JP2002536018A5 - - Google Patents

Download PDF

Info

Publication number
JP2002536018A5
JP2002536018A5 JP2000598639A JP2000598639A JP2002536018A5 JP 2002536018 A5 JP2002536018 A5 JP 2002536018A5 JP 2000598639 A JP2000598639 A JP 2000598639A JP 2000598639 A JP2000598639 A JP 2000598639A JP 2002536018 A5 JP2002536018 A5 JP 2002536018A5
Authority
JP
Japan
Prior art keywords
glycosylated
seq
protein
nucleic acid
glycosylated leptin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000598639A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002536018A (ja
JP4841037B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/003652 external-priority patent/WO2000047741A1/en
Publication of JP2002536018A publication Critical patent/JP2002536018A/ja
Publication of JP2002536018A5 publication Critical patent/JP2002536018A5/ja
Application granted granted Critical
Publication of JP4841037B2 publication Critical patent/JP4841037B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2000598639A 1999-02-12 2000-02-11 グリコシル化レプチン組成物および関連する方法 Expired - Fee Related JP4841037B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24967599A 1999-02-12 1999-02-12
US09/249,675 1999-02-12
PCT/US2000/003652 WO2000047741A1 (en) 1999-02-12 2000-02-11 Glycosylated leptin compositions and related methods

Publications (3)

Publication Number Publication Date
JP2002536018A JP2002536018A (ja) 2002-10-29
JP2002536018A5 true JP2002536018A5 (https=) 2006-11-30
JP4841037B2 JP4841037B2 (ja) 2011-12-21

Family

ID=22944511

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000598639A Expired - Fee Related JP4841037B2 (ja) 1999-02-12 2000-02-11 グリコシル化レプチン組成物および関連する方法

Country Status (11)

Country Link
EP (1) EP1151102B1 (https=)
JP (1) JP4841037B2 (https=)
AT (1) ATE323766T1 (https=)
AU (1) AU781460B2 (https=)
CA (1) CA2359840C (https=)
CY (1) CY1107470T1 (https=)
DE (1) DE60027409T2 (https=)
DK (1) DK1151102T3 (https=)
ES (1) ES2257287T3 (https=)
PT (1) PT1151102E (https=)
WO (1) WO2000047741A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002079415A2 (en) * 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
WO2003020303A1 (en) * 2001-08-29 2003-03-13 The University Of Buckingham Use of leptin for infant with low birth weight for prevention of obesity
PT2219031E (pt) * 2001-10-22 2013-05-17 Amgen Inc Uso de leptina para tratamento de lipoatrofia humana e método para determinar predisposição ao referido tratamento
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
ATE521701T1 (de) 2003-01-22 2011-09-15 Univ Duke Verbesserte konstrukte zur expression lysosomaler polypeptide
WO2005030963A1 (en) 2003-09-26 2005-04-07 Applied Research Systems Ars Holding N.V. Leader sequences for use in production of proteins
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
US8716220B2 (en) 2005-09-07 2014-05-06 Nikolaos Tezapsidis Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta
US8642543B2 (en) 2005-09-07 2014-02-04 Neurotez, Inc. Methods for treating progressive cognitive disorders related to neurofibrillary tangles
WO2008067599A1 (en) * 2006-12-04 2008-06-12 Apollo Life Sciences Limited Isolated leptin and adiponectin molecules and chimeric molecules thereof
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
JP2009126856A (ja) * 2007-11-28 2009-06-11 Fancl Corp 血中中性脂肪上昇抑制剤
WO2009149379A2 (en) 2008-06-05 2009-12-10 Regents Of The University Of Michigan Use of leptin for the treatment of fatty liver diseases and conditions
ES2630031T3 (es) 2010-09-28 2017-08-17 Aegerion Pharmaceuticals, Inc. Un polipéptido de leptina pinnípedo-humano quimérico con solubilidad aumentada
CN108524919A (zh) 2012-05-17 2018-09-14 延伸生物科学股份有限公司 用于改进的药物递送的载体
RU2650646C2 (ru) 2012-09-27 2018-04-16 Дзе Чилдрен'З Медикал Сентер Корпорейшн Соединения, предназначенные для лечения ожирения, и способы их применения
SI3074033T1 (sl) 2013-11-26 2019-03-29 The Children's Medical Center Corporation Spojine za zdravljenje debelosti in postopki njihove uporabe
US20170209408A1 (en) 2014-04-03 2017-07-27 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
CN110267674A (zh) * 2016-07-08 2019-09-20 奥美药业有限公司 包含瘦素的融合蛋白及其生产和使用方法
CA3036551A1 (en) 2016-09-12 2018-03-15 Aegerion Pharmaceuticals, Inc. Methods of detecting anti-leptin neutralizing antibodies
EP4593867A2 (en) 2022-09-30 2025-08-06 Extend Biosciences, Inc. Long-acting parathyroid hormone

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326700A (en) * 1990-11-06 1994-07-05 Eli Lilly And Company DNA sequences encoding t-PA derivatives with cleavable sites
CN1057534C (zh) * 1993-08-17 2000-10-18 柯瑞英-艾格公司 促红细胞生成素类似物
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
AU4766596A (en) * 1995-01-31 1996-08-21 Eli Lilly And Company Ob gene product antibodies
WO1997018833A1 (en) * 1995-11-22 1997-05-29 Amgen Inc. Methods of increasing lean tissue mass using ob protein compositions
WO1997020933A2 (en) * 1995-12-06 1997-06-12 Schering Corporation MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS
JPH09176198A (ja) * 1995-12-28 1997-07-08 Kikkoman Corp 抗肥満タンパク質モノクローナル抗体及びハイブリドーマ
JP2000505791A (ja) * 1996-01-25 2000-05-16 イーライ・リリー・アンド・カンパニー 肥満症タンパク質類似体化合物およびその製剤
EP0827750A3 (en) * 1996-08-23 2002-11-20 Eli Lilly And Company Obesity protein formulations
WO1999023115A1 (en) * 1997-10-31 1999-05-14 Eli Lilly And Company Glycosylated obesity protein analogs
JP4199421B2 (ja) * 1998-08-10 2008-12-17 アムジエン・インコーポレーテツド デキストラン−レプチン結合体、医薬組成物および関連方法
US6420339B1 (en) * 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility

Similar Documents

Publication Publication Date Title
JP2002536018A5 (https=)
CA2359840A1 (en) Glycosylated leptin compositions and related methods
CN1119421C (zh) 生长激素和血清白蛋白重组融合蛋白
Kontermann Half-life extended biotherapeutics
Chen et al. Fusion protein linkers: property, design and functionality
CN102939304B (zh) 白蛋白衍生物和变体
CA2288992A1 (en) Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
CN102164949B (zh) 新型重组融合蛋白
RU2007132188A (ru) Конъюгаты биологически активных белков, имеющие модифицированное время полужизни in vivo
JP4156024B2 (ja) 修飾されたタンパク質及びペプチド医薬品
CN101255197B (zh) 血清白蛋白与白介素1受体拮抗剂的融合蛋白及应用
AU2020407365B2 (en) Ultra-long acting insulin-Fc fusion proteins and methods of use
CA2304254A1 (en) Trimerising module
ATE169959T1 (de) Anthrax-toxin-fusionsproteine und deren verwendungen
JP2007500744A5 (https=)
Huang et al. Preparation and characterization of a potent, long-lasting recombinant human serum albumin-interferon-α2b fusion protein expressed in Pichia pastoris
JP2018527288A (ja) 極性の組換え延長部を有するインスリン
WO2014165093A2 (en) Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto
TW201336865A (zh) 免疫球蛋白Ｆｃ變體
JP2009525052A5 (https=)
CN103641896B (zh) 明胶样单元的用途
US20210284690A1 (en) Fusion protein with half-life extending polypeptide
CN105524147B (zh) 重组聚多肽及其应用
US10618970B2 (en) Method of treating cancer with IL-10 and antibodies that induce ADCC
EP4441084A2 (en) Il10 variants and uses thereof