AR039185A1 - Celulas hospedantes que tienen propiedades mejoradas de supervivencia celular y metodos para generar estas celulas - Google Patents
Celulas hospedantes que tienen propiedades mejoradas de supervivencia celular y metodos para generar estas celulasInfo
- Publication number
- AR039185A1 AR039185A1 ARP030101098A ARP030101098A AR039185A1 AR 039185 A1 AR039185 A1 AR 039185A1 AR P030101098 A ARP030101098 A AR P030101098A AR P030101098 A ARP030101098 A AR P030101098A AR 039185 A1 AR039185 A1 AR 039185A1
- Authority
- AR
- Argentina
- Prior art keywords
- cells
- methods
- host cells
- hospeding
- generate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Suspension/Interruption
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/48—Regulators of apoptosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Células hospedantes de mamífero tratadas por ingeniería genética, que comprenden un nivel aumentado de genes anti-apoptosis activos y a métodos para generar estas células hospedantes. Más particularmente, la invención se refiere a métodos que modulan el nivel de genes activos anti-apoptosis en células hospedantes y células hospedantes que muestran una viabilidad celular aumentada retrasando / inhibiendo la muerte celular programada que se produce de forma natural en estas células. Reivindicación 1: Una célula hospedante de hámster genéticamente modificada mediante la introducción de secuencias de ácidos nucleicos que codifican un gen anti-apoptosis, un gen marcador amplificable y seleccionable y al menos un gen de interés.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02007144A EP1348758A1 (en) | 2002-03-28 | 2002-03-28 | Host cells having improved cell survival properties and methods to generate such cells |
Publications (1)
Publication Number | Publication Date |
---|---|
AR039185A1 true AR039185A1 (es) | 2005-02-09 |
Family
ID=27798823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030101098A Suspension/Interruption AR039185A1 (es) | 2002-03-28 | 2003-03-28 | Celulas hospedantes que tienen propiedades mejoradas de supervivencia celular y metodos para generar estas celulas |
Country Status (19)
Country | Link |
---|---|
EP (2) | EP1348758A1 (es) |
JP (1) | JP2005521406A (es) |
KR (1) | KR101080626B1 (es) |
CN (1) | CN1646683A (es) |
AR (1) | AR039185A1 (es) |
AT (1) | ATE459705T1 (es) |
AU (1) | AU2003222777A1 (es) |
BR (1) | BR0308810A (es) |
CA (1) | CA2480684C (es) |
DE (1) | DE60331529D1 (es) |
DK (1) | DK1490482T3 (es) |
ES (1) | ES2339760T3 (es) |
IL (1) | IL163599A0 (es) |
MX (1) | MXPA04009336A (es) |
NZ (1) | NZ536077A (es) |
PE (1) | PE20040166A1 (es) |
TW (2) | TWI332990B (es) |
UY (1) | UY27739A1 (es) |
WO (1) | WO2003083093A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002315534B2 (en) | 2001-07-10 | 2008-05-22 | Biogen Idec Inc. | Inhibition of apoptosis process and improvement of cell performance |
KR100454016B1 (ko) * | 2002-01-05 | 2004-10-26 | 한국과학기술원 | 항예정사 유전자로 형질전환되고 dhfr 유전자가결핍된 신규한 cho 세포주, 그의 제조 방법 및 상기형질전환된 cho 숙주 세포를 이용한 목적단백질의 생산방법 |
JP2006503555A (ja) * | 2002-06-26 | 2006-02-02 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | タンパク質産生方法および使用するための改変細胞 |
WO2004062554A2 (en) * | 2003-01-08 | 2004-07-29 | Nsgene A/S | Enhancement of dopaminergic neuron generation and survital |
US7829306B2 (en) * | 2003-10-24 | 2010-11-09 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Protein highly producing recombinant animal cell, method for preparing the same, and method for mass-producing protein using the same |
US7531327B2 (en) * | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
US7608425B2 (en) | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
EP1953222A1 (en) | 2007-01-24 | 2008-08-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Improvement of cell growth |
EP2209891A1 (en) * | 2007-11-13 | 2010-07-28 | Boehringer Ingelheim Pharma GmbH & Co. KG | Improving the secretory capacity in host cells |
DK2331678T3 (en) * | 2008-06-13 | 2015-10-12 | Janssen Biotech Inc | PROCEDURES FOR Gaining High-Viable Cell Density in Mammalian Cell Culture |
US8962312B2 (en) | 2008-07-23 | 2015-02-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Production host cell lines |
CA2857640C (en) | 2011-12-02 | 2021-11-16 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
CN104673754B (zh) * | 2015-02-14 | 2018-03-02 | 百泰生物药业有限公司 | 重组骨髓瘤细胞克隆的筛选方法及由此获得的抗体分子 |
JP7214962B2 (ja) * | 2018-01-17 | 2023-01-31 | 東ソー株式会社 | アルカリホスファターゼ高発現動物細胞 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143291A (en) * | 1995-05-04 | 2000-11-07 | Us Navy | Methods for modulating T cell survival by modulating bcl-XL protein level |
AU5403100A (en) * | 1999-06-08 | 2000-12-28 | Novartis Ag | Enforced expression of bcl-xl |
-
2002
- 2002-03-28 EP EP02007144A patent/EP1348758A1/en not_active Withdrawn
-
2003
- 2003-03-25 BR BR0308810-3A patent/BR0308810A/pt not_active Expired - Fee Related
- 2003-03-25 NZ NZ536077A patent/NZ536077A/en unknown
- 2003-03-25 DE DE60331529T patent/DE60331529D1/de not_active Expired - Lifetime
- 2003-03-25 DK DK03718706.9T patent/DK1490482T3/da active
- 2003-03-25 ES ES03718706T patent/ES2339760T3/es not_active Expired - Lifetime
- 2003-03-25 AU AU2003222777A patent/AU2003222777A1/en not_active Abandoned
- 2003-03-25 CA CA2480684A patent/CA2480684C/en not_active Expired - Fee Related
- 2003-03-25 JP JP2003580529A patent/JP2005521406A/ja active Pending
- 2003-03-25 WO PCT/EP2003/003063 patent/WO2003083093A1/en active Application Filing
- 2003-03-25 IL IL16359903A patent/IL163599A0/xx unknown
- 2003-03-25 KR KR1020047015421A patent/KR101080626B1/ko not_active IP Right Cessation
- 2003-03-25 AT AT03718706T patent/ATE459705T1/de active
- 2003-03-25 CN CNA038068818A patent/CN1646683A/zh active Pending
- 2003-03-25 MX MXPA04009336A patent/MXPA04009336A/es not_active Application Discontinuation
- 2003-03-25 EP EP03718706A patent/EP1490482B1/en not_active Expired - Lifetime
- 2003-03-26 TW TW092106773A patent/TWI332990B/zh not_active IP Right Cessation
- 2003-03-26 TW TW098132019A patent/TWI332991B/zh not_active IP Right Cessation
- 2003-03-26 PE PE2003000306A patent/PE20040166A1/es not_active Application Discontinuation
- 2003-03-27 UY UY27739A patent/UY27739A1/es not_active Application Discontinuation
- 2003-03-28 AR ARP030101098A patent/AR039185A1/es not_active Suspension/Interruption
Also Published As
Publication number | Publication date |
---|---|
DK1490482T3 (da) | 2010-07-05 |
DE60331529D1 (de) | 2010-04-15 |
ATE459705T1 (de) | 2010-03-15 |
EP1490482A1 (en) | 2004-12-29 |
TWI332990B (en) | 2010-11-11 |
TW201000633A (en) | 2010-01-01 |
EP1490482B1 (en) | 2010-03-03 |
KR20040099373A (ko) | 2004-11-26 |
UY27739A1 (es) | 2003-10-31 |
CA2480684A1 (en) | 2003-10-09 |
CA2480684C (en) | 2011-01-25 |
EP1348758A1 (en) | 2003-10-01 |
ES2339760T3 (es) | 2010-05-25 |
KR101080626B1 (ko) | 2011-11-08 |
IL163599A0 (en) | 2005-12-18 |
MXPA04009336A (es) | 2005-01-25 |
CN1646683A (zh) | 2005-07-27 |
JP2005521406A (ja) | 2005-07-21 |
TW200307044A (en) | 2003-12-01 |
PE20040166A1 (es) | 2004-05-20 |
AU2003222777A1 (en) | 2003-10-13 |
WO2003083093A1 (en) | 2003-10-09 |
NZ536077A (en) | 2006-04-28 |
BR0308810A (pt) | 2005-06-28 |
TWI332991B (en) | 2010-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |