ATE537269T1 - Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen - Google Patents
Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungenInfo
- Publication number
- ATE537269T1 ATE537269T1 AT05857432T AT05857432T ATE537269T1 AT E537269 T1 ATE537269 T1 AT E537269T1 AT 05857432 T AT05857432 T AT 05857432T AT 05857432 T AT05857432 T AT 05857432T AT E537269 T1 ATE537269 T1 AT E537269T1
- Authority
- AT
- Austria
- Prior art keywords
- coa
- isoprenoid
- hmg
- present
- invention further
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 150000003505 terpenes Chemical class 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 abstract 2
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 abstract 2
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 abstract 2
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000035508 accumulation Effects 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000001177 diphosphate Substances 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000007154 intracellular accumulation Effects 0.000 abstract 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 abstract 1
- -1 isoprenoid compounds Chemical class 0.000 abstract 1
- 229920001550 polyprenyl Polymers 0.000 abstract 1
- 125000001185 polyprenyl group Polymers 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57349204P | 2004-05-21 | 2004-05-21 | |
| PCT/US2005/017874 WO2006085899A2 (en) | 2004-05-21 | 2005-05-20 | Method for enhancing production of isoprenoid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE537269T1 true ATE537269T1 (de) | 2011-12-15 |
Family
ID=36793476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05857432T ATE537269T1 (de) | 2004-05-21 | 2005-05-20 | Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7183089B2 (https=) |
| EP (2) | EP2365090A1 (https=) |
| JP (1) | JP4926061B2 (https=) |
| CN (1) | CN101023181A (https=) |
| AT (1) | ATE537269T1 (https=) |
| AU (1) | AU2005327292B2 (https=) |
| BR (1) | BRPI0510115B1 (https=) |
| CA (1) | CA2567547C (https=) |
| ES (1) | ES2379368T3 (https=) |
| MX (1) | MXPA06013502A (https=) |
| WO (1) | WO2006085899A2 (https=) |
Families Citing this family (65)
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| ATE286063T1 (de) * | 1996-04-17 | 2005-01-15 | Hubert Dr Koester | Kombinatorische schutzgruppestrategie für multifunktionelle molekule |
| US20050287596A9 (en) * | 1998-06-26 | 2005-12-29 | Braisted Andrew C | Novel ligands and libraries of ligands |
| WO2002010398A2 (en) * | 2000-07-31 | 2002-02-07 | Hahn Frederick M | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| EP1502102B1 (en) * | 2002-03-11 | 2009-01-14 | caprotec bioanalytics GmbH | Compounds and methods for analyzing the proteome |
| EP2259068B1 (en) * | 2003-01-16 | 2013-08-14 | caprotec bioanalytics GmbH | Capture compounds and methods for analyzing the proteome |
| AU2006325040B2 (en) | 2005-06-07 | 2012-04-19 | Dsm Nutritional Products Ag | Eukaryotic microorganisms for producing lipids and antioxidants |
| WO2007044688A1 (en) * | 2005-10-07 | 2007-04-19 | The Regents Of The University Of California | Nucleic acids encoding modified cytochrome p450 enzymes and methods of use thereof |
| US8114645B2 (en) * | 2006-05-19 | 2012-02-14 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| CA2652801C (en) * | 2006-05-26 | 2018-05-22 | Amyris Biotechnologies, Inc. | Apparatus for making bio-organic compounds |
| CA2659603C (en) * | 2006-08-01 | 2017-03-07 | Ocean Nutrition Canada Limited | Oil producing microbes and methods of modification thereof |
| EP2066778B1 (en) * | 2006-09-26 | 2016-01-27 | The Regents of The University of California | Production of isoprenoids and isoprenoid precursors |
| US8234641B2 (en) * | 2006-10-17 | 2012-07-31 | Managelq, Inc. | Compliance-based adaptations in managed virtual systems |
| WO2008094546A2 (en) * | 2007-01-31 | 2008-08-07 | The Regents Of The University Of California | Genetically modified host cells for increased p450 activity levels and methods of use thereof |
| WO2009006386A2 (en) | 2007-06-29 | 2009-01-08 | The Regents Of The University Of California | Host cells and methods for producing isoprenyl alkanoates |
| US8067632B2 (en) * | 2007-07-26 | 2011-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Process to produce prostratin and structural or functional analogs thereof |
| WO2009064910A2 (en) * | 2007-11-13 | 2009-05-22 | Synthetic Genomics, Inc. | Dimethyloctane as an advanced biofuel |
| CN105368764B (zh) | 2007-12-13 | 2019-03-12 | 丹尼斯科美国公司 | 用于生产异戊二烯的组合物和方法 |
| BRPI0906620A8 (pt) * | 2008-01-31 | 2016-01-19 | Amyris Biotechnologies Inc | Método para quanitificar um cofator e um metabólico da via do mevalonato, extrato de um célula, e, método de fermentação |
| CN102066551B (zh) * | 2008-03-27 | 2013-10-09 | 基因组股份公司 | 用于产生己二酸和其他化合物的微生物 |
| US20090253174A1 (en) * | 2008-04-08 | 2009-10-08 | Zach Serber | Expression of Heterologous Sequences |
| WO2009132220A2 (en) * | 2008-04-23 | 2009-10-29 | Danisco Us Inc. | Isoprene synthase variants for improved microbial production of isoprene |
| JP2011520455A (ja) | 2008-05-16 | 2011-07-21 | エルエス９・インコーポレイテッド | 炭化水素を製造するための方法および組成物 |
| CA2725175A1 (en) * | 2008-05-23 | 2009-11-26 | Cibus Oils, Llc | Production of squalene using yeast |
| JP5624980B2 (ja) * | 2008-06-30 | 2014-11-12 | ザ・グッドイヤー・タイヤ・アンド・ラバー・カンパニーＴｈｅ Ｇｏｏｄｙｅａｒｔｉｒｅ ＆ Ｒｕｂｂｅｒ Ｃｏｍｐａｎｙ | 再生資源に由来するイソプレンの重合体 |
| MX318543B (es) | 2008-07-02 | 2014-03-18 | Danisco Us Inc | Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros. |
| CA2737082A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| WO2010031062A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| KR101700296B1 (ko) | 2008-10-28 | 2017-01-26 | 알이지 라이프 사이언시스, 엘엘씨 | 지방족 알코올들을 생산하기 위한 방법들과 조성물들 |
| AU2010238770A1 (en) | 2009-04-23 | 2011-11-03 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| HUE034245T2 (en) * | 2009-11-23 | 2018-02-28 | Nucelis Llc | Methods and preparations for the preparation of squalene using yeast |
| EP2575432B1 (en) | 2010-06-02 | 2019-08-14 | Evolva, Inc. | Recombinant production of steviol glycosides |
| CA2816306A1 (en) | 2010-10-27 | 2012-05-03 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
| CA3128532A1 (en) | 2011-08-08 | 2013-02-14 | Evolva Sa | Recombinant production of steviol glycosides |
| IN2014CN01129A (https=) | 2011-08-08 | 2015-04-10 | Evolva Sa | |
| CN104039974B (zh) * | 2011-11-09 | 2016-10-12 | 阿迈瑞斯公司 | 乙酰辅酶a衍生的类异戊二烯的生产 |
| US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| JP5827601B2 (ja) * | 2012-07-04 | 2015-12-02 | 住友ゴム工業株式会社 | 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| CN103087972B (zh) | 2013-02-01 | 2014-11-05 | 中国科学院天津工业生物技术研究所 | 生产萜类化合物的重组微生物及构建方法 |
| MY199452A (en) | 2013-02-06 | 2023-10-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| BR112015019160A2 (pt) | 2013-02-11 | 2017-08-22 | Dalgaard Mikkelsen Michael | Produção de glicosídeos de esteviol em hospedeiros recombinantes |
| EP2970926B1 (en) | 2013-03-13 | 2018-01-31 | DSM Nutritional Products AG | Engineering microorganisms |
| JP6282813B2 (ja) * | 2013-07-16 | 2018-02-21 | 住友ゴム工業株式会社 | ヒドロキシメチルグルタリルＣｏＡレダクターゼの発現をｂＺＩＰ型転写因子により調整する方法、ｂＺＩＰ型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| CN103602626B (zh) * | 2013-10-12 | 2016-02-10 | 中国科学院青岛生物能源与过程研究所 | 一种以油脂为原料生产甲羟戊酸的方法及其构建的基因工程菌 |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2960693A1 (en) | 2014-09-09 | 2016-03-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3250686A1 (en) | 2015-01-30 | 2017-12-06 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| MX2018001620A (es) | 2015-08-07 | 2018-06-11 | Evolva Sa | Produccion de glucosidos de esteviol en hospedadores recombinantes. |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| CN106367508B (zh) * | 2016-09-13 | 2019-10-29 | 东北农业大学 | 一种用于鉴定杂合型类异戊二烯化合物产生菌的简并引物与应用 |
| WO2018083338A1 (en) | 2016-11-07 | 2018-05-11 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2019055325A2 (en) * | 2017-09-12 | 2019-03-21 | Biocapital Holdings, Llc | BIOOGICAL DEVICES AND METHODS OF USING THE SAME TO PRODUCE STEVIOL GLYCOSIDES |
| WO2019090286A2 (en) * | 2017-11-06 | 2019-05-09 | The Regents Of The University Of California | Production of valerenic acid in fungal cells |
| WO2019113387A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| JP2021506316A (ja) | 2017-12-21 | 2021-02-22 | ザイマージェン インコーポレイテッド | ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物 |
| CN109777815B (zh) * | 2019-03-28 | 2021-10-29 | 昆明理工大学 | HMG-CoA合成酶基因RKHMGCS及其应用 |
| CN117165502A (zh) * | 2022-05-26 | 2023-12-05 | 牛津大学(苏州)科技有限公司 | 一种合成萜类化合物的共培养系统和方法 |
| NL2032683B1 (en) * | 2022-07-18 | 2024-01-26 | Sestina Bio Llc | Bioproduction of isoprenoids |
| EP4565691A1 (en) * | 2022-11-14 | 2025-06-11 | Agency for Science, Technology and Research | Biosynthesis of isoprenoid |
| CN116925991B (zh) * | 2023-07-28 | 2024-08-09 | 天津大学 | 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用 |
| CN120041291A (zh) * | 2023-11-24 | 2025-05-27 | 牛津大学(苏州)科技有限公司 | 用于合成目标化合物的共培养系统和方法 |
| WO2025217176A1 (en) * | 2024-04-08 | 2025-10-16 | Board Of Trustees Of Michigan State University | Genetically engineered bacteria as a chassis host for high yield terpenoid production |
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| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| KR20060099543A (ko) | 1994-12-09 | 2006-09-19 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의 동정 |
| US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
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| GB9925453D0 (en) * | 1999-10-27 | 1999-12-29 | Univ Bristol | Increasing isoprenoid biosynthesis |
| WO2002010398A2 (en) * | 2000-07-31 | 2002-02-07 | Hahn Frederick M | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
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| US7238514B2 (en) * | 2001-01-05 | 2007-07-03 | William Marsh Rice University | Diterpene-producing unicellular organism |
| GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
| AU2002316966B2 (en) * | 2001-06-06 | 2007-05-17 | Dsm Ip Assets B.V. | Improved isoprenoid production |
| US20040110259A1 (en) | 2001-08-03 | 2004-06-10 | Baugh Mariah R | Drug metabolizing enzymes |
| US7172886B2 (en) * | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US7927794B2 (en) * | 2003-09-29 | 2011-04-19 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
-
2005
- 2005-05-20 AT AT05857432T patent/ATE537269T1/de active
- 2005-05-20 AU AU2005327292A patent/AU2005327292B2/en not_active Expired
- 2005-05-20 BR BRPI0510115-8A patent/BRPI0510115B1/pt not_active IP Right Cessation
- 2005-05-20 US US11/134,705 patent/US7183089B2/en not_active Expired - Lifetime
- 2005-05-20 CA CA2567547A patent/CA2567547C/en not_active Expired - Lifetime
- 2005-05-20 EP EP10177421A patent/EP2365090A1/en not_active Withdrawn
- 2005-05-20 WO PCT/US2005/017874 patent/WO2006085899A2/en not_active Ceased
- 2005-05-20 MX MXPA06013502A patent/MXPA06013502A/es active IP Right Grant
- 2005-05-20 CN CNA2005800243430A patent/CN101023181A/zh active Pending
- 2005-05-20 ES ES05857432T patent/ES2379368T3/es not_active Expired - Lifetime
- 2005-05-20 EP EP05857432A patent/EP1765418B1/en not_active Expired - Lifetime
- 2005-05-20 JP JP2007527501A patent/JP4926061B2/ja not_active Expired - Lifetime
-
2007
- 2007-01-17 US US11/624,094 patent/US7670825B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20060079476A1 (en) | 2006-04-13 |
| EP1765418B1 (en) | 2011-12-14 |
| US20090004724A1 (en) | 2009-01-01 |
| CN101023181A (zh) | 2007-08-22 |
| BRPI0510115B1 (pt) | 2022-09-27 |
| MXPA06013502A (es) | 2007-03-01 |
| US7670825B2 (en) | 2010-03-02 |
| JP4926061B2 (ja) | 2012-05-09 |
| EP1765418A4 (en) | 2008-07-02 |
| CA2567547A1 (en) | 2006-08-17 |
| EP2365090A1 (en) | 2011-09-14 |
| US7183089B2 (en) | 2007-02-27 |
| CA2567547C (en) | 2012-10-23 |
| WO2006085899A3 (en) | 2007-05-18 |
| WO2006085899A2 (en) | 2006-08-17 |
| AU2005327292B2 (en) | 2010-11-04 |
| BRPI0510115A (pt) | 2007-09-25 |
| ES2379368T3 (es) | 2012-04-25 |
| JP2008500063A (ja) | 2008-01-10 |
| EP1765418A2 (en) | 2007-03-28 |
| AU2005327292A1 (en) | 2006-08-17 |
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