JP2011501959A5 - - Google Patents
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- JP2011501959A5 JP2011501959A5 JP2010532056A JP2010532056A JP2011501959A5 JP 2011501959 A5 JP2011501959 A5 JP 2011501959A5 JP 2010532056 A JP2010532056 A JP 2010532056A JP 2010532056 A JP2010532056 A JP 2010532056A JP 2011501959 A5 JP2011501959 A5 JP 2011501959A5
- Authority
- JP
- Japan
- Prior art keywords
- albumin
- fusion protein
- seq
- fragment
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108010088751 Albumins Proteins 0.000 claims 105
- 102000009027 Albumins Human genes 0.000 claims 105
- 108020001507 fusion proteins Proteins 0.000 claims 47
- 102000037865 fusion proteins Human genes 0.000 claims 47
- 150000001413 amino acids Chemical group 0.000 claims 34
- 239000012634 fragment Substances 0.000 claims 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 26
- 102000002723 Atrial Natriuretic Factor Human genes 0.000 claims 14
- 101800001288 Atrial natriuretic factor Proteins 0.000 claims 14
- 101800001890 Atrial natriuretic peptide Proteins 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 8
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 229960003920 cocaine Drugs 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 3
- 230000000747 cardiac effect Effects 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 241000972773 Aulopiformes Species 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 101000693916 Gallus gallus Albumin Proteins 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 101000930455 Ovis aries Albumin Proteins 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 208000033626 Renal failure acute Diseases 0.000 claims 2
- 201000011040 acute kidney failure Diseases 0.000 claims 2
- 208000012998 acute renal failure Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 208000008784 apnea Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000001784 detoxification Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 230000009610 hypersensitivity Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 claims 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims 2
- 235000019515 salmon Nutrition 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- 208000003918 Acute Kidney Tubular Necrosis Diseases 0.000 claims 1
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims 1
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010003162 Arterial injury Diseases 0.000 claims 1
- 102000021944 Butyrylcholinesterase Human genes 0.000 claims 1
- 108010053652 Butyrylcholinesterase Proteins 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 206010016803 Fluid overload Diseases 0.000 claims 1
- 208000022461 Glomerular disease Diseases 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims 1
- 208000007201 Myocardial reperfusion injury Diseases 0.000 claims 1
- 206010070606 Post stroke depression Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010038540 Renal tubular necrosis Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010047139 Vasoconstriction Diseases 0.000 claims 1
- 208000033774 Ventricular Remodeling Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 229960002478 aldosterone Drugs 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 231100000852 glomerular disease Toxicity 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000025033 vasoconstriction Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/932,823 US20080194481A1 (en) | 2001-12-21 | 2007-10-31 | Albumin Fusion Proteins |
| PCT/US2008/012306 WO2009058322A1 (en) | 2007-10-31 | 2008-10-30 | Albumin fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013233069A Division JP5856131B2 (ja) | 2007-10-31 | 2013-11-11 | アルブミン融合タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011501959A JP2011501959A (ja) | 2011-01-20 |
| JP2011501959A5 true JP2011501959A5 (https=) | 2011-12-15 |
Family
ID=40591364
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532056A Pending JP2011501959A (ja) | 2007-10-31 | 2008-10-30 | アルブミン融合タンパク質 |
| JP2013233069A Active JP5856131B2 (ja) | 2007-10-31 | 2013-11-11 | アルブミン融合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013233069A Active JP5856131B2 (ja) | 2007-10-31 | 2013-11-11 | アルブミン融合タンパク質 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20080194481A1 (https=) |
| EP (1) | EP2211888A4 (https=) |
| JP (2) | JP2011501959A (https=) |
| AU (1) | AU2008319332B2 (https=) |
| CA (1) | CA2703943A1 (https=) |
| IL (1) | IL204839A0 (https=) |
| WO (1) | WO2009058322A1 (https=) |
Families Citing this family (98)
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2010
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2013
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