JP2009525052A5 - - Google Patents
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- Publication number
- JP2009525052A5 JP2009525052A5 JP2008553393A JP2008553393A JP2009525052A5 JP 2009525052 A5 JP2009525052 A5 JP 2009525052A5 JP 2008553393 A JP2008553393 A JP 2008553393A JP 2008553393 A JP2008553393 A JP 2008553393A JP 2009525052 A5 JP2009525052 A5 JP 2009525052A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- polypeptide
- polynucleotide
- interest
- chorionic gonadotropin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 84
- 229920001184 polypeptide Polymers 0.000 claims 41
- 102000004196 processed proteins & peptides Human genes 0.000 claims 41
- 239000002157 polynucleotide Substances 0.000 claims 23
- 102000040430 polynucleotide Human genes 0.000 claims 23
- 108091033319 polynucleotide Proteins 0.000 claims 23
- 101800005309 Carboxy-terminal peptide Proteins 0.000 claims 19
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 17
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 17
- 229940015047 chorionic gonadotropin Drugs 0.000 claims 17
- 102100028471 Eosinophil peroxidase Human genes 0.000 claims 9
- 210000004899 c-terminal region Anatomy 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 5
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 4
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 4
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 4
- 108010050904 Interferons Proteins 0.000 claims 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 230000004071 biological effect Effects 0.000 claims 4
- 230000002503 metabolic effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108010051696 Growth Hormone Proteins 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229960004407 chorionic gonadotrophin Drugs 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76476106P | 2006-02-03 | 2006-02-03 | |
| US60/764,761 | 2006-02-03 | ||
| PCT/US2007/003014 WO2007094985A2 (en) | 2006-02-03 | 2007-02-05 | Long-acting polypeptides and methods of producing and administering same |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015096597A Division JP6188741B2 (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015096578A Division JP2015155458A (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015096615A Division JP6333214B2 (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015247398A Division JP6182200B2 (ja) | 2006-02-03 | 2015-12-18 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009525052A JP2009525052A (ja) | 2009-07-09 |
| JP2009525052A5 true JP2009525052A5 (https=) | 2012-01-19 |
| JP5905185B2 JP5905185B2 (ja) | 2016-04-20 |
Family
ID=38345655
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553393A Active JP5905185B2 (ja) | 2006-02-03 | 2007-02-05 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015096615A Expired - Fee Related JP6333214B2 (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015096597A Expired - Fee Related JP6188741B2 (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015096578A Withdrawn JP2015155458A (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015247398A Active JP6182200B2 (ja) | 2006-02-03 | 2015-12-18 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015096615A Expired - Fee Related JP6333214B2 (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015096597A Expired - Fee Related JP6188741B2 (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015096578A Withdrawn JP2015155458A (ja) | 2006-02-03 | 2015-05-11 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
| JP2015247398A Active JP6182200B2 (ja) | 2006-02-03 | 2015-12-18 | 長期間作用型ポリペプチド並びにその製造方法及び投与方法。 |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US7553941B2 (https=) |
| EP (8) | EP2471807B1 (https=) |
| JP (5) | JP5905185B2 (https=) |
| KR (5) | KR101651978B1 (https=) |
| CN (3) | CN104292340A (https=) |
| AU (1) | AU2007215466C1 (https=) |
| CA (2) | CA2641342C (https=) |
| DK (3) | DK2471807T3 (https=) |
| ES (5) | ES2663365T3 (https=) |
| HK (1) | HK1205945A1 (https=) |
| HU (1) | HUE048307T2 (https=) |
| IL (5) | IL193198A (https=) |
| PL (2) | PL3202779T3 (https=) |
| PT (2) | PT3202779T (https=) |
| SI (3) | SI3202779T1 (https=) |
| WO (2) | WO2007092252A2 (https=) |
Families Citing this family (40)
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| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8476234B2 (en) * | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
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| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8450269B2 (en) * | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
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| AU2015201906B2 (en) * | 2009-07-09 | 2017-07-13 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| EP4488289A3 (en) * | 2012-02-14 | 2025-03-19 | OPKO Biologics Ltd. | Long-acting coagulation factors and uses thereof |
| BR112014025951A2 (pt) * | 2012-04-19 | 2017-07-11 | Opko Biologics Ltd | variantes de oxintomodulina de longa ação e métodos de produção do mesmo |
| EA033788B1 (ru) * | 2012-11-20 | 2019-11-26 | Opko Biologics Ltd | Способ увеличения гидродинамического объема полипептида путем присоединения карбоксиконцевого пептида гонадотропина |
| CN103864913A (zh) * | 2012-12-18 | 2014-06-18 | 联亚生技开发股份有限公司 | 重组蛋白 |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US20150126444A1 (en) * | 2013-10-21 | 2015-05-07 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| RU2746943C2 (ru) * | 2013-10-21 | 2021-04-22 | Опко Байолоджикс Лтд. | Полипептиды длительного действия и способы их получения и введения |
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| CN105440138A (zh) * | 2014-09-30 | 2016-03-30 | 复旦大学 | 一种长效内皮抑素融合蛋白的制备方法和用途 |
| JP7000153B2 (ja) * | 2014-12-10 | 2022-01-19 | オプコ バイオロジクス リミテッド | 長時間作用性ｃｔｐ修飾成長ホルモンポリペプチドを生成する方法 |
| HRP20230405T8 (hr) | 2014-12-10 | 2023-09-29 | Opko Biologics Ltd. | Metode proizvodnje dugo djelujućih ctp-modificiranih polipeptida hormona rasta |
| ES2893616T3 (es) * | 2015-06-19 | 2022-02-09 | Opko Biologics Ltd | Factores de coagulación de acción prolongada y métodos para la producción de los mismos |
| MY206271A (en) | 2016-07-11 | 2024-12-06 | Opko Biologics Ltd | Long-acting coagulation factor vii and methods of producing same |
| JP2020507350A (ja) * | 2017-02-10 | 2020-03-12 | ヴィヴィババ インコーポレイテッド | 組換え神経成長因子のための組成物及び方法 |
| JP7555398B2 (ja) * | 2019-08-30 | 2024-09-24 | シンテックス エス．エー． | 組換え絨毛性性腺刺激ホルモン、その調製のための方法、医薬組成物、及び使用 |
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