促進する方法 - Google Patents
イソプレノイド化合物の産生を促進する方法 Download PDFInfo
- Publication number
- JP4926061B2 JP4926061B2 JP2007527501A JP2007527501A JP4926061B2 JP 4926061 B2 JP4926061 B2 JP 4926061B2 JP 2007527501 A JP2007527501 A JP 2007527501A JP 2007527501 A JP2007527501 A JP 2007527501A JP 4926061 B2 JP4926061 B2 JP 4926061B2
- Authority
- JP
- Japan
- Prior art keywords
- coa
- cell
- genetically modified
- host cell
- hmg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57349204P | 2004-05-21 | 2004-05-21 | |
| US60/573,492 | 2004-05-21 | ||
| PCT/US2005/017874 WO2006085899A2 (en) | 2004-05-21 | 2005-05-20 | Method for enhancing production of isoprenoid compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008500063A JP2008500063A (ja) | 2008-01-10 |
| JP2008500063A5 JP2008500063A5 (https=) | 2008-04-24 |
| JP4926061B2 true JP4926061B2 (ja) | 2012-05-09 |
Family
ID=36793476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527501A Expired - Lifetime JP4926061B2 (ja) | 2004-05-21 | 2005-05-20 | イソプレノイド化合物の産生を促進する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7183089B2 (https=) |
| EP (2) | EP2365090A1 (https=) |
| JP (1) | JP4926061B2 (https=) |
| CN (1) | CN101023181A (https=) |
| AT (1) | ATE537269T1 (https=) |
| AU (1) | AU2005327292B2 (https=) |
| BR (1) | BRPI0510115B1 (https=) |
| CA (1) | CA2567547C (https=) |
| ES (1) | ES2379368T3 (https=) |
| MX (1) | MXPA06013502A (https=) |
| WO (1) | WO2006085899A2 (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE286063T1 (de) * | 1996-04-17 | 2005-01-15 | Hubert Dr Koester | Kombinatorische schutzgruppestrategie für multifunktionelle molekule |
| US20050287596A9 (en) * | 1998-06-26 | 2005-12-29 | Braisted Andrew C | Novel ligands and libraries of ligands |
| WO2002010398A2 (en) * | 2000-07-31 | 2002-02-07 | Hahn Frederick M | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| EP1502102B1 (en) * | 2002-03-11 | 2009-01-14 | caprotec bioanalytics GmbH | Compounds and methods for analyzing the proteome |
| EP2259068B1 (en) * | 2003-01-16 | 2013-08-14 | caprotec bioanalytics GmbH | Capture compounds and methods for analyzing the proteome |
| AU2006325040B2 (en) | 2005-06-07 | 2012-04-19 | Dsm Nutritional Products Ag | Eukaryotic microorganisms for producing lipids and antioxidants |
| WO2007044688A1 (en) * | 2005-10-07 | 2007-04-19 | The Regents Of The University Of California | Nucleic acids encoding modified cytochrome p450 enzymes and methods of use thereof |
| US8114645B2 (en) * | 2006-05-19 | 2012-02-14 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| CA2652801C (en) * | 2006-05-26 | 2018-05-22 | Amyris Biotechnologies, Inc. | Apparatus for making bio-organic compounds |
| CA2659603C (en) * | 2006-08-01 | 2017-03-07 | Ocean Nutrition Canada Limited | Oil producing microbes and methods of modification thereof |
| EP2066778B1 (en) * | 2006-09-26 | 2016-01-27 | The Regents of The University of California | Production of isoprenoids and isoprenoid precursors |
| US8234641B2 (en) * | 2006-10-17 | 2012-07-31 | Managelq, Inc. | Compliance-based adaptations in managed virtual systems |
| WO2008094546A2 (en) * | 2007-01-31 | 2008-08-07 | The Regents Of The University Of California | Genetically modified host cells for increased p450 activity levels and methods of use thereof |
| WO2009006386A2 (en) | 2007-06-29 | 2009-01-08 | The Regents Of The University Of California | Host cells and methods for producing isoprenyl alkanoates |
| US8067632B2 (en) * | 2007-07-26 | 2011-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Process to produce prostratin and structural or functional analogs thereof |
| WO2009064910A2 (en) * | 2007-11-13 | 2009-05-22 | Synthetic Genomics, Inc. | Dimethyloctane as an advanced biofuel |
| CN105368764B (zh) | 2007-12-13 | 2019-03-12 | 丹尼斯科美国公司 | 用于生产异戊二烯的组合物和方法 |
| BRPI0906620A8 (pt) * | 2008-01-31 | 2016-01-19 | Amyris Biotechnologies Inc | Método para quanitificar um cofator e um metabólico da via do mevalonato, extrato de um célula, e, método de fermentação |
| CN102066551B (zh) * | 2008-03-27 | 2013-10-09 | 基因组股份公司 | 用于产生己二酸和其他化合物的微生物 |
| US20090253174A1 (en) * | 2008-04-08 | 2009-10-08 | Zach Serber | Expression of Heterologous Sequences |
| WO2009132220A2 (en) * | 2008-04-23 | 2009-10-29 | Danisco Us Inc. | Isoprene synthase variants for improved microbial production of isoprene |
| JP2011520455A (ja) | 2008-05-16 | 2011-07-21 | エルエス9・インコーポレイテッド | 炭化水素を製造するための方法および組成物 |
| CA2725175A1 (en) * | 2008-05-23 | 2009-11-26 | Cibus Oils, Llc | Production of squalene using yeast |
| JP5624980B2 (ja) * | 2008-06-30 | 2014-11-12 | ザ・グッドイヤー・タイヤ・アンド・ラバー・カンパニーThe Goodyeartire & Rubber Company | 再生資源に由来するイソプレンの重合体 |
| MX318543B (es) | 2008-07-02 | 2014-03-18 | Danisco Us Inc | Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros. |
| CA2737082A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| WO2010031062A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| KR101700296B1 (ko) | 2008-10-28 | 2017-01-26 | 알이지 라이프 사이언시스, 엘엘씨 | 지방족 알코올들을 생산하기 위한 방법들과 조성물들 |
| AU2010238770A1 (en) | 2009-04-23 | 2011-11-03 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| HUE034245T2 (en) * | 2009-11-23 | 2018-02-28 | Nucelis Llc | Methods and preparations for the preparation of squalene using yeast |
| EP2575432B1 (en) | 2010-06-02 | 2019-08-14 | Evolva, Inc. | Recombinant production of steviol glycosides |
| CA2816306A1 (en) | 2010-10-27 | 2012-05-03 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
| CA3128532A1 (en) | 2011-08-08 | 2013-02-14 | Evolva Sa | Recombinant production of steviol glycosides |
| IN2014CN01129A (https=) | 2011-08-08 | 2015-04-10 | Evolva Sa | |
| CN104039974B (zh) * | 2011-11-09 | 2016-10-12 | 阿迈瑞斯公司 | 乙酰辅酶a衍生的类异戊二烯的生产 |
| US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| JP5827601B2 (ja) * | 2012-07-04 | 2015-12-02 | 住友ゴム工業株式会社 | 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| CN103087972B (zh) | 2013-02-01 | 2014-11-05 | 中国科学院天津工业生物技术研究所 | 生产萜类化合物的重组微生物及构建方法 |
| MY199452A (en) | 2013-02-06 | 2023-10-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| BR112015019160A2 (pt) | 2013-02-11 | 2017-08-22 | Dalgaard Mikkelsen Michael | Produção de glicosídeos de esteviol em hospedeiros recombinantes |
| EP2970926B1 (en) | 2013-03-13 | 2018-01-31 | DSM Nutritional Products AG | Engineering microorganisms |
| JP6282813B2 (ja) * | 2013-07-16 | 2018-02-21 | 住友ゴム工業株式会社 | ヒドロキシメチルグルタリルCoAレダクターゼの発現をbZIP型転写因子により調整する方法、bZIP型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| CN103602626B (zh) * | 2013-10-12 | 2016-02-10 | 中国科学院青岛生物能源与过程研究所 | 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌 |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2960693A1 (en) | 2014-09-09 | 2016-03-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3250686A1 (en) | 2015-01-30 | 2017-12-06 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| MX2018001620A (es) | 2015-08-07 | 2018-06-11 | Evolva Sa | Produccion de glucosidos de esteviol en hospedadores recombinantes. |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| CN106367508B (zh) * | 2016-09-13 | 2019-10-29 | 东北农业大学 | 一种用于鉴定杂合型类异戊二烯化合物产生菌的简并引物与应用 |
| WO2018083338A1 (en) | 2016-11-07 | 2018-05-11 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2019055325A2 (en) * | 2017-09-12 | 2019-03-21 | Biocapital Holdings, Llc | BIOOGICAL DEVICES AND METHODS OF USING THE SAME TO PRODUCE STEVIOL GLYCOSIDES |
| WO2019090286A2 (en) * | 2017-11-06 | 2019-05-09 | The Regents Of The University Of California | Production of valerenic acid in fungal cells |
| WO2019113387A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| JP2021506316A (ja) | 2017-12-21 | 2021-02-22 | ザイマージェン インコーポレイテッド | ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物 |
| CN109777815B (zh) * | 2019-03-28 | 2021-10-29 | 昆明理工大学 | HMG-CoA合成酶基因RKHMGCS及其应用 |
| CN117165502A (zh) * | 2022-05-26 | 2023-12-05 | 牛津大学(苏州)科技有限公司 | 一种合成萜类化合物的共培养系统和方法 |
| NL2032683B1 (en) * | 2022-07-18 | 2024-01-26 | Sestina Bio Llc | Bioproduction of isoprenoids |
| EP4565691A1 (en) * | 2022-11-14 | 2025-06-11 | Agency for Science, Technology and Research | Biosynthesis of isoprenoid |
| CN116925991B (zh) * | 2023-07-28 | 2024-08-09 | 天津大学 | 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用 |
| CN120041291A (zh) * | 2023-11-24 | 2025-05-27 | 牛津大学(苏州)科技有限公司 | 用于合成目标化合物的共培养系统和方法 |
| WO2025217176A1 (en) * | 2024-04-08 | 2025-10-16 | Board Of Trustees Of Michigan State University | Genetically engineered bacteria as a chassis host for high yield terpenoid production |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001031043A1 (en) * | 1999-10-27 | 2001-05-03 | The University Of Bristol | Increasing isoprenoid biosynthesis |
| US20030148416A1 (en) * | 2001-06-06 | 2003-08-07 | Roche Vitamins Inc. | Isoprenoid production |
| WO2005033287A2 (en) * | 2003-09-29 | 2005-04-14 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| KR20060099543A (ko) | 1994-12-09 | 2006-09-19 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의 동정 |
| US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| JP2002515738A (ja) | 1996-01-23 | 2002-05-28 | アフィメトリックス,インコーポレイティド | 核酸分析法 |
| US6080849A (en) | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| US6033861A (en) | 1997-11-19 | 2000-03-07 | Incyte Genetics, Inc. | Methods for obtaining nucleic acid containing a mutation |
| CN1308623A (zh) * | 1998-07-06 | 2001-08-15 | 伊斯曼化学公司 | 生产维生素e的方法 |
| JP4579415B2 (ja) | 1998-07-06 | 2010-11-10 | ディーシーブイ・インコーポレイテッド・ドゥーイング・ビジネス・アズ・バイオ−テクニカル・リソーシィズ | ビタミン製造方法 |
| US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| AR022383A1 (es) * | 1998-09-18 | 2002-09-04 | Univ Kentucky Res Found | Sintasas |
| US6645747B1 (en) | 1999-09-21 | 2003-11-11 | E. I. Du Pont De Nemours And Company | Cis-prenyltransferases from plants |
| WO2002010398A2 (en) * | 2000-07-31 | 2002-02-07 | Hahn Frederick M | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| AU2001291114A1 (en) | 2000-09-19 | 2002-04-02 | Microbia, Inc. | Modulation of secondary metabolite production by zinc binuclear cluster proteins |
| US20040063182A1 (en) | 2000-12-28 | 2004-04-01 | Chikara Ohto | Process for producing prenyl alcohol |
| JP3838033B2 (ja) | 2000-12-28 | 2006-10-25 | トヨタ自動車株式会社 | プレニルアルコールの製造方法 |
| US7238514B2 (en) * | 2001-01-05 | 2007-07-03 | William Marsh Rice University | Diterpene-producing unicellular organism |
| GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
| US20040110259A1 (en) | 2001-08-03 | 2004-06-10 | Baugh Mariah R | Drug metabolizing enzymes |
| US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
-
2005
- 2005-05-20 AT AT05857432T patent/ATE537269T1/de active
- 2005-05-20 AU AU2005327292A patent/AU2005327292B2/en not_active Expired
- 2005-05-20 BR BRPI0510115-8A patent/BRPI0510115B1/pt not_active IP Right Cessation
- 2005-05-20 US US11/134,705 patent/US7183089B2/en not_active Expired - Lifetime
- 2005-05-20 CA CA2567547A patent/CA2567547C/en not_active Expired - Lifetime
- 2005-05-20 EP EP10177421A patent/EP2365090A1/en not_active Withdrawn
- 2005-05-20 WO PCT/US2005/017874 patent/WO2006085899A2/en not_active Ceased
- 2005-05-20 MX MXPA06013502A patent/MXPA06013502A/es active IP Right Grant
- 2005-05-20 CN CNA2005800243430A patent/CN101023181A/zh active Pending
- 2005-05-20 ES ES05857432T patent/ES2379368T3/es not_active Expired - Lifetime
- 2005-05-20 EP EP05857432A patent/EP1765418B1/en not_active Expired - Lifetime
- 2005-05-20 JP JP2007527501A patent/JP4926061B2/ja not_active Expired - Lifetime
-
2007
- 2007-01-17 US US11/624,094 patent/US7670825B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001031043A1 (en) * | 1999-10-27 | 2001-05-03 | The University Of Bristol | Increasing isoprenoid biosynthesis |
| US20030148416A1 (en) * | 2001-06-06 | 2003-08-07 | Roche Vitamins Inc. | Isoprenoid production |
| WO2005033287A2 (en) * | 2003-09-29 | 2005-04-14 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
Also Published As
| Publication number | Publication date |
|---|---|
| US20060079476A1 (en) | 2006-04-13 |
| EP1765418B1 (en) | 2011-12-14 |
| US20090004724A1 (en) | 2009-01-01 |
| CN101023181A (zh) | 2007-08-22 |
| BRPI0510115B1 (pt) | 2022-09-27 |
| MXPA06013502A (es) | 2007-03-01 |
| US7670825B2 (en) | 2010-03-02 |
| EP1765418A4 (en) | 2008-07-02 |
| CA2567547A1 (en) | 2006-08-17 |
| ATE537269T1 (de) | 2011-12-15 |
| EP2365090A1 (en) | 2011-09-14 |
| US7183089B2 (en) | 2007-02-27 |
| CA2567547C (en) | 2012-10-23 |
| WO2006085899A3 (en) | 2007-05-18 |
| WO2006085899A2 (en) | 2006-08-17 |
| AU2005327292B2 (en) | 2010-11-04 |
| BRPI0510115A (pt) | 2007-09-25 |
| ES2379368T3 (es) | 2012-04-25 |
| JP2008500063A (ja) | 2008-01-10 |
| EP1765418A2 (en) | 2007-03-28 |
| AU2005327292A1 (en) | 2006-08-17 |
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| JP4926061B2 (ja) | イソプレノイド化合物の産生を促進する方法 | |
| US10435717B2 (en) | Genetically modified host cells and use of same for producing isoprenoid compounds | |
| CA2826554C (en) | Methods of developing terpene synthase variants | |
| US7927794B2 (en) | Methods for identifying a biosynthetic pathway gene product | |
| US20090053797A1 (en) | Genetically modified host cells and use of same for producing isoprenoid compounds |
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