JP4845730B2 - Ｐｐａｒ活性化合物 - Google Patents

Ｐｐａｒ活性化合物 Download PDF

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Publication number
JP4845730B2
JP4845730B2 JP2006520413A JP2006520413A JP4845730B2 JP 4845730 B2 JP4845730 B2 JP 4845730B2 JP 2006520413 A JP2006520413 A JP 2006520413A JP 2006520413 A JP2006520413 A JP 2006520413A JP 4845730 B2 JP4845730 B2 JP 4845730B2
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compound
methoxy
indol
propionic acid
binding
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Japanese (ja)
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JP2007534625A (ja
Inventor
アーノルド，ジェームズ
アーティス，ディーン，アール
ハート，クラレンス
イブラヒム，プラバ，エヌ
クルプカ，ハイケ
リン，ジャック
ミルバーン，マイケル，ブイ
ワン，ウェイルー
ジャン，チャオ
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Plexxikon Inc
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Plexxikon Inc
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
JP2006520413A 2003-07-17 2004-07-16 Ｐｐａｒ活性化合物 Active JP4845730B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48852303P 2003-07-17 2003-07-17
US60/488,523 2003-07-17
US55299404P 2004-03-12 2004-03-12
US60/552,994 2004-03-12
PCT/US2004/023234 WO2005009958A1 (en) 2003-07-17 2004-07-16 Ppar active compounds

Publications (2)

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JP2007534625A JP2007534625A (ja) 2007-11-29
JP4845730B2 true JP4845730B2 (ja) 2011-12-28

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EP (1) EP1648867B1 (US07476746-20090113-C00054.png)
JP (1) JP4845730B2 (US07476746-20090113-C00054.png)
KR (2) KR20130023381A (US07476746-20090113-C00054.png)
CN (1) CN102875441A (US07476746-20090113-C00054.png)
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KR20130023381A (ko) 2003-07-17 2013-03-07 플렉시콘, 인코퍼레이티드 Ｐｐａｒ 활성 화합물
US7348338B2 (en) * 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
WO2005026193A2 (en) * 2003-09-08 2005-03-24 United States Army Medical Research And Materiel Command Small molecules and a pharmacophore model for inhibition of botulinum toxin and methods of making and using thereof
PE20060303A1 (es) 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
US7531568B2 (en) 2004-11-30 2009-05-12 Plexxikon, Inc. PPAR active compounds
EP1833787A2 (en) * 2004-11-30 2007-09-19 Plexxikon, Inc. Indole derivatives for use as ppar active compounds
WO2007010965A1 (ja) * 2005-07-22 2007-01-25 Shionogi & Co., Ltd. Ｐｇｄ２受容体アンタゴニスト活性を有するアザインドール酸誘導体
FR2890071B1 (fr) * 2005-08-30 2007-11-09 Fournier Sa Sa Lab Nouveaux composes de l'indole
FR2890072A1 (fr) 2005-09-01 2007-03-02 Fournier S A Sa Lab Nouveaux composesde pyrrolopyridine
CA2621474A1 (en) * 2005-09-07 2007-03-15 Plexxikon, Inc. 1,3-disubstituted indole derivatives for use as ppar modulators
EP1931658A2 (en) * 2005-09-07 2008-06-18 Plexxikon, Inc. 1 , 4 and 1 , 5-disubstituted indole derivatives for use as ppar active compounds
KR20080042170A (ko) * 2005-09-07 2008-05-14 플렉시콘, 인코퍼레이티드 Ｐｐａｒ 활성 화합물
JP5093096B2 (ja) 2006-03-02 2012-12-05 アステラス製薬株式会社 １７βＨＳＤｔｙｐｅ５阻害剤
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
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