JP4841037B2 - グリコシル化レプチン組成物および関連する方法 - Google Patents
グリコシル化レプチン組成物および関連する方法 Download PDFInfo
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- JP4841037B2 JP4841037B2 JP2000598639A JP2000598639A JP4841037B2 JP 4841037 B2 JP4841037 B2 JP 4841037B2 JP 2000598639 A JP2000598639 A JP 2000598639A JP 2000598639 A JP2000598639 A JP 2000598639A JP 4841037 B2 JP4841037 B2 JP 4841037B2
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
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- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- Biochemistry (AREA)
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- Emergency Medicine (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24967599A | 1999-02-12 | 1999-02-12 | |
| US09/249,675 | 1999-02-12 | ||
| PCT/US2000/003652 WO2000047741A1 (en) | 1999-02-12 | 2000-02-11 | Glycosylated leptin compositions and related methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002536018A JP2002536018A (ja) | 2002-10-29 |
| JP2002536018A5 JP2002536018A5 (https=) | 2006-11-30 |
| JP4841037B2 true JP4841037B2 (ja) | 2011-12-21 |
Family
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| JP2000598639A Expired - Fee Related JP4841037B2 (ja) | 1999-02-12 | 2000-02-11 | グリコシル化レプチン組成物および関連する方法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1151102B1 (https=) |
| JP (1) | JP4841037B2 (https=) |
| AT (1) | ATE323766T1 (https=) |
| AU (1) | AU781460B2 (https=) |
| CA (1) | CA2359840C (https=) |
| CY (1) | CY1107470T1 (https=) |
| DE (1) | DE60027409T2 (https=) |
| DK (1) | DK1151102T3 (https=) |
| ES (1) | ES2257287T3 (https=) |
| PT (1) | PT1151102E (https=) |
| WO (1) | WO2000047741A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| WO2003020303A1 (en) * | 2001-08-29 | 2003-03-13 | The University Of Buckingham | Use of leptin for infant with low birth weight for prevention of obesity |
| PT2219031E (pt) * | 2001-10-22 | 2013-05-17 | Amgen Inc | Uso de leptina para tratamento de lipoatrofia humana e método para determinar predisposição ao referido tratamento |
| US7094579B2 (en) * | 2002-02-13 | 2006-08-22 | Xoma Technology Ltd. | Eukaryotic signal sequences for prokaryotic expression |
| ATE521701T1 (de) | 2003-01-22 | 2011-09-15 | Univ Duke | Verbesserte konstrukte zur expression lysosomaler polypeptide |
| WO2005030963A1 (en) | 2003-09-26 | 2005-04-07 | Applied Research Systems Ars Holding N.V. | Leader sequences for use in production of proteins |
| US20080176790A1 (en) | 2004-10-29 | 2008-07-24 | Defrees Shawn | Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) |
| US8716220B2 (en) | 2005-09-07 | 2014-05-06 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta |
| US8642543B2 (en) | 2005-09-07 | 2014-02-04 | Neurotez, Inc. | Methods for treating progressive cognitive disorders related to neurofibrillary tangles |
| WO2008067599A1 (en) * | 2006-12-04 | 2008-06-12 | Apollo Life Sciences Limited | Isolated leptin and adiponectin molecules and chimeric molecules thereof |
| WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
| JP2009126856A (ja) * | 2007-11-28 | 2009-06-11 | Fancl Corp | 血中中性脂肪上昇抑制剤 |
| WO2009149379A2 (en) | 2008-06-05 | 2009-12-10 | Regents Of The University Of Michigan | Use of leptin for the treatment of fatty liver diseases and conditions |
| ES2630031T3 (es) | 2010-09-28 | 2017-08-17 | Aegerion Pharmaceuticals, Inc. | Un polipéptido de leptina pinnípedo-humano quimérico con solubilidad aumentada |
| CN108524919A (zh) | 2012-05-17 | 2018-09-14 | 延伸生物科学股份有限公司 | 用于改进的药物递送的载体 |
| RU2650646C2 (ru) | 2012-09-27 | 2018-04-16 | Дзе Чилдрен'З Медикал Сентер Корпорейшн | Соединения, предназначенные для лечения ожирения, и способы их применения |
| SI3074033T1 (sl) | 2013-11-26 | 2019-03-29 | The Children's Medical Center Corporation | Spojine za zdravljenje debelosti in postopki njihove uporabe |
| US20170209408A1 (en) | 2014-04-03 | 2017-07-27 | The Children's Medical Center Corporation | Hsp90 inhibitors for the treatment of obesity and methods of use thereof |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| CN110267674A (zh) * | 2016-07-08 | 2019-09-20 | 奥美药业有限公司 | 包含瘦素的融合蛋白及其生产和使用方法 |
| CA3036551A1 (en) | 2016-09-12 | 2018-03-15 | Aegerion Pharmaceuticals, Inc. | Methods of detecting anti-leptin neutralizing antibodies |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0576374A (ja) * | 1990-11-06 | 1993-03-30 | Eli Lilly & Co | 組織プラスミノーゲンアクチベーターの翻訳後プロセツシングを改変するための方法 |
| WO1996023815A1 (en) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Ob gene product antibodies |
| WO1997018833A1 (en) * | 1995-11-22 | 1997-05-29 | Amgen Inc. | Methods of increasing lean tissue mass using ob protein compositions |
| WO1997020933A2 (en) * | 1995-12-06 | 1997-06-12 | Schering Corporation | MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS |
| JPH09176198A (ja) * | 1995-12-28 | 1997-07-08 | Kikkoman Corp | 抗肥満タンパク質モノクローナル抗体及びハイブリドーマ |
| WO1997026916A1 (en) * | 1996-01-25 | 1997-07-31 | Eli Lilly And Company | Obesity protein analog compounds and formulations thereof |
| WO1998007446A1 (en) * | 1996-08-23 | 1998-02-26 | Eli Lilly And Company | Protein formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057534C (zh) * | 1993-08-17 | 2000-10-18 | 柯瑞英-艾格公司 | 促红细胞生成素类似物 |
| US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| WO1999023115A1 (en) * | 1997-10-31 | 1999-05-14 | Eli Lilly And Company | Glycosylated obesity protein analogs |
| JP4199421B2 (ja) * | 1998-08-10 | 2008-12-17 | アムジエン・インコーポレーテツド | デキストラン−レプチン結合体、医薬組成物および関連方法 |
| US6420339B1 (en) * | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
-
2000
- 2000-02-11 ES ES00911784T patent/ES2257287T3/es not_active Expired - Lifetime
- 2000-02-11 PT PT00911784T patent/PT1151102E/pt unknown
- 2000-02-11 JP JP2000598639A patent/JP4841037B2/ja not_active Expired - Fee Related
- 2000-02-11 WO PCT/US2000/003652 patent/WO2000047741A1/en not_active Ceased
- 2000-02-11 DK DK00911784T patent/DK1151102T3/da active
- 2000-02-11 AT AT00911784T patent/ATE323766T1/de active
- 2000-02-11 CA CA2359840A patent/CA2359840C/en not_active Expired - Fee Related
- 2000-02-11 AU AU33623/00A patent/AU781460B2/en not_active Ceased
- 2000-02-11 EP EP00911784A patent/EP1151102B1/en not_active Expired - Lifetime
- 2000-02-11 DE DE60027409T patent/DE60027409T2/de not_active Expired - Lifetime
-
2006
- 2006-07-07 CY CY20061100939T patent/CY1107470T1/el unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0576374A (ja) * | 1990-11-06 | 1993-03-30 | Eli Lilly & Co | 組織プラスミノーゲンアクチベーターの翻訳後プロセツシングを改変するための方法 |
| WO1996023815A1 (en) * | 1995-01-31 | 1996-08-08 | Eli Lilly And Company | Ob gene product antibodies |
| WO1997018833A1 (en) * | 1995-11-22 | 1997-05-29 | Amgen Inc. | Methods of increasing lean tissue mass using ob protein compositions |
| WO1997020933A2 (en) * | 1995-12-06 | 1997-06-12 | Schering Corporation | MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS |
| JPH09176198A (ja) * | 1995-12-28 | 1997-07-08 | Kikkoman Corp | 抗肥満タンパク質モノクローナル抗体及びハイブリドーマ |
| WO1997026916A1 (en) * | 1996-01-25 | 1997-07-31 | Eli Lilly And Company | Obesity protein analog compounds and formulations thereof |
| WO1998007446A1 (en) * | 1996-08-23 | 1998-02-26 | Eli Lilly And Company | Protein formulations |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60027409T2 (de) | 2007-04-12 |
| DE60027409D1 (de) | 2006-05-24 |
| CA2359840C (en) | 2012-10-23 |
| WO2000047741A1 (en) | 2000-08-17 |
| ATE323766T1 (de) | 2006-05-15 |
| AU781460B2 (en) | 2005-05-26 |
| EP1151102B1 (en) | 2006-04-19 |
| AU3362300A (en) | 2000-08-29 |
| DK1151102T3 (da) | 2006-05-29 |
| CY1107470T1 (el) | 2012-12-19 |
| JP2002536018A (ja) | 2002-10-29 |
| ES2257287T3 (es) | 2006-08-01 |
| CA2359840A1 (en) | 2000-08-17 |
| PT1151102E (pt) | 2006-07-31 |
| EP1151102A1 (en) | 2001-11-07 |
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